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Degradome of soluble ADAM10 and ADAM17 metalloproteases.

Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C.

Cell Mol Life Sci. 2019 Jun 17. doi: 10.1007/s00018-019-03184-4. [Epub ahead of print]


Combination of SCX fractionation and charge-reversal derivatization facilitates the identification of non-tryptic peptides in C-terminomics.

Kaleja P, Helbig AO, Tholey A.

J Proteome Res. 2019 Jun 13. doi: 10.1021/acs.jproteome.9b00264. [Epub ahead of print]


Cationic Intrinsically Disordered Antimicrobial Peptides (CIDAMPs) Represent a New Paradigm of Innate Defense with a Potential for Novel Anti-Infectives.

Latendorf T, Gerstel U, Wu Z, Bartels J, Becker A, Tholey A, Schröder JM.

Sci Rep. 2019 Mar 4;9(1):3331. doi: 10.1038/s41598-019-39219-w.


Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.

Mentrup T, Theodorou K, Cabrera-Cabrera F, Helbig AO, Happ K, Gijbels M, Gradtke AC, Rabe B, Fukumori A, Steiner H, Tholey A, Fluhrer R, Donners M, Schröder B.

J Exp Med. 2019 Apr 1;216(4):807-830. doi: 10.1084/jem.20171438. Epub 2019 Feb 28.


Depletion of High-Molecular-Mass Proteins for the Identification of Small Proteins and Short Open Reading Frame Encoded Peptides in Cellular Proteomes.

Cassidy L, Kaulich PT, Tholey A.

J Proteome Res. 2019 Apr 5;18(4):1725-1734. doi: 10.1021/acs.jproteome.8b00948. Epub 2019 Feb 27.


Enzyme-fusion strategies for redirecting and improving carotenoid synthesis in S. cerevisiae.

Rabeharindranto H, Castaño-Cerezo S, Lautier T, Garcia-Alles LF, Treitz C, Tholey A, Truan G.

Metab Eng Commun. 2019 Jan 18;8:e00086. doi: 10.1016/j.mec.2019.e00086. eCollection 2019 Jun.


Soluble Lactobacillus delbrueckii subsp. bulgaricus 92059 PrtB proteinase derivatives for production of bioactive peptide hydrolysates from casein.

Li B, Habermann D, Kliche T, Klempt M, Wutkowski A, Clawin-Rädecker I, Koberg S, Brinks E, Koudelka T, Tholey A, Bockelmann W, Franz CMAP, Heller KJ.

Appl Microbiol Biotechnol. 2019 Mar;103(6):2731-2743. doi: 10.1007/s00253-018-09586-x. Epub 2019 Jan 21.


Hornerin contains a Linked Series of Ribosome-Targeting Peptide Antibiotics.

Gerstel U, Latendorf T, Bartels J, Becker A, Tholey A, Schröder JM.

Sci Rep. 2018 Nov 1;8(1):16158. doi: 10.1038/s41598-018-34467-8.


Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH.

Beiroth F, Koudelka T, Overath T, Knight SD, Tholey A, Lindhorst TK.

Beilstein J Org Chem. 2018 Jul 24;14:1890-1900. doi: 10.3762/bjoc.14.163. eCollection 2018.


Neolithic and medieval virus genomes reveal complex evolution of hepatitis B.

Krause-Kyora B, Susat J, Key FM, Kühnert D, Bosse E, Immel A, Rinne C, Kornell SC, Yepes D, Franzenburg S, Heyne HO, Meier T, Lösch S, Meller H, Friederich S, Nicklisch N, Alt KW, Schreiber S, Tholey A, Herbig A, Nebel A, Krause J.

Elife. 2018 May 10;7. pii: e36666. doi: 10.7554/eLife.36666.


In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15.

Seipold L, Altmeppen H, Koudelka T, Tholey A, Kasparek P, Sedlacek R, Schweizer M, Bär J, Mikhaylova M, Glatzel M, Saftig P.

Cell Mol Life Sci. 2018 Sep;75(17):3251-3267. doi: 10.1007/s00018-018-2791-2. Epub 2018 Mar 8.


The Caenorhabditis elegans Proteome Response to Naturally Associated Microbiome Members of the Genus Ochrobactrum.

Cassidy L, Petersen C, Treitz C, Dierking K, Schulenburg H, Leippe M, Tholey A.

Proteomics. 2018 Apr;18(8):e1700426. doi: 10.1002/pmic.201700426. Epub 2018 Mar 30.


Miniaturized dispersive liquid-liquid microextraction and MALDI MS using ionic liquid matrices for the detection of bacterial communication molecules and virulence factors.

Leipert J, Bobis I, Schubert S, Fickenscher H, Leippe M, Tholey A.

Anal Bioanal Chem. 2018 Jul;410(19):4737-4748. doi: 10.1007/s00216-018-0937-6. Epub 2018 Feb 22.


Site-specific and endothelial-mediated dysfunction of the alveolar-capillary barrier in response to lipopolysaccharides.

Janga H, Cassidy L, Wang F, Spengler D, Oestern-Fitschen S, Krause MF, Seekamp A, Tholey A, Fuchs S.

J Cell Mol Med. 2018 Feb;22(2):982-998. doi: 10.1111/jcmm.13421. Epub 2017 Dec 5.


Insights into Microalga and Bacteria Interactions of Selected Phycosphere Biofilms Using Metagenomic, Transcriptomic, and Proteomic Approaches.

Krohn-Molt I, Alawi M, Förstner KU, Wiegandt A, Burkhardt L, Indenbirken D, Thieß M, Grundhoff A, Kehr J, Tholey A, Streit WR.

Front Microbiol. 2017 Oct 10;8:1941. doi: 10.3389/fmicb.2017.01941. eCollection 2017.


MALDI Mass Spectrometry Imaging: A Novel Tool for the Identification and Classification of Amyloidosis.

Winter M, Tholey A, Kristen A, Röcken C.

Proteomics. 2017 Nov;17(22). doi: 10.1002/pmic.201700236.


GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation.

Schäfer M, Granato DC, Krossa S, Bartels AK, Yokoo S, Düsterhöft S, Koudelka T, Scheidig AJ, Tholey A, Paes Leme AF, Grötzinger J, Lorenzen I.

FEBS Lett. 2017 Nov;591(21):3567-3587. doi: 10.1002/1873-3468.12858. Epub 2017 Oct 11.


We Are Not Alone: The iMOP Initiative and Its Roles in a Biology- and Disease-Driven Human Proteome Project.

Tholey A, Taylor NL, Heazlewood JL, Bendixen E.

J Proteome Res. 2017 Dec 1;16(12):4273-4280. doi: 10.1021/acs.jproteome.7b00408. Epub 2017 Oct 31. Review.


Host modification of a bacterial quorum-sensing signal induces a phenotypic switch in bacterial symbionts.

Pietschke C, Treitz C, Forêt S, Schultze A, Künzel S, Tholey A, Bosch TCG, Fraune S.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8488-E8497. doi: 10.1073/pnas.1706879114. Epub 2017 Sep 18.


Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.

Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C.

Oncotarget. 2017 Jul 4;8(33):54873-54888. doi: 10.18632/oncotarget.18966. eCollection 2017 Aug 15.


Methanosarcina Spherical Virus, a Novel Archaeal Lytic Virus Targeting Methanosarcina Strains.

Weidenbach K, Nickel L, Neve H, Alkhnbashi OS, Künzel S, Kupczok A, Bauersachs T, Cassidy L, Tholey A, Backofen R, Schmitz RA.

J Virol. 2017 Oct 27;91(22). pii: e00955-17. doi: 10.1128/JVI.00955-17. Print 2017 Nov 15.


Identification and Quantification of N-Acyl Homoserine Lactones Involved in Bacterial Communication by Small-Scale Synthesis of Internal Standards and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.

Leipert J, Treitz C, Leippe M, Tholey A.

J Am Soc Mass Spectrom. 2017 Dec;28(12):2538-2547. doi: 10.1007/s13361-017-1777-x. Epub 2017 Aug 30.


Microbiomarkers in inflammatory bowel diseases: caveats come with caviar.

Sommer F, Rühlemann MC, Bang C, Höppner M, Rehman A, Kaleta C, Schmitt-Kopplin P, Dempfle A, Weidinger S, Ellinghaus E, Krauss-Etschmann S, Schmidt-Arras D, Aden K, Schulte D, Ellinghaus D, Schreiber S, Tholey A, Rupp J, Laudes M, Baines JF, Rosenstiel P, Franke A.

Gut. 2017 Oct;66(10):1734-1738. doi: 10.1136/gutjnl-2016-313678. Epub 2017 Jul 21. No abstract available.


Top-down proteomics for the analysis of proteolytic events - Methods, applications and perspectives.

Tholey A, Becker A.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2191-2199. doi: 10.1016/j.bbamcr.2017.07.002. Epub 2017 Jul 12. Review.


A novel tertiary prep-HPLC method for the isolation of single amino acids for AMS-radiocarbon measurement.

Fernandes R, Koudelka T, Tholey A, Dreves A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jul 15;1058:85-92. doi: 10.1016/j.jchromb.2017.05.017. Epub 2017 May 15.


Multiplexed Protease Specificity Profiling Using Isobaric Labeling.

Tucher J, Tholey A.

Methods Mol Biol. 2017;1574:171-182. doi: 10.1007/978-1-4939-6850-3_12.


Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.

Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.


Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.

PLoS Biol. 2017 Jan 6;15(1):e2000080. doi: 10.1371/journal.pbio.2000080. eCollection 2017 Jan.


Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.

Bedau T, Peters F, Prox J, Arnold P, Schmidt F, Finkernagel M, Köllmann S, Wichert R, Otte A, Ohler A, Stirnberg M, Lucius R, Koudelka T, Tholey A, Biasin V, Pietrzik CU, Kwapiszewska G, Becker-Pauly C.

FASEB J. 2017 Mar;31(3):1226-1237. doi: 10.1096/fj.201601113R. Epub 2016 Dec 21.


Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection.

Ott SJ, Waetzig GH, Rehman A, Moltzau-Anderson J, Bharti R, Grasis JA, Cassidy L, Tholey A, Fickenscher H, Seegert D, Rosenstiel P, Schreiber S.

Gastroenterology. 2017 Mar;152(4):799-811.e7. doi: 10.1053/j.gastro.2016.11.010. Epub 2016 Nov 17.


Reduction of GAPDH in lenses of Parkinson's disease patients: A possible new biomarker.

Klettner A, Tholey A, Wiegandt A, Richert E, Nölle B, Deuschl G, Roider J, Schneider SA.

Mov Disord. 2017 Mar;32(3):459-462. doi: 10.1002/mds.26863. Epub 2016 Nov 10.


Differential quantitative proteome analysis of Escherichia coli grown on acetate versus glucose.

Treitz C, Enjalbert B, Portais JC, Letisse F, Tholey A.

Proteomics. 2016 Nov;16(21):2742-2746. doi: 10.1002/pmic.201600303. Epub 2016 Oct 10.


Comparative Proteome Analysis in Schizosaccharomyces pombe Identifies Metabolic Targets to Improve Protein Production and Secretion.

Hung CW, Klein T, Cassidy L, Linke D, Lange S, Anders U, Bureik M, Heinzle E, Schneider K, Tholey A.

Mol Cell Proteomics. 2016 Oct;15(10):3090-3106. Epub 2016 Jul 31.


Phosphatidylserine exposure is required for ADAM17 sheddase function.

Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.

Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523.


Characterization of post-translational modifications in full-length human BMP-1 confirms the presence of a rare vicinal disulfide linkage in the catalytic domain and highlights novel features of the EGF domain.

Hung CW, Koudelka T, Anastasi C, Becker A, Moali C, Tholey A.

J Proteomics. 2016 Apr 14;138:136-45. doi: 10.1016/j.jprot.2016.02.031. Epub 2016 Mar 2.


C-Terminal Charge-Reversal Derivatization and Parallel Use of Multiple Proteases Facilitates Identification of Protein C-Termini by C-Terminomics.

Somasundaram P, Koudelka T, Linke D, Tholey A.

J Proteome Res. 2016 Apr 1;15(4):1369-78. doi: 10.1021/acs.jproteome.6b00146. Epub 2016 Mar 17.


From top-down to bottom-up: Time-dependent monitoring of proteolytic protein degradation by LC-MS.

Tucher J, Koudelka T, Schlenk J, Tholey A.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:111-120. doi: 10.1016/j.jchromb.2016.02.021. Epub 2016 Feb 17.


Enhancing metaproteomics--The value of models and defined environmental microbial systems.

Herbst FA, Lünsmann V, Kjeldal H, Jehmlich N, Tholey A, von Bergen M, Nielsen JL, Hettich RL, Seifert J, Nielsen PH.

Proteomics. 2016 Mar;16(5):783-98. doi: 10.1002/pmic.201500305. Epub 2016 Jan 21. Review.


β-Lactoglobulin as nanotransporter--Part II: Characterization of the covalent protein modification by allicin and diallyl disulfide.

Wilde SC, Treitz C, Keppler JK, Koudelka T, Palani K, Tholey A, Rawel HM, Schwarz K.

Food Chem. 2016 Apr 15;197(Pt A):1022-9. doi: 10.1016/j.foodchem.2015.11.011. Epub 2015 Nov 4.


Conserved phosphorylation sites in the activation loop of the Arabidopsis phytosulfokine receptor PSKR1 differentially affect kinase and receptor activity.

Hartmann J, Linke D, Bönniger C, Tholey A, Sauter M.

Biochem J. 2015 Dec 15;472(3):379-91. doi: 10.1042/BJ20150147. Epub 2015 Oct 15.


Characterization of an Equine α-S2-Casein Variant Due to a 1.3 kb Deletion Spanning Two Coding Exons.

Brinkmann J, Koudelka T, Keppler JK, Tholey A, Schwarz K, Thaller G, Tetens J.

PLoS One. 2015 Oct 7;10(10):e0139700. doi: 10.1371/journal.pone.0139700. eCollection 2015.


Identification and relative quantification of phosphopeptides by a combination of multi-protease digestion and isobaric labeling.

Linke D, Koudelka T, Becker A, Tholey A.

Rapid Commun Mass Spectrom. 2015 May 30;29(10):919-26. doi: 10.1002/rcm.7185.


Multi-Organism Proteomes (iMOP): Advancing our Understanding of Human Biology.

Heazlewood JL, Schrimpf SP, Becher D, Riedel K, Tholey A, Bendixen E.

Proteomics. 2015 Sep;15(17):2885-94. doi: 10.1002/pmic.201570153. No abstract available.


Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.

Jäckle F, Schmidt F, Wichert R, Arnold P, Prox J, Mangold M, Ohler A, Pietrzik CU, Koudelka T, Tholey A, Gütschow M, Stirnberg M, Becker-Pauly C.

Biochem J. 2015 Aug 15;470(1):91-103. doi: 10.1042/BJ20141417. Epub 2015 Jun 15.


Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2.

Menzel S, Rissiek B, Bannas P, Jakoby T, Miksiewicz M, Schwarz N, Nissen M, Haag F, Tholey A, Koch-Nolte F.

J Immunol. 2015 Sep 1;195(5):2057-66. doi: 10.4049/jimmunol.1401677. Epub 2015 Jul 24.


MALDI-mass spectrometry imaging identifies vitronectin as a common constituent of amyloid deposits.

Winter M, Tholey A, Krüger S, Schmidt H, Röcken C.

J Histochem Cytochem. 2015 Oct;63(10):772-9. doi: 10.1369/0022155415595264. Epub 2015 Jun 22.


Overlapping and unique signatures in the proteomic and transcriptomic responses of the nematode Caenorhabditis elegans toward pathogenic Bacillus thuringiensis.

Yang W, Dierking K, Esser D, Tholey A, Leippe M, Rosenstiel P, Schulenburg H.

Dev Comp Immunol. 2015 Jul;51(1):1-9. doi: 10.1016/j.dci.2015.02.010. Epub 2015 Feb 23.


Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease.

Krishna A, Biryukov M, Trefois C, Antony PM, Hussong R, Lin J, Heinäniemi M, Glusman G, Köglsberger S, Boyd O, van den Berg BH, Linke D, Huang D, Wang K, Hood L, Tholey A, Schneider R, Galas DJ, Balling R, May P.

BMC Genomics. 2014 Dec 20;15:1154. doi: 10.1186/1471-2164-15-1154.


Quantitative proteome analysis of Caenorhabditis elegans upon exposure to nematicidal Bacillus thuringiensis.

Treitz C, Cassidy L, Höckendorf A, Leippe M, Tholey A.

J Proteomics. 2015 Jan 15;113:337-50. doi: 10.1016/j.jprot.2014.09.027. Epub 2014 Oct 30.


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