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Items: 36

1.

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics.

Zhang HE, Hamson EJ, Koczorowska MM, Tholen S, Chowdhury S, Bailey CG, Lay AJ, Twigg SM, Lee Q, Roediger B, Biniossek ML, O'Rourke MB, McCaughan GW, Keane FM, Schilling O, Gorrell MD.

Mol Cell Proteomics. 2019 Jan;18(1):65-85. doi: 10.1074/mcp.RA118.001046. Epub 2018 Sep 26.

PMID:
30257879
2.

A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation.

Bahrami-Nejad Z, Zhao ML, Tholen S, Hunerdosse D, Tkach KE, van Schie S, Chung M, Teruel MN.

Cell Metab. 2018 Apr 3;27(4):854-868.e8. doi: 10.1016/j.cmet.2018.03.012.

PMID:
29617644
3.

Proteomics highlights decrease of matricellular proteins in left ventricular assist device therapy†.

Shahinian JH, Mayer B, Tholen S, Brehm K, Biniossek ML, Füllgraf H, Kiefer S, Heizmann U, Heilmann C, Rüter F, Grapow M, Reuthebuch OT, Eckstein F, Beyersdorf F, Schilling O, Siepe M.

Eur J Cardiothorac Surg. 2017 Jun 1;51(6):1063-1071. doi: 10.1093/ejcts/ezx023.

PMID:
28329269
4.

The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B.

Paireder M, Tholen S, Porodko A, Biniossek ML, Mayer B, Novinec M, Schilling O, Mach L.

Biochim Biophys Acta Proteins Proteom. 2017 Apr;1865(4):444-452. doi: 10.1016/j.bbapap.2017.02.007. Epub 2017 Feb 7.

5.

Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival.

Shahinian JH, Fuellgraf H, Tholen S, Mastroianni J, Knopf JD, Kuehs M, Mayer B, Schlimpert M, Kulemann B, Kuesters S, Hoeppner J, Wellner UF, Werner M, Hopt UT, Zeiser R, Bronsert P, Schilling O.

J Cancer. 2016 Oct 17;7(14):2018-2027. eCollection 2016.

6.

Rationale and study design of the prospective, longitudinal, observational cohort study "rISk strAtification in end-stage renal disease" (ISAR) study.

Schmaderer C, Tholen S, Hasenau AL, Hauser C, Suttmann Y, Wassertheurer S, Mayer CC, Bauer A, Rizas KD, Kemmner S, Kotliar K, Haller B, Mann J, Renders L, Heemann U, Baumann M.

BMC Nephrol. 2016 Oct 26;17(1):161.

7.

The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity.

Paireder M, Mehofer U, Tholen S, Porodko A, Schähs P, Maresch D, Biniossek ML, van der Hoorn RA, Lenarcic B, Novinec M, Schilling O, Mach L.

Arch Biochem Biophys. 2016 Aug 1;603:110-7. doi: 10.1016/j.abb.2016.05.017. Epub 2016 May 28.

8.

Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations.

Tholen S, Wolf C, Mayer B, Knopf JD, Löffek S, Qian Y, Kizhakkedathu JN, Biniossek ML, Franzke CW, Schilling O.

J Proteome Res. 2016 May 6;15(5):1402-17. doi: 10.1021/acs.jproteome.5b00691. Epub 2016 Apr 21.

PMID:
27089454
9.

Plasma total C-terminal agrin fragment (tCAF) as a marker for kidney function in patients with chronic kidney disease.

Steubl D, Roos M, Hettwer S, Satanovskij R, Tholen S, Wen M, Schmaderer C, Hasenau AL, Luppa P, Stecher L, Heemann U, Renders L.

Clin Chem Lab Med. 2016 Sep 1;54(9):1487-95. doi: 10.1515/cclm-2015-1027.

PMID:
26876812
10.

Reduction of Amyloid-β Plasma Levels by Hemodialysis: An Anti-Amyloid Treatment Strategy?

Tholen S, Schmaderer C, Chmielewski S, Förstl H, Heemann U, Baumann M, Steubl D, Grimmer T.

J Alzheimers Dis. 2016;50(3):791-6. doi: 10.3233/JAD-150662.

PMID:
26682683
11.

Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations.

Koczorowska MM, Tholen S, Bucher F, Lutz L, Kizhakkedathu JN, De Wever O, Wellner UF, Biniossek ML, Stahl A, Lassmann S, Schilling O.

Mol Oncol. 2016 Jan;10(1):40-58. doi: 10.1016/j.molonc.2015.08.001. Epub 2015 Aug 11.

12.

The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia.

Knopf JD, Tholen S, Koczorowska MM, De Wever O, Biniossek ML, Schilling O.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2515-25. doi: 10.1016/j.bbamcr.2015.07.013. Epub 2015 Jul 23.

13.

Early postoperative C-terminal agrin fragment (CAF) serum levels predict graft loss and proteinuria in renal transplant recipients.

Steubl D, Vogel A, Hettwer S, Tholen S, Luppa PB, Rondak IC, Renders L, Heemann U, Roos M.

Clin Chem Lab Med. 2016 Jan;54(1):63-72. doi: 10.1515/cclm-2015-0369.

PMID:
26087066
14.

Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo.

Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T.

Nat Commun. 2014 Sep 15;5:4931. doi: 10.1038/ncomms5931.

PMID:
25222295
15.

Variability of cognitive performance during hemodialysis: standardization of cognitive assessment.

Tholen S, Schmaderer C, Kusmenkov E, Chmielewski S, Förstl H, Kehl V, Heemann U, Baumann M, Grimmer T.

Dement Geriatr Cogn Disord. 2014;38(1-2):31-8. doi: 10.1159/000357803. Epub 2014 Feb 20.

PMID:
24556891
16.

Understanding fibroblast activation protein (FAP): substrates, activities, expression and targeting for cancer therapy.

Hamson EJ, Keane FM, Tholen S, Schilling O, Gorrell MD.

Proteomics Clin Appl. 2014 Jun;8(5-6):454-63. doi: 10.1002/prca.201300095. Epub 2014 Mar 24. Review.

PMID:
24470260
17.

Proteomic identification of protease cleavage sites: cell-biological and biomedical applications.

Shahinian H, Tholen S, Schilling O.

Expert Rev Proteomics. 2013 Oct;10(5):421-33. doi: 10.1586/14789450.2013.841547. Review.

PMID:
24117201
18.

Progression of aortic pulse wave velocity in patients with chronic kidney disease.

Tholen S, Klofat K, Pan CR, Schmaderer C, Lutz J, Heemann U, Baumann M.

J Clin Hypertens (Greenwich). 2013 Nov;15(11):833-8. doi: 10.1111/jch.12198. Epub 2013 Sep 16.

19.

Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis.

Tholen S, Biniossek ML, Gansz M, Ahrens TD, Schlimpert M, Kizhakkedathu JN, Reinheckel T, Schilling O.

Cell Mol Life Sci. 2014 Mar;71(5):899-916. doi: 10.1007/s00018-013-1406-1. Epub 2013 Jun 29.

PMID:
23811845
20.

Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.

Tholen S, Biniossek ML, Gansz M, Gomez-Auli A, Bengsch F, Noel A, Kizhakkedathu JN, Boerries M, Busch H, Reinheckel T, Schilling O.

Mol Cell Proteomics. 2013 Mar;12(3):611-25. doi: 10.1074/mcp.M112.017962. Epub 2012 Dec 10.

21.

A high-frequency mutation in Bacillus subtilis: requirements for the decryptification of the gudB glutamate dehydrogenase gene.

Gunka K, Tholen S, Gerwig J, Herzberg C, Stülke J, Commichau FM.

J Bacteriol. 2012 Mar;194(5):1036-44. doi: 10.1128/JB.06470-11. Epub 2011 Dec 16.

22.

Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.

Tholen S, Biniossek ML, Gessler AL, Müller S, Weisser J, Kizhakkedathu JN, Reinheckel T, Schilling O.

Biol Chem. 2011 Nov;392(11):961-71. doi: 10.1515/BC.2011.162.

PMID:
21972973
23.

SPABBATS: A pathway-discovery method based on Boolean satisfiability that facilitates the characterization of suppressor mutants.

Flórez LA, Gunka K, Polanía R, Tholen S, Stülke J.

BMC Syst Biol. 2011 Jan 11;5:5. doi: 10.1186/1752-0509-5-5.

24.

Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease.

Grimmer T, Tholen S, Yousefi BH, Alexopoulos P, Förschler A, Förstl H, Henriksen G, Klunk WE, Mathis CA, Perneczky R, Sorg C, Kurz A, Drzezga A.

Biol Psychiatry. 2010 Nov 15;68(10):879-84. doi: 10.1016/j.biopsych.2010.05.013. Epub 2010 Jul 2.

25.

Empirically and clinically useful decision making in psychotherapy: differential predictions with treatment response models.

Lutz W, Saunders SM, Leon SC, Martinovich Z, Kosfelder J, Schulte D, Grawe K, Tholen S.

Psychol Assess. 2006 Jun;18(2):133-41.

PMID:
16768589
26.

The natural course of DSM-IV somatoform disorders and syndromes among adolescents and young adults: a prospective-longitudinal community study.

Lieb R, Zimmermann P, Friis RH, Höfler M, Tholen S, Wittchen HU.

Eur Psychiatry. 2002 Oct;17(6):321-31.

PMID:
12457742
27.

Con law is as con law does: a survey of Planned Parenthood v. Casey in the state and federal courts.

Tholen SL, Baird L.

Loyola Los Angel Law Rev. 1995 Apr;28(3):971-1046. No abstract available.

PMID:
11656518
28.

Effect of 4He on the surface scattering of 3He.

Tholen SM, Parpia JM.

Phys Rev B Condens Matter. 1993 Jan 1;47(1):319-329. No abstract available.

PMID:
10004448
29.

Hysteretic solidification of surface 4He measured by the modification of the specularity of 3He.

Tholen SM, Parpia JM.

Phys Rev Lett. 1992 May 4;68(18):2810-2813. No abstract available.

PMID:
10045498
30.

Slip and the effect of 4He at the 3He-silicon interface.

Tholen SM, Parpia JM.

Phys Rev Lett. 1991 Jul 15;67(3):334-337. No abstract available.

PMID:
10044862
31.

[Contact allergies to recently introduced preservatives].

Senff H, Köllner A, Tholen S, Frosch PJ.

Hautarzt. 1991 Apr;42(4):215-9. Review. German.

PMID:
1830567
32.

Allergic contact dermatitis to naftifine. Report of two cases.

Senff H, Tholen S, Stieler W, Reinel D, Hausen BM.

Dermatologica. 1989;178(2):107-8.

PMID:
2522401
33.

[Changes in the oral mucosa in psoriasis pustulosa generalisata].

Tholen S, Lubach D.

Hautarzt. 1987 Jul;38(7):419-21. German.

PMID:
3654210
34.

[Sex hormones in lupus erythematosus].

Vennemann F, Tholen S.

Z Hautkr. 1986 Jun 1;61(11):791-9. German.

PMID:
2943085
35.

[Drug-induced pemphigus].

Tholen S.

Z Hautkr. 1986 May 15;61(10):719-23. German.

PMID:
3521113
36.

[Human alpha leukocyte interferon. Preliminary results of a pilot study on the treatment of virus dermatoses].

Vennemann F, Tholen S, Wolters M.

Fortschr Med. 1985 Nov 14;103(42):977-80. German. No abstract available.

PMID:
4076990

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