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Items: 1 to 50 of 440

1.

An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing.

Waise S, Parker R, Rose-Zerilli MJJ, Layfield DM, Wood O, West J, Ottensmeier CH, Thomas GJ, Hanley CJ.

Sci Rep. 2019 Jul 3;9(1):9580. doi: 10.1038/s41598-019-45842-4.

2.

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer.

Clarke J, Panwar B, Madrigal A, Singh D, Gujar R, Wood O, Chee SJ, Eschweiler S, King EV, Awad AS, Hanley CJ, McCann KJ, Bhattacharyya S, Woo E, Alzetani A, Seumois G, Thomas GJ, Ganesan AP, Friedmann PS, Sanchez-Elsner T, Ay F, Ottensmeier CH, Vijayanand P.

J Exp Med. 2019 Jun 21. pii: jem.20190249. doi: 10.1084/jem.20190249. [Epub ahead of print]

PMID:
31227543
3.

HPV Epitope Processing Differences Correlate with ERAP1 Allotype and Extent of CD8+ T-cell Tumor Infiltration in OPSCC.

Reeves E, Wood O, Ottensmeier CH, King EV, Thomas GJ, Elliott T, James E.

Cancer Immunol Res. 2019 Jul;7(7):1202-1213. doi: 10.1158/2326-6066.CIR-18-0498. Epub 2019 May 31.

PMID:
31151965
4.

Survey of UK histopathology consultants' attitudes towards academic and molecular pathology.

Brockmoeller S, Young C, Lee J, Arends MJ, Wilkins BS, Thomas GJ, Oien KA, Jones L, Hunter KD.

J Clin Pathol. 2019 Jun;72(6):399-405. doi: 10.1136/jclinpath-2018-205568. Epub 2019 Mar 25.

5.

Author Correction: Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.

Garcia E, Hayden A, Birts C, Britton E, Rogerson C, Bleaney CW, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, Thomas GJ, Ang Y, Sharrocks AD, Fitzgerald RC, Underwood TJ; OCCAMS consortium.

Sci Rep. 2019 Jan 22;9(1):318. doi: 10.1038/s41598-018-37591-7.

6.

HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma.

Fleming JC, Woo J, Moutasim K, Mellone M, Frampton SJ, Mead A, Ahmed W, Wood O, Robinson H, Ward M, Woelk CH, Ottensmeier CH, King E, Kim D, Blaydes JP, Thomas GJ.

Br J Cancer. 2019 Feb;120(3):356-367. doi: 10.1038/s41416-018-0364-7. Epub 2019 Jan 17.

7.

Treatment of actinic keratosis through inhibition of cyclooxygenase-2: Potential mechanism of action of diclofenac sodium 3% in hyaluronic acid 2.5.

Thomas GJ, Herranz P, Cruz SB, Parodi A.

Dermatol Ther. 2019 May;32(3):e12800. doi: 10.1111/dth.12800. Epub 2019 Apr 9. Review.

PMID:
30523664
8.

Author Correction: Pan-cancer deconvolution of tumour composition using DNA methylation.

Chakravarthy A, Furness A, Joshi K, Ghorani E, Ford K, Ward MJ, King EV, Lechner M, Marafioti T, Quezada SA, Thomas GJ, Feber A, Fenton TR.

Nat Commun. 2018 Nov 2;9(1):4642. doi: 10.1038/s41467-018-07155-4.

9.

Barriers to the release of human tissue for clinical trials research in the UK: a national survey of cellular pathology laboratories on behalf of the National Cancer Research Institute's Cellular Molecular Pathology (CM-Path) initiative.

Macklin PS, Hall A, Lee J, Hair J, Speirs V, Thomas GJ, Oien KA, Verrill C.

J Clin Pathol. 2019 Jan;72(1):52-57. doi: 10.1136/jclinpath-2018-205476. Epub 2018 Oct 1.

PMID:
30275096
10.

YAP drives cutaneous squamous cell carcinoma formation and progression.

Vincent-Mistiaen Z, Elbediwy A, Vanyai H, Cotton J, Stamp G, Nye E, Spencer-Dene B, Thomas GJ, Mao J, Thompson B.

Elife. 2018 Sep 20;7. pii: e33304. doi: 10.7554/eLife.33304.

11.

Implications of Tuberculosis Reactivation after Immune Checkpoint Inhibition.

Elkington PT, Bateman AC, Thomas GJ, Ottensmeier CH.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1451-1453. doi: 10.1164/rccm.201807-1250LE. No abstract available.

12.

Pan-cancer deconvolution of tumour composition using DNA methylation.

Chakravarthy A, Furness A, Joshi K, Ghorani E, Ford K, Ward MJ, King EV, Lechner M, Marafioti T, Quezada SA, Thomas GJ, Feber A, Fenton TR.

Nat Commun. 2018 Aug 13;9(1):3220. doi: 10.1038/s41467-018-05570-1. Erratum in: Nat Commun. 2018 Nov 2;9(1):4642.

13.

The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer.

Caldwell A, Coleby R, Tovar C, Stammnitz MR, Kwon YM, Owen RS, Tringides M, Murchison EP, Skjødt K, Thomas GJ, Kaufman J, Elliott T, Woods GM, Siddle HV.

Elife. 2018 Aug 14;7. pii: e35314. doi: 10.7554/eLife.35314.

14.

Harnessing citizen science through mobile phone technology to screen for immunohistochemical biomarkers in bladder cancer.

Smittenaar P, Walker AK, McGill S, Kartsonaki C, Robinson-Vyas RJ, McQuillan JP, Christie S, Harris L, Lawson J, Henderson E, Howat W, Hanby A, Thomas GJ, Bhattarai S, Browning L, Kiltie AE.

Br J Cancer. 2018 Jul;119(2):220-229. doi: 10.1038/s41416-018-0156-0. Epub 2018 Jul 11.

15.

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.

Georgilis A, Klotz S, Hanley CJ, Herranz N, Weirich B, Morancho B, Leote AC, D'Artista L, Gallage S, Seehawer M, Carroll T, Dharmalingam G, Wee KB, Mellone M, Pombo J, Heide D, Guccione E, Arribas J, Barbosa-Morais NL, Heikenwalder M, Thomas GJ, Zender L, Gil J.

Cancer Cell. 2018 Jul 9;34(1):85-102.e9. doi: 10.1016/j.ccell.2018.06.007.

16.

Corrigendum: A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 Jul 4. doi: 10.1093/carcin/bgy083. [Epub ahead of print] No abstract available.

PMID:
29982353
17.

Targeting Head and Neck Cancer by Vaccination.

Wang C, Dickie J, Sutavani RV, Pointer C, Thomas GJ, Savelyeva N.

Front Immunol. 2018 Apr 23;9:830. doi: 10.3389/fimmu.2018.00830. eCollection 2018. Review.

18.

Quantitative proteomic profiling of primary cancer-associated fibroblasts in oesophageal adenocarcinoma.

Manousopoulou A, Hayden A, Mellone M, Garay-Baquero DJ, White CH, Noble F, Lopez M, Thomas GJ, Underwood TJ, Garbis SD.

Br J Cancer. 2018 May;118(9):1200-1207. doi: 10.1038/s41416-018-0042-9. Epub 2018 Mar 29.

19.

The Colorectal Cancer Microenvironment: Strategies for Studying the Role of Cancer-Associated Fibroblasts.

Bhome R, Mellone M, Emo K, Thomas GJ, Sayan AE, Mirnezami AH.

Methods Mol Biol. 2018;1765:87-98. doi: 10.1007/978-1-4939-7765-9_6.

20.

A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.

Melling GE, Flannery SE, Abidin SA, Clemmens H, Prajapati P, Hinsley EE, Hunt S, Catto JWF, Coletta RD, Mellone M, Thomas GJ, Parkinson EK, Prime SS, Paterson IC, Buttle DJ, Lambert DW.

Carcinogenesis. 2018 May 28;39(6):798-807. doi: 10.1093/carcin/bgy032.

21.

Association between miR-31-3p expression and cetuximab efficacy in patients with KRAS wild-type metastatic colorectal cancer: a post-hoc analysis of the New EPOC trial.

Pugh S, Thiébaut R, Bridgewater J, Grisoni ML, Moutasim K, Rousseau F, Thomas GJ, Griffiths G, Liebaert F, Primrose J, Laurent-Puig P.

Oncotarget. 2017 Sep 27;8(55):93856-93866. doi: 10.18632/oncotarget.21291. eCollection 2017 Nov 7.

22.

Head and Neck Squamous Cell Carcinomas Are Characterized by a Stable Immune Signature Within the Primary Tumor Over Time and Space.

Wood O, Clarke J, Woo J, Mirza AH, Woelk CH, Thomas GJ, Vijayanand P, King E, Ottensmeier CH.

Clin Cancer Res. 2017 Dec 15;23(24):7641-7649. doi: 10.1158/1078-0432.CCR-17-0373. Epub 2017 Sep 26.

23.

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4.

Hanley CJ, Mellone M, Ford K, Thirdborough SM, Mellows T, Frampton SJ, Smith DM, Harden E, Szyndralewiez C, Bullock M, Noble F, Moutasim KA, King EV, Vijayanand P, Mirnezami AH, Underwood TJ, Ottensmeier CH, Thomas GJ.

J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx121.

24.

Evaluating the effect of immune cells on the outcome of patients with mesothelioma.

Chee SJ, Lopez M, Mellows T, Gankande S, Moutasim KA, Harris S, Clarke J, Vijayanand P, Thomas GJ, Ottensmeier CH.

Br J Cancer. 2017 Oct 24;117(9):1341-1348. doi: 10.1038/bjc.2017.269. Epub 2017 Aug 17.

25.

Human tissue models in cancer research: looking beyond the mouse.

Jackson SJ, Thomas GJ.

Dis Model Mech. 2017 Aug 1;10(8):939-942. doi: 10.1242/dmm.031260. Review.

26.

Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer.

Ganesan AP, Clarke J, Wood O, Garrido-Martin EM, Chee SJ, Mellows T, Samaniego-Castruita D, Singh D, Seumois G, Alzetani A, Woo E, Friedmann PS, King EV, Thomas GJ, Sanchez-Elsner T, Vijayanand P, Ottensmeier CH.

Nat Immunol. 2017 Aug;18(8):940-950. doi: 10.1038/ni.3775. Epub 2017 Jun 19.

27.

Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.

Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez MA, Kiely P, Moutasim KA, Frampton SJ, Sabnis D, Fine DR, Johnson C, Marshall JF, Scita G, Jenei V, Thomas GJ.

J Pathol. 2017 Sep;243(1):37-50. doi: 10.1002/path.4923. Epub 2017 Aug 7.

28.

Cyclooxygenase in Cancer Prevention and Treatments for Actinic Keratosis.

Thomas GJ, Morton CA.

Dermatol Ther (Heidelb). 2017 Jan;7(Suppl 1):21-29. doi: 10.1007/s13555-016-0166-x. Epub 2017 Feb 1. Review.

29.

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis.

Mellone M, Hanley CJ, Thirdborough S, Mellows T, Garcia E, Woo J, Tod J, Frampton S, Jenei V, Moutasim KA, Kabir TD, Brennan PA, Venturi G, Ford K, Herranz N, Lim KP, Clarke J, Lambert DW, Prime SS, Underwood TJ, Vijayanand P, Eliceiri KW, Woelk C, King EV, Gil J, Ottensmeier CH, Thomas GJ.

Aging (Albany NY). 2016 Dec 15;9(1):114-132. doi: 10.18632/aging.101127.

30.

Crowdsourcing for translational research: analysis of biomarker expression using cancer microarrays.

Lawson J, Robinson-Vyas RJ, McQuillan JP, Paterson A, Christie S, Kidza-Griffiths M, McDuffus LA, Moutasim KA, Shaw EC, Kiltie AE, Howat WJ, Hanby AM, Thomas GJ, Smittenaar P.

Br J Cancer. 2017 Jan 17;116(2):237-245. doi: 10.1038/bjc.2016.404. Epub 2016 Dec 13.

31.

Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx.

Chakravarthy A, Henderson S, Thirdborough SM, Ottensmeier CH, Su X, Lechner M, Feber A, Thomas GJ, Fenton TR.

J Clin Oncol. 2016 Dec;34(34):4132-4141. Epub 2016 Oct 31.

32.

HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology.

Schache AG, Powell NG, Cuschieri KS, Robinson M, Leary S, Mehanna H, Rapozo D, Long A, Cubie H, Junor E, Monaghan H, Harrington KJ, Nutting CM, Schick U, Lau AS, Upile N, Sheard J, Brougham K, West CM, Oguejiofor K, Thomas S, Ness AR, Pring M, Thomas GJ, King EV, McCance DJ, James JA, Moran M, Sloan P, Shaw RJ, Evans M, Jones TM.

Cancer Res. 2016 Nov 15;76(22):6598-6606. doi: 10.1158/0008-5472.CAN-16-0633. Epub 2016 Aug 28.

33.

Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.

Garcia E, Hayden A, Birts C, Britton E, Cowie A, Pickard K, Mellone M, Choh C, Derouet M, Duriez P, Noble F, White MJ, Primrose JN, Strefford JC, Rose-Zerilli M, Thomas GJ, Ang Y, Sharrocks AD, Fitzgerald RC, Underwood TJ; OCCAMS consortium.

Sci Rep. 2016 Sep 7;6:32417. doi: 10.1038/srep32417. Erratum in: Sci Rep. 2019 Jan 22;9(1):318.

34.

Metalloproteinases ADAM10 and ADAM17 Mediate Migration and Differentiation in Glioblastoma Sphere-Forming Cells.

Siney EJ, Holden A, Casselden E, Bulstrode H, Thomas GJ, Willaime-Morawek S.

Mol Neurobiol. 2017 Jul;54(5):3893-3905. doi: 10.1007/s12035-016-0053-6. Epub 2016 Aug 19.

35.

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.

Kabir TD, Leigh RJ, Tasena H, Mellone M, Coletta RD, Parkinson EK, Prime SS, Thomas GJ, Paterson IC, Zhou D, McCall J, Speight PM, Lambert DW.

Aging (Albany NY). 2016 Aug;8(8):1608-35. doi: 10.18632/aging.100987.

36.

Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside.

Bhome R, Al Saihati HA, Goh RW, Bullock MD, Primrose JN, Thomas GJ, Sayan AE, Mirnezami AH.

New Horiz Transl Med. 2016 Jan;3(1):9-21.

37.

Fibroblast activation and senescence in oral cancer.

Prime SS, Cirillo N, Hassona Y, Lambert DW, Paterson IC, Mellone M, Thomas GJ, James EN, Parkinson EK.

J Oral Pathol Med. 2017 Feb;46(2):82-88. doi: 10.1111/jop.12456. Epub 2016 May 30. Review.

PMID:
27237745
38.

Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma.

Ottensmeier CH, Perry KL, Harden EL, Stasakova J, Jenei V, Fleming J, Wood O, Woo J, Woelk CH, Thomas GJ, Thirdborough SM.

Cancer Res. 2016 Jul 15;76(14):4136-48. doi: 10.1158/0008-5472.CAN-15-3121. Epub 2016 May 20.

39.

Targeting Carcinoembryonic Antigen with DNA Vaccination: On-Target Adverse Events Link with Immunologic and Clinical Outcomes.

McCann KJ, Mander A, Cazaly A, Chudley L, Stasakova J, Thirdborough S, King A, Lloyd-Evans P, Buxton E, Edwards C, Halford S, Bateman A, O'Callaghan A, Clive S, Anthoney A, Jodrell DI, Weinschenk T, Simon P, Sahin U, Thomas GJ, Stevenson FK, Ottensmeier CH.

Clin Cancer Res. 2016 Oct 1;22(19):4827-4836. doi: 10.1158/1078-0432.CCR-15-2507. Epub 2016 Apr 18.

40.

Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma.

Noble F, Mellows T, McCormick Matthews LH, Bateman AC, Harris S, Underwood TJ, Byrne JP, Bailey IS, Sharland DM, Kelly JJ, Primrose JN, Sahota SS, Bateman AR, Thomas GJ, Ottensmeier CH.

Cancer Immunol Immunother. 2016 Jun;65(6):651-62. doi: 10.1007/s00262-016-1826-5. Epub 2016 Mar 28.

41.

Tumour-infiltrating lymphocyte scores effectively stratify outcomes over and above p16 post chemo-radiotherapy in anal cancer.

Gilbert DC, Serup-Hansen E, Linnemann D, Høgdall E, Bailey C, Summers J, Havsteen H, Thomas GJ.

Br J Cancer. 2016 Jan 19;114(2):134-7. doi: 10.1038/bjc.2015.448. Epub 2016 Jan 5.

42.

A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers.

Hanley CJ, Noble F, Ward M, Bullock M, Drifka C, Mellone M, Manousopoulou A, Johnston HE, Hayden A, Thirdborough S, Liu Y, Smith DM, Mellows T, Kao WJ, Garbis SD, Mirnezami A, Underwood TJ, Eliceiri KW, Thomas GJ.

Oncotarget. 2016 Feb 2;7(5):6159-74. doi: 10.18632/oncotarget.6740.

43.

Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma.

Matthews LM, Noble F, Tod J, Jaynes E, Harris S, Primrose JN, Ottensmeier C, Thomas GJ, Underwood TJ.

Br J Cancer. 2015 Dec 22;113(12):1746. doi: 10.1038/bjc.2015.460. No abstract available.

44.

Erratum: mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J.

Nat Cell Biol. 2015 Oct;17(10):1370. doi: 10.1038/ncb3243. No abstract available.

PMID:
26419804
45.

Periductal stromal collagen topology of pancreatic ductal adenocarcinoma differs from that of normal and chronic pancreatitis.

Drifka CR, Tod J, Loeffler AG, Liu Y, Thomas GJ, Eliceiri KW, Kao WJ.

Mod Pathol. 2015 Nov;28(11):1470-80. doi: 10.1038/modpathol.2015.97. Epub 2015 Sep 4.

46.

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype.

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J.

Nat Cell Biol. 2015 Sep;17(9):1205-17. doi: 10.1038/ncb3225. Epub 2015 Aug 17. Erratum in: Nat Cell Biol. 2015 Oct;17(10):1370.

47.

Systematic review and meta-analysis of immunohistochemical prognostic biomarkers in resected oesophageal adenocarcinoma.

McCormick Matthews LH, Noble F, Tod J, Jaynes E, Harris S, Primrose JN, Ottensmeier C, Thomas GJ, Underwood TJ.

Br J Cancer. 2015 Jun 30;113(1):107-18. doi: 10.1038/bjc.2015.179. Epub 2015 Jun 25. Review. Erratum in: Br J Cancer. 2015 Dec 22;113(12):1746.

48.

miR-19-Mediated Inhibition of Transglutaminase-2 Leads to Enhanced Invasion and Metastasis in Colorectal Cancer.

Cellura D, Pickard K, Quaratino S, Parker H, Strefford JC, Thomas GJ, Mitter R, Mirnezami AH, Peake NJ.

Mol Cancer Res. 2015 Jul;13(7):1095-1105. doi: 10.1158/1541-7786.MCR-14-0466. Epub 2015 May 1.

49.

Novel association between microglia and stem cells in human gliomas: A contributor to tumour proliferation?

Noorani I, Petty G, Grundy PL, Sharpe G, Willaime-Morawek S, Harris S, Thomas GJ, Nicoll JA, Boche D.

J Pathol Clin Res. 2015 Jan 14;1(2):67-75. doi: 10.1002/cjp2.7. eCollection 2015 Apr.

50.

Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs.

Bullock MD, Pickard K, Mitter R, Sayan AE, Primrose JN, Ivan C, Calin GA, Thomas GJ, Packham GK, Mirnezami AH.

Oncotarget. 2015 Mar 30;6(9):7262-79.

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