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A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene.

Hecker M, Boxberger N, Illner N, Fitzner B, Schröder I, Winkelmann A, Dudesek A, Meister S, Koczan D, Lorenz P, Thiesen HJ, Zettl UK.

PLoS Genet. 2019 Feb 7;15(2):e1007961. doi: 10.1371/journal.pgen.1007961. eCollection 2019 Feb.


Transcriptome profiling of peripheral blood immune cell populations in multiple sclerosis patients before and during treatment with a sphingosine-1-phosphate receptor modulator.

Angerer IC, Hecker M, Koczan D, Roch L, Friess J, Rüge A, Fitzner B, Boxberger N, Schröder I, Flechtner K, Thiesen HJ, Winkelmann A, Meister S, Zettl UK.

CNS Neurosci Ther. 2018 Mar;24(3):193-201. doi: 10.1111/cns.12793. Epub 2018 Jan 3.


Loss of cadherin related family member 5 (CDHR5) expression in clear cell renal cell carcinoma is a prognostic marker of disease progression.

Bläsius FM, Meller S, Stephan C, Jung K, Ellinger J, Glocker MO, Thiesen HJ, Tolkach Y, Kristiansen G.

Oncotarget. 2017 Aug 24;8(43):75076-75086. doi: 10.18632/oncotarget.20507. eCollection 2017 Sep 26.


Intact Transition Epitope Mapping (ITEM).

Yefremova Y, Opuni KFM, Danquah BD, Thiesen HJ, Glocker MO.

J Am Soc Mass Spectrom. 2017 Aug;28(8):1612-1622. doi: 10.1007/s13361-017-1654-7. Epub 2017 Jun 14.


Stratification of clear cell renal cell carcinoma (ccRCC) genomes by gene-directed copy number alteration (CNA) analysis.

Thiesen HJ, Steinbeck F, Maruschke M, Koczan D, Ziems B, Hakenberg OW.

PLoS One. 2017 May 9;12(5):e0176659. doi: 10.1371/journal.pone.0176659. eCollection 2017.


Big-Data-Driven Stem Cell Science and Tissue Engineering: Vision and Unique Opportunities.

Del Sol A, Thiesen HJ, Imitola J, Carazo Salas RE.

Cell Stem Cell. 2017 Feb 2;20(2):157-160. doi: 10.1016/j.stem.2017.01.006.


Fingolimod alters the transcriptome profile of circulating CD4+ cells in multiple sclerosis.

Friess J, Hecker M, Roch L, Koczan D, Fitzner B, Angerer IC, Schröder I, Flechtner K, Thiesen HJ, Winkelmann A, Zettl UK.

Sci Rep. 2017 Feb 3;7:42087. doi: 10.1038/srep42087.


High-Resolution Expression Profiling of Peripheral Blood CD8+ Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution.

Roch L, Hecker M, Friess J, Angerer IC, Koczan D, Fitzner B, Schröder I, Flechtner K, Thiesen HJ, Meister S, Winkelmann A, Zettl UK.

Mol Neurobiol. 2017 Sep;54(7):5511-5525. doi: 10.1007/s12035-016-0075-0. Epub 2016 Sep 8.


SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study.

Reimer T, Kempert S, Gerber B, Thiesen HJ, Hartmann S, Koczan D.

BMC Cancer. 2016 May 27;16:337. doi: 10.1186/s12885-016-2373-3.


A computational method for designing diverse linear epitopes including citrullinated peptides with desired binding affinities to intravenous immunoglobulin.

Patro R, Norel R, Prill RJ, Saez-Rodriguez J, Lorenz P, Steinbeck F, Ziems B, Luštrek M, Barbarini N, Tiengo A, Bellazzi R, Thiesen HJ, Stolovitzky G, Kingsford C.

BMC Bioinformatics. 2016 Apr 8;17:155. doi: 10.1186/s12859-016-1008-7.


High-Density Peptide Microarray Analysis of IgG Autoantibody Reactivities in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients.

Hecker M, Fitzner B, Wendt M, Lorenz P, Flechtner K, Steinbeck F, Schröder I, Thiesen HJ, Zettl UK.

Mol Cell Proteomics. 2016 Apr;15(4):1360-80. doi: 10.1074/mcp.M115.051664. Epub 2016 Feb 1.


Ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for phosphopeptide analysis with a solidified ionic liquid matrix.

Mukherjee G, Claudia Röwer C, Koy C, Protzel C, Lorenz P, Thiesen HJ, Hakenberg OW, Glocker MO.

Eur J Mass Spectrom (Chichester). 2015;21(2):65-77. doi: 10.1255/ejms.1362.


A novel strategy for the rapid preparation and isolation of intact immune complexes from peptide mixtures.

Al-Majdoub M, Opuni KF, Yefremova Y, Koy C, Lorenz P, El-Kased RF, Thiesen HJ, Glocker MO.

J Mol Recognit. 2014 Sep;27(9):566-74. doi: 10.1002/jmr.2375.


The B-subdomain of the Xenopus laevis XFIN KRAB-AB domain is responsible for its weaker transcriptional repressor activity compared to human ZNF10/Kox1.

Born N, Thiesen HJ, Lorenz P.

PLoS One. 2014 Feb 3;9(2):e87609. doi: 10.1371/journal.pone.0087609. eCollection 2014.


Oxidatively modified LDL particles in the human placenta in early and late onset intrauterine growth restriction.

Pecks U, Rath W, Caspers R, Sosnowsky K, Ziems B, Thiesen HJ, Maass N, Huppertz B.

Placenta. 2013 Dec;34(12):1142-9.


miRNA expression profiles determined in maternal sera of patients with HELLP syndrome.

Stubert J, Koczan D, Richter DU, Dieterich M, Ziems B, Thiesen HJ, Gerber B, Reimer T.

Hypertens Pregnancy. 2014 May;33(2):215-35. doi: 10.3109/10641955.2013.858743. Epub 2013 Dec 4.


Epitope predictions indicate the presence of two distinct types of epitope-antibody-reactivities determined by epitope profiling of intravenous immunoglobulins.

Luštrek M, Lorenz P, Kreutzer M, Qian Z, Steinbeck F, Wu D, Born N, Ziems B, Hecker M, Blank M, Shoenfeld Y, Cao Z, Glocker MO, Li Y, Fuellen G, Thiesen HJ.

PLoS One. 2013 Nov 11;8(11):e78605. doi: 10.1371/journal.pone.0078605. eCollection 2013.


Glatiramer acetate treatment effects on gene expression in monocytes of multiple sclerosis patients.

Thamilarasan M, Hecker M, Goertsches RH, Paap BK, Schröder I, Koczan D, Thiesen HJ, Zettl UK.

J Neuroinflammation. 2013 Oct 17;10:126. doi: 10.1186/1742-2094-10-126.


MicroRNA expression changes during interferon-beta treatment in the peripheral blood of multiple sclerosis patients.

Hecker M, Thamilarasan M, Koczan D, Schröder I, Flechtner K, Freiesleben S, Füllen G, Thiesen HJ, Zettl UK.

Int J Mol Sci. 2013 Aug 5;14(8):16087-110. doi: 10.3390/ijms140816087.


Interferon-beta therapy in multiple sclerosis: the short-term and long-term effects on the patients' individual gene expression in peripheral blood.

Hecker M, Hartmann C, Kandulski O, Paap BK, Koczan D, Thiesen HJ, Zettl UK.

Mol Neurobiol. 2013 Dec;48(3):737-56. doi: 10.1007/s12035-013-8463-1. Epub 2013 May 1.


The advantage of specific intravenous immunoglobulin (sIVIG) on regular IVIG: experience of the last decade.

Svetlicky N, Ortega-Hernandez OD, Mouthon L, Guillevin L, Thiesen HJ, Altman A, Kravitz MS, Blank M, Shoenfeld Y.

J Clin Immunol. 2013 Jan;33 Suppl 1:S27-32. doi: 10.1007/s10875-012-9842-5. Epub 2012 Dec 11. Review.


Network analysis of transcriptional regulation in response to intramuscular interferon-β-1a multiple sclerosis treatment.

Hecker M, Goertsches RH, Fatum C, Koczan D, Thiesen HJ, Guthke R, Zettl UK.

Pharmacogenomics J. 2012 Aug;12(4):360. doi: 10.1038/tpj.2011.12. Epub 2011 Mar 29. No abstract available.


Cell type specificity of signaling: view from membrane receptors distribution and their downstream transduction networks.

He Y, Yu Z, Ge D, Wang-Sattler R, Thiesen HJ, Xie L, Li Y.

Protein Cell. 2012 Sep;3(9):701-13. doi: 10.1007/s13238-012-2049-y. Epub 2012 Jul 16.


Elevated type I interferon-like activity in a subset of multiple sclerosis patients: molecular basis and clinical relevance.

Hundeshagen A, Hecker M, Paap BK, Angerstein C, Kandulski O, Fatum C, Hartmann C, Koczan D, Thiesen HJ, Zettl UK.

J Neuroinflammation. 2012 Jun 22;9:140. doi: 10.1186/1742-2094-9-140.


Integration of MicroRNA databases to study MicroRNAs associated with multiple sclerosis.

Angerstein C, Hecker M, Paap BK, Koczan D, Thamilarasan M, Thiesen HJ, Zettl UK.

Mol Neurobiol. 2012 Jun;45(3):520-35. doi: 10.1007/s12035-012-8270-0. Epub 2012 May 2.


Clonality characterization of natural epitope-specific antibodies against the tumor-related antigen topoisomerase IIa by peptide chip and proteome analysis: a pilot study with colorectal carcinoma patient samples.

Linnebacher M, Lorenz P, Koy C, Jahnke A, Born N, Steinbeck F, Wollbold J, Latzkow T, Thiesen HJ, Glocker MO.

Anal Bioanal Chem. 2012 Apr;403(1):227-38. doi: 10.1007/s00216-012-5781-5. Epub 2012 Feb 16.


Reassessment of blood gene expression markers for the prognosis of relapsing-remitting multiple sclerosis.

Hecker M, Paap BK, Goertsches RH, Kandulski O, Fatum C, Koczan D, Hartung HP, Thiesen HJ, Zettl UK.

PLoS One. 2011;6(12):e29648. doi: 10.1371/journal.pone.0029648. Epub 2011 Dec 27.


Putative biomarker genes for grading clear cell renal cell carcinoma.

Maruschke M, Koczan D, Reuter D, Ziems B, Nizze H, Hakenberg OW, Thiesen HJ.

Urol Int. 2011;87(2):205-17. doi: 10.1159/000328196. Epub 2011 Jul 14.


Toponostics of invasive ductal breast carcinoma: combination of spatial protein expression imaging and quantitative proteome signature analysis.

Röwer C, Ziems B, Radtke A, Schmitt O, Reimer T, Koy C, Thiesen HJ, Gerber B, Glocker MO.

Int J Clin Exp Pathol. 2011 Mar 31;4(5):454-67. Epub 2011 Feb 28.


Computational analysis of high-density peptide microarray data with application from systemic sclerosis to multiple sclerosis.

Hecker M, Lorenz P, Steinbeck F, Hong L, Riemekasten G, Li Y, Zettl UK, Thiesen HJ.

Autoimmun Rev. 2012 Jan;11(3):180-90. doi: 10.1016/j.autrev.2011.05.010. Epub 2011 May 18. Review.


Mass spectrometric characterization of protein structure details refines the proteome signature for invasive ductal breast carcinoma.

Röwer C, Koy C, Hecker M, Reimer T, Gerber B, Thiesen HJ, Glocker MO.

J Am Soc Mass Spectrom. 2011 Mar;22(3):440-56. doi: 10.1007/s13361-010-0031-6. Epub 2011 Feb 8.


Gene expression analysis in clear cell renal cell carcinoma using gene set enrichment analysis for biostatistical management.

Maruschke M, Reuter D, Koczan D, Hakenberg OW, Thiesen HJ.

BJU Int. 2011 Jul;108(2 Pt 2):E29-35. doi: 10.1111/j.1464-410X.2010.09794.x. Epub 2011 Mar 16.


Network analysis of transcriptional regulation in response to intramuscular interferon-β-1a multiple sclerosis treatment.

Hecker M, Goertsches RH, Fatum C, Koczan D, Thiesen HJ, Guthke R, Zettl UK.

Pharmacogenomics J. 2012 Apr;12(2):134-46. doi: 10.1038/tpj.2010.77. Epub 2010 Oct 19. Erratum in: Pharmacogenomics J. 2012 Aug;12(4):360.


Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis.

Ungethuem U, Haeupl T, Witt H, Koczan D, Krenn V, Huber H, von Helversen TM, Drungowski M, Seyfert C, Zacher J, Pruss A, Neidel J, Lehrach H, Thiesen HJ, Ruiz P, Bläss S.

Physiol Genomics. 2010 Nov 29;42A(4):267-82. doi: 10.1152/physiolgenomics.00004.2010. Epub 2010 Sep 21.


Long-lived plasma cells and memory B cells produce pathogenic anti-GAD65 autoantibodies in Stiff Person Syndrome.

Rizzi M, Knoth R, Hampe CS, Lorenz P, Gougeon ML, Lemercier B, Venhoff N, Ferrera F, Salzer U, Thiesen HJ, Peter HH, Walker UA, Eibel H.

PLoS One. 2010 May 26;5(5):e10838. doi: 10.1371/journal.pone.0010838.


The ancient mammalian KRAB zinc finger gene cluster on human chromosome 8q24.3 illustrates principles of C2H2 zinc finger evolution associated with unique expression profiles in human tissues.

Lorenz P, Dietmann S, Wilhelm T, Koczan D, Autran S, Gad S, Wen G, Ding G, Li Y, Rousseau-Merck MF, Thiesen HJ.

BMC Genomics. 2010 Mar 26;11:206. doi: 10.1186/1471-2164-11-206.


Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS.

Goertsches RH, Hecker M, Koczan D, Serrano-Fernandez P, Moeller S, Thiesen HJ, Zettl UK.

Pharmacogenomics. 2010 Feb;11(2):147-61. doi: 10.2217/pgs.09.152.


Mass spectrometric and peptide chip epitope mapping of rheumatoid arthritis autoantigen RA33.

El-Kased RF, Koy C, Deierling T, Lorenz P, Qian Z, Li Y, Thiesen HJ, Glocker MO.

Eur J Mass Spectrom (Chichester). 2009;15(6):747-59. doi: 10.1255/ejms.1040.


Time course transcriptomics of IFNB1b drug therapy in multiple sclerosis.

Serrano-Fernández P, Möller S, Goertsches R, Fiedler H, Koczan D, Thiesen HJ, Zettl UK.

Autoimmunity. 2010 Mar;43(2):172-8. doi: 10.3109/08916930903219040.


Towards a proteome signature for invasive ductal breast carcinoma derived from label-free nanoscale LC-MS protein expression profiling of tumorous and glandular tissue.

Röwer C, Vissers JP, Koy C, Kipping M, Hecker M, Reimer T, Gerber B, Thiesen HJ, Glocker MO.

Anal Bioanal Chem. 2009 Dec;395(8):2443-56. doi: 10.1007/s00216-009-3187-9. Epub 2009 Oct 29.


Integrative modeling of transcriptional regulation in response to antirheumatic therapy.

Hecker M, Goertsches RH, Engelmann R, Thiesen HJ, Guthke R.

BMC Bioinformatics. 2009 Aug 24;10:262. doi: 10.1186/1471-2105-10-262.


MS characterization of apheresis samples from rheumatoid arthritis patients for the improvement of immunoadsorption therapy - a pilot study.

Kienbaum M, Koy C, Montgomery HV, Drynda S, Lorenz P, Illges H, Tanaka K, Kekow J, Guthke R, Thiesen HJ, Glocker MO.

Proteomics Clin Appl. 2009 Jul;3(7):797-809. doi: 10.1002/prca.200800232.


Immunomodulatory effects of holothurian triterpene glycosides on mammalian splenocytes determined by mass spectrometric proteome analysis.

Aminin DL, Koy C, Dmitrenok PS, Müller-Hilke B, Koczan D, Arbogast B, Silchenko AA, Kalinin VI, Avilov SA, Stonik VA, Collin PD, Thiesen HJ, Deinzer ML, Glocker MO.

J Proteomics. 2009 Jul 21;72(5):886-906. doi: 10.1016/j.jprot.2009.04.004. Epub 2009 May 3.


Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease.

Lorenz P, Kreutzer M, Zerweck J, Schutkowski M, Thiesen HJ.

Methods Mol Biol. 2009;524:247-58. doi: 10.1007/978-1-59745-450-6_18.


Molecular subtypes of systemic sclerosis in association with anti-centromere antibodies and digital ulcers.

Bos CL, van Baarsen LG, Timmer TC, Overbeek MJ, Basoski NM, Rustenburg F, Baggen JM, Thiesen HJ, Dijkmans BA, van der Pouw Kraan TC, Voskuyl AE, Verweij CL.

Genes Immun. 2009 Apr;10(3):210-8. doi: 10.1038/gene.2008.98. Epub 2009 Jan 8.


Age-dependent gene expression profile and protein expression in a transgenic rat model of Huntington's disease.

Nguyen HP, Metzger S, Holzmann C, Koczan D, Thiesen HJ, von Hörsten S, Riess O, Bonin M.

Proteomics Clin Appl. 2008 Dec;2(12):1638-50. doi: 10.1002/prca.200800018. Epub 2008 Oct 22.


SysZNF: the C2H2 zinc finger gene database.

Ding G, Lorenz P, Kreutzer M, Li Y, Thiesen HJ.

Nucleic Acids Res. 2009 Jan;37(Database issue):D267-73. doi: 10.1093/nar/gkn782. Epub 2008 Oct 30.


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