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Items: 1 to 50 of 159

1.

X-ray structures of the high-affinity copper transporter Ctr1.

Ren F, Logeman BL, Zhang X, Liu Y, Thiele DJ, Yuan P.

Nat Commun. 2019 Mar 27;10(1):1386. doi: 10.1038/s41467-019-09376-7.

2.

Phosphorylation and Proteasome Recognition of the mRNA-Binding Protein Cth2 Facilitates Yeast Adaptation to Iron Deficiency.

Romero AM, Martínez-Pastor M, Du G, Solé C, Carlos M, Vergara SV, Sanvisens N, Wohlschlegel JA, Toczyski DP, Posas F, de Nadal E, Martínez-Pastor MT, Thiele DJ, Puig S.

MBio. 2018 Sep 18;9(5). pii: e01694-18. doi: 10.1128/mBio.01694-18.

3.

Reconstitution of a thermophilic Cu+ importer in vitro reveals intrinsic high-affinity slow transport driving accumulation of an essential metal ion.

Logeman BL, Thiele DJ.

J Biol Chem. 2018 Oct 5;293(40):15497-15512. doi: 10.1074/jbc.RA118.004802. Epub 2018 Aug 21.

PMID:
30131336
4.

Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1).

Ran X, Burchfiel ET, Dong B, Rettko NJ, Dunyak BM, Shao H, Thiele DJ, Gestwicki JE.

Bioorg Med Chem. 2018 Oct 15;26(19):5299-5306. doi: 10.1016/j.bmc.2018.04.018. Epub 2018 Apr 7.

PMID:
29661622
5.

Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans.

Garcia-Santamarina S, Festa RA, Smith AD, Yu CH, Probst C, Ding C, Homer CM, Yin J, Noonan JP, Madhani H, Perfect JR, Thiele DJ.

Mol Microbiol. 2018 Jun;108(5):473-494. doi: 10.1111/mmi.13960. Epub 2018 Apr 24.

6.

Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress.

Garcia-Santamarina S, Uzarska MA, Festa RA, Lill R, Thiele DJ.

MBio. 2017 Oct 31;8(5). pii: e01742-17. doi: 10.1128/mBio.01742-17.

7.

Copper Acquisition and Utilization in Fungi.

Smith AD, Logeman BL, Thiele DJ.

Annu Rev Microbiol. 2017 Sep 8;71:597-623. doi: 10.1146/annurev-micro-030117-020444. Review.

PMID:
28886682
8.

Regulation of heat shock transcription factors and their roles in physiology and disease.

Gomez-Pastor R, Burchfiel ET, Thiele DJ.

Nat Rev Mol Cell Biol. 2018 Jan;19(1):4-19. doi: 10.1038/nrm.2017.73. Epub 2017 Aug 30. Review.

9.

Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.

Logeman BL, Wood LK, Lee J, Thiele DJ.

J Biol Chem. 2017 Jul 7;292(27):11531-11546. doi: 10.1074/jbc.M117.793356. Epub 2017 May 15.

10.

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.

Gomez-Pastor R, Burchfiel ET, Neef DW, Jaeger AM, Cabiscol E, McKinstry SU, Doss A, Aballay A, Lo DC, Akimov SS, Ross CA, Eroglu C, Thiele DJ.

Nat Commun. 2017 Feb 13;8:14405. doi: 10.1038/ncomms14405.

11.

Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans.

Yang DH, Jung KW, Bang S, Lee JW, Song MH, Floyd-Averette A, Festa RA, Ianiri G, Idnurm A, Thiele DJ, Heitman J, Bahn YS.

Genetics. 2017 Jan;205(1):201-219. doi: 10.1534/genetics.116.190595. Epub 2016 Nov 18.

12.

Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1.

Srivastava S, Panda S, Li Z, Fuhs SR, Hunter T, Thiele DJ, Hubbard SR, Skolnik EY.

Elife. 2016 Aug 19;5. pii: e16093. doi: 10.7554/eLife.16093.

13.

Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.

Öhrvik H, Logeman B, Turk B, Reinheckel T, Thiele DJ.

J Biol Chem. 2016 Jul 1;291(27):13905-16. doi: 10.1074/jbc.M116.731281. Epub 2016 May 3.

14.

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors.

Jaeger AM, Pemble CW 4th, Sistonen L, Thiele DJ.

Nat Struct Mol Biol. 2016 Feb;23(2):147-54. doi: 10.1038/nsmb.3150. Epub 2016 Jan 4.

15.

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans.

Öhrvik H, Logeman B, Noguchi G, Eriksson I, Kjellén L, Thiele DJ, Pejler G.

J Immunol. 2015 Oct 15;195(8):3654-64. doi: 10.4049/jimmunol.1500283. Epub 2015 Sep 4.

16.

Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese.

Shawki A, Anthony SR, Nose Y, Engevik MA, Niespodzany EJ, Barrientos T, Öhrvik H, Worrell RT, Thiele DJ, Mackenzie B.

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G635-47. doi: 10.1152/ajpgi.00160.2015. Epub 2015 Aug 20.

17.

Copper at the Fungal Pathogen-Host Axis.

García-Santamarina S, Thiele DJ.

J Biol Chem. 2015 Jul 31;290(31):18945-53. doi: 10.1074/jbc.R115.649129. Epub 2015 Jun 8. Review.

18.

Preface. Biometals 2014--Proceedings of the 9th International Symposium Biometals 2014 at Duke University, Durham, NC, USA.

Crumbliss AL, Franz KJ, Thiele DJ.

Biometals. 2015 Jun;28(3):431. doi: 10.1007/s10534-015-9854-8. No abstract available.

PMID:
25929460
19.

Disulfiram (DSF) acts as a copper ionophore to induce copper-dependent oxidative stress and mediate anti-tumor efficacy in inflammatory breast cancer.

Allensworth JL, Evans MK, Bertucci F, Aldrich AJ, Festa RA, Finetti P, Ueno NT, Safi R, McDonnell DP, Thiele DJ, Van Laere S, Devi GR.

Mol Oncol. 2015 Jun;9(6):1155-68. doi: 10.1016/j.molonc.2015.02.007. Epub 2015 Feb 21.

20.

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Howe MK, Bodoor K, Carlson DA, Hughes PF, Alwarawrah Y, Loiselle DR, Jaeger AM, Darr DB, Jordan JL, Hunter LM, Molzberger ET, Gobillot TA, Thiele DJ, Brodsky JL, Spector NL, Haystead TA.

Chem Biol. 2014 Dec 18;21(12):1648-59. doi: 10.1016/j.chembiol.2014.10.016. Epub 2014 Dec 11.

21.

A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1.

Neef DW, Jaeger AM, Gomez-Pastor R, Willmund F, Frydman J, Thiele DJ.

Cell Rep. 2014 Nov 6;9(3):955-66. doi: 10.1016/j.celrep.2014.09.056. Epub 2014 Oct 30.

22.

Reciprocal functions of Cryptococcus neoformans copper homeostasis machinery during pulmonary infection and meningoencephalitis.

Sun TS, Ju X, Gao HL, Wang T, Thiele DJ, Li JY, Wang ZY, Ding C.

Nat Commun. 2014 Nov 24;5:5550. doi: 10.1038/ncomms6550.

PMID:
25417972
23.

Genomic heat shock element sequences drive cooperative human heat shock factor 1 DNA binding and selectivity.

Jaeger AM, Makley LN, Gestwicki JE, Thiele DJ.

J Biol Chem. 2014 Oct 31;289(44):30459-69. doi: 10.1074/jbc.M114.591578. Epub 2014 Sep 9.

24.

Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection.

Festa RA, Helsel ME, Franz KJ, Thiele DJ.

Chem Biol. 2014 Aug 14;21(8):977-87. doi: 10.1016/j.chembiol.2014.06.009. Epub 2014 Jul 31.

25.

Introduction to Human Disorders of Copper Metabolism.

Graper ML, Huster D, Kaler SG, Lutsenko S, Schilsky ML, Thiele DJ.

Ann N Y Acad Sci. 2014 May;1314:v-vi. doi: 10.1111/nyas.12448. No abstract available.

26.

Copper is required for oncogenic BRAF signalling and tumorigenesis.

Brady DC, Crowe MS, Turski ML, Hobbs GA, Yao X, Chaikuad A, Knapp S, Xiao K, Campbell SL, Thiele DJ, Counter CM.

Nature. 2014 May 22;509(7501):492-6. doi: 10.1038/nature13180. Epub 2014 Apr 9.

27.

The role of Ctr1 and Ctr2 in mammalian copper homeostasis and platinum-based chemotherapy.

Öhrvik H, Thiele DJ.

J Trace Elem Med Biol. 2015;31:178-82. doi: 10.1016/j.jtemb.2014.03.006. Epub 2014 Mar 24. Review.

28.

How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1.

Ohrvik H, Thiele DJ.

Ann N Y Acad Sci. 2014 May;1314:32-41. doi: 10.1111/nyas.12371. Epub 2014 Feb 20.

29.

Full characterization of the Cu-, Zn-, and Cd-binding properties of CnMT1 and CnMT2, two metallothioneins of the pathogenic fungus Cryptococcus neoformans acting as virulence factors.

Palacios Ò, Espart A, Espín J, Ding C, Thiele DJ, Atrian S, Capdevila M.

Metallomics. 2014 Feb;6(2):279-91. doi: 10.1039/c3mt00266g.

30.

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.

Öhrvik H, Nose Y, Wood LK, Kim BE, Gleber SC, Ralle M, Thiele DJ.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4279-88. doi: 10.1073/pnas.1311749110. Epub 2013 Oct 28.

31.

Genetic selection for constitutively trimerized human HSF1 mutants identifies a role for coiled-coil motifs in DNA binding.

Neef DW, Jaeger AM, Thiele DJ.

G3 (Bethesda). 2013 Aug 7;3(8):1315-24. doi: 10.1534/g3.113.006692.

32.

Negative feedback regulation of the yeast CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation.

Martínez-Pastor M, Vergara SV, Puig S, Thiele DJ.

Mol Cell Biol. 2013 Jun;33(11):2178-87. doi: 10.1128/MCB.01458-12. Epub 2013 Mar 25.

33.

Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence.

Ding C, Festa RA, Chen YL, Espart A, Palacios Ò, Espín J, Capdevila M, Atrian S, Heitman J, Thiele DJ.

Cell Host Microbe. 2013 Mar 13;13(3):265-76. doi: 10.1016/j.chom.2013.02.002.

34.

Yeast protective response to arsenate involves the repression of the high affinity iron uptake system.

Batista-Nascimento L, Toledano MB, Thiele DJ, Rodrigues-Pousada C.

Biochim Biophys Acta. 2013 May;1833(5):997-1005. doi: 10.1016/j.bbamcr.2012.12.018. Epub 2013 Jan 4.

35.

Copper at the front line of the host-pathogen battle.

Festa RA, Thiele DJ.

PLoS Pathog. 2012 Sep;8(9):e1002887. doi: 10.1371/journal.ppat.1002887. Epub 2012 Sep 20. No abstract available.

36.

Charting the travels of copper in eukaryotes from yeast to mammals.

Nevitt T, Ohrvik H, Thiele DJ.

Biochim Biophys Acta. 2012 Sep;1823(9):1580-93. doi: 10.1016/j.bbamcr.2012.02.011. Epub 2012 Feb 24. Review.

37.

Copper in microbial pathogenesis: meddling with the metal.

Samanovic MI, Ding C, Thiele DJ, Darwin KH.

Cell Host Microbe. 2012 Feb 16;11(2):106-15. doi: 10.1016/j.chom.2012.01.009. Review.

38.

A novel role for copper in Ras/mitogen-activated protein kinase signaling.

Turski ML, Brady DC, Kim HJ, Kim BE, Nose Y, Counter CM, Winge DR, Thiele DJ.

Mol Cell Biol. 2012 Apr;32(7):1284-95. doi: 10.1128/MCB.05722-11. Epub 2012 Jan 30.

39.

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases.

Neef DW, Jaeger AM, Thiele DJ.

Nat Rev Drug Discov. 2011 Dec 1;10(12):930-44. doi: 10.1038/nrd3453. Review.

40.

Copper: an essential metal in biology.

Festa RA, Thiele DJ.

Curr Biol. 2011 Nov 8;21(21):R877-83. doi: 10.1016/j.cub.2011.09.040. No abstract available.

41.

The copper regulon of the human fungal pathogen Cryptococcus neoformans H99.

Ding C, Yin J, Tovar EM, Fitzpatrick DA, Higgins DG, Thiele DJ.

Mol Microbiol. 2011 Sep;81(6):1560-76. doi: 10.1111/j.1365-2958.2011.07794.x. Epub 2011 Aug 23.

42.

Host iron withholding demands siderophore utilization for Candida glabrata to survive macrophage killing.

Nevitt T, Thiele DJ.

PLoS Pathog. 2011 Mar;7(3):e1001322. doi: 10.1371/journal.ppat.1001322. Epub 2011 Mar 17.

43.

Model peptides provide new insights into the role of histidine residues as potential ligands in human cellular copper acquisition via Ctr1.

Haas KL, Putterman AB, White DR, Thiele DJ, Franz KJ.

J Am Chem Soc. 2011 Mar 30;133(12):4427-37. doi: 10.1021/ja108890c. Epub 2011 Mar 4.

44.

Dissection of the relative contribution of the Schizosaccharomyces pombe Ctr4 and Ctr5 proteins to the copper transport and cell surface delivery functions.

Beaudoin J, Thiele DJ, Labbé S, Puig S.

Microbiology. 2011 Apr;157(Pt 4):1021-31. doi: 10.1099/mic.0.046854-0. Epub 2011 Jan 27.

45.

Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast.

Batista-Nascimento L, Neef DW, Liu PC, Rodrigues-Pousada C, Thiele DJ.

PLoS One. 2011 Jan 6;6(1):e15976. doi: 10.1371/journal.pone.0015976.

46.

Early recruitment of AU-rich element-containing mRNAs determines their cytosolic fate during iron deficiency.

Vergara SV, Puig S, Thiele DJ.

Mol Cell Biol. 2011 Feb;31(3):417-29. doi: 10.1128/MCB.00754-10. Epub 2010 Dec 6.

47.

Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability.

Nose Y, Wood LK, Kim BE, Prohaska JR, Fry RS, Spears JW, Thiele DJ.

J Biol Chem. 2010 Oct 15;285(42):32385-92. doi: 10.1074/jbc.M110.143826. Epub 2010 Aug 10.

48.

Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.

Kim BE, Turski ML, Nose Y, Casad M, Rockman HA, Thiele DJ.

Cell Metab. 2010 May 5;11(5):353-63. doi: 10.1016/j.cmet.2010.04.003.

49.

The Drosophila copper transporter Ctr1C functions in male fertility.

Steiger D, Fetchko M, Vardanyan A, Atanesyan L, Steiner K, Turski ML, Thiele DJ, Georgiev O, Schaffner W.

J Biol Chem. 2010 May 28;285(22):17089-97. doi: 10.1074/jbc.M109.090282. Epub 2010 Mar 29.

50.

Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease.

Neef DW, Turski ML, Thiele DJ.

PLoS Biol. 2010 Jan 19;8(1):e1000291. doi: 10.1371/journal.pbio.1000291.

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