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Items: 1 to 50 of 89

1.

Characteristics, behaviour and role of biomarkers in metastatic triple-negative breast cancer.

Goto Y, Thike AA, Ong CCH, Lim JX, Md Nasir ND, Li H, Koh VCY, Chen XY, Yeong JPS, Sasano H, Tan PH.

J Clin Pathol. 2019 Sep 28. pii: jclinpath-2019-206078. doi: 10.1136/jclinpath-2019-206078. [Epub ahead of print]

PMID:
31563883
2.

Genomic characterisation of breast fibroepithelial lesions in an international cohort.

Md Nasir ND, Ng CCY, Rajasegaran V, Wong SF, Liu W, Ng GXP, Lee JY, Guan P, Lim JQ, Thike AA, Koh VCY, Loke BN, Chang KTE, Gudi MA, Lian DWQ, Madhukumar P, Tan BKT, Tan VKM, Wong CY, Yong WS, Ho GH, Ong KW; International Fibroepithelial Consortium, Tan P, Teh BT, Tan PH.

J Pathol. 2019 Aug 8. doi: 10.1002/path.5333. [Epub ahead of print]

PMID:
31411343
3.

Evaluation of phospho-histone H3 in Asian triple-negative breast cancer using multiplex immunofluorescence.

Lai CPT, Yeong JPS, Tan AS, Ong CHC, Lee B, Lim JCT, Thike AA, Iqbal J, Dent RA, Lim EH, Tan PH.

Breast Cancer Res Treat. 2019 Nov;178(2):295-305. doi: 10.1007/s10549-019-05396-5. Epub 2019 Aug 13.

PMID:
31410680
4.

The role of Ki-67 in Asian triple negative breast cancers: a novel combinatory panel approach.

Tan AS, Yeong JPS, Lai CPT, Ong CHC, Lee B, Lim JCT, Thike AA, Iqbal J, Dent RA, Lim EH, Tan PH.

Virchows Arch. 2019 Aug 12. doi: 10.1007/s00428-019-02635-4. [Epub ahead of print]

PMID:
31407032
5.

Prognostic role of immune infiltrates in breast ductal carcinoma in situ.

Chen XY, Yeong J, Thike AA, Bay BH, Tan PH.

Breast Cancer Res Treat. 2019 Aug;177(1):17-27. doi: 10.1007/s10549-019-05272-2. Epub 2019 May 27. Review.

PMID:
31134489
6.

Behaviour and characteristics of low-grade ductal carcinoma in situ of the breast: literature review and single-centre retrospective series.

Koh VCY, Lim JCT, Thike AA, Cheok PY, Thu MMM, Li H, Tan VKM, Ong KW, Tan BKT, Ho GH, Thilagaratnam S, Wong JSL, Wong FY, Ellis IO, Tan PH.

Histopathology. 2019 Jun;74(7):970-987. doi: 10.1111/his.13837. Epub 2019 Mar 28. Review.

PMID:
30734334
7.

Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer.

Yeong J, Lim JCT, Lee B, Li H, Ong CCH, Thike AA, Yeap WH, Yang Y, Lim AYH, Tay TKY, Liu J, Wong SC, Chen J, Lim EH, Iqbal J, Dent R, Newell EW, Tan PH.

J Immunother Cancer. 2019 Feb 6;7(1):34. doi: 10.1186/s40425-019-0499-y.

8.

Elevated WBP2 Expression in HER2-positive Breast Cancers Correlates with Sensitivity to Trastuzumab-based Neoadjuvant Therapy: A Retrospective and Multicentric Study.

Kang SA, Guan JS, Tan HJ, Chu T, Thike AA, Bernadó C, Arribas J, Wong CY, Tan PH, Gudi M, Putti TC, Sohn J, Lim SH, Lee SC, Lim YP.

Clin Cancer Res. 2019 Apr 15;25(8):2588-2600. doi: 10.1158/1078-0432.CCR-18-3228. Epub 2018 Dec 28.

PMID:
30593516
9.

Genomic profile of breast sarcomas: a comparison with malignant phyllodes tumours.

Lim SZ, Ng CCY, Rajasegaran V, Guan P, Selvarajan S, Thike AA, Nasir NDBM, Koh VCY, Tan BKT, Ong KW, Teh BT, Tan PH.

Breast Cancer Res Treat. 2019 Apr;174(2):365-373. doi: 10.1007/s10549-018-5067-5. Epub 2018 Dec 3.

PMID:
30511242
10.

Triple-negative and HER2 positive ductal carcinoma in situ of the breast: characteristics, behavior, and biomarker profile.

Takahashi S, Thike AA, Koh VCY, Sasano H, Tan PH.

Virchows Arch. 2018 Sep;473(3):275-283. doi: 10.1007/s00428-018-2416-z. Epub 2018 Jul 23.

PMID:
30033510
11.

Molecular insights into paediatric breast fibroepithelial tumours.

Tay TKY, Guan P, Loke BN, Nasir NDM, Rajasegaran V, Thike AA, Lian D, Chang KTE, Teh BT, Ng CCY, Tan PH.

Histopathology. 2018 Nov;73(5):809-818. doi: 10.1111/his.13701. Epub 2018 Aug 22.

PMID:
29969836
12.

Breast cancer in women with neurofibromatosis type 1 (NF1): a comprehensive case series with molecular insights into its aggressive phenotype.

Yap YS, Munusamy P, Lim C, Chan CHT, Prawira A, Loke SY, Lim SH, Ong KW, Yong WS, Ng SBH, Tan IBH, Callen DF, Lim JCT, Thike AA, Tan PH, Lee ASG.

Breast Cancer Res Treat. 2018 Oct;171(3):719-735. doi: 10.1007/s10549-018-4851-6. Epub 2018 Jun 21.

PMID:
29926297
13.

High Densities of Tumor-Associated Plasma Cells Predict Improved Prognosis in Triple Negative Breast Cancer.

Yeong J, Lim JCT, Lee B, Li H, Chia N, Ong CCH, Lye WK, Putti TC, Dent R, Lim E, Thike AA, Tan PH, Iqbal J.

Front Immunol. 2018 May 30;9:1209. doi: 10.3389/fimmu.2018.01209. eCollection 2018.

14.

Using computer assisted image analysis to determine the optimal Ki67 threshold for predicting outcome of invasive breast cancer.

Tay TKY, Thike AA, Pathmanathan N, Jara-Lazaro AR, Iqbal J, Sng ASH, Ye HS, Lim JCT, Koh VCY, Tan JSY, Yeong JPS, Chow ZL, Li HH, Cheng CL, Tan PH.

Oncotarget. 2018 Feb 5;9(14):11619-11630. doi: 10.18632/oncotarget.24398. eCollection 2018 Feb 20.

15.

GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway, functions in gastric carcinogenesis.

Khanna P, Chua PJ, Wong BSE, Yin C, Thike AA, Wan WK, Tan PH, Baeg GH.

Oncotarget. 2017 Dec 15;8(70):115370-115383. doi: 10.18632/oncotarget.23265. eCollection 2017 Dec 29.

17.

Genetics and genomics of breast fibroadenomas.

Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH.

J Clin Pathol. 2018 May;71(5):381-387. doi: 10.1136/jclinpath-2017-204838. Epub 2017 Dec 16. Review.

PMID:
29248888
18.

Size and heterologous elements predict metastases in malignant phyllodes tumours of the breast.

Koh VCY, Thike AA, Nasir NDM, Yip GWC, Bay BH, Tan PH.

Virchows Arch. 2018 Apr;472(4):615-621. doi: 10.1007/s00428-017-2257-1. Epub 2017 Nov 10.

PMID:
29127495
19.

A genetic mutation panel for differentiating malignant phyllodes tumour from metaplastic breast carcinoma.

Yeong J, Thike AA, Young Ng CC, Md Nasir ND, Loh K, Teh BT, Tan PH.

Pathology. 2017 Dec;49(7):786-789. doi: 10.1016/j.pathol.2017.07.011. Epub 2017 Oct 21. No abstract available.

PMID:
29066183
20.

Caveolin-1 expression as a prognostic marker in triple negative breast cancers of Asian women.

Yeong J, Thike AA, Ikeda M, Lim JCT, Lee B, Nakamura S, Iqbal J, Tan PH.

J Clin Pathol. 2018 Feb;71(2):161-167. doi: 10.1136/jclinpath-2017-204495. Epub 2017 Jul 22.

PMID:
28735300
21.

Higher densities of Foxp3+ regulatory T cells are associated with better prognosis in triple-negative breast cancer.

Yeong J, Thike AA, Lim JC, Lee B, Li H, Wong SC, Hue SS, Tan PH, Iqbal J.

Breast Cancer Res Treat. 2017 May;163(1):21-35. doi: 10.1007/s10549-017-4161-4. Epub 2017 Feb 23.

PMID:
28233108
22.

Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.

Ler LD, Ghosh S, Chai X, Thike AA, Heng HL, Siew EY, Dey S, Koh LK, Lim JQ, Lim WK, Myint SS, Loh JL, Ong P, Sam XX, Huang D, Lim T, Tan PH, Nagarajan S, Cheng CW, Ho H, Ng LG, Yuen J, Lin PH, Chuang CK, Chang YH, Weng WH, Rozen SG, Tan P, Creasy CL, Pang ST, McCabe MT, Poon SL, Teh BT.

Sci Transl Med. 2017 Feb 22;9(378). pii: eaai8312. doi: 10.1126/scitranslmed.aai8312.

PMID:
28228601
23.

Identifying progression predictors of breast ductal carcinoma in situ.

Yeong J, Thike AA, Tan PH, Iqbal J.

J Clin Pathol. 2017 Feb;70(2):102-108. doi: 10.1136/jclinpath-2016-204154. Epub 2016 Nov 18. Review.

PMID:
27864452
24.

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.

Lim SK, Lu SY, Kang SA, Tan HJ, Li Z, Adrian Wee ZN, Guan JS, Reddy Chichili VP, Sivaraman J, Putti T, Thike AA, Tan PH, Sudol M, Virshup DM, Chan SW, Hong W, Lim YP.

Cancer Res. 2016 Nov 1;76(21):6278-6289. Epub 2016 Aug 30.

25.

Clinicopathological characteristics of oestrogen receptor negative, progesterone receptor positive breast cancers: re-evaluating subsets within this group.

Ahmed SS, Thike AA, Zhang K, Lim JC, Tan PH.

J Clin Pathol. 2017 Apr;70(4):320-326. doi: 10.1136/jclinpath-2016-203847. Epub 2016 Sep 9.

PMID:
27612503
26.

Breast sarcomas and malignant phyllodes tumours: comparison of clinicopathological features, treatment strategies, prognostic factors and outcomes.

Lim SZ, Selvarajan S, Thike AA, Nasir ND, Tan BK, Ong KW, Tan PH.

Breast Cancer Res Treat. 2016 Sep;159(2):229-44. doi: 10.1007/s10549-016-3946-1. Epub 2016 Aug 19.

PMID:
27541020
27.

Clinicopathologic Characteristics of Solid Papillary Carcinoma of the Breast.

Tan BY, Thike AA, Ellis IO, Tan PH.

Am J Surg Pathol. 2016 Oct;40(10):1334-42. doi: 10.1097/PAS.0000000000000702.

PMID:
27438988
28.

MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.

Tan WJ, Chan JY, Thike AA, Lim JC, Md Nasir ND, Tan JS, Koh VC, Lim WK, Tan J, Ng CC, Rajasegaran V, Nagarajan S, Bay BH, Teh BT, Tan PH.

J Clin Pathol. 2016 Oct;69(10):858-65. doi: 10.1136/jclinpath-2015-203590. Epub 2016 Apr 7.

PMID:
27056456
29.

A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions.

Tan WJ, Cima I, Choudhury Y, Wei X, Lim JC, Thike AA, Tan MH, Tan PH.

Breast Cancer Res. 2016 Mar 9;18(1):31. doi: 10.1186/s13058-016-0692-6.

30.

Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer.

Matsumoto H, Thike AA, Li H, Yeong J, Koo SL, Dent RA, Tan PH, Iqbal J.

Breast Cancer Res Treat. 2016 Apr;156(2):237-47. doi: 10.1007/s10549-016-3743-x. Epub 2016 Mar 9.

PMID:
26960711
31.

Prognostic significance of Claudin 12 in estrogen receptor-negative breast cancer.

Iravani O, Yip GW, Thike AA, Chua PJ, Jane Scully O, Tan PH, Bay BH.

J Clin Pathol. 2016 Oct;69(10):878-83. doi: 10.1136/jclinpath-2015-203265. Epub 2016 Feb 29.

PMID:
26926102
33.

Breast carcinoma and phyllodes tumour: a case series.

Sin EI, Wong CY, Yong WS, Ong KW, Madhukumar P, Tan VK, Thike AA, Tan PH, Tan BK.

J Clin Pathol. 2016 Apr;69(4):364-9. doi: 10.1136/jclinpath-2015-203475. Epub 2015 Dec 15.

PMID:
26670744
34.

Genomic landscapes of breast fibroepithelial tumors.

Tan J, Ong CK, Lim WK, Ng CC, Thike AA, Ng LM, Rajasegaran V, Myint SS, Nagarajan S, Thangaraju S, Dey S, Nasir ND, Wijaya GC, Lim JQ, Huang D, Li Z, Wong BH, Chan JY, McPherson JR, Cutcutache I, Poore G, Tay ST, Tan WJ, Putti TC, Ahmad BS, Iau P, Chan CW, Tang AP, Yong WS, Madhukumar P, Ho GH, Tan VK, Wong CY, Hartman M, Ong KW, Tan BK, Rozen SG, Tan P, Tan PH, Teh BT.

Nat Genet. 2015 Nov;47(11):1341-5. doi: 10.1038/ng.3409. Epub 2015 Oct 5.

PMID:
26437033
35.

Whole-exome sequencing of breast cancer, malignant peripheral nerve sheath tumor and neurofibroma from a patient with neurofibromatosis type 1.

McPherson JR, Ong CK, Ng CC, Rajasegaran V, Heng HL, Yu WS, Tan BK, Madhukumar P, Teo MC, Ngeow J, Thike AA, Rozen SG, Tan PH, Lee AS, Teh BT, Yap YS.

Cancer Med. 2015 Dec;4(12):1871-8. doi: 10.1002/cam4.551. Epub 2015 Oct 3.

36.

Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple-negative breast cancer, adversely affects survival.

Thike AA, Tan PH, Ikeda M, Iqbal J.

Histopathology. 2016 Apr;68(5):702-12. doi: 10.1111/his.12801. Epub 2015 Nov 2.

PMID:
26259780
37.

Predictive Factors for BRCA1 and BRCA2 Genetic Testing in an Asian Clinic-Based Population.

Wong ES, Shekar S, Chan CH, Hong LZ, Poon SY, Silla T, Lin C, Kumar V, Davila S, Voorhoeve M, Thike AA, Ho GH, Yap YS, Tan PH, Tan MH, Ang P, Lee AS.

PLoS One. 2015 Jul 29;10(7):e0134408. doi: 10.1371/journal.pone.0134408. eCollection 2015.

38.

Second harmonic generation microscopy is a novel technique for differential diagnosis of breast fibroepithelial lesions.

Tan WJ, Yan J, Xu S, Thike AA, Bay BH, Yu H, Tan MH, Tan PH.

J Clin Pathol. 2015 Dec;68(12):1033-5. doi: 10.1136/jclinpath-2015-203231. Epub 2015 Jul 24.

PMID:
26209730
39.

Role of epithelial-mesenchymal transition markers in triple-negative breast cancer.

Cheung SY, Boey YJ, Koh VC, Thike AA, Lim JC, Iqbal J, Tan PH.

Breast Cancer Res Treat. 2015 Aug;152(3):489-98. doi: 10.1007/s10549-015-3485-1. Epub 2015 Jun 30.

PMID:
26123543
40.

Characteristics and behaviour of screen-detected ductal carcinoma in situ of the breast: comparison with symptomatic patients.

Koh VC, Lim JC, Thike AA, Cheok PY, Thu MM, Tan VK, Tan BK, Ong KW, Ho GH, Tan WJ, Tan Y, Salahuddin AS, Busmanis I, Chong AP, Iqbal J, Thilagaratnam S, Wong JS, Tan PH.

Breast Cancer Res Treat. 2015 Jul;152(2):293-304. doi: 10.1007/s10549-015-3472-6. Epub 2015 Jun 16.

PMID:
26077641
41.

MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases.

Ng CC, Tan J, Ong CK, Lim WK, Rajasegaran V, Nasir ND, Lim JC, Thike AA, Salahuddin SA, Iqbal J, Busmanis I, Chong AP, Teh BT, Tan PH.

J Clin Pathol. 2015 Sep;68(9):685-91. doi: 10.1136/jclinpath-2015-202896. Epub 2015 May 27.

PMID:
26018969
42.

Paediatric fibroepithelial lesions revisited: pathological insights.

Tay TK, Chang KT, Thike AA, Tan PH.

J Clin Pathol. 2015 Aug;68(8):633-41. doi: 10.1136/jclinpath-2015-202956. Epub 2015 May 21.

PMID:
25998513
43.

Expression of FGFR1 is an independent prognostic factor in triple-negative breast cancer.

Cheng CL, Thike AA, Tan SY, Chua PJ, Bay BH, Tan PH.

Breast Cancer Res Treat. 2015 May;151(1):99-111. doi: 10.1007/s10549-015-3371-x. Epub 2015 Apr 14.

PMID:
25868865
44.

False negative rate for intraoperative sentinel lymph node frozen section in patients with breast cancer: a retrospective analysis of patients in a single Asian institution.

Wong J, Yong WS, Thike AA, Iqbal J, Salahuddin AS, Ho GH, Madhukumar P, Tan BK, Ong KW, Tan PH.

J Clin Pathol. 2015 Jul;68(7):536-40. doi: 10.1136/jclinpath-2014-202799. Epub 2015 Apr 8.

PMID:
25855801
45.

Clinicopathological significance of ARID1B in breast invasive ductal carcinoma.

Shao F, Guo T, Chua PJ, Tang L, Thike AA, Tan PH, Bay BH, Baeg GH.

Histopathology. 2015 Nov;67(5):709-18. doi: 10.1111/his.12701. Epub 2015 May 17.

PMID:
25817822
46.

Cancer stem cell and epithelial-mesenchymal transition markers predict worse outcome in metaplastic carcinoma of the breast.

Oon ML, Thike AA, Tan SY, Tan PH.

Breast Cancer Res Treat. 2015 Feb;150(1):31-41. doi: 10.1007/s10549-015-3299-1. Epub 2015 Feb 13.

PMID:
25677743
47.

Prognostic significance of epithelial-mesenchymal transition proteins Twist and Foxc2 in phyllodes tumours of the breast.

Lim JC, Koh VC, Tan JS, Tan WJ, Thike AA, Tan PH.

Breast Cancer Res Treat. 2015 Feb;150(1):19-29. doi: 10.1007/s10549-015-3296-4. Epub 2015 Feb 13.

PMID:
25677742
48.

Complement component 1, q subcomponent binding protein is a marker for proliferation in breast cancer.

Scully OJ, Yu Y, Salim A, Thike AA, Yip GW, Baeg GH, Tan PH, Matsumoto K, Bay BH.

Exp Biol Med (Maywood). 2015 Jul;240(7):846-53. doi: 10.1177/1535370214565075. Epub 2015 Jan 7.

49.

CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival.

Chong TW, Goh FY, Sim MY, Huang HH, Thike AA, Lim WK, Teh BT, Tan PH.

J Clin Pathol. 2015 Mar;68(3):200-5. doi: 10.1136/jclinpath-2014-202735. Epub 2014 Dec 4. Erratum in: J Clin Pathol. 2015 Nov;68(11):912. Thike, Daw Aye Aye [corrected to Thike, Aye Aye].

50.

Syndecan-1 is a potential biomarker for triple-positive breast carcinomas in Asian women with correlation to survival.

Lim GH, Tan PH, Jara-Lazaro AR, Thike AA, Sim WC, Yap VB, Yip GW.

Singapore Med J. 2014 Sep;55(9):468-72.

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