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Items: 28


Cyclophosphamide Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage FcγR Expression.

Roghanian A, Hu G, Fraser C, Singh M, Foxall RB, Meyer MJ, Lees E, Huet H, Glennie MJ, Beers SA, Lim SH, Ashton-Key M, Thirdborough SM, Cragg MS, Chen J.

Cancer Immunol Res. 2019 Nov;7(11):1876-1890. doi: 10.1158/2326-6066.CIR-18-0835. Epub 2019 Aug 26.


PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.

Buchan SL, Fallatah M, Thirdborough SM, Taraban VY, Rogel A, Thomas LJ, Penfold CA, He LZ, Curran MA, Keler T, Al-Shamkhani A.

Clin Cancer Res. 2018 May 15;24(10):2383-2394. doi: 10.1158/1078-0432.CCR-17-3057. Epub 2018 Mar 7.


Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression.

Bhome R, Goh RW, Bullock MD, Pillar N, Thirdborough SM, Mellone M, Mirnezami R, Galea D, Veselkov K, Gu Q, Underwood TJ, Primrose JN, De Wever O, Shomron N, Sayan AE, Mirnezami AH.

Aging (Albany NY). 2017 Dec 28;9(12):2666-2694. doi: 10.18632/aging.101355.


Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Turaj AH, Hussain K, Cox KL, Rose-Zerilli MJJ, Testa J, Dahal LN, Chan HTC, James S, Field VL, Carter MJ, Kim HJ, West JJ, Thomas LJ, He LZ, Keler T, Johnson PWM, Al-Shamkhani A, Thirdborough SM, Beers SA, Cragg MS, Glennie MJ, Lim SH.

Cancer Cell. 2017 Dec 11;32(6):777-791.e6. doi: 10.1016/j.ccell.2017.11.001. Epub 2017 Nov 30.


Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4.

Hanley CJ, Mellone M, Ford K, Thirdborough SM, Mellows T, Frampton SJ, Smith DM, Harden E, Szyndralewiez C, Bullock M, Noble F, Moutasim KA, King EV, Vijayanand P, Mirnezami AH, Underwood TJ, Ottensmeier CH, Thomas GJ.

J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx121.


Akt signaling is critical for memory CD8+ T-cell development and tumor immune surveillance.

Rogel A, Willoughby JE, Buchan SL, Leonard HJ, Thirdborough SM, Al-Shamkhani A.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1178-E1187. doi: 10.1073/pnas.1611299114. Epub 2017 Jan 30.


Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx.

Chakravarthy A, Henderson S, Thirdborough SM, Ottensmeier CH, Su X, Lechner M, Feber A, Thomas GJ, Fenton TR.

J Clin Oncol. 2016 Dec;34(34):4132-4141. Epub 2016 Oct 31.


Upregulated Glucose Metabolism Correlates Inversely with CD8+ T-cell Infiltration and Survival in Squamous Cell Carcinoma.

Ottensmeier CH, Perry KL, Harden EL, Stasakova J, Jenei V, Fleming J, Wood O, Woo J, Woelk CH, Thomas GJ, Thirdborough SM.

Cancer Res. 2016 Jul 15;76(14):4136-48. doi: 10.1158/0008-5472.CAN-15-3121. Epub 2016 May 20.


Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.

Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Hidalgo MS, Leonard E, Ishfaq M, Wagner SD, Willis AE, Steele AJ, Stevenson FK, Forconi F, Coldwell MJ, Packham G.

Blood. 2016 Jan 28;127(4):449-57. doi: 10.1182/blood-2015-07-660969. Epub 2015 Oct 21.


Tumour-infiltrating lymphocytes predict for outcome in HPV-positive oropharyngeal cancer.

Ward MJ, Thirdborough SM, Mellows T, Riley C, Harris S, Suchak K, Webb A, Hampton C, Patel NN, Randall CJ, Cox HJ, Jogai S, Primrose J, Piper K, Ottensmeier CH, King EV, Thomas GJ.

Br J Cancer. 2014 Jan 21;110(2):489-500. doi: 10.1038/bjc.2013.639. Epub 2013 Oct 29.


Distinct molecular signature of human skin Langerhans cells denotes critical differences in cutaneous dendritic cell immune regulation.

Polak ME, Thirdborough SM, Ung CY, Elliott T, Healy E, Freeman TC, Ardern-Jones MR.

J Invest Dermatol. 2014 Mar;134(3):695-703. doi: 10.1038/jid.2013.375. Epub 2013 Sep 4.


CD8+ T-cell cross-competition is governed by peptide-MHC class I stability.

Galea I, Stasakova J, Dunscombe MS, Ottensmeier CH, Elliott T, Thirdborough SM.

Eur J Immunol. 2012 Jan;42(1):256-63. doi: 10.1002/eji.201142010. Epub 2011 Nov 28.


Bystander stimulation of activated CD4+ T cells of unrelated specificity following a booster vaccination with tetanus toxoid.

Di Genova G, Savelyeva N, Suchacki A, Thirdborough SM, Stevenson FK.

Eur J Immunol. 2010 Apr;40(4):976-85. doi: 10.1002/eji.200940017.


Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide-MHC class I complexes.

Thirdborough SM, Roddick JS, Radcliffe JN, Howarth M, Stevenson FK, Elliott T.

Eur J Immunol. 2008 Feb;38(2):364-9. doi: 10.1002/eji.200737832.


Prolonged antigen expression following DNA vaccination impairs effector CD8+ T cell function and memory development.

Radcliffe JN, Roddick JS, Stevenson FK, Thirdborough SM.

J Immunol. 2007 Dec 15;179(12):8313-21.


DNA fusion gene vaccines against cancer: from the laboratory to the clinic.

Stevenson FK, Rice J, Ottensmeier CH, Thirdborough SM, Zhu D.

Immunol Rev. 2004 Jun;199:156-80. Review.


Vaccination with DNA encoding a single-chain TCR fusion protein induces anticlonotypic immunity and protects against T-cell lymphoma.

Thirdborough SM, Radcliffe JN, Friedmann PS, Stevenson FK.

Cancer Res. 2002 Mar 15;62(6):1757-60.


Islet cryopreservation: a detailed study of total functional losses.

Rich SJ, Swift S, Thirdborough SM, James RF, Bell PR, London NJ.

Transplant Proc. 1994 Apr;26(2):823-4. No abstract available.


Cryopreservation of rat islets of Langerhans: a comparison of two techniques.

Rich SJ, Swift S, Thirdborough SM, Rumford G, James RF, London NJ.

Cryobiology. 1993 Aug;30(4):407-12.


The kinetics of SCID-hu reconstitution: a comparison between human splenocytes and peripheral blood leucocytes.

Thirdborough SM, Chamberlain JC, Swift SM, James RF, London NJ.

Cell Transplant. 1993 Jul-Aug;2(4):339-43.


A method for the isolation of human lymphoid dendritic cells from the spleen.

Thirdborough SM, London NJ, James RF, Bell PR.

Transpl Immunol. 1993;1(2):143-5. No abstract available.


Human islet preparations and the expression of MHC antigens.

Swift SM, Thirdborough SM, London NJ, Cahill M, James RF.

Transplant Proc. 1992 Jun;24(3):1029. No abstract available.


Isogeneic islet transplantation. The effect of gamma irradiation.

Loftus IM, London NJ, Thirdborough SM, Bell PR, James RF.

Transplantation. 1991 Sep;52(3):567-9. No abstract available.


The diabetic "human reconstituted" severe combined immunodeficient (SCID-hu) mouse: a model for isogeneic, allogeneic, and xenogeneic human islet transplantation.

London NJ, Thirdborough SM, Swift SM, Bell PR, James RF.

Transplant Proc. 1991 Feb;23(1 Pt 1):749. No abstract available.


Renal subcapsular islet transplantation in the rat: a comparison of three techniques.

London NJ, Thirdborough SM, Loftus IM, Lake SP, Bell PR, James RF.

Diabetes Res. 1991 Feb;16(2):81-3.


The cryobiology of rat and human dendritic cells: preservation and destruction of membrane integrity by freezing.

Taylor MJ, London NJ, Thirdborough SM, Lake SP, James RF.

Cryobiology. 1990 Jun;27(3):269-78.


Long-term survival of rat islet allografts after pretreatment with low dose gamma irradiation.

James RF, Lake SP, Chamberlain J, Thirdborough SM, Mistry N, Bassett PD, Bell PR.

Transplant Proc. 1989 Feb;21(1 Pt 3):2725-6. No abstract available.


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