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Items: 1 to 50 of 52

1.

A Lotus japonicus cytoplasmic kinase connects Nod factor perception by the NFR5 LysM receptor to nodulation.

Wong JEMM, Nadzieja M, Madsen LH, Bücherl CA, Dam S, Sandal NN, Couto D, Derbyshire P, Uldum-Berentsen M, Schroeder S, Schwämmle V, Nogueira FCS, Asmussen MH, Thirup S, Radutoiu S, Blaise M, Andersen KR, Menke FLH, Zipfel C, Stougaard J.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14339-14348. doi: 10.1073/pnas.1815425116. Epub 2019 Jun 25.

2.

E. coli elongation factor Tu bound to a GTP analogue displays an open conformation equivalent to the GDP-bound form.

Johansen JS, Kavaliauskas D, Pfeil SH, Blaise M, Cooperman BS, Goldman YE, Thirup SS, Knudsen CR.

Nucleic Acids Res. 2018 Sep 19;46(16):8641-8650. doi: 10.1093/nar/gky697.

3.

Acidic Environment Induces Dimerization and Ligand Binding Site Collapse in the Vps10p Domain of Sortilin.

Januliene D, Andersen JL, Nielsen JA, Quistgaard EM, Hansen M, Strandbygaard D, Moeller A, Petersen CM, Madsen P, Thirup SS.

Structure. 2017 Dec 5;25(12):1809-1819.e3. doi: 10.1016/j.str.2017.09.015.

4.

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.

Gustafsen C, Olsen D, Vilstrup J, Lund S, Reinhardt A, Wellner N, Larsen T, Andersen CBF, Weyer K, Li JP, Seeberger PH, Thirup S, Madsen P, Glerup S.

Nat Commun. 2017 Sep 11;8(1):503. doi: 10.1038/s41467-017-00568-7.

5.

Hidden Twins: SorCS Neuroreceptors Form Stable Dimers.

Januliene D, Manavalan A, Ovesen PL, Pedersen KM, Thirup S, Nykjær A, Moeller A.

J Mol Biol. 2017 Sep 15;429(19):2907-2917. doi: 10.1016/j.jmb.2017.08.006. Epub 2017 Aug 18.

PMID:
28827148
6.

The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin.

Andersen JL, Lindberg S, Langgård M, Maltas PJ, Rønn LCB, Bundgaard C, Strandbygaard D, Thirup S, Watson SP.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2629-2633. doi: 10.1016/j.bmcl.2017.02.028. Epub 2017 Feb 20.

PMID:
28462834
7.

Receptor-mediated exopolysaccharide perception controls bacterial infection.

Kawaharada Y, Kelly S, Nielsen MW, Hjuler CT, Gysel K, Muszyński A, Carlson RW, Thygesen MB, Sandal N, Asmussen MH, Vinther M, Andersen SU, Krusell L, Thirup S, Jensen KJ, Ronson CW, Blaise M, Radutoiu S, Stougaard J.

Nature. 2015 Jul 16;523(7560):308-12. doi: 10.1038/nature14611. Epub 2015 Jul 8.

PMID:
26153863
8.

Structural outline of the detailed mechanism for elongation factor Ts-mediated guanine nucleotide exchange on elongation factor Tu.

Thirup SS, Van LB, Nielsen TK, Knudsen CR.

J Struct Biol. 2015 Jul;191(1):10-21. doi: 10.1016/j.jsb.2015.06.011. Epub 2015 Jun 11.

9.

An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase.

Wong JE, Midtgaard SR, Gysel K, Thygesen MB, Sørensen KK, Jensen KJ, Stougaard J, Thirup S, Blaise M.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):592-605. doi: 10.1107/S139900471402793X. Epub 2015 Feb 26.

10.

Revisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensin.

Quistgaard EM, Grøftehauge MK, Madsen P, Pallesen LT, Christensen B, Sørensen ES, Nissen P, Petersen CM, Thirup SS.

Protein Sci. 2014 Sep;23(9):1291-300. doi: 10.1002/pro.2512. Epub 2014 Jul 22.

11.

Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.

Andersen JL, Schrøder TJ, Christensen S, Strandbygård D, Pallesen LT, García-Alai MM, Lindberg S, Langgård M, Eskildsen JC, David L, Tagmose L, Simonsen KB, Maltas PJ, Rønn LC, de Jong IE, Malik IJ, Egebjerg J, Karlsson JJ, Uppalanchi S, Sakumudi DR, Eradi P, Watson SP, Thirup S.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):451-60. doi: 10.1107/S1399004713030149. Epub 2014 Jan 29.

12.

The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin.

Schrøder TJ, Christensen S, Lindberg S, Langgård M, David L, Maltas PJ, Eskildsen J, Jacobsen J, Tagmose L, Simonsen KB, Biilmann Rønn LC, de Jong IE, Malik IJ, Karlsson JJ, Bundgaard C, Egebjerg J, Stavenhagen JB, Strandbygård D, Thirup S, Andersen JL, Uppalanchi S, Pervaram S, Kasturi SP, Eradi P, Sakumudi DR, Watson SP.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. doi: 10.1016/j.bmcl.2013.11.046. Epub 2013 Nov 27.

PMID:
24355129
13.

Cooperative binding of LysM domains determines the carbohydrate affinity of a bacterial endopeptidase protein.

Wong JE, Alsarraf HM, Kaspersen JD, Pedersen JS, Stougaard J, Thirup S, Blaise M.

FEBS J. 2014 Feb;281(4):1196-208. doi: 10.1111/febs.12698. Epub 2014 Jan 13.

14.

Up, down, and around: identifying recurrent interactions within and between super-secondary structures in β-propellers.

Thirup S, Gupta V, Quistgaard EM.

Methods Mol Biol. 2013;932:35-50. doi: 10.1007/978-1-62703-065-6_3.

PMID:
22987345
15.

Legume receptors perceive the rhizobial lipochitin oligosaccharide signal molecules by direct binding.

Broghammer A, Krusell L, Blaise M, Sauer J, Sullivan JT, Maolanon N, Vinther M, Lorentzen A, Madsen EB, Jensen KJ, Roepstorff P, Thirup S, Ronson CW, Thygesen MB, Stougaard J.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13859-64. doi: 10.1073/pnas.1205171109. Epub 2012 Aug 2.

16.

Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish.

Blaise M, Alsarraf HM, Wong JE, Midtgaard SR, Laroche F, Schack L, Spaink H, Stougaard J, Thirup S.

Proteins. 2012 Jun;80(6):1694-8. doi: 10.1002/prot.24050. Epub 2012 Mar 20.

PMID:
22434723
17.

Purification, crystallization and preliminary crystallographic studies of the TLDc domain of oxidation resistance protein 2 from zebrafish.

Alsarraf HM, Laroche F, Spaink H, Thirup S, Blaise M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1253-6. doi: 10.1107/S1744309111027990. Epub 2011 Sep 29.

18.

Crystallization of Escherichia coli maltoporin in the trigonal space group R3.

Blaise M, Thirup S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt 1):114-6. doi: 10.1107/S1744309110047305. Epub 2010 Dec 23.

19.

Crystal structure of a transfer-ribonucleoprotein particle that promotes asparagine formation.

Blaise M, Bailly M, Frechin M, Behrens MA, Fischer F, Oliveira CL, Becker HD, Pedersen JS, Thirup S, Kern D.

EMBO J. 2010 Sep 15;29(18):3118-29. doi: 10.1038/emboj.2010.192. Epub 2010 Aug 17.

20.

Evolution and regulation of the Lotus japonicus LysM receptor gene family.

Lohmann GV, Shimoda Y, Nielsen MW, Jørgensen FG, Grossmann C, Sandal N, Sørensen K, Thirup S, Madsen LH, Tabata S, Sato S, Stougaard J, Radutoiu S.

Mol Plant Microbe Interact. 2010 Apr;23(4):510-21. doi: 10.1094/MPMI-23-4-0510.

21.

GGA autoinhibition revisited.

Cramer JF, Gustafsen C, Behrens MA, Oliveira CL, Pedersen JS, Madsen P, Petersen CM, Thirup SS.

Traffic. 2010 Feb;11(2):259-73. doi: 10.1111/j.1600-0854.2009.01017.x. Epub 2009 Nov 10.

22.

Improved characterization of nod factors and genetically based variation in LysM Receptor domains identify amino acids expendable for nod factor recognition in Lotus spp.

Bek AS, Sauer J, Thygesen MB, Duus JØ, Petersen BO, Thirup S, James E, Jensen KJ, Stougaard J, Radutoiu S.

Mol Plant Microbe Interact. 2010 Jan;23(1):58-66. doi: 10.1094/MPMI-23-1-0058.

24.

Isolation, crystallization and preliminary X-ray analysis of the transamidosome, a ribonucleoprotein involved in asparagine formation.

Bailly M, Blaise M, Lorber B, Thirup S, Kern D.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):577-81. doi: 10.1107/S1744309109015000. Epub 2009 May 22.

25.

Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain.

Quistgaard EM, Madsen P, Grøftehauge MK, Nissen P, Petersen CM, Thirup SS.

Nat Struct Mol Biol. 2009 Jan;16(1):96-8. doi: 10.1038/nsmb.1543. Epub 2009 Jan 4.

PMID:
19122660
26.

LysM domains mediate lipochitin-oligosaccharide recognition and Nfr genes extend the symbiotic host range.

Radutoiu S, Madsen LH, Madsen EB, Jurkiewicz A, Fukai E, Quistgaard EM, Albrektsen AS, James EK, Thirup S, Stougaard J.

EMBO J. 2007 Sep 5;26(17):3923-35. Epub 2007 Aug 9.

27.

A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex.

Nielsen MJ, Petersen SV, Jacobsen C, Thirup S, Enghild JJ, Graversen JH, Moestrup SK.

J Biol Chem. 2007 Jan 12;282(2):1072-9. Epub 2006 Nov 13.

28.

Functional effects of deleting the coiled-coil motif in Escherichia coli elongation factor Ts.

Karring H, Björnsson A, Thirup S, Clark BF, Knudsen CR.

Eur J Biochem. 2003 Nov;270(21):4294-305.

29.

Isolation, crystallisation, and preliminary X-ray analysis of the bovine mitochondrial EF-Tu:GDP and EF-Tu:EF-Ts complexes.

Karring H, Andersen GR, Thirup SS, Nyborg J, Spremulli LL, Clark BF.

Biochim Biophys Acta. 2002 Dec 16;1601(2):172-7.

PMID:
12445479
30.

High resolution crystal structure of bovine mitochondrial EF-Tu in complex with GDP.

Andersen GR, Thirup S, Spremulli LL, Nyborg J.

J Mol Biol. 2000 Mar 24;297(2):421-36.

PMID:
10715211
31.

Structural information for explaining the molecular mechanism of protein biosynthesis.

Clark BF, Thirup S, Kjeldgaard M, Nyborg J.

FEBS Lett. 1999 Jun 4;452(1-2):41-6. Review.

32.
33.

Crystallization of human complement component C5.

Discipio RG, Jenner L, Thirup S, Sottrup-Jensen L, Nyborg J, Stura E.

Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):643-6.

PMID:
9761862
34.

Crystal structure of the receptor-binding domain of alpha 2-macroglobulin.

Jenner L, Husted L, Thirup S, Sottrup-Jensen L, Nyborg J.

Structure. 1998 May 15;6(5):595-604.

35.

Crystallization and preliminary X-ray diffraction studies of psoriasin.

Nolsøe S, Thirup S, Etzerodt M, Thøgersen HC, Nyborg J.

Acta Crystallogr D Biol Crystallogr. 1997 Jan 1;53(Pt 1):119-21.

PMID:
15299981
36.

Macromolecular mimicry in protein biosynthesis.

Nyborg J, Nissen P, Kjeldgaard M, Thirup S, Polekhina G, Clark BF, Reshetnikova L.

Fold Des. 1997;2(3):S7-11.

PMID:
9218959
37.

Isolation, crystallization and X-ray analysis of the quaternary complex of Phe-tRNA(Phe), EF-Tu, a GTP analog and kirromycin.

Kristensen O, Reshetnikova L, Nissen P, Siboska G, Thirup S, Nyborg J.

FEBS Lett. 1996 Dec 9;399(1-2):59-62.

38.

Helix unwinding in the effector region of elongation factor EF-Tu-GDP.

Polekhina G, Thirup S, Kjeldgaard M, Nissen P, Lippmann C, Nyborg J.

Structure. 1996 Oct 15;4(10):1141-51.

39.

Structure of the ternary complex of EF-Tu: macromolecular mimicry in translation.

Nyborg J, Nissen P, Kjeldgaard M, Thirup S, Polekhina G, Clark BF.

Trends Biochem Sci. 1996 Mar;21(3):81-2. No abstract available.

PMID:
8882578
40.

The ternary complex of aminoacylated tRNA and EF-Tu-GTP. Recognition of a bond and a fold.

Nissen P, Kjeldgaard M, Thirup S, Clark BF, Nyborg J.

Biochimie. 1996;78(11-12):921-33. Review.

PMID:
9150869
41.

Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog.

Nissen P, Kjeldgaard M, Thirup S, Polekhina G, Reshetnikova L, Clark BF, Nyborg J.

Science. 1995 Dec 1;270(5241):1464-72.

PMID:
7491491
42.

Crystallisation and preliminary X-ray analysis of the receptor-binding domain of human and bovine alpha 2-macroglobulin.

Dolmer K, Jenner LB, Jacobsen L, Andersen GR, Koch TJ, Thirup S, Sottrup-Jensen L, Nyborg J.

FEBS Lett. 1995 Sep 18;372(1):93-5.

43.

Analysis and crystallization of a 25 kDa C-terminal fragment of cloned elongation factor Ts from Escherichia coli.

Bøgestrand S, Wiborg O, Thirup S, Nyborg J.

FEBS Lett. 1995 Jul 10;368(1):49-54.

44.

Purification and crystallization of the ternary complex of elongation factor Tu:GTP and Phe-tRNA(Phe).

Nissen P, Reshetnikova L, Siboska G, Polekhina G, Thirup S, Kjeldgaard M, Clark BF, Nyborg J.

FEBS Lett. 1994 Dec 19;356(2-3):165-8.

45.

Crystallization of proteins of the alpha 2-macroglobulin superfamily.

Andersen GR, Koch T, Sørensen AH, Thirup S, Nyborg J, Dolmer K, Jacobsen L, Sottrup-Jensen L.

Ann N Y Acad Sci. 1994 Sep 10;737:444-6. No abstract available.

PMID:
7524418
46.

Crystallization of human methylamine-treated complement C3 and C3b.

Sørensen AH, Dolmer K, Thirup S, Andersen GR, Sottrup-Jensen L, Nyborg J.

Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):786-9.

PMID:
15299379
47.

The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation.

Kjeldgaard M, Nissen P, Thirup S, Nyborg J.

Structure. 1993 Sep 15;1(1):35-50.

PMID:
8069622
48.

Crystallization and preliminary X-ray analysis of methylamine-treated alpha 2-macroglobulin and 3 alpha 2-macroglobulin-proteinase complexes.

Andersen GR, Jacobsen L, Thirup S, Nyborg J, Sottrup-Jensen L.

FEBS Lett. 1991 Nov 4;292(1-2):267-70.

49.

Structural determination of the functional sites of E. coli elongation factor Tu.

Clark BF, Kjeldgaard M, la Cour TF, Thirup S, Nyborg J.

Biochim Biophys Acta. 1990 Aug 27;1050(1-3):203-8.

PMID:
2207145
50.

ALMA, an editor for large sequence alignments.

Thirup S, Larsen NE.

Proteins. 1990;7(3):291-5.

PMID:
2362948

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