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Items: 22

1.

Decarboxylative Annulation of α-Amino Acids with β-Ketoaldehydes.

Paul A, Thimmegowda NR, Galani Cruz T, Seidel D.

Org Lett. 2018 Feb 2;20(3):602-604. doi: 10.1021/acs.orglett.7b03721. Epub 2018 Jan 12.

2.

Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice.

Suk S, Kwon GT, Lee E, Jang WJ, Yang H, Kim JH, Thimmegowda NR, Chung MY, Kwon JY, Yang S, Kim JK, Park JHY, Lee KW.

Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201700139. Epub 2017 Jul 20.

3.

Anticancer activity of a novel small molecule tubulin inhibitor STK899704.

Sakchaisri K, Kim SO, Hwang J, Soung NK, Lee KH, Choi TW, Lee Y, Park CM, Thimmegowda NR, Lee PY, Shwetha B, Srinivasrao G, Pham TT, Jang JH, Yum HW, Surh YJ, Lee KS, Park H, Kim SJ, Kwon YT, Ahn JS, Kim BY.

PLoS One. 2017 Mar 15;12(3):e0173311. doi: 10.1371/journal.pone.0173311. eCollection 2017.

4.

Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways.

Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW.

J Biol Chem. 2015 Sep 25;290(39):23553-62. doi: 10.1074/jbc.M115.662445. Epub 2015 Aug 4.

5.

Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes.

Cheong LY, Suk S, Thimmegowda NR, Chung MY, Yang H, Seo SG, Shwetha B, Kim JE, Kwon JY, Kim BY, Lee KW.

J Cell Biochem. 2015 Jul;116(7):1361-70. doi: 10.1002/jcb.25093.

PMID:
25756947
6.

Synthesis and antitumor activity of natural compound aloe emodin derivatives.

Thimmegowda NR, Park C, Shwetha B, Sakchaisri K, Liu K, Hwang J, Lee S, Jeong SJ, Soung NK, Jang JH, Ryoo IJ, Ahn JS, Erikson RL, Kim BY.

Chem Biol Drug Des. 2015 May;85(5):638-44. doi: 10.1111/cbdd.12448. Epub 2014 Nov 5.

PMID:
25323822
7.

Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation.

Kang S, Kim JE, Li Y, Jung SK, Song NR, Thimmegowda NR, Kim BY, Lee HJ, Bode AM, Dong Z, Lee KW.

Mol Carcinog. 2015 Nov;54(11):1354-62. doi: 10.1002/mc.22211. Epub 2014 Sep 11.

PMID:
25213146
8.

Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling.

Liu K, Park C, Chen H, Hwang J, Thimmegowda NR, Bae EY, Lee KW, Kim HG, Liu H, Soung NK, Peng C, Jang JH, Kim KE, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.

Mol Carcinog. 2015 Sep;54(9):751-60. doi: 10.1002/mc.22139. Epub 2014 Apr 4.

9.

A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1.

Liu H, Hwang J, Li W, Choi TW, Liu K, Huang Z, Jang JH, Thimmegowda NR, Lee KW, Ryoo IJ, Ahn JS, Bode AM, Zhou X, Yang Y, Erikson RL, Kim BY, Dong Z.

Cancer Prev Res (Phila). 2014 Jan;7(1):74-85. doi: 10.1158/1940-6207.CAPR-13-0133. Epub 2013 Oct 29.

10.

A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases.

Liu H, Liu K, Huang Z, Park CM, Thimmegowda NR, Jang JH, Ryoo IJ, He L, Kim SO, Oi N, Lee KW, Soung NK, Bode AM, Yang Y, Zhou X, Erikson RL, Ahn JS, Hwang J, Kim KE, Dong Z, Kim BY.

J Biol Chem. 2013 Sep 6;288(36):25924-37. doi: 10.1074/jbc.M113.464669. Epub 2013 Jul 25.

11.

STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage.

Kim SO, Sakchaisri K, Thimmegowda NR, Soung NK, Jang JH, Kim YS, Lee KS, Kwon YT, Asami Y, Ahn JS, Erikson RL, Kim BY.

PLoS One. 2013;8(1):e53908. doi: 10.1371/journal.pone.0053908. Epub 2013 Jan 22. Erratum in: PLoS One. 2013;8(6): 10.1371/annotation/c5f432f6-1e92-42c0-8727-7ae972215d6f. N R, Thimmegowda [corrected to Thimmegowda, N R].

12.

Patulin induces colorectal cancer cells apoptosis through EGR-1 dependent ATF3 up-regulation.

Kwon O, Soung NK, Thimmegowda NR, Jeong SJ, Jang JH, Moon DO, Chung JK, Lee KS, Kwon YT, Erikson RL, Ahn JS, Kim BY.

Cell Signal. 2012 Apr;24(4):943-50. doi: 10.1016/j.cellsig.2011.12.017. Epub 2011 Dec 30.

13.

7-Chloro-5-cyclo-propyl-9-methyl-5H-4,5,6,10-tetra-aza-dibenzo[a,d]cyclo-hepten-11(10H)-one.

Naveen S, Thimmegowda NR, Manjunath HR, Sridhar MA, Prasad JS, Rangappa KS.

Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 1;67(Pt 6):o1445-6. doi: 10.1107/S1600536811018022. Epub 2011 May 20.

14.

Synthesis of 1-(4-methoxybenzyl)-3-cyclopropyl-1H-pyrazol-5-amine derivatives as antimicrobial agents.

Raju H, Nagamani TS, Chandrappa S, Ananda H, Vinaya K, Thimmegowda NR, Byregowda SM, Rangappa KS.

J Enzyme Inhib Med Chem. 2010 Aug;25(4):537-43. doi: 10.3109/14756360903357601.

PMID:
20235748
15.

Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines.

Ananda Kumar CS, Benaka Prasad SB, Vinaya K, Chandrappa S, Thimmegowda NR, Kumar YC, Swarup S, Rangappa KS.

Eur J Med Chem. 2009 Mar;44(3):1223-9. doi: 10.1016/j.ejmech.2008.09.025. Epub 2008 Sep 30.

PMID:
18973966
16.

Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: a SAR study.

Ananda Kumar CS, Kavitha CV, Vinaya K, Benaka Prasad SB, Thimmegowda NR, Chandrappa S, Raghavan SC, Rangappa KS.

Invest New Drugs. 2009 Aug;27(4):327-37. doi: 10.1007/s10637-008-9179-3. Epub 2008 Oct 7.

PMID:
18839066
17.

Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of tumor growth and tumor angiogenesis of mouse ehrlich ascites tumor in vivo.

Kumar CS, Chandru H, Sharada AC, Thimmegowda NR, Prasad SB, Kumar MK, Rangappa KS.

Med Chem. 2008 Sep;4(5):466-72.

PMID:
18782043
18.

Synthesis and antimicrobial studies of novel 1-benzhydryl-piperazine sulfonamide and carboxamide derivatives.

Kumar CS, Vinaya K, Chandra JN, Thimmegowda NR, Prasad SB, Sadashiva CT, Rangappa KS.

J Enzyme Inhib Med Chem. 2008 Aug;23(4):462-9. doi: 10.1080/14756360701654969 .

PMID:
18608768
19.

Synthesis and antiproliferative activity of substituted diazaspiro hydantoins: a structure-activity relationship study.

Ananda Kumar CS, Prasad SB, Vinaya K, Chandrappa S, Thimmegowda NR, Ranganatha SR, Swarup S, Rangappa KS.

Invest New Drugs. 2009 Apr;27(2):131-9. doi: 10.1007/s10637-008-9150-3. Epub 2008 Jul 8.

PMID:
18607541
20.

Synthesis and in vitro antiproliferative activity against human cancer cell lines of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-diones.

Chandrappa S, Benaka Prasad SB, Vinaya K, Ananda Kumar CS, Thimmegowda NR, Rangappa KS.

Invest New Drugs. 2008 Oct;26(5):437-44. doi: 10.1007/s10637-008-9130-7. Epub 2008 May 13.

PMID:
18473120
21.

Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation.

Thimmegowda NR, Nanjunda Swamy S, Kumar CS, Kumar YC, Chandrappa S, Yip GW, Rangappa KS.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):432-5. Epub 2007 Oct 24.

PMID:
17981032
22.

Synthesis and evaluation of tricyclic dipyrido diazepinone derivatives as inhibitors of secretory phospholipase A2 with anti-inflammatory activity.

Thimmegowda NR, Dharmappa KK, Kumar CS, Sadashiva MP, Sathish AD, Nanda BL, Vishwanath BS, Rangappa KS.

Curr Top Med Chem. 2007;7(8):811-20.

PMID:
17456044

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