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Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction.

Favier AL, Reynard O, Gout E, van Eijk M, Haagsman HP, Crouch E, Volchkov V, Peyrefitte C, Thielens NM.

Viruses. 2018 Dec 26;11(1). pii: E15. doi: 10.3390/v11010015.


Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex.

Schiela B, Bernklau S, Malekshahi Z, Deutschmann D, Koske I, Banki Z, Thielens NM, Würzner R, Speth C, Weiss G, Stiasny K, Steinmann E, Stoiber H.

Front Immunol. 2018 Oct 17;9:2177. doi: 10.3389/fimmu.2018.02177. eCollection 2018.


Recognition protein C1q of innate immunity agglutinates nanodiamonds without activating complement.

Belime A, Thielens NM, Gravel E, Frachet P, Ancelet S, Tacnet P, Caneiro C, Chuprin J, Gaboriaud C, Schoehn G, Doris E, Ling WL.

Nanomedicine. 2018 Oct 24. pii: S1549-9634(18)30528-8. doi: 10.1016/j.nano.2018.09.009. [Epub ahead of print]


Antibodies targeting circulating protective molecules in lupus nephritis: Interest as serological biomarkers.

Dumestre-Pérard C, Clavarino G, Colliard S, Cesbron JY, Thielens NM.

Autoimmun Rev. 2018 Sep;17(9):890-899. doi: 10.1016/j.autrev.2018.03.013. Epub 2018 Jul 29. Review.


C1q restrains autoimmunity and viral infection by regulating CD8+ T cell metabolism.

Ling GS, Crawford G, Buang N, Bartok I, Tian K, Thielens NM, Bally I, Harker JA, Ashton-Rickardt PG, Rutschmann S, Strid J, Botto M.

Science. 2018 May 4;360(6388):558-563. doi: 10.1126/science.aao4555.


C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.

Jacquet M, Cioci G, Fouet G, Bally I, Thielens NM, Gaboriaud C, Rossi V.

Front Immunol. 2018 Mar 7;9:453. doi: 10.3389/fimmu.2018.00453. eCollection 2018.


Interaction of Complement Defence Collagens C1q and Mannose-Binding Lectin with BMP-1/Tolloid-like Proteinases.

Lacroix M, Tessier A, Dumestre-Pérard C, Vadon-Le Goff S, Gout E, Bruckner-Tuderman L, Kiritsi D, Nyström A, Ricard-Blum S, Moali C, Hulmes DJS, Thielens NM.

Sci Rep. 2017 Dec 5;7(1):16958. doi: 10.1038/s41598-017-17318-w.


Impact of the surface charge of polydiacetylene micelles on their interaction with human innate immune protein C1q and the complement system.

Thielens NM, Belime A, Gravel E, Ancelet S, Caneiro C, Doris E, Ling WL.

Int J Pharm. 2018 Jan 30;536(1):434-439. doi: 10.1016/j.ijpharm.2017.11.072. Epub 2017 Dec 5.


Autoantibodies Targeting Ficolin-2 in Systemic Lupus Erythematosus Patients With Active Nephritis.

Colliard S, Jourde-Chiche N, Clavarino G, Sarrot-Reynauld F, Gout E, Deroux A, Fougere M, Bardin N, Bouillet L, Cesbron JY, Thielens NM, Dumestre-Pérard C.

Arthritis Care Res (Hoboken). 2018 Aug;70(8):1263-1268. doi: 10.1002/acr.23449. Epub 2018 Jun 21.


Structure of the C1 complex of complement.

Arlaud GJ, Gaboriaud C, Ling WL, Thielens NM.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5766-E5767. doi: 10.1073/pnas.1703977114. Epub 2017 Jul 12. No abstract available.


C1q: A fresh look upon an old molecule.

Thielens NM, Tedesco F, Bohlson SS, Gaboriaud C, Tenner AJ.

Mol Immunol. 2017 Sep;89:73-83. doi: 10.1016/j.molimm.2017.05.025. Epub 2017 Jun 7. Review.


Deciphering Key Residues Involved in the Virulence-promoting Interactions between Streptococcus pneumoniae and Human Plasminogen.

Moreau C, Terrasse R, Thielens NM, Vernet T, Gaboriaud C, Di Guilmi AM.

J Biol Chem. 2017 Feb 10;292(6):2217-2225. doi: 10.1074/jbc.M116.764209. Epub 2016 Dec 23.


Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties.

Moreau C, Cioci G, Iannello M, Laffly E, Chouquet A, Ferreira A, Thielens NM, Gaboriaud C.

IUCrJ. 2016 Sep 14;3(Pt 6):408-419. eCollection 2016 Nov 1.


Editorial: State-of-the-Art Research on C1q and the Classical Complement Pathway.

Kishore U, Thielens NM, Gaboriaud C.

Front Immunol. 2016 Oct 4;7:398. eCollection 2016. No abstract available.


Association between the Presence of Autoantibodies Targeting Ficolin-3 and Active Nephritis in Patients with Systemic Lupus Erythematosus.

Plawecki M, Lheritier E, Clavarino G, Jourde-Chiche N, Ouili S, Paul S, Gout E, Sarrot-Reynauld F, Bardin N, Boëlle PY, Chiche L, Bouillet L, Thielens NM, Cesbron JY, Dumestre-Pérard C.

PLoS One. 2016 Sep 15;11(9):e0160879. doi: 10.1371/journal.pone.0160879. eCollection 2016.


Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein.

Favier AL, Gout E, Reynard O, Ferraris O, Kleman JP, Volchkov V, Peyrefitte C, Thielens NM.

J Virol. 2016 May 12;90(11):5256-5269. doi: 10.1128/JVI.00232-16. Print 2016 Jun 1.


Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats.

Sharp JA, Hair PS, Pallera HK, Kumar PS, Mauriello CT, Nyalwidhe JO, Phelps CA, Park D, Thielens NM, Pascal SM, Chen W, Duffy DM, Lattanzio FA, Cunnion KM, Krishna NK.

PLoS One. 2015 Jul 21;10(7):e0132446. doi: 10.1371/journal.pone.0132446. eCollection 2015.


Human ficolin-2 recognition versatility extended: an update on the binding of ficolin-2 to sulfated/phosphated carbohydrates.

Laffly E, Lacroix M, Martin L, Vassal-Stermann E, Thielens NM, Gaboriaud C.

FEBS Lett. 2014 Dec 20;588(24):4694-700. doi: 10.1016/j.febslet.2014.10.042. Epub 2014 Nov 11.


Deciphering the fine details of c1 assembly and activation mechanisms: "mission impossible"?

Gaboriaud C, Ling WL, Thielens NM, Bally I, Rossi V.

Front Immunol. 2014 Nov 6;5:565. doi: 10.3389/fimmu.2014.00565. eCollection 2014. Review.


Human L-ficolin recognizes phosphocholine moieties of pneumococcal teichoic acid.

Vassal-Stermann E, Lacroix M, Gout E, Laffly E, Pedersen CM, Martin L, Amoroso A, Schmidt RR, Zähringer U, Gaboriaud C, Di Guilmi AM, Thielens NM.

J Immunol. 2014 Dec 1;193(11):5699-708. doi: 10.4049/jimmunol.1400127. Epub 2014 Oct 24.


Classical complement pathway components C1r and C1s: purification from human serum and in recombinant form and functional characterization.

Rossi V, Bally I, Lacroix M, Arlaud GJ, Thielens NM.

Methods Mol Biol. 2014;1100:43-60. doi: 10.1007/978-1-62703-724-2_4.


Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system.

Henriksen ML, Brandt J, Andrieu JP, Nielsen C, Jensen PH, Holmskov U, Jorgensen TJ, Palarasah Y, Thielens NM, Hansen S.

J Immunol. 2013 Dec 15;191(12):6117-27. doi: 10.4049/jimmunol.1302121. Epub 2013 Oct 30.


Characterization of the interaction between collectin 11 (CL-11, CL-K1) and nucleic acids.

Henriksen ML, Brandt J, Iyer SS, Thielens NM, Hansen S.

Mol Immunol. 2013 Dec;56(4):757-67. doi: 10.1016/j.molimm.2013.07.011. Epub 2013 Aug 14.


The serine protease domain of MASP-3: enzymatic properties and crystal structure in complex with ecotin.

Gaboriaud C, Gupta RK, Martin L, Lacroix M, Serre L, Teillet F, Arlaud GJ, Rossi V, Thielens NM.

PLoS One. 2013 Jul 4;8(7):e67962. doi: 10.1371/journal.pone.0067962. Print 2013.


Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites.

Bally I, Ancelet S, Moriscot C, Gonnet F, Mantovani A, Daniel R, Schoehn G, Arlaud GJ, Thielens NM.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8650-5. doi: 10.1073/pnas.1304894110. Epub 2013 May 6.


Protective effect of surfactant protein d in pulmonary vaccinia virus infection: implication of A27 viral protein.

Perino J, Thielens NM, Crouch E, Spehner D, Crance JM, Favier AL.

Viruses. 2013 Mar 21;5(3):928-53. doi: 10.3390/v5030928.


Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner.

Joseph K, Kulik L, Coughlin B, Kunchithapautham K, Bandyopadhyay M, Thiel S, Thielens NM, Holers VM, Rohrer B.

J Biol Chem. 2013 May 3;288(18):12753-65. doi: 10.1074/jbc.M112.421891. Epub 2013 Mar 14.


Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.

Jacquet M, Lacroix M, Ancelet S, Gout E, Gaboriaud C, Thielens NM, Rossi V.

J Immunol. 2013 Apr 1;190(7):3721-31. doi: 10.4049/jimmunol.1202451. Epub 2013 Mar 4.


Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein.

Terrasse R, Tacnet-Delorme P, Moriscot C, Pérard J, Schoehn G, Vernet T, Thielens NM, Di Guilmi AM, Frachet P.

J Biol Chem. 2012 Dec 14;287(51):42620-33. doi: 10.1074/jbc.M112.423731. Epub 2012 Oct 18.


A novel peptide inhibitor of classical and lectin complement activation including ABO incompatibility.

Mauriello CT, Pallera HK, Sharp JA, Woltmann JL Jr, Qian S, Hair PS, van der Pol P, van Kooten C, Thielens NM, Lattanzio FA, Cunnion KM, Krishna NK.

Mol Immunol. 2013 Jan;53(1-2):132-9. doi: 10.1016/j.molimm.2012.07.012. Epub 2012 Aug 18.


MASP interactions with plasma-derived MBL.

Laursen IA, Thielens NM, Christiansen M, Houen G.

Mol Immunol. 2012 Sep;52(2):79-87. doi: 10.1016/j.molimm.2012.04.014. Epub 2012 May 18.


The role of nanometer-scaled ligand patterns in polyvalent binding by large mannan-binding lectin oligomers.

Gjelstrup LC, Kaspersen JD, Behrens MA, Pedersen JS, Thiel S, Kingshott P, Oliveira CL, Thielens NM, Vorup-Jensen T.

J Immunol. 2012 Feb 1;188(3):1292-306. doi: 10.4049/jimmunol.1103012. Epub 2012 Jan 4.


M-ficolin and leukosialin (CD43): new partners in neutrophil adhesion.

Moreno-Amaral AN, Gout E, Danella-Polli C, Tabarin F, Lesavre P, Pereira-da-Silva G, Thielens NM, Halbwachs-Mecarelli L.

J Leukoc Biol. 2012 Mar;91(3):469-74. doi: 10.1189/jlb.0911460. Epub 2011 Dec 13.


Structure and properties of the Ca(2+)-binding CUB domain, a widespread ligand-recognition unit involved in major biological functions.

Gaboriaud C, Gregory-Pauron L, Teillet F, Thielens NM, Bally I, Arlaud GJ.

Biochem J. 2011 Oct 15;439(2):185-93. doi: 10.1042/BJ20111027. Review.


The double life of M-ficolin: what functions when circulating in serum and tethered to leukocyte surfaces?

Thielens NM.

J Leukoc Biol. 2011 Sep;90(3):410-2. doi: 10.1189/jlb.0611281. No abstract available.


M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules.

Gout E, Moriscot C, Doni A, Dumestre-Pérard C, Lacroix M, Pérard J, Schoehn G, Mantovani A, Arlaud GJ, Thielens NM.

J Immunol. 2011 May 15;186(10):5815-22. doi: 10.4049/jimmunol.1100180. Epub 2011 Apr 13.


The human c1q globular domain: structure and recognition of non-immune self ligands.

Gaboriaud C, Frachet P, Thielens NM, Arlaud GJ.

Front Immunol. 2012 Jan 6;2:92. doi: 10.3389/fimmu.2011.00092. eCollection 2011.


CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site.

Duus K, Thielens NM, Lacroix M, Tacnet P, Frachet P, Holmskov U, Houen G.

FEBS J. 2010 Dec;277(23):4956-64. doi: 10.1111/j.1742-4658.2010.07901.x. Epub 2010 Nov 5.


Direct interaction between CD91 and C1q.

Duus K, Hansen EW, Tacnet P, Frachet P, Arlaud GJ, Thielens NM, Houen G.

FEBS J. 2010 Sep;277(17):3526-37. doi: 10.1111/j.1742-4658.2010.07762.x.


Cutting edge: C1q binds deoxyribose and heparan sulfate through neighboring sites of its recognition domain.

Garlatti V, Chouquet A, Lunardi T, Vivès R, Païdassi H, Lortat-Jacob H, Thielens NM, Arlaud GJ, Gaboriaud C.

J Immunol. 2010 Jul 15;185(2):808-12. doi: 10.4049/jimmunol.1000184. Epub 2010 Jun 14.


Complement protein C1q forms a complex with cytotoxic prion protein oligomers.

Erlich P, Dumestre-Pérard C, Ling WL, Lemaire-Vieille C, Schoehn G, Arlaud GJ, Thielens NM, Gagnon J, Cesbron JY.

J Biol Chem. 2010 Jun 18;285(25):19267-76. doi: 10.1074/jbc.M109.071860. Epub 2010 Apr 21.


Structural insights into the recognition properties of human ficolins.

Garlatti V, Martin L, Lacroix M, Gout E, Arlaud GJ, Thielens NM, Gaboriaud C.

J Innate Immun. 2010;2(1):17-23. doi: 10.1159/000233475. Epub 2009 Aug 6. Review.


Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin.

Gout E, Garlatti V, Smith DF, Lacroix M, Dumestre-Pérard C, Lunardi T, Martin L, Cesbron JY, Arlaud GJ, Gaboriaud C, Thielens NM.

J Biol Chem. 2010 Feb 26;285(9):6612-22. doi: 10.1074/jbc.M109.065854. Epub 2009 Dec 23.


Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation.

Hair PS, Gronemus JQ, Crawford KB, Salvi VP, Cunnion KM, Thielens NM, Arlaud GJ, Rawal N, Krishna NK.

Mol Immunol. 2010 Jan;47(4):792-8. doi: 10.1016/j.molimm.2009.10.006. Epub 2009 Nov 6.


Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children.

Vallès X, Sarrias MR, Casals F, Farnós M, Piñer R, Suárez B, Morais L, Mandomando I, Sigaúque B, Roca A, Alonso PL, Torres A, Thielens NM, Lozano F.

Tissue Antigens. 2009 Oct;74(4):298-307. doi: 10.1111/j.1399-0039.2009.01328.x.


Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition.

Ma YJ, Doni A, Hummelshøj T, Honoré C, Bastone A, Mantovani A, Thielens NM, Garred P.

J Biol Chem. 2009 Oct 9;284(41):28263-75. doi: 10.1074/jbc.M109.009225. Epub 2009 Jul 24.


Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement.

Bally I, Rossi V, Lunardi T, Thielens NM, Gaboriaud C, Arlaud GJ.

J Biol Chem. 2009 Jul 17;284(29):19340-8. doi: 10.1074/jbc.M109.004473. Epub 2009 May 27.


The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition.

Païdassi H, Tacnet-Delorme P, Lunardi T, Arlaud GJ, Thielens NM, Frachet P.

FEBS Lett. 2008 Sep 3;582(20):3111-6. doi: 10.1016/j.febslet.2008.08.001. Epub 2008 Aug 12.


Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins.

Teillet F, Gaboriaud C, Lacroix M, Martin L, Arlaud GJ, Thielens NM.

J Biol Chem. 2008 Sep 12;283(37):25715-24. doi: 10.1074/jbc.M803551200. Epub 2008 Jul 2.

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