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Items: 1 to 50 of 233

1.

The anion transporter SLC26A9 localizes to tight junctions and is degraded by the proteasome when co-expressed with F508del-CFTR.

Sato Y, Thomas DY, Hanrahan JW.

J Biol Chem. 2019 Nov 29;294(48):18269-18284. doi: 10.1074/jbc.RA119.010192. Epub 2019 Oct 23.

PMID:
31645438
2.

Cystic Fibrosis: Proteostatic correctors of CFTR trafficking and alternative therapeutic targets.

Hanrahan JW, Sato Y, Carlile GW, Jansen G, Young JC, Thomas DY.

Expert Opin Ther Targets. 2019 Aug;23(8):711-724. doi: 10.1080/14728222.2019.1628948. Epub 2019 Jun 9.

PMID:
31169041
3.

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.

Maurel M, Obacz J, Avril T, Ding YP, Papadodima O, Treton X, Daniel F, Pilalis E, Hörberg J, Hou W, Beauchamp MC, Tourneur-Marsille J, Cazals-Hatem D, Sommerova L, Samali A, Tavernier J, Hrstka R, Dupont A, Fessart D, Delom F, Fernandez-Zapico ME, Jansen G, Eriksson LA, Thomas DY, Jerome-Majewska L, Hupp T, Chatziioannou A, Chevet E, Ogier-Denis E.

EMBO Mol Med. 2019 Jun;11(6). pii: e10120. doi: 10.15252/emmm.201810120.

4.

Variable Responses to CFTR Correctors in vitro: Estimating the Design Effect in Precision Medicine.

Matthes E, Goepp J, Martini C, Shan J, Liao J, Thomas DY, Hanrahan JW.

Front Pharmacol. 2018 Dec 19;9:1490. doi: 10.3389/fphar.2018.01490. eCollection 2018.

5.

A novel triple combination of pharmacological chaperones improves F508del-CFTR correction.

Carlile GW, Yang Q, Matthes E, Liao J, Radinovic S, Miyamoto C, Robert R, Hanrahan JW, Thomas DY.

Sci Rep. 2018 Jul 30;8(1):11404. doi: 10.1038/s41598-018-29276-y.

6.

Corrector combination therapies for F508del-CFTR.

Hanrahan JW, Matthes E, Carlile G, Thomas DY.

Curr Opin Pharmacol. 2017 Jun;34:105-111. doi: 10.1016/j.coph.2017.09.016. Epub 2017 Nov 5. Review.

PMID:
29080476
7.

Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells.

Wong FH, AbuArish A, Matthes E, Turner MJ, Greene LE, Cloutier A, Robert R, Thomas DY, Cosa G, Cantin AM, Hanrahan JW.

Am J Physiol Cell Physiol. 2018 Jan 1;314(1):C118-C134. doi: 10.1152/ajpcell.00099.2017. Epub 2017 Oct 4.

8.

Proteomics Identifies Golgi phosphoprotein 3 (GOLPH3) with A Link Between Golgi Structure, Cancer, DNA Damage and Protection from Cell Death.

Bergeron JJM, Au CE, Thomas DY, Hermo L.

Mol Cell Proteomics. 2017 Dec;16(12):2048-2054. doi: 10.1074/mcp.MR117.000068. Epub 2017 Sep 27. Review.

9.

An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases.

Kristof AS, Petrof BJ, Hamid Q, Kolb M, Landry JS, MacKenzie A, McCormack FX, Murawski IJ, Moss J, Rauch F, Rosas IO, Shapiro AJ, Smith BM, Thomas DY, Trapnell BC, Young LR, Zariwala MA; ATS Assembly on Respiratory Cell and Molecular Biology.

Ann Am Thorac Soc. 2017 Aug;14(8):1239-1247. doi: 10.1513/AnnalsATS.201705-406WS.

10.

Editorial.

Thomas DY.

J Taibah Univ Med Sci. 2017 May 20;12(3):187-188. doi: 10.1016/j.jtumed.2017.05.001. eCollection 2017 Jun. No abstract available.

11.

Latonduine Analogs Restore F508del-Cystic Fibrosis Transmembrane Conductance Regulator Trafficking through the Modulation of Poly-ADP Ribose Polymerase 3 and Poly-ADP Ribose Polymerase 16 Activity.

Carlile GW, Robert R, Matthes E, Yang Q, Solari R, Hatley R, Edge CM, Hanrahan JW, Andersen R, Thomas DY, Birault V.

Mol Pharmacol. 2016 Aug;90(2):65-79. doi: 10.1124/mol.115.102418. Epub 2016 May 18.

PMID:
27193581
12.

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

Stevers LM, Lam CV, Leysen SF, Meijer FA, van Scheppingen DS, de Vries RM, Carlile GW, Milroy LG, Thomas DY, Brunsveld L, Ottmann C.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61. doi: 10.1073/pnas.1516631113. Epub 2016 Feb 17.

13.

A Covalent Cysteine-Targeting Kinase Inhibitor of Ire1 Permits Allosteric Control of Endoribonuclease Activity.

Waller DD, Jansen G, Golizeh M, Martel-Lorion C, Dejgaard K, Shiao TC, Mancuso J, Tsantrizos YS, Roy R, Sebag M, Sleno L, Thomas DY.

Chembiochem. 2016 May 3;17(9):843-51. doi: 10.1002/cbic.201500485. Epub 2016 Mar 7.

PMID:
26792008
14.

Unravelling druggable signalling networks that control F508del-CFTR proteostasis.

Hegde RN, Parashuraman S, Iorio F, Ciciriello F, Capuani F, Carissimo A, Carrella D, Belcastro V, Subramanian A, Bounti L, Persico M, Carlile G, Galietta L, Thomas DY, Di Bernardo D, Luini A.

Elife. 2015 Dec 23;4. pii: e10365. doi: 10.7554/eLife.10365.

15.

The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epithelia.

Turner MJ, Matthes E, Billet A, Ferguson AJ, Thomas DY, Randell SH, Ostrowski LE, Abbott-Banner K, Hanrahan JW.

Am J Physiol Lung Cell Mol Physiol. 2016 Jan 1;310(1):L59-70. doi: 10.1152/ajplung.00324.2015. Epub 2015 Nov 6.

16.

Low free drug concentration prevents inhibition of F508del CFTR functional expression by the potentiator VX-770 (ivacaftor).

Matthes E, Goepp J, Carlile GW, Luo Y, Dejgaard K, Billet A, Robert R, Thomas DY, Hanrahan JW.

Br J Pharmacol. 2016 Feb;173(3):459-70. doi: 10.1111/bph.13365. Epub 2016 Jan 13.

17.

Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking.

Carlile GW, Robert R, Goepp J, Matthes E, Liao J, Kus B, Macknight SD, Rotin D, Hanrahan JW, Thomas DY.

J Cyst Fibros. 2015 Jan;14(1):16-25. doi: 10.1016/j.jcf.2014.06.001. Epub 2014 Jun 25.

18.

Carbamazepine as a novel small molecule corrector of trafficking-impaired ATP-sensitive potassium channels identified in congenital hyperinsulinism.

Chen PC, Olson EM, Zhou Q, Kryukova Y, Sampson HM, Thomas DY, Shyng SL.

J Biol Chem. 2013 Jul 19;288(29):20942-54. doi: 10.1074/jbc.M113.470948. Epub 2013 Jun 6.

19.

Correctors of the basic trafficking defect of the mutant F508del-CFTR that causes cystic fibrosis.

Birault V, Solari R, Hanrahan J, Thomas DY.

Curr Opin Chem Biol. 2013 Jun;17(3):353-60. doi: 10.1016/j.cbpa.2013.04.020. Epub 2013 May 24. Review.

PMID:
23711435
20.

Novel pharmacological strategies to treat cystic fibrosis.

Hanrahan JW, Sampson HM, Thomas DY.

Trends Pharmacol Sci. 2013 Feb;34(2):119-25. doi: 10.1016/j.tips.2012.11.006. Review.

PMID:
23380248
21.

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines.

Sampson HM, Lam H, Chen PC, Zhang D, Mottillo C, Mirza M, Qasim K, Shrier A, Shyng SL, Hanrahan JW, Thomas DY.

Orphanet J Rare Dis. 2013 Jan 14;8:11. doi: 10.1186/1750-1172-8-11.

22.

Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP.

Carlile GW, Keyzers RA, Teske KA, Robert R, Williams DE, Linington RG, Gray CA, Centko RM, Yan L, Anjos SM, Sampson HM, Zhang D, Liao J, Hanrahan JW, Andersen RJ, Thomas DY.

Chem Biol. 2012 Oct 26;19(10):1288-99. doi: 10.1016/j.chembiol.2012.08.014.

23.

Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells.

Zhang D, Ciciriello F, Anjos SM, Carissimo A, Liao J, Carlile GW, Balghi H, Robert R, Luini A, Hanrahan JW, Thomas DY.

Front Pharmacol. 2012 Oct 4;3:176. doi: 10.3389/fphar.2012.00176. eCollection 2012.

24.

Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking.

Anjos SM, Robert R, Waller D, Zhang DL, Balghi H, Sampson HM, Ciciriello F, Lesimple P, Carlile GW, Goepp J, Liao J, Ferraro P, Phillipe R, Dantzer F, Hanrahan JW, Thomas DY.

Front Pharmacol. 2012 Sep 12;3:165. doi: 10.3389/fphar.2012.00165. eCollection 2012.

25.

An interaction map of endoplasmic reticulum chaperones and foldases.

Jansen G, Määttänen P, Denisov AY, Scarffe L, Schade B, Balghi H, Dejgaard K, Chen LY, Muller WJ, Gehring K, Thomas DY.

Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.

26.

Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways.

Balghi H, Robert R, Rappaz B, Zhang X, Wohlhuter-Haddad A, Evagelidis A, Luo Y, Goepp J, Ferraro P, Roméo P, Trebak M, Wiseman PW, Thomas DY, Hanrahan JW.

FASEB J. 2011 Dec;25(12):4274-91. doi: 10.1096/fj.11-187682. Epub 2011 Aug 26.

27.

Intracellular eukaryotic parasites have a distinct unfolded protein response.

Gosline SJ, Nascimento M, McCall LI, Zilberstein D, Thomas DY, Matlashewski G, Hallett M.

PLoS One. 2011 Apr 29;6(4):e19118. doi: 10.1371/journal.pone.0019118.

28.

Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR.

Sampson HM, Robert R, Liao J, Matthes E, Carlile GW, Hanrahan JW, Thomas DY.

Chem Biol. 2011 Feb 25;18(2):231-42. doi: 10.1016/j.chembiol.2010.11.016.

29.

Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.

Kozlov G, Bastos-Aristizabal S, Määttänen P, Rosenauer A, Zheng F, Killikelly A, Trempe JF, Thomas DY, Gehring K.

J Biol Chem. 2010 Nov 12;285(46):35551-7. doi: 10.1074/jbc.M110.160101. Epub 2010 Aug 27.

30.

A structural overview of the PDI family of proteins.

Kozlov G, Määttänen P, Thomas DY, Gehring K.

FEBS J. 2010 Oct;277(19):3924-36. doi: 10.1111/j.1742-4658.2010.07793.x. Epub 2010 Aug 26. Review.

31.

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.

Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, Glebov A, Koupaki O, Boukh-Viner T, Gregg C, Juneau M, English AM, Thomas DY, Titorenko VI.

Aging (Albany NY). 2010 Jul;2(7):393-414.

32.

Structure of the catalytic a(0)a fragment of the protein disulfide isomerase ERp72.

Kozlov G, Azeroual S, Rosenauer A, Määttänen P, Denisov AY, Thomas DY, Gehring K.

J Mol Biol. 2010 Aug 27;401(4):618-25. doi: 10.1016/j.jmb.2010.06.045. Epub 2010 Jun 26.

PMID:
20600112
33.

Protein quality control in the ER: the recognition of misfolded proteins.

Määttänen P, Gehring K, Bergeron JJ, Thomas DY.

Semin Cell Dev Biol. 2010 Jul;21(5):500-11. doi: 10.1016/j.semcdb.2010.03.006. Epub 2010 Mar 25. Review.

PMID:
20347046
34.

Correction of the Delta phe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine.

Robert R, Carlile GW, Liao J, Balghi H, Lesimple P, Liu N, Kus B, Rotin D, Wilke M, de Jonge HR, Scholte BJ, Thomas DY, Hanrahan JW.

Mol Pharmacol. 2010 Jun;77(6):922-30. doi: 10.1124/mol.109.062679. Epub 2010 Mar 3.

PMID:
20200141
35.

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence.

Epp E, Vanier G, Harcus D, Lee AY, Jansen G, Hallett M, Sheppard DC, Thomas DY, Munro CA, Mullick A, Whiteway M.

PLoS Pathog. 2010 Feb 5;6(2):e1000753. doi: 10.1371/journal.ppat.1000753.

36.

Organization of the Sec61 translocon, studied by high resolution native electrophoresis.

Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY.

J Proteome Res. 2010 Apr 5;9(4):1763-71. doi: 10.1021/pr900900x.

PMID:
20112977
37.

Chemogenomic profiling predicts antifungal synergies.

Jansen G, Lee AY, Epp E, Fredette A, Surprenant J, Harcus D, Scott M, Tan E, Nishimura T, Whiteway M, Hallett M, Thomas DY.

Mol Syst Biol. 2009;5:338. doi: 10.1038/msb.2009.95. Epub 2009 Dec 22.

38.

A biochemical genomics screen for substrates of Ste20p kinase enables the in silico prediction of novel substrates.

Annan RB, Lee AY, Reid ID, Sayad A, Whiteway M, Hallett M, Thomas DY.

PLoS One. 2009 Dec 16;4(12):e8279. doi: 10.1371/journal.pone.0008279.

39.

Calnexin phosphorylation: linking cytoplasmic signalling to endoplasmic reticulum lumenal functions.

Chevet E, Smirle J, Cameron PH, Thomas DY, Bergeron JJ.

Semin Cell Dev Biol. 2010 Jul;21(5):486-90. doi: 10.1016/j.semcdb.2009.12.005. Epub 2010 Jan 6. Review.

PMID:
20005969
40.

Calnexin phosphorylation attenuates the release of partially misfolded alpha1-antitrypsin to the secretory pathway.

Cameron PH, Chevet E, Pluquet O, Thomas DY, Bergeron JJ.

J Biol Chem. 2009 Dec 11;284(50):34570-9. doi: 10.1074/jbc.M109.053165. Epub 2009 Oct 8.

41.

Structure of the noncatalytic domains and global fold of the protein disulfide isomerase ERp72.

Kozlov G, Määttänen P, Schrag JD, Hura GL, Gabrielli L, Cygler M, Thomas DY, Gehring K.

Structure. 2009 May 13;17(5):651-9. doi: 10.1016/j.str.2009.02.016.

42.

Solution structure of the bb' domains of human protein disulfide isomerase.

Denisov AY, Määttänen P, Dabrowski C, Kozlov G, Thomas DY, Gehring K.

FEBS J. 2009 Mar;276(5):1440-9. doi: 10.1111/j.1742-4658.2009.06884.x.

43.

ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.

Ushioda R, Hoseki J, Araki K, Jansen G, Thomas DY, Nagata K.

Science. 2008 Jul 25;321(5888):569-72. doi: 10.1126/science.1159293.

44.

Rho5p is involved in mediating the osmotic stress response in Saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination.

Annan RB, Wu C, Waller DD, Whiteway M, Thomas DY.

Eukaryot Cell. 2008 Sep;7(9):1441-9. doi: 10.1128/EC.00120-08. Epub 2008 Jul 11.

45.

BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex.

Wang B, Heath-Engel H, Zhang D, Nguyen N, Thomas DY, Hanrahan JW, Shore GC.

Cell. 2008 Jun 13;133(6):1080-92. doi: 10.1016/j.cell.2008.04.042.

46.

Canadian Chemical Biology Network: biochemistry back to the future.

Brown ED, Thomas DY.

Biochem Cell Biol. 2008 Apr;86(2):ix, xi-xii. doi: 10.1139/o08-903. English, French. No abstract available.

PMID:
18509890
47.

Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect.

Robert R, Carlile GW, Pavel C, Liu N, Anjos SM, Liao J, Luo Y, Zhang D, Thomas DY, Hanrahan JW.

Mol Pharmacol. 2008 Feb;73(2):478-89. Epub 2007 Nov 1.

PMID:
17975008
48.

1H, 13C and 15N resonance assignments of the bb' domains of human protein disulfide isomerase.

Denisov AY, Maattanen P, Sprules T, Thomas DY, Gehring K.

Biomol NMR Assign. 2007 Jul;1(1):129-30. doi: 10.1007/s12104-007-9035-y. Epub 2007 Aug 7.

PMID:
19636846
49.

Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import.

Bhangoo MK, Tzankov S, Fan AC, Dejgaard K, Thomas DY, Young JC.

Mol Biol Cell. 2007 Sep;18(9):3414-28. Epub 2007 Jun 27.

50.

Correctors of protein trafficking defects identified by a novel high-throughput screening assay.

Carlile GW, Robert R, Zhang D, Teske KA, Luo Y, Hanrahan JW, Thomas DY.

Chembiochem. 2007 Jun 18;8(9):1012-20.

PMID:
17497613

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