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Items: 1 to 50 of 124

1.

APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.

Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT.

Cell Rep. 2019 Apr 30;27(5):1345-1355.e6. doi: 10.1016/j.celrep.2019.03.087.

2.

A versatile method for producing labeled or unlabeled Aβ55, Aβ40, and other β-amyloid family peptides.

Zerweck J, Venkata BS, Pittman JM, Srivastava AK, Moore PC, Sachleben JR, Thinakaran G, Meredith SC.

Protein Expr Purif. 2019 Oct;162:72-82. doi: 10.1016/j.pep.2019.04.006. Epub 2019 Apr 22.

PMID:
31022450
3.

Matrix metalloproteinase 13, a new target for therapy in Alzheimer's disease.

Paumier JM, Thinakaran G.

Genes Dis. 2019 Feb 16;6(1):1-2. doi: 10.1016/j.gendis.2019.02.004. eCollection 2019 Mar. No abstract available.

4.

Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model.

Andrew RJ, De Rossi P, Nguyen P, Kowalski HR, Recupero AJ, Guerbette T, Krause SV, Rice RC, Laury-Kleintop L, Wagner SL, Thinakaran G.

J Biol Chem. 2019 Mar 22;294(12):4477-4487. doi: 10.1074/jbc.RA118.006379. Epub 2019 Jan 28.

PMID:
30692199
5.

Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.

De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, Thinakaran G.

Brain Pathol. 2019 Jul;29(4):485-501. doi: 10.1111/bpa.12687. Epub 2018 Dec 27.

6.

BMP9-induced osteoblastic differentiation requires functional Notch signaling in mesenchymal stem cells.

Cui J, Zhang W, Huang E, Wang J, Liao J, Li R, Yu X, Zhao C, Zeng Z, Shu Y, Zhang R, Yan S, Lei J, Yang C, Wu K, Wu Y, Huang S, Ji X, Li A, Gong C, Yuan C, Zhang L, Liu W, Huang B, Feng Y, An L, Zhang B, Dai Z, Shen Y, Luo W, Wang X, Huang A, Luu HH, Reid RR, Wolf JM, Thinakaran G, Lee MJ, He TC.

Lab Invest. 2019 Jan;99(1):58-71. doi: 10.1038/s41374-018-0087-7. Epub 2018 Oct 23.

7.

Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells.

Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M, Andrew RJ, Thinakaran G, Posse de Chaves E, Kar S.

Mol Cell Biol. 2018 May 15;38(11). pii: e00529-17. doi: 10.1128/MCB.00529-17. Print 2018 Jun 1.

8.

BIN1 localization is distinct from Tau tangles in Alzheimer's disease.

De Rossi P, Buggia-Prevot V, Andrew RJ, Krause SV, Woo E, Nelson PT, Pytel P, Thinakaran G.

Matters (Zur). 2017 Jan;2017. doi: 10.19185/matters.201611000018. Epub 2017 Jan 12.

9.

Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.

Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9665-E9674. doi: 10.1073/pnas.1708568114. Epub 2017 Oct 23.

10.

The Effects of Extracellular Serum Concentration on APP Processing in Npc1-Deficient APP-Overexpressing N2a Cells.

Maulik M, Vergote D, Phukan G, Chung J, Thinakaran G, Kar S.

Mol Neurobiol. 2018 Jul;55(7):5757-5766. doi: 10.1007/s12035-017-0799-5. Epub 2017 Oct 19.

PMID:
29052144
11.

Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts.

De Rossi P, Buggia-Prévot V, Clayton BL, Vasquez JB, van Sanford C, Andrew RJ, Lesnick R, Botté A, Deyts C, Salem S, Rao E, Rice RC, Parent A, Kar S, Popko B, Pytel P, Estus S, Thinakaran G.

Mol Neurodegener. 2016 Aug 3;11(1):59. doi: 10.1186/s13024-016-0124-1.

12.

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis.

Andrew RJ, Kellett KA, Thinakaran G, Hooper NM.

J Biol Chem. 2016 Sep 9;291(37):19235-44. doi: 10.1074/jbc.R116.746032. Epub 2016 Jul 29. Review.

13.

Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases.

Wang Y, MacDonald RG, Thinakaran G, Kar S.

Mol Neurobiol. 2017 May;54(4):2636-2658. doi: 10.1007/s12035-016-9849-7. Epub 2016 Mar 19. Review.

14.

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.

Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R.

Acta Neuropathol. 2016 Aug;132(2):235-56. doi: 10.1007/s00401-016-1558-9. Epub 2016 Mar 18.

15.

APP Receptor? To Be or Not To Be.

Deyts C, Thinakaran G, Parent AT.

Trends Pharmacol Sci. 2016 May;37(5):390-411. doi: 10.1016/j.tips.2016.01.005. Epub 2016 Jan 31. Review.

16.

Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin.

Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME.

Sci Rep. 2015 Nov 26;5:17042. doi: 10.1038/srep17042.

17.

APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.

Tkatchenko AV, Tkatchenko TV, Guggenheim JA, Verhoeven VJ, Hysi PG, Wojciechowski R, Singh PK, Kumar A, Thinakaran G; Consortium for Refractive Error and Myopia (CREAM), Williams C.

PLoS Genet. 2015 Aug 27;11(8):e1005432. doi: 10.1371/journal.pgen.1005432. eCollection 2015 Aug.

18.

Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.

Buggia-Prévot V, Thinakaran G.

Bioessays. 2015 Aug;37(8):888-98. doi: 10.1002/bies.201500019. Epub 2015 Jun 30.

19.

Overexpression of the Insulin-Like Growth Factor II Receptor Increases β-Amyloid Production and Affects Cell Viability.

Wang Y, Buggia-Prévot V, Zavorka ME, Bleackley RC, MacDonald RG, Thinakaran G, Kar S.

Mol Cell Biol. 2015 Jul;35(14):2368-84. doi: 10.1128/MCB.01338-14. Epub 2015 May 4.

20.

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.

Marquer C, Laine J, Dauphinot L, Hanbouch L, Lemercier-Neuillet C, Pierrot N, Bossers K, Le M, Corlier F, Benstaali C, Saudou F, Thinakaran G, Cartier N, Octave JN, Duyckaerts C, Potier MC.

Mol Neurodegener. 2014 Dec 18;9:60. doi: 10.1186/1750-1326-9-60.

21.
22.

Sorting the role of SORLA in Alzheimer's disease.

Buggia-Prévot V, Thinakaran G.

Sci Transl Med. 2014 Feb 12;6(223):223fs8. doi: 10.1126/scitranslmed.3008562.

PMID:
24523319
23.

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase.

Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G.

Mol Neurodegener. 2014 Jan 4;9:1. doi: 10.1186/1750-1326-9-1.

24.

A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production.

Buggia-Prévot V, Fernandez CG, Udayar V, Vetrivel KS, Elie A, Roseman J, Sasse VA, Lefkow M, Meckler X, Bhattacharyya S, George M, Kar S, Bindokas VP, Parent AT, Rajendran L, Band H, Vassar R, Thinakaran G.

Cell Rep. 2013 Dec 26;5(6):1552-63. doi: 10.1016/j.celrep.2013.12.006.

25.

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.

Udayar V, Buggia-Prévot V, Guerreiro RL, Siegel G, Rambabu N, Soohoo AL, Ponnusamy M, Siegenthaler B, Bali J; AESG, Simons M, Ries J, Puthenveedu MA, Hardy J, Thinakaran G, Rajendran L.

Cell Rep. 2013 Dec 26;5(6):1536-51. doi: 10.1016/j.celrep.2013.12.005.

26.

Rheb GTPase regulates β-secretase levels and amyloid β generation.

Shahani N, Pryor W, Swarnkar S, Kholodilov N, Thinakaran G, Burke RE, Subramaniam S.

J Biol Chem. 2014 Feb 28;289(9):5799-808. doi: 10.1074/jbc.M113.532713. Epub 2013 Dec 24.

27.

Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion.

Zeiger W, Vetrivel KS, Buggia-Prévot V, Nguyen PD, Wagner SL, Villereal ML, Thinakaran G.

J Biol Chem. 2013 Sep 13;288(37):26955-66. doi: 10.1074/jbc.M113.473355. Epub 2013 Jul 31.

28.

Alterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 protein.

Maulik M, Thinakaran G, Kar S.

PLoS One. 2013;8(1):e54605. doi: 10.1371/journal.pone.0054605. Epub 2013 Jan 29.

29.

Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs.

Sato N, Okochi M, Shinohara M, Thinakaran G, Takeda S, Fukumori A, Shinohara-Noma M, Mori-Ueda M, Hamada H, Takeda M, Rakugi H, Morishita R.

PLoS One. 2012;7(11):e48551. doi: 10.1371/journal.pone.0048551. Epub 2012 Nov 12. Erratum in: PLoS One. 2012;7(11). doi:10.1371/annotation/5cac3524-f2a4-4997-ba21-a5f1d8551f59.

30.

Trafficking and proteolytic processing of APP.

Haass C, Kaether C, Thinakaran G, Sisodia S.

Cold Spring Harb Perspect Med. 2012 May;2(5):a006270. doi: 10.1101/cshperspect.a006270. Review.

31.

Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain.

Deyts C, Vetrivel KS, Das S, Shepherd YM, Dupré DJ, Thinakaran G, Parent AT.

J Neurosci. 2012 Feb 1;32(5):1714-29. doi: 10.1523/JNEUROSCI.5433-11.2012.

32.

Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice.

Gong P, Roseman J, Fernandez CG, Vetrivel KS, Bindokas VP, Zitzow LA, Kar S, Parent AT, Thinakaran G.

Mol Neurodegener. 2011 Dec 28;6:87. doi: 10.1186/1750-1326-6-87.

33.

Stanniocalcin 2 is a negative modulator of store-operated calcium entry.

Zeiger W, Ito D, Swetlik C, Oh-hora M, Villereal ML, Thinakaran G.

Mol Cell Biol. 2011 Sep;31(18):3710-22. doi: 10.1128/MCB.05140-11. Epub 2011 Jul 11.

34.

Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.

Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G.

J Biol Chem. 2011 Jul 22;286(29):26166-77. doi: 10.1074/jbc.M111.260471. Epub 2011 Jun 3.

35.

Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.

Meckler X, Roseman J, Das P, Cheng H, Pei S, Keat M, Kassarjian B, Golde TE, Parent AT, Thinakaran G.

J Neurosci. 2010 Dec 1;30(48):16160-9. doi: 10.1523/JNEUROSCI.4436-10.2010.

36.

Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.

Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G.

J Biol Chem. 2010 Dec 3;285(49):38042-52. doi: 10.1074/jbc.M110.132613. Epub 2010 Oct 4.

37.

Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function.

Parent AT, Thinakaran G.

Int J Alzheimers Dis. 2010 Jul 20;2010. pii: 825918. doi: 10.4061/2010/825918.

38.

Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains.

Kodam A, Maulik M, Peake K, Amritraj A, Vetrivel KS, Thinakaran G, Vance JE, Kar S.

Glia. 2010 Aug 15;58(11):1267-81. doi: 10.1002/glia.21001.

39.

Membrane rafts in Alzheimer's disease beta-amyloid production.

Vetrivel KS, Thinakaran G.

Biochim Biophys Acta. 2010 Aug;1801(8):860-7. doi: 10.1016/j.bbalip.2010.03.007. Epub 2010 Mar 18. Review.

40.

Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture.

White AB, Givogri MI, Lopez-Rosas A, Cao H, van Breemen R, Thinakaran G, Bongarzone ER.

J Neurosci. 2009 May 13;29(19):6068-77. doi: 10.1523/JNEUROSCI.5597-08.2009.

41.

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.

Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G.

J Biol Chem. 2009 Feb 6;284(6):3793-803. doi: 10.1074/jbc.M808920200. Epub 2008 Dec 12.

42.

S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.

Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G.

J Biol Chem. 2009 Jan 16;284(3):1373-84. doi: 10.1074/jbc.M806380200. Epub 2008 Nov 20.

43.

Localization and regional distribution of p23/TMP21 in the brain.

Vetrivel KS, Kodam A, Gong P, Chen Y, Parent AT, Kar S, Thinakaran G.

Neurobiol Dis. 2008 Oct;32(1):37-49. doi: 10.1016/j.nbd.2008.06.012. Epub 2008 Jul 3.

44.

Amyloid precursor protein trafficking, processing, and function.

Thinakaran G, Koo EH.

J Biol Chem. 2008 Oct 31;283(44):29615-9. doi: 10.1074/jbc.R800019200. Epub 2008 Jul 23. Review.

45.

Thematic minireview series on the molecular basis of Alzheimer disease.

Neet KE, Thinakaran G.

J Biol Chem. 2008 Oct 31;283(44):29613-4. doi: 10.1074/jbc.R800051200. Epub 2008 Jul 23. No abstract available.

46.

Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.

Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, Thinakaran G.

J Biol Chem. 2008 Jul 11;283(28):19489-98. doi: 10.1074/jbc.M801037200. Epub 2008 May 1.

47.

Biogenesis of gamma-secretase early in the secretory pathway.

Kim J, Kleizen B, Choy R, Thinakaran G, Sisodia SS, Schekman RW.

J Cell Biol. 2007 Dec 3;179(5):951-63.

48.

Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons.

Barnes NY, Shi J, Yajima H, Thinakaran G, Parent AT.

J Neurochem. 2008 Mar;104(6):1637-48. Epub 2007 Nov 7.

49.

Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts.

Cheng H, Vetrivel KS, Gong P, Meckler X, Parent A, Thinakaran G.

Nat Clin Pract Neurol. 2007 Jul;3(7):374-82. Review.

50.

Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism.

Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G.

Mol Neurodegener. 2007 Feb 8;2:4.

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