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Items: 1 to 50 of 172

1.

Structural Analysis of Cj1427, an Essential NAD-Dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides of Campylobacter jejuni.

Huddleston JP, Anderson TK, Spencer KD, Thoden JB, Raushel FM, Holden HM.

Biochemistry. 2020 Mar 23. doi: 10.1021/acs.biochem.0c00096. [Epub ahead of print]

PMID:
32168450
2.

Biochemical analysis of a sugar 4,6-dehydratase from Acanthamoeba polyphaga Mimivirus.

Ferek JD, Thoden JB, Holden HM.

Protein Sci. 2020 Feb 21. doi: 10.1002/pro.3843. [Epub ahead of print]

PMID:
32083779
3.

Misannotations of the genes encoding sugar N-formyltransferases.

Girardi NM, Thoden JB, Holden HM.

Protein Sci. 2020 Apr;29(4):930-940. doi: 10.1002/pro.3807. Epub 2020 Jan 20.

PMID:
31867814
4.

Structural and Functional Characterization of YdjI, an Aldolase of Unknown Specificity in Escherichia coli K12.

Huddleston JP, Thoden JB, Dopkins BJ, Narindoshvili T, Fose BJ, Holden HM, Raushel FM.

Biochemistry. 2019 Aug 6;58(31):3340-3353. doi: 10.1021/acs.biochem.9b00326. Epub 2019 Jul 26.

PMID:
31322866
5.

Investigation of a sugar N-formyltransferase from the plant pathogen Pantoea ananatis.

Hofmeister DL, Thoden JB, Holden HM.

Protein Sci. 2019 Apr;28(4):707-716. doi: 10.1002/pro.3577. Epub 2019 Feb 8.

6.

[Opportunistic infections: What's new?]

Boesecke C, Rockstroh JK, Thoden J.

Dtsch Med Wochenschr. 2018 Dec;143(24):1755-1758. doi: 10.1055/a-0641-9456. Epub 2018 Dec 3. German.

PMID:
30508854
7.

Sleep apnea in Sjögren's syndrome potentially influences the EULAR Sjögren's syndrome patient reported index.

Jülich M, Budweiser S, Thoden J, Voll RE, Kollert F.

Mod Rheumatol. 2019 May;29(3):563-565. doi: 10.1080/14397595.2018.1467526. Epub 2018 Aug 13. No abstract available.

PMID:
29669457
8.

The three-dimensional structure of NeoB: An aminotransferase involved in the biosynthesis of neomycin.

Dow GT, Thoden JB, Holden HM.

Protein Sci. 2018 May;27(5):945-956. doi: 10.1002/pro.3400. Epub 2018 Apr 2.

9.

Incidence and risk factors for relapses in HIV-associated non-Hodgkin lymphoma as observed in the German HIV-related lymphoma cohort study.

Schommers P, Gillor D, Hentrich M, Wyen C, Wolf T, Oette M, Zoufaly A, Wasmuth JC, Bogner JR, Müller M, Esser S, Schleicher A, Jensen B, Stoehr A, Behrens G, Schultze A, Siehl J, Thoden J, Taylor N, Hoffmann C.

Haematologica. 2018 May;103(5):857-864. doi: 10.3324/haematol.2017.180893. Epub 2018 Feb 8.

10.

Computational Redesign of Acyl-ACP Thioesterase with Improved Selectivity toward Medium-Chain-Length Fatty Acids.

Grisewood MJ, Hernandez Lozada NJ, Thoden JB, Gifford NP, Mendez-Perez D, Schoenberger HA, Allan MF, Floy ME, Lai RY, Holden HM, Pfleger BF, Maranas CD.

ACS Catal. 2017 Jun 2;7(6):3837-3849. doi: 10.1021/acscatal.7b00408. Epub 2017 Apr 20.

11.

Molecular architectures of Pen and Pal: Key enzymes required for CMP-pseudaminic acid biosynthesis in Bacillus thuringiensis.

Delvaux NA, Thoden JB, Holden HM.

Protein Sci. 2018 Mar;27(3):738-749. doi: 10.1002/pro.3368. Epub 2018 Feb 5.

12.

The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes.

Brown HA, Thoden JB, Tipton PA, Holden HM.

Protein Sci. 2018 Feb;27(2):441-450. doi: 10.1002/pro.3333. Epub 2017 Nov 9.

13.

Structural and Biochemical Investigation of PglF from Campylobacter jejuni Reveals a New Mechanism for a Member of the Short Chain Dehydrogenase/Reductase Superfamily.

Riegert AS, Thoden JB, Schoenhofen IC, Watson DC, Young NM, Tipton PA, Holden HM.

Biochemistry. 2017 Nov 14;56(45):6030-6040. doi: 10.1021/acs.biochem.7b00910. Epub 2017 Nov 3.

14.

The structure of RbmB from Streptomyces ribosidificus, an aminotransferase involved in the biosynthesis of ribostamycin.

Zachman-Brockmeyer TR, Thoden JB, Holden HM.

Protein Sci. 2017 Sep;26(9):1886-1892. doi: 10.1002/pro.3221. Epub 2017 Jul 23.

15.

Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis.

Dunsirn MM, Thoden JB, Gilbert M, Holden HM.

Biochemistry. 2017 Jul 25;56(29):3818-3825. doi: 10.1021/acs.biochem.7b00506. Epub 2017 Jul 14.

16.

Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis.

Riegert AS, Chantigian DP, Thoden JB, Tipton PA, Holden HM.

Biochemistry. 2017 Jul 18;56(28):3657-3668. doi: 10.1021/acs.biochem.7b00494. Epub 2017 Jul 5.

17.

Molecular architecture of an N-formyltransferase from Salmonella enterica O60.

Woodford CR, Thoden JB, Holden HM.

J Struct Biol. 2017 Dec;200(3):267-278. doi: 10.1016/j.jsb.2017.03.002. Epub 2017 Mar 2.

18.

Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116.

Li ZZ, Riegert AS, Goneau MF, Cunningham AM, Vinogradov E, Li J, Schoenhofen IC, Thoden JB, Holden HM, Gilbert M.

Glycobiology. 2017 Apr 1;27(4):358-369. doi: 10.1093/glycob/cww136.

19.

Structural investigation on WlaRG from Campylobacter jejuni: A sugar aminotransferase.

Dow GT, Gilbert M, Thoden JB, Holden HM.

Protein Sci. 2017 Mar;26(3):586-599. doi: 10.1002/pro.3109. Epub 2017 Feb 9.

20.

Structural studies on KijD1, a sugar C-3'-methyltransferase.

Dow GT, Thoden JB, Holden HM.

Protein Sci. 2016 Dec;25(12):2282-2289. doi: 10.1002/pro.3034. Epub 2016 Sep 16.

21.

Structural and Functional Investigation of FdhC from Acinetobacter nosocomialis: A Sugar N-Acyltransferase Belonging to the GNAT Superfamily.

Salinger AJ, Thoden JB, Holden HM.

Biochemistry. 2016 Aug 16;55(32):4509-18. doi: 10.1021/acs.biochem.6b00602. Epub 2016 Aug 4.

22.

Structural Studies on a Glucosamine/Glucosaminide N-Acetyltransferase.

Dopkins BJ, Tipton PA, Thoden JB, Holden HM.

Biochemistry. 2016 Aug 16;55(32):4495-508. doi: 10.1021/acs.biochem.6b00536. Epub 2016 Aug 4.

23.

Structures of KdnB and KdnA from Shewanella oneidensis: Key Enzymes in the Formation of 8-Amino-3,8-Dideoxy-d-Manno-Octulosonic Acid.

Zachman-Brockmeyer TR, Thoden JB, Holden HM.

Biochemistry. 2016 Aug 16;55(32):4485-94. doi: 10.1021/acs.biochem.6b00439. Epub 2016 Aug 4.

24.

Enzymes required for the biosynthesis of N-formylated sugars.

Holden HM, Thoden JB, Gilbert M.

Curr Opin Struct Biol. 2016 Dec;41:1-9. doi: 10.1016/j.sbi.2016.04.003. Epub 2016 May 20. Review.

25.

Structure of the Escherichia coli ArnA N-formyltransferase domain in complex with N(5) -formyltetrahydrofolate and UDP-Ara4N.

Genthe NA, Thoden JB, Holden HM.

Protein Sci. 2016 Aug;25(8):1555-62. doi: 10.1002/pro.2938. Epub 2016 May 17.

26.

A Methylene Group on C-2 of 24,24-Difluoro-19-nor-1α,25-dihydroxyvitamin D3 Markedly Increases Bone Calcium Mobilization in Vivo.

Flores A, Massarelli I, Thoden JB, Plum LA, DeLuca HF.

J Med Chem. 2015 Dec 24;58(24):9731-41. doi: 10.1021/acs.jmedchem.5b01564. Epub 2015 Dec 9.

27.

German-Austrian guidelines on anal dysplasia and anal cancer in HIV-positive individuals: prevention, diagnosis, and treatment.

Esser S, Kreuter A, Oette M, Gingelmaier A, Mosthaf F, Sautter-Bihl ML, Jongen J, Brockmeyer NH, Eldering G, Swoboda J, Postel N, Degen O, Schalk H, Jessen A, Knechten H, Thoden J, Stellbrink HJ, Schafberger A, Wieland U.

J Dtsch Dermatol Ges. 2015 Dec;13(12):1302-19. doi: 10.1111/ddg.12726. No abstract available.

PMID:
26612810
28.

Structure of the external aldimine form of PglE, an aminotransferase required for N,N'-diacetylbacillosamine biosynthesis.

Riegert AS, Young NM, Watson DC, Thoden JB, Holden HM.

Protein Sci. 2015 Oct;24(10):1609-16. doi: 10.1002/pro.2745. Epub 2015 Jul 30.

29.

Molecular architecture of KedS8, a sugar N-methyltransferase from Streptoalloteichus sp. ATCC 53650.

Delvaux NA, Thoden JB, Holden HM.

Protein Sci. 2015 Oct;24(10):1593-9. doi: 10.1002/pro.2742. Epub 2015 Jul 21.

30.

Biochemical studies on WbcA, a sugar epimerase from Yersinia enterocolitica.

Salinger AJ, Brown HA, Thoden JB, Holden HM.

Protein Sci. 2015 Oct;24(10):1633-9. doi: 10.1002/pro.2747. Epub 2015 Aug 13.

31.

Bacterial Sugar 3,4-Ketoisomerases: Structural Insight into Product Stereochemistry.

Thoden JB, Vinogradov E, Gilbert M, Salinger AJ, Holden HM.

Biochemistry. 2015 Jul 28;54(29):4495-506. doi: 10.1021/acs.biochem.5b00541. Epub 2015 Jul 13.

32.

Molecular structure of an N-formyltransferase from Providencia alcalifaciens O30.

Genthe NA, Thoden JB, Benning MM, Holden HM.

Protein Sci. 2015 Jun;24(6):976-86. doi: 10.1002/pro.2675. Epub 2015 Apr 2.

33.

New role for the ankyrin repeat revealed by a study of the N-formyltransferase from Providencia alcalifaciens.

Woodford CR, Thoden JB, Holden HM.

Biochemistry. 2015 Jan 27;54(3):631-8. doi: 10.1021/bi501539a. Epub 2015 Jan 15.

34.

Survival of AIDS-related diffuse large B-cell lymphoma, Burkitt lymphoma, and plasmablastic lymphoma in the German HIV Lymphoma Cohort.

Schommers P, Hentrich M, Hoffmann C, Gillor D, Zoufaly A, Jensen B, Bogner JR, Thoden J, Wasmuth JC, Wolf T, Oette M, Müller M, Esser S, Vehreschild JJ, Fätkenheuer G, Wyen C.

Br J Haematol. 2015 Mar;168(6):806-10. doi: 10.1111/bjh.13221. Epub 2014 Nov 17.

PMID:
25403997
35.

Structure of L-serine dehydratase from Legionella pneumophila: novel use of the C-terminal cysteine as an intrinsic competitive inhibitor.

Thoden JB, Holden HM, Grant GA.

Biochemistry. 2014 Dec 9;53(48):7615-24. doi: 10.1021/bi501253w. Epub 2014 Nov 24.

36.

Hodgkin lymphoma is as common as non-Hodgkin lymphoma in HIV-positive patients with sustained viral suppression and limited immune deficiency: a prospective cohort study.

Hoffmann C, Hentrich M, Gillor D, Behrens G, Jensen B, Stoehr A, Esser S, van Lunzen J, Krznaric I, Müller M, Oette M, Hensel M, Thoden J, Fätkenheuer G, Wyen C.

HIV Med. 2015 Apr;16(4):261-4. doi: 10.1111/hiv.12200. Epub 2014 Sep 23.

37.

The molecular architecture of QdtA, a sugar 3,4-ketoisomerase from Thermoanaerobacterium thermosaccharolyticum.

Thoden JB, Holden HM.

Protein Sci. 2014 Jun;23(6):683-92. doi: 10.1002/pro.2451. Epub 2014 Mar 25.

38.

Production of a novel N-monomethylated dideoxysugar.

Thoden JB, Holden HM.

Biochemistry. 2014 Feb 25;53(7):1105-7. doi: 10.1021/bi500098a. Epub 2014 Feb 11.

39.

Dose-intensive chemotherapy including rituximab is highly effective but toxic in human immunodeficiency virus-infected patients with Burkitt lymphoma/leukemia: parallel study of 81 patients.

Xicoy B, Ribera JM, Müller M, García O, Hoffmann C, Oriol A, Hentrich M, Grande C, Wasmuth JC, Esteve J, van Lunzen J, Del Potro E, Knechten H, Brunet S, Mayr C, Escoda L, Schommers P, Alonso N, Vall-Llovera F, Pérez M, Morgades M, González J, Fernández A, Thoden J, Gökbuget N, Hoelzer D, Fätkenheuer G, Wyen C; PETHEMA Group and German HIV Lymphoma Cohort.

Leuk Lymphoma. 2014 Oct;55(10):2341-8. doi: 10.3109/10428194.2013.878933. Epub 2014 Feb 25.

PMID:
24397614
40.

Three-dimensional structure of a sugar N-formyltransferase from Francisella tularensis.

Zimmer AL, Thoden JB, Holden HM.

Protein Sci. 2014 Mar;23(3):273-83. doi: 10.1002/pro.2409. Epub 2014 Jan 22.

41.

Structural and biochemical characterization of a bifunctional ketoisomerase/N-acetyltransferase from Shewanella denitrificans.

Chantigian DP, Thoden JB, Holden HM.

Biochemistry. 2013 Nov 19;52(46):8374-85. doi: 10.1021/bi401170t. Epub 2013 Nov 4.

42.

Therapy and prophylaxis of opportunistic infections in HIV-infected patients: a guideline by the German and Austrian AIDS societies (DAIG/ÖAG) (AWMF 055/066).

Thoden J, Potthoff A, Bogner JR, Brockmeyer NH, Esser S, Grabmeier-Pfistershammer K, Haas B, Hahn K, Härter G, Hartmann M, Herzmann C, Hutterer J, Jordan AR, Lange C, Mauss S, Meyer-Olson D, Mosthaf F, Oette M, Reuter S, Rieger A, Rosenkranz T, Ruhnke M, Schaaf B, Schwarze S, Stellbrink HJ, Stocker H, Stoehr A, Stoll M, Träder C, Vogel M, Wagner D, Wyen C, Hoffmann C; Deutsche AIDS Gesellschaft; Österreichische AIDS-Gesellschaft.

Infection. 2013 Sep;41 Suppl 2:S91-115. doi: 10.1007/s15010-013-0504-1. Epub 2013 Sep 14.

43.

Structure of a sugar N-formyltransferase from Campylobacter jejuni.

Thoden JB, Goneau MF, Gilbert M, Holden HM.

Biochemistry. 2013 Sep 3;52(35):6114-26. doi: 10.1021/bi4009006. Epub 2013 Aug 20.

44.

pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis).

Reinhardt LA, Thoden JB, Peters GS, Holden HM, Cleland WW.

FEBS Lett. 2013 Sep 2;587(17):2876-81. doi: 10.1016/j.febslet.2013.07.017. Epub 2013 Jul 19.

45.

Active site architecture of a sugar N-oxygenase.

Thoden JB, Branch MC, Zimmer AL, Bruender NA, Holden HM.

Biochemistry. 2013 May 14;52(19):3191-3. doi: 10.1021/bi400407x. Epub 2013 Apr 30.

PMID:
23621882
46.

Poor outcome of HIV-infected patients with plasmablastic lymphoma: results from the German AIDS-related lymphoma cohort study.

Schommers P, Wyen C, Hentrich M, Gillor D, Zoufaly A, Jensen B, Bogner JR, Thoden J, Wasmuth JC, Fätkenheuer G, Hoffmann C.

AIDS. 2013 Mar 13;27(5):842-5. doi: 10.1097/QAD.0b013e32835e069d.

PMID:
23574794
47.

Structure of EvaA: a paradigm for sugar 2,3-dehydratases.

Kubiak RL, Thoden JB, Holden HM.

Biochemistry. 2013 Mar 26;52(12):2078-88. doi: 10.1021/bi400176n. Epub 2013 Mar 12.

PMID:
23473392
48.

The structure of DesR from Streptomyces venezuelae, a β-glucosidase involved in macrolide activation.

Zmudka MW, Thoden JB, Holden HM.

Protein Sci. 2013 Jul;22(7):883-92. doi: 10.1002/pro.2204. Epub 2013 Jan 17.

49.

Spuriously low IgG levels in lupus-associated mixed cryoglobulinaemia type II complicated by iatrogenic immunoglobulin-induced immune complex vasculitis.

Kollert F, Balcarek K, Müller-Schmah C, Thoden J, Thiel J, Venhoff N, Effelsberg N, Schlesier M, Warnatz K, Vaith P, Voll RE.

Clin Exp Rheumatol. 2012 Nov-Dec;30(6):982-3. Epub 2012 Dec 17. No abstract available.

PMID:
23101461
50.

The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU.

Song F, Thoden JB, Zhuang Z, Latham J, Trujillo M, Holden HM, Dunaway-Mariano D.

Biochemistry. 2012 Sep 4;51(35):7000-16. doi: 10.1021/bi301059m. Epub 2012 Aug 20.

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