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Items: 10

1.

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.

Paugh SW, Bonten EJ, Savic D, Ramsey LB, Thierfelder WE, Gurung P, Malireddi RK, Actis M, Mayasundari A, Min J, Coss DR, Laudermilk LT, Panetta JC, McCorkle JR, Fan Y, Crews KR, Stocco G, Wilkinson MR, Ferreira AM, Cheng C, Yang W, Karol SE, Fernandez CA, Diouf B, Smith C, Hicks JK, Zanut A, Giordanengo A, Crona D, Bianchi JJ, Holmfeldt L, Mullighan CG, den Boer ML, Pieters R, Jeha S, Dunwell TL, Latif F, Bhojwani D, Carroll WL, Pui CH, Myers RM, Guy RK, Kanneganti TD, Relling MV, Evans WE.

Nat Genet. 2015 Jun;47(6):607-14. doi: 10.1038/ng.3283. Epub 2015 May 4.

2.

PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity.

Stocco G, Yang W, Crews KR, Thierfelder WE, Decorti G, Londero M, Franca R, Rabusin M, Valsecchi MG, Pei D, Cheng C, Paugh SW, Ramsey LB, Diouf B, McCorkle JR, Jones TS, Pui CH, Relling MV, Evans WE.

Hum Mol Genet. 2012 Nov 1;21(21):4793-804. doi: 10.1093/hmg/dds302. Epub 2012 Jul 30.

3.

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.

Diouf B, Cheng Q, Krynetskaia NF, Yang W, Cheok M, Pei D, Fan Y, Cheng C, Krynetskiy EY, Geng H, Chen S, Thierfelder WE, Mullighan CG, Downing JR, Hsieh P, Pui CH, Relling MV, Evans WE.

Nat Med. 2011 Sep 25;17(10):1298-303. doi: 10.1038/nm.2430.

4.

Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development.

Carpino N, Thierfelder WE, Chang MS, Saris C, Turner SJ, Ziegler SF, Ihle JN.

Mol Cell Biol. 2004 Mar;24(6):2584-92.

5.

Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6.

Heydeck D, Thomas L, Schnurr K, Trebus F, Thierfelder WE, Ihle JN, Kühn H.

Blood. 1998 Oct 1;92(7):2503-10.

PMID:
9746791
6.

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells.

Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, Ihle JN.

Nature. 1996 Jul 11;382(6587):171-4.

PMID:
8700208
7.

Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.

Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y, Ihle JN.

Mol Cell Biol. 1996 Apr;16(4):1622-31.

8.

Defective lymphoid development in mice lacking Jak3.

Nosaka T, van Deursen JM, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN.

Science. 1995 Nov 3;270(5237):800-2. Erratum in: Science 1996 Jan 5;271(5245):17.

PMID:
7481769
9.

Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.

Yamamoto K, Quelle FW, Thierfelder WE, Kreider BL, Gilbert DJ, Jenkins NA, Copeland NG, Silvennoinen O, Ihle JN.

Mol Cell Biol. 1994 Jul;14(7):4342-9.

10.

Signaling by the cytokine receptor superfamily: JAKs and STATs.

Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Thierfelder WE, Kreider B, Silvennoinen O.

Trends Biochem Sci. 1994 May;19(5):222-7. Review.

PMID:
8048164

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