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Items: 1 to 50 of 475

1.
2.

Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice.

Mareninova OA, Jia W, Gretler SR, Holthaus CL, Thomas DDH, Pimienta M, Dillon DL, Gukovskaya AS, Gukovsky I, Groblewski GE.

Autophagy. 2020 Jan 16:1-14. doi: 10.1080/15548627.2020.1715047. [Epub ahead of print]

PMID:
31942816
3.

Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study.

Thomas DD, Stockman MC, Yu L, Meshulam T, McCarthy AC, Ionson A, Burritt N, Deeney J, Cabral H, Corkey B, Istfan N, Apovian CM.

PLoS One. 2019 Dec 23;14(12):e0226200. doi: 10.1371/journal.pone.0226200. eCollection 2019.

4.

Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs.

Stroik DR, Ceholski DK, Bidwell PA, Mleczko J, Thanel PF, Kamdar F, Autry JM, Cornea RL, Thomas DD.

J Mol Cell Cardiol. 2019 Nov 18;138:59-65. doi: 10.1016/j.yjmcc.2019.11.147. [Epub ahead of print]

PMID:
31751570
5.

Trajectory-Based Simulation of EPR Spectra: Models of Rotational Motion for Spin Labels on Proteins.

Martin PD, Svensson B, Thomas DD, Stoll S.

J Phys Chem B. 2019 Dec 5;123(48):10131-10141. doi: 10.1021/acs.jpcb.9b02693. Epub 2019 Nov 21.

6.

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies.

Lo CH, Lim CK, Ding Z, Wickramasinghe SP, Braun AR, Ashe KH, Rhoades E, Thomas DD, Sachs JN.

Alzheimers Dement. 2019 Nov;15(11):1489-1502. doi: 10.1016/j.jalz.2019.06.4954. Epub 2019 Oct 22.

PMID:
31653529
7.

Electronic consultations (E-consults) and their outcomes: a systematic review.

Vimalananda VG, Orlander JD, Afable MK, Fincke BG, Solch AK, Rinne ST, Kim EJ, Cutrona SL, Thomas DD, Strymish JL, Simon SR.

J Am Med Inform Assoc. 2019 Oct 17. pii: ocz185. doi: 10.1093/jamia/ocz185. [Epub ahead of print]

PMID:
31621847
8.

Hyperinsulinemia: An Early Indicator of Metabolic Dysfunction.

Thomas DD, Corkey BE, Istfan NW, Apovian CM.

J Endocr Soc. 2019 Jul 24;3(9):1727-1747. doi: 10.1210/js.2019-00065. eCollection 2019 Sep 1. Review.

9.

Noncompetitive inhibitors of TNFR1 probe conformational activation states.

Lo CH, Schaaf TM, Grant BD, Lim CK, Bawaskar P, Aldrich CC, Thomas DD, Sachs JN.

Sci Signal. 2019 Jul 30;12(592). pii: eaav5637. doi: 10.1126/scisignal.aav5637.

PMID:
31363069
10.

Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label.

Binder BP, Thompson AR, Thomas DD.

Biophys J. 2019 Jul 23;117(2):319-330. doi: 10.1016/j.bpj.2019.04.042. Epub 2019 Jun 20.

PMID:
31301803
11.

Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels.

Savich Y, Binder BP, Thompson AR, Thomas DD.

J Gen Physiol. 2019 Aug 5;151(8):1007-1016. doi: 10.1085/jgp.201812210. Epub 2019 Jun 21.

PMID:
31227551
12.

TGFβ signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond Syndrome.

Joyce CE, Saadatpour A, Ruiz-Gutierrez M, Bolukbasi OV, Jiang L, Thomas DD, Young S, Hofmann I, Sieff CA, Myers KC, Whangbo J, Libermann TA, Nusbaum C, Yuan GC, Shimamura A, Novina CD.

J Clin Invest. 2019 Jun 18;130:3821-3826. doi: 10.1172/JCI125375.

13.

The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21.

Schmidt K, Carroll JS, Yee E, Thomas DD, Wert-Lamas L, Neier SC, Sheynkman G, Ritz J, Novina CD.

Cell Rep. 2019 May 21;27(8):2493-2507.e4. doi: 10.1016/j.celrep.2019.04.101.

14.

Patient Characteristics Associated with Receipt of Prescription Weight-Management Medications Among Veterans Participating in MOVE!

Thomas DD, Waring ME, Ameli O, Reisman JI, Vimalananda VG.

Obesity (Silver Spring). 2019 Jul;27(7):1168-1176. doi: 10.1002/oby.22503. Epub 2019 May 15.

PMID:
31090207
15.

Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis.

Valberg SJ, Soave K, Williams ZJ, Perumbakkam S, Schott M, Finno CJ, Petersen JL, Fenger C, Autry JM, Thomas DD.

J Vet Intern Med. 2019 Mar;33(2):933-941. doi: 10.1111/jvim.15425. Epub 2019 Feb 5.

16.

Sustained Improvement in Type 2 Diabetes Mellitus is Common After Treatment of Hepatitis C Virus With Direct-acting Antiviral Therapy.

Gilad A, Fricker ZP, Hsieh A, Thomas DD, Zahorian T, Nunes DP.

J Clin Gastroenterol. 2019 Sep;53(8):616-620. doi: 10.1097/MCG.0000000000001168.

PMID:
30614943
17.

Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.

Lake EW, Muretta JM, Thompson AR, Rasmussen DM, Majumdar A, Faber EB, Ruff EF, Thomas DD, Levinson NM.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11894-E11903. doi: 10.1073/pnas.1811158115. Epub 2018 Dec 5.

18.

Converter domain mutations in myosin alter structural kinetics and motor function.

Gunther LK, Rohde JA, Tang W, Walton SD, Unrath WC, Trivedi DV, Muretta JM, Thomas DD, Yengo CM.

J Biol Chem. 2019 Feb 1;294(5):1554-1567. doi: 10.1074/jbc.RA118.006128. Epub 2018 Dec 5.

PMID:
30518549
19.

Weight Recidivism After Roux-en-Y Gastric Bypass Surgery: An 11-Year Experience in a Multiethnic Medical Center.

Thomas DD, Anderson WA, Apovian CM, Hess DT, Yu L, Velazquez A, Carmine B, Istfan NW.

Obesity (Silver Spring). 2019 Feb;27(2):217-225. doi: 10.1002/oby.22360. Epub 2018 Nov 13.

PMID:
30421862
20.

Red-Shifted FRET Biosensors for High-Throughput Fluorescence Lifetime Screening.

Schaaf TM, Li A, Grant BD, Peterson K, Yuen S, Bawaskar P, Kleinboehl E, Li J, Thomas DD, Gillispie GD.

Biosensors (Basel). 2018 Oct 24;8(4). pii: E99. doi: 10.3390/bios8040099.

21.

Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice.

Phung LA, Karvinen SM, Colson BA, Thomas DD, Lowe DA.

PLoS One. 2018 Sep 18;13(9):e0199062. doi: 10.1371/journal.pone.0199062. eCollection 2018.

22.

Actin-Myosin Interaction: Structure, Function and Drug Discovery.

Guhathakurta P, Prochniewicz E, Thomas DD.

Int J Mol Sci. 2018 Sep 5;19(9). pii: E2628. doi: 10.3390/ijms19092628. Review.

23.

Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells.

Stroik DR, Yuen SL, Janicek KA, Schaaf TM, Li J, Ceholski DK, Hajjar RJ, Cornea RL, Thomas DD.

Sci Rep. 2018 Aug 22;8(1):12560. doi: 10.1038/s41598-018-29685-z.

24.

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin.

Rohde JA, Roopnarine O, Thomas DD, Muretta JM.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7486-E7494. doi: 10.1073/pnas.1720342115. Epub 2018 Jul 17.

25.

Structural dynamics of calmodulin-ryanodine receptor interactions: electron paramagnetic resonance using stereospecific spin labels.

Her C, Thompson AR, Karim CB, Thomas DD.

Sci Rep. 2018 Jul 16;8(1):10681. doi: 10.1038/s41598-018-29064-8.

26.

Dynamics of Dystrophin's Actin-Binding Domain.

Fealey ME, Horn B, Coffman C, Miller R, Lin AY, Thompson AR, Schramel J, Groth E, Hinderliter A, Cembran A, Thomas DD.

Biophys J. 2018 Aug 7;115(3):445-454. doi: 10.1016/j.bpj.2018.05.039. Epub 2018 Jun 20.

27.

Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban.

Martin PD, James ZM, Thomas DD.

Biophys J. 2018 Jun 5;114(11):2573-2583. doi: 10.1016/j.bpj.2018.04.035.

28.

High-throughput screen, using time-resolved FRET, yields actin-binding compounds that modulate actin-myosin structure and function.

Guhathakurta P, Prochniewicz E, Grant BD, Peterson KC, Thomas DD.

J Biol Chem. 2018 Aug 3;293(31):12288-12298. doi: 10.1074/jbc.RA118.002702. Epub 2018 Jun 4.

29.

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes.

Ceholski DK, Turnbull IC, Kong CW, Koplev S, Mayourian J, Gorski PA, Stillitano F, Skodras AA, Nonnenmacher M, Cohen N, Björkegren JLM, Stroik DR, Cornea RL, Thomas DD, Li RA, Costa KD, Hajjar RJ.

J Mol Cell Cardiol. 2018 Jun;119:147-154. doi: 10.1016/j.yjmcc.2018.05.007. Epub 2018 May 9.

30.

Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction, and Metabolism.

Somasundaram V, Basudhar D, Bharadwaj G, No JH, Ridnour LA, Cheng RYS, Fujita M, Thomas DD, Anderson SK, McVicar DW, Wink DA.

Antioxid Redox Signal. 2019 Mar 10;30(8):1124-1143. doi: 10.1089/ars.2018.7527. Epub 2018 May 2.

PMID:
29634348
31.

Nitric oxide reduces oxidative stress in cancer cells by forming dinitrosyliron complexes.

Sahni S, Hickok JR, Thomas DD.

Nitric Oxide. 2018 Jun 1;76:37-44. doi: 10.1016/j.niox.2018.03.003. Epub 2018 Mar 6.

32.

Effects of the Arg9Cys and Arg25Cys mutations on phospholamban's conformational equilibrium in membrane bilayers.

Nelson SED, Ha KN, Gopinath T, Exline MH, Mascioni A, Thomas DD, Veglia G.

Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1335-1341. doi: 10.1016/j.bbamem.2018.02.030. Epub 2018 Mar 2.

33.

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.

Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM.

Elife. 2018 Feb 21;7. pii: e32766. doi: 10.7554/eLife.32766.

34.

A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function.

Muretta JM, Reddy BJN, Scarabelli G, Thompson AF, Jariwala S, Major J, Venere M, Rich JN, Willard B, Thomas DD, Stumpff J, Grant BJ, Gross SP, Rosenfeld SS.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1779-E1788. doi: 10.1073/pnas.1718290115. Epub 2018 Feb 5. Erratum in: Proc Natl Acad Sci U S A. 2018 Mar 5;:.

35.

Structural Impact of Phosphorylation and Dielectric Constant Variation on Synaptotagmin's IDR.

Fealey ME, Binder BP, Uversky VN, Hinderliter A, Thomas DD.

Biophys J. 2018 Feb 6;114(3):550-561. doi: 10.1016/j.bpj.2017.12.013.

36.

Differential mitochondrial dinitrosyliron complex formation by nitrite and nitric oxide.

Thomas DD, Corey C, Hickok J, Wang Y, Shiva S.

Redox Biol. 2018 May;15:277-283. doi: 10.1016/j.redox.2017.12.007. Epub 2017 Dec 23.

37.

Self-Appraised Readiness of Senior and Graduating General Surgery Residents to Perform Thoracic Surgery.

DeBoard ZM, Paisley M, Thomas DD.

J Surg Educ. 2018 Jul - Aug;75(4):877-883. doi: 10.1016/j.jsurg.2017.11.010. Epub 2017 Dec 19.

PMID:
29273336
38.

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms.

O'Rourke AR, Lindsay A, Tarpey MD, Yuen S, McCourt P, Nelson DM, Perrin BJ, Thomas DD, Spangenburg EE, Lowe DA, Ervasti JM.

FEBS J. 2018 Feb;285(3):481-500. doi: 10.1111/febs.14367. Epub 2018 Jan 8.

39.

Protein sparing therapies in acute illness and obesity: a review of George Blackburn's contributions to nutrition science.

Thomas DD, Istfan NW, Bistrian BR, Apovian CM.

Metabolism. 2018 Feb;79:83-96. doi: 10.1016/j.metabol.2017.11.020. Epub 2017 Dec 7. Review.

40.

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation.

Avery AW, Fealey ME, Wang F, Orlova A, Thompson AR, Thomas DD, Hays TS, Egelman EH.

Nat Commun. 2017 Nov 7;8(1):1350. doi: 10.1038/s41467-017-01367-w.

41.

β-III-spectrin spinocerebellar ataxia type 5 mutation reveals a dominant cytoskeletal mechanism that underlies dendritic arborization.

Avery AW, Thomas DD, Hays TS.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9376-E9385. doi: 10.1073/pnas.1707108114. Epub 2017 Oct 16.

42.

Phosphomimetic S3D cofilin binds but only weakly severs actin filaments.

Elam WA, Cao W, Kang H, Huehn A, Hocky GM, Prochniewicz E, Schramm AC, Negrón K, Garcia J, Bonello TT, Gunning PW, Thomas DD, Voth GA, Sindelar CV, De La Cruz EM.

J Biol Chem. 2017 Dec 1;292(48):19565-19579. doi: 10.1074/jbc.M117.808378. Epub 2017 Sep 22.

43.

Hip Arthroscopy for Femoroacetabular Impingement in a Military Population.

Thomas DD, Bernhardson AS, Bernstein E, Dewing CB.

Am J Sports Med. 2017 Dec;45(14):3298-3304. doi: 10.1177/0363546517726984. Epub 2017 Sep 22.

PMID:
28937803
44.

Human Pancreatic Acinar Cells: Proteomic Characterization, Physiologic Responses, and Organellar Disorders in ex Vivo Pancreatitis.

Lugea A, Waldron RT, Mareninova OA, Shalbueva N, Deng N, Su HY, Thomas DD, Jones EK, Messenger SW, Yang J, Hu C, Gukovsky I, Liu Z, Groblewski GE, Gukovskaya AS, Gorelick FS, Pandol SJ.

Am J Pathol. 2017 Dec;187(12):2726-2743. doi: 10.1016/j.ajpath.2017.08.017. Epub 2017 Sep 19.

45.

Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor-Receptor Interactions.

Vunnam N, Lo CH, Grant BD, Thomas DD, Sachs JN.

J Mol Biol. 2017 Sep 15;429(19):2943-2953. doi: 10.1016/j.jmb.2017.08.009. Epub 2017 Aug 20.

PMID:
28834692
46.

A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure.

Guhathakurta P, Prochniewicz E, Roopnarine O, Rohde JA, Thomas DD.

Biophys J. 2017 Jul 11;113(1):91-100. doi: 10.1016/j.bpj.2017.05.027.

47.

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors.

Lo CH, Vunnam N, Lewis AK, Chiu TL, Brummel BE, Schaaf TM, Grant BD, Bawaskar P, Thomas DD, Sachs JN.

SLAS Discov. 2017 Sep;22(8):950-961. doi: 10.1177/2472555217706478. Epub 2017 May 22.

48.

NOS2 as an Emergent Player in Progression of Cancer.

Thomas DD, Wink DA.

Antioxid Redox Signal. 2017 Jun 10;26(17):963-965. doi: 10.1089/ars.2016.6835.

PMID:
28506076
49.

Epigenetics: The third pillar of nitric oxide signaling.

Socco S, Bovee RC, Palczewski MB, Hickok JR, Thomas DD.

Pharmacol Res. 2017 Jul;121:52-58. doi: 10.1016/j.phrs.2017.04.011. Epub 2017 Apr 17. Review.

PMID:
28428114
50.

Acute acinar pancreatitis blocks vesicle-associated membrane protein 8 (VAMP8)-dependent secretion, resulting in intracellular trypsin accumulation.

Messenger SW, Jones EK, Holthaus CL, Thomas DDH, Cooley MM, Byrne JA, Mareninova OA, Gukovskaya AS, Groblewski GE.

J Biol Chem. 2017 May 12;292(19):7828-7839. doi: 10.1074/jbc.M117.781815. Epub 2017 Feb 27.

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