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Items: 37


Tannic acid protects against experimental acute lung injury through downregulation of TLR4 and MAPK.

Sivanantham A, Pattarayan D, Bethunaickan R, Kar A, Mahapatra SK, Thimmulappa RK, Palanichamy R, Rajasekaran S.

J Cell Physiol. 2019 May;234(5):6463-6476. doi: 10.1002/jcp.27383. Epub 2018 Sep 24.


Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.

Wu M, Gibbons JG, DeLoid GM, Bedugnis AS, Thimmulappa RK, Biswal S, Kobzik L.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L138-L153. doi: 10.1152/ajplung.00075.2017. Epub 2017 Apr 13.


Diagnostic Potential of Extracellular MicroRNA in Respiratory Diseases.

Pattarayan D, Thimmulappa RK, Ravikumar V, Rajasekaran S.

Clin Rev Allergy Immunol. 2018 Jun;54(3):480-492. doi: 10.1007/s12016-016-8589-9. Review.


MicroRNA Regulation of Acute Lung Injury and Acute Respiratory Distress Syndrome.

Rajasekaran S, Pattarayan D, Rajaguru P, Sudhakar Gandhi PS, Thimmulappa RK.

J Cell Physiol. 2016 Oct;231(10):2097-106. doi: 10.1002/jcp.25316. Epub 2016 Feb 4. Review.


Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A.

Wei Y, Gong J, Xu Z, Thimmulappa RK, Mitchell KL, Welsbie DS, Biswal S, Duh EJ.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6927-36. doi: 10.1073/pnas.1512683112. Epub 2015 Nov 30.


Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy.

Lounsbury N, Mateo G, Jones B, Papaiahgari S, Thimmulappa RK, Teijaro C, Gordon J, Korzekwa K, Ye M, Allaway G, Abou-Gharbia M, Biswal S, Childers W Jr.

Bioorg Med Chem. 2015 Sep 1;23(17):5352-9. doi: 10.1016/j.bmc.2015.07.056. Epub 2015 Jul 29.


Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.

Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ.

J Neurochem. 2015 Apr;133(2):233-41. doi: 10.1111/jnc.13064. Epub 2015 Mar 4.


Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model.

Sussan TE, Gajghate S, Thimmulappa RK, Ma J, Kim JH, Sudini K, Consolini N, Cormier SA, Lomnicki S, Hasan F, Pekosz A, Biswal S.

PLoS One. 2015 Feb 4;10(2):e0116861. doi: 10.1371/journal.pone.0116861. eCollection 2015.


Marburgvirus hijacks nrf2-dependent pathway by targeting nrf2-negative regulator keap1.

Page A, Volchkova VA, Reid SP, Mateo M, Bagnaud-Baule A, Nemirov K, Shurtleff AC, Lawrence P, Reynard O, Ottmann M, Lotteau V, Biswal SS, Thimmulappa RK, Bavari S, Volchkov VE.

Cell Rep. 2014 Mar 27;6(6):1026-1036. doi: 10.1016/j.celrep.2014.02.027. Epub 2014 Mar 13.


NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.

Kim JH, Thimmulappa RK, Kumar V, Cui W, Kumar S, Kombairaju P, Zhang H, Margolick J, Matsui W, Macvittie T, Malhotra SV, Biswal S.

J Clin Invest. 2014 Feb;124(2):730-41. doi: 10.1172/JCI70812. Epub 2014 Jan 27.


Nrf2 is required for normal postnatal bone acquisition in mice.

Kim JH, Singhal V, Biswal S, Thimmulappa RK, DiGirolamo DJ.

Bone Res. 2014 Nov 11;2:14033. doi: 10.1038/boneres.2014.33. eCollection 2014.


Nrf2 acts cell-autonomously in endothelium to regulate tip cell formation and vascular branching.

Wei Y, Gong J, Thimmulappa RK, Kosmider B, Biswal S, Duh EJ.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):E3910-8. doi: 10.1073/pnas.1309276110. Epub 2013 Sep 23.


Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke.

Thimmulappa RK, Gang X, Kim JH, Sussan TE, Witztum JL, Biswal S.

Biochem Biophys Res Commun. 2012 Sep 21;426(2):253-9. doi: 10.1016/j.bbrc.2012.08.076. Epub 2012 Aug 22.


Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.

Kombairaju P, Ma J, Thimmulappa RK, Yan SG, Gabrielson E, Singh A, Biswal S.

J Carcinog. 2012;11:8. doi: 10.4103/1477-3163.98459. Epub 2012 Jul 13.


Upregulation of TLR1, TLR2, TLR4, and IRAK-2 Expression During ML-1 Cell Differentiation to Macrophages: Role in the Potentiation of Cellular Responses to LPS and LTA.

Traore K, Zirkin B, Thimmulappa RK, Biswal S, Trush MA.

ISRN Oncol. 2012;2012:641246. doi: 10.5402/2012/641246. Epub 2012 May 21.


Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD.

Biswal S, Thimmulappa RK, Harvey CJ.

Proc Am Thorac Soc. 2012 May;9(2):47-51. doi: 10.1513/pats.201201-009MS.


Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.

Malhotra D, Thimmulappa RK, Mercado N, Ito K, Kombairaju P, Kumar S, Ma J, Feller-Kopman D, Wise R, Barnes P, Biswal S.

J Clin Invest. 2011 Nov;121(11):4289-302. doi: 10.1172/JCI45144. Epub 2011 Oct 17. Retraction in: J Clin Invest. 2014 Dec;124(12):5521.


Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.

Kumar V, Kumar S, Hassan M, Wu H, Thimmulappa RK, Kumar A, Sharma SK, Parmar VS, Biswal S, Malhotra SV.

J Med Chem. 2011 Jun 23;54(12):4147-59. doi: 10.1021/jm2002348. Epub 2011 May 19.


Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model.

Harvey CJ, Thimmulappa RK, Sethi S, Kong X, Yarmus L, Brown RH, Feller-Kopman D, Wise R, Biswal S.

Sci Transl Med. 2011 Apr 13;3(78):78ra32. doi: 10.1126/scitranslmed.3002042.


Design, synthesis and evaluation of novel PEGylated curcumin analogs as potent Nrf2 activators in human bronchial epithelial cells.

Pandey MK, Kumar S, Thimmulappa RK, Parmar VS, Biswal S, Watterson AC.

Eur J Pharm Sci. 2011 May 18;43(1-2):16-24. doi: 10.1016/j.ejps.2011.03.003. Epub 2011 Mar 21.


Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema.

Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM.

Nat Med. 2010 Jul;16(7):767-73. doi: 10.1038/nm.2157. Epub 2010 May 16.


Nrf2 is a critical modulator of the innate immune response in a model of uveitis.

Nagai N, Thimmulappa RK, Cano M, Fujihara M, Izumi-Nagai K, Kong X, Sporn MB, Kensler TW, Biswal S, Handa JT.

Free Radic Biol Med. 2009 Aug 1;47(3):300-6. doi: 10.1016/j.freeradbiomed.2009.04.033. Epub 2009 May 3.


Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia.

McGrath-Morrow S, Lauer T, Yee M, Neptune E, Podowski M, Thimmulappa RK, O'Reilly M, Biswal S.

Am J Physiol Lung Cell Mol Physiol. 2009 Apr;296(4):L565-73. doi: 10.1152/ajplung.90487.2008. Epub 2009 Jan 16.


Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress.

Harvey CJ, Thimmulappa RK, Singh A, Blake DJ, Ling G, Wakabayashi N, Fujii J, Myers A, Biswal S.

Free Radic Biol Med. 2009 Feb 15;46(4):443-53. doi: 10.1016/j.freeradbiomed.2008.10.040. Epub 2008 Nov 5.


RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy.

Singh A, Boldin-Adamsky S, Thimmulappa RK, Rath SK, Ashush H, Coulter J, Blackford A, Goodman SN, Bunz F, Watson WH, Gabrielson E, Feinstein E, Biswal S.

Cancer Res. 2008 Oct 1;68(19):7975-84. doi: 10.1158/0008-5472.CAN-08-1401.


Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs.

Thimmulappa RK, Rangasamy T, Alam J, Biswal S.

Med Chem. 2008 Sep;4(5):473-81.


Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells.

Traore K, Sharma R, Thimmulappa RK, Watson WH, Biswal S, Trush MA.

J Cell Physiol. 2008 Jul;216(1):276-85. doi: 10.1002/jcp.21403.


Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.

Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S.

Antioxid Redox Signal. 2007 Nov;9(11):1963-70.


Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes.

Misra V, Lee H, Singh A, Huang K, Thimmulappa RK, Mitzner W, Biswal S, Tankersley CG.

Physiol Genomics. 2007 Nov 14;31(3):429-40. Epub 2007 Aug 28.


Role of Nrf2 in protection against intracerebral hemorrhage injury in mice.

Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S.

Free Radic Biol Med. 2007 Aug 1;43(3):408-14. Epub 2007 Apr 29.


Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury.

Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S.

Neuroscience. 2007 Jun 15;147(1):53-9. Epub 2007 May 15.


Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide.

Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, Biswal S.

Biochem Biophys Res Commun. 2006 Dec 29;351(4):883-9. Epub 2006 Oct 30.


Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.

Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S.

PLoS Med. 2006 Oct;3(10):e420.


Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2.

Singh A, Rangasamy T, Thimmulappa RK, Lee H, Osburn WO, Brigelius-Flohé R, Kensler TW, Yamamoto M, Biswal S.

Am J Respir Cell Mol Biol. 2006 Dec;35(6):639-50. Epub 2006 Jun 22. Erratum in: Am J Respir Cell Mol Biol. 2007 May;36(5):642.


Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.

Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S.

J Clin Invest. 2006 Apr;116(4):984-95.


Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.

Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S.

J Clin Invest. 2004 Nov;114(9):1248-59.


Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.

Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S.

Cancer Res. 2002 Sep 15;62(18):5196-203.

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