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Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries.

De Backer G, Jankowski P, Kotseva K, Mirrakhimov E, Reiner Ž, Rydén L, Tokgözoğlu L, Wood D, De Bacquer D; EUROASPIRE V collaborators; Writing Committee; Scientific Steering/ Executive Committee; Coordinating centre; Diabetes centre; Data management centre; Statistical analysis centre; Central laboratory; Study centres, organisations, investigators and other research personnel (National Co-ordinators in each country are indicated by asterisk.

Atherosclerosis. 2019 Jun;285:135-146. doi: 10.1016/j.atherosclerosis.2019.03.014. Epub 2019 Apr 24.


Replica moulded poly(dimethylsiloxane) microwell arrays induce localized endothelial cell immobilization for coculture with pancreatic islets.

Burzava ALS, Forget A, Harding FJ, Cockshell MP, Penko D, Rouzaud C, Ahmadi V, Marina PF, Rojas-Canales D, Bonder CS, Coates PTH, Waibel M, Thomas HE, Kay TW, Loudovaris T, Blencowe A, Voelcker NH.

Biointerphases. 2019 Jan 30;14(1):011002. doi: 10.1116/1.5087737.


Balancing yield, purity and practicality: a modified differential ultracentrifugation protocol for efficient isolation of small extracellular vesicles from human serum.

Langevin SM, Kuhnell D, Orr-Asman MA, Biesiada J, Zhang X, Medvedovic M, Thomas HE.

RNA Biol. 2019 Jan;16(1):5-12. doi: 10.1080/15476286.2018.1564465. Epub 2019 Jan 13.


IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4+ T Cell Migration.

Scott NA, Zhao Y, Krishnamurthy B, Mannering SI, Kay TWH, Thomas HE.

Front Immunol. 2018 Nov 28;9:2800. doi: 10.3389/fimmu.2018.02800. eCollection 2018.


Type I Interferon Signaling Is Required for Dacryoadenitis in the Nonobese Diabetic Mouse Model of Sjögren Syndrome.

Chaly Y, Barr JY, Sullivan DA, Thomas HE, Brodnicki TC, Lieberman SM.

Int J Mol Sci. 2018 Oct 20;19(10). pii: E3259. doi: 10.3390/ijms19103259.


Proinsulin C-peptide is an autoantigen in people with type 1 diabetes.

So M, Elso CM, Tresoldi E, Pakusch M, Pathiraja V, Wentworth JM, Harrison LC, Krishnamurthy B, Thomas HE, Rodda C, Cameron FJ, McMahon J, Kay TWH, Mannering SI.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10732-10737. doi: 10.1073/pnas.1809208115. Epub 2018 Oct 1.


Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology.

Zhang C, Seo J, Murakami K, Salem ESB, Bernhard E, Borra VJ, Choi K, Yuan CL, Chan CC, Chen X, Huang T, Weirauch MT, Divanovic S, Qi NR, Thomas HE, Mercer CA, Siomi H, Nakamura T.

Nat Commun. 2018 Sep 10;9(1):3658. doi: 10.1038/s41467-018-05870-6.


Mitochondrial Complex I Activity Is Required for Maximal Autophagy.

Thomas HE, Zhang Y, Stefely JA, Veiga SR, Thomas G, Kozma SC, Mercer CA.

Cell Rep. 2018 Aug 28;24(9):2404-2417.e8. doi: 10.1016/j.celrep.2018.07.101.


An update on cardiac implantable electronic devices for the general physician.

Peal JE, Mathews IG, Runnett C, Thomas HE, Ripley DP.

J R Coll Physicians Edinb. 2018 Jun;48(2):141-147. doi: 10.4997/JRCPE.2018.208.


Expression of miR-206 in human islets and its role in glucokinase regulation.

Joglekar MV, Wong WKM, Maynard CL, Umrani MR, Martin D, Loudovaris T, Thomas HE, Dalgaard LT, Hardikar AA.

Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E634-E637. doi: 10.1152/ajpendo.00152.2018. Epub 2018 Jul 10.


Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.

Veiga SR, Ge X, Mercer CA, Hernández-Álvarez MI, Thomas HE, Hernandez-Losa J, Ramón Y Cajal S, Zorzano A, Thomas G, Kozma SC.

Clin Cancer Res. 2018 Aug 1;24(15):3767-3780. doi: 10.1158/1078-0432.CCR-18-0177. Epub 2018 Apr 24.


Immune checkpoint inhibitors in large cell neuroendocrine carcinoma: current status.

Chauhan A, Arnold SM, Kolesar J, Thomas HE, Evers M, Anthony L.

Oncotarget. 2018 Feb 22;9(18):14738-14740. doi: 10.18632/oncotarget.24553. eCollection 2018 Mar 6.


NF-κB is weakly activated in the NOD mouse model of type 1 diabetes.

Irvin AE, Jhala G, Zhao Y, Blackwell TS, Krishnamurthy B, Thomas HE, Kay TWH.

Sci Rep. 2018 Mar 9;8(1):4217. doi: 10.1038/s41598-018-22738-3.


Oxygen-permeable microwell device maintains islet mass and integrity during shipping.

Rojas-Canales DM, Waibel M, Forget A, Penko D, Nitschke J, Harding FJ, Delalat B, Blencowe A, Loudovaris T, Grey ST, Thomas HE, Kay TWH, Drogemuller CJ, Voelcker NH, Coates PT.

Endocr Connect. 2018 Mar;7(3):490-503. doi: 10.1530/EC-17-0349. Epub 2018 Feb 26.


Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans.

Simeonovic CJ, Popp SK, Starrs LM, Brown DJ, Ziolkowski AF, Ludwig B, Bornstein SR, Wilson JD, Pugliese A, Kay TWH, Thomas HE, Loudovaris T, Choong FJ, Freeman C, Parish CR.

PLoS One. 2018 Feb 7;13(2):e0191360. doi: 10.1371/journal.pone.0191360. eCollection 2018.


Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells.

Augstein P, Loudovaris T, Bandala-Sanchez E, Heinke P, Naselli G, Lee L, Hawthorne WJ, Góñez LJ, Neale AM, Vaillant F, Thomas HE, Kay TW, Banakh I, Harrison LC.

Pancreas. 2018 Jan;47(1):25-34. doi: 10.1097/MPA.0000000000000950.


Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice.

Wali JA, Galic S, Tan CY, Gurzov EN, Frazier AE, Connor T, Ge J, Pappas EG, Stroud D, Varanasi LC, Selck C, Ryan MT, Thorburn DR, Kemp BE, Krishnamurthy B, Kay TW, McGee SL, Thomas HE.

Cell Death Differ. 2018 Jan;25(1):217-225. doi: 10.1038/cdd.2017.168. Epub 2017 Oct 20.


JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity.

Litwak SA, Pang L, Galic S, Igoillo-Esteve M, Stanley WJ, Turatsinze JV, Loh K, Thomas HE, Sharma A, Trepo E, Moreno C, Gough DJ, Eizirik DL, de Haan JB, Gurzov EN.

Diabetes. 2017 Dec;66(12):2973-2986. doi: 10.2337/db17-0348. Epub 2017 Sep 19.


Inhibition of Y1 receptor signaling improves islet transplant outcome.

Loh K, Shi YC, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan JY, Gurzov EN, Thomas HE, Waibel M, Cantley J, Kay TW, Yada T, Laybutt DR, Grey ST, Herzog H.

Nat Commun. 2017 Sep 8;8(1):490. doi: 10.1038/s41467-017-00624-2.


mTOR Kinase Inhibition Effectively Decreases Progression of a Subset of Neuroendocrine Tumors that Progress on Rapalog Therapy and Delays Cardiac Impairment.

Orr-Asman MA, Chu Z, Jiang M, Worley M, LaSance K, Koch SE, Carreira VS, Dahche HM, Plas DR, Komurov K, Qi X, Mercer CA, Anthony LB, Rubinstein J, Thomas HE.

Mol Cancer Ther. 2017 Nov;16(11):2432-2441. doi: 10.1158/1535-7163.MCT-17-0058. Epub 2017 Sep 1.


Differential regulation of pro-inflammatory cytokine signalling by protein tyrosine phosphatases in pancreatic β-cells.

Stanley WJ, Trivedi PM, Sutherland AP, Thomas HE, Gurzov EN.

J Mol Endocrinol. 2017 Nov;59(4):325-337. doi: 10.1530/JME-17-0089. Epub 2017 Aug 21.


Transplantation sites for human and murine islets.

Stokes RA, Cheng K, Lalwani A, Swarbrick MM, Thomas HE, Loudovaris T, Kay TW, Hawthorne WJ, O'Connell PJ, Gunton JE.

Diabetologia. 2017 Oct;60(10):1961-1971. doi: 10.1007/s00125-017-4362-8. Epub 2017 Jul 22.


Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway.

Mollah ZUA, Quah HS, Graham KL, Jhala G, Krishnamurthy B, Dharma JFM, Chee J, Trivedi PM, Pappas EG, Mackin L, Chu EPF, Akazawa S, Fynch S, Hodson C, Deans AJ, Trapani JA, Chong MMW, Bird PI, Brodnicki TC, Thomas HE, Kay TWH.

Diabetes. 2017 Dec;66(12):3041-3050. doi: 10.2337/db17-0517. Epub 2017 Jul 21.


A Phase Ib Study of the Dual PI3K/mTOR Inhibitor Dactolisib (BEZ235) Combined with Everolimus in Patients with Advanced Solid Malignancies.

Wise-Draper TM, Moorthy G, Salkeni MA, Karim NA, Thomas HE, Mercer CA, Beg MS, O'Gara S, Olowokure O, Fathallah H, Kozma SC, Thomas G, Rixe O, Desai P, Morris JC.

Target Oncol. 2017 Jun;12(3):323-332. doi: 10.1007/s11523-017-0482-9.


Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice.

Trivedi PM, Graham KL, Scott NA, Jenkins MR, Majaw S, Sutherland RM, Fynch S, Lew AM, Burns CJ, Krishnamurthy B, Brodnicki TC, Mannering SI, Kay TW, Thomas HE.

Diabetes. 2017 Jun;66(6):1650-1660. doi: 10.2337/db16-1250. Epub 2017 Mar 14.


Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia.

Liu H, Feng X, Ennis KN, Behrmann CA, Sarma P, Jiang TT, Kofuji S, Niu L, Stratton Y, Thomas HE, Yoon SO, Sasaki AT, Plas DR.

Cell Rep. 2017 Feb 28;18(9):2088-2095. doi: 10.1016/j.celrep.2017.02.022.


Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility.

Chu EP, Elso CM, Pollock AH, Alsayb MA, Mackin L, Thomas HE, Kay TW, Silveira PA, Mansell AS, Gaus K, Brodnicki TC.

Mol Immunol. 2017 Feb;82:19-33. doi: 10.1016/j.molimm.2016.12.007. Epub 2016 Dec 19.


Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes.

Jhala G, Chee J, Trivedi PM, Selck C, Gurzov EN, Graham KL, Thomas HE, Kay TW, Krishnamurthy B.

JCI Insight. 2016 Jul 7;1(10):e86065. doi: 10.1172/jci.insight.86065.


Genetic strategies to bring islet xenotransplantation to the clinic.

Hawthorne WJ, Lew AM, Thomas HE.

Curr Opin Organ Transplant. 2016 Oct;21(5):476-83. doi: 10.1097/MOT.0000000000000353. Review.


Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling.

Pane JA, Fleming FE, Graham KL, Thomas HE, Kay TW, Coulson BS.

Sci Rep. 2016 Jul 13;6:29697. doi: 10.1038/srep29697.


Bias in determining aluminum concentrations: Comparison of digestion methods and implications on Al management.

He YT, Ziemkiewicz PF.

Chemosphere. 2016 Sep;159:570-576. doi: 10.1016/j.chemosphere.2016.06.052. Epub 2016 Jun 22.


How to Make Mice Tell the Truth.

Thomas HE, Brodnicki TC, Kay TW.

Diabetes. 2016 May;65(5):1161-3. doi: 10.2337/dbi16-0001. No abstract available.


Artificial cloud test confirms volcanic ash detection using infrared spectral imaging.

Prata AJ, Dezitter F, Davies I, Weber K, Birnfeld M, Moriano D, Bernardo C, Vogel A, Prata GS, Mather TA, Thomas HE, Cammas J, Weber M.

Sci Rep. 2016 May 9;6:25620. doi: 10.1038/srep25620.


p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.

Litwak SA, Loh K, Stanley WJ, Pappas EG, Wali JA, Selck C, Strasser A, Thomas HE, Gurzov EN.

Sci Rep. 2016 Apr 1;6:23802. doi: 10.1038/srep23802.


The JAK/STAT pathway in obesity and diabetes.

Gurzov EN, Stanley WJ, Pappas EG, Thomas HE, Gough DJ.

FEBS J. 2016 Aug;283(16):3002-15. doi: 10.1111/febs.13709. Epub 2016 Apr 1. Review.


Human islet cells are killed by BID-independent mechanisms in response to FAS ligand.

Joglekar MV, Trivedi PM, Kay TW, Hawthorne WJ, O'Connell PJ, Jenkins AJ, Hardikar AA, Thomas HE.

Apoptosis. 2016 Apr;21(4):379-89. doi: 10.1007/s10495-016-1212-y.


Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells.

Augstein P, Naselli G, Loudovaris T, Hawthorne WJ, Campbell P, Bandala-Sanchez E, Rogers K, Heinke P, Thomas HE, Kay TW, Harrison LC.

Diabetes Res Clin Pract. 2015 Dec;110(3):291-300. doi: 10.1016/j.diabres.2015.10.010. Epub 2015 Oct 26.


Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes.

Trivedi P, Graham KL, Krishnamurthy B, Fynch S, Slattery RM, Kay TW, Thomas HE.

Immunol Cell Biol. 2016 Apr;94(4):334-41. doi: 10.1038/icb.2015.89. Epub 2015 Oct 8.


Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes.

Pang D, Irvine KM, Mehdi AM, Thomas HE, Harris M, Hamilton-Williams EE, Thomas R.

Clin Transl Immunology. 2015 Aug 28;4(8):e41. doi: 10.1038/cti.2015.17. eCollection 2015 Aug.


Pancreatic Alpha Cells Hold the Key to Survival.

Wali JA, Thomas HE.

EBioMedicine. 2015 Apr 22;2(5):368-9. doi: 10.1016/j.ebiom.2015.04.014. eCollection 2015 May. No abstract available.


Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

Scott JW, Galic S, Graham KL, Foitzik R, Ling NX, Dite TA, Issa SM, Langendorf CG, Weng QP, Thomas HE, Kay TW, Birnberg NC, Steinberg GR, Kemp BE, Oakhill JS.

Chem Biol. 2015 Jun 18;22(6):705-11. doi: 10.1016/j.chembiol.2015.05.011.


Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.

Litwak SA, Wali JA, Pappas EG, Saadi H, Stanley WJ, Varanasi LC, Kay TW, Thomas HE, Gurzov EN.

J Diabetes Res. 2015;2015:280615. doi: 10.1155/2015/280615. Epub 2015 May 6.


A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy.

Farr RJ, Januszewski AS, Joglekar MV, Liang H, McAulley AK, Hewitt AW, Thomas HE, Loudovaris T, Kay TW, Jenkins A, Hardikar AA.

Sci Rep. 2015 Jun 2;5:10375. doi: 10.1038/srep10375.


Mouse pancreatic beta cells express MHC class II and stimulate CD4(+) T cells to proliferate.

Zhao Y, Scott NA, Quah HS, Krishnamurthy B, Bond F, Loudovaris T, Mannering SI, Kay TW, Thomas HE.

Eur J Immunol. 2015 Sep;45(9):2494-503. doi: 10.1002/eji.201445378. Epub 2015 May 28.


Evolution of water chemistry during Marcellus Shale gas development: A case study in West Virginia.

Ziemkiewicz PF, Thomas He Y.

Chemosphere. 2015 Sep;134:224-31. doi: 10.1016/j.chemosphere.2015.04.040. Epub 2015 May 15.


BIM Deficiency Protects NOD Mice From Diabetes by Diverting Thymocytes to Regulatory T Cells.

Krishnamurthy B, Chee J, Jhala G, Trivedi P, Catterall T, Selck C, Gurzov EN, Brodnicki TC, Graham KL, Wali JA, Zhan Y, Gray D, Strasser A, Allison J, Thomas HE, Kay TW.

Diabetes. 2015 Sep;64(9):3229-38. doi: 10.2337/db14-1851. Epub 2015 May 6.


Measuring death of pancreatic beta cells in response to stress and cytotoxic T cells.

Wali JA, Trivedi P, Kay TW, Thomas HE.

Methods Mol Biol. 2015;1292:165-76. doi: 10.1007/978-1-4939-2522-3_12.


Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets.

Stanley WJ, Litwak SA, Quah HS, Tan SM, Kay TW, Tiganis T, de Haan JB, Thomas HE, Gurzov EN.

Diabetes. 2015 Jul;64(7):2489-96. doi: 10.2337/db14-1575. Epub 2015 Mar 2.


Investigation of MCHM transport mechanisms and fate: implications for coal beneficiation.

He YT, Noble A, Ziemkiewicz P.

Chemosphere. 2015 May;127:158-63. doi: 10.1016/j.chemosphere.2015.01.054. Epub 2015 Feb 17.


Protein tyrosine phosphatases: molecular switches in metabolism and diabetes.

Gurzov EN, Stanley WJ, Brodnicki TC, Thomas HE.

Trends Endocrinol Metab. 2015 Jan;26(1):30-9. Review.


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