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Highlights from the 2018 European Respiratory Society International Congress: sleep and clinical physiology.

Almendros I, Baillieul S, Caballero C, Degani-Costa LH, Furian M, Hirotsu C, Louvaris Z, Thiel S, Turnbull CD.

ERJ Open Res. 2019 Jul 8;5(3). pii: 00201-2018. doi: 10.1183/23120541.00201-2018. eCollection 2019 Jul.

Free PMC Article

Effect of long-term remote ischemic conditioning on inflammation and cardiac remodeling.

Pryds K, Rahbek Schmidt M, Bjerre M, Thiel S, Refsgaard J, Bøtker HE, Drage Østgård R, Ranghøj Nielsen R.

Scand Cardiovasc J. 2019 Aug;53(4):183-191. doi: 10.1080/14017431.2019.1622770. Epub 2019 Jun 5.


Circulating lectin pathway proteins do not predict short-term cardiac outcomes after myocardial infarction.

Holt CB, Østergaard JA, Thiel S, Hansen TK, Mellbin L, Sörensson P, Bjerre M.

Clin Exp Immunol. 2019 May 18. doi: 10.1111/cei.13315. [Epub ahead of print]


Efficacy of pharmacotherapy for OSA in adults: A systematic review and network meta-analysis.

Gaisl T, Haile SR, Thiel S, Osswald M, Kohler M.

Sleep Med Rev. 2019 Aug;46:74-86. doi: 10.1016/j.smrv.2019.04.009. Epub 2019 Apr 19. Review.


Ficolin-3 Deficiency Is Associated with Disease and an Increased Risk of Systemic Lupus Erythematosus.

Troldborg A, Steffensen R, Trendelenburg M, Hauser T, Winther KG, Hansen AG, Stengaard-Pedersen K, Voss A, Thiel S.

J Clin Immunol. 2019 May;39(4):421-429. doi: 10.1007/s10875-019-00627-2. Epub 2019 May 1.


Clinical Experience of Immunotherapy Treatment: Efficacy and Toxicity Analysis of the Compassionate Use Program of Nivolumab in Patients with Advanced Squamous Cell Non-Small Cell Lung Cancer.

Krefting F, Basara N, Schütte W, Späth-Schwalbe E, Alt J, Thiel S, Kimmich M, Fischer JR, Kurz S, Griesinger F, Christoph DC.

Oncol Res Treat. 2019;42(5):243-255. doi: 10.1159/000499321. Epub 2019 Apr 17.


Reduced Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 is Associated with Disturbed Coagulation in Septic Shock.

Larsen JB, Laursen MA, Hvas CL, Larsen KM, Thiel S, Hvas AM.

Thromb Haemost. 2019 Jun;119(6):952-961. doi: 10.1055/s-0039-1685140. Epub 2019 Apr 15.


Return of sleep apnoea and sleep fragmentation following CPAP withdrawal in patients with obstructive sleep apnoea.

Turnbull C, Pattenden S, Gaisl T, Rossi V, Thiel S, Kohler M, Stradling J.

Eur Respir J. 2019 May 9;53(5). pii: 1802351. doi: 10.1183/13993003.02351-2018. Print 2019 May. No abstract available.


Factors involved in initiation and regulation of complement lectin pathway influence postoperative outcome after pediatric cardiac surgery involving cardiopulmonary bypass.

Michalski M, Pągowska-Klimek I, Thiel S, Świerzko AS, Hansen AG, Jensenius JC, Cedzyński M.

Sci Rep. 2019 Feb 27;9(1):2930. doi: 10.1038/s41598-019-39742-w.


Lectin pathway proteins of the complement system in normotensive pregnancy and pre-eclampsia.

Larsen JB, Andersen AS, Hvas CL, Thiel S, Lassen MR, Hvas AM, Hansen AT.

Am J Reprod Immunol. 2019 Apr;81(4):e13092. doi: 10.1111/aji.13092. Epub 2019 Feb 23.


A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein.

Yatime L, Merle NS, Hansen AG, Friis NA, Østergaard JA, Bjerre M, Roumenina LT, Thiel S, Kristensen P, Andersen GR.

Front Immunol. 2018 Nov 29;9:2822. doi: 10.3389/fimmu.2018.02822. eCollection 2018.


MASP-1 and MASP-2 Serum Levels Are Associated With Worse Prognostic in Cervical Cancer Progression.

Maestri CA, Nisihara R, Mendes HW, Jensenius J, Thiel S, Messias-Reason I, de Carvalho NS.

Front Immunol. 2018 Nov 23;9:2742. doi: 10.3389/fimmu.2018.02742. eCollection 2018.


Effects of short-term continuous positive airway pressure withdrawal on cerebral vascular reactivity measured by blood oxygen level-dependent magnetic resonance imaging in obstructive sleep apnoea: a randomised controlled trial.

Thiel S, Lettau F, Rejmer P, Rossi C, Haile SR, Schwarz EI, Stöberl AS, Sievi NA, Boss A, Becker AS, Winklhofer S, Stradling JR, Kohler M.

Eur Respir J. 2019 Feb 21;53(2). pii: 1801854. doi: 10.1183/13993003.01854-2018. Print 2019 Feb.


To Scan or Not to Scan: Overutilization of Computed Tomography for Minor Head Injury at a Pediatric Trauma Center.

Kauffman JD, Litz CN, Thiel SA, Nguyen ATH, Carey A, Danielson PD, Chandler NM.

J Surg Res. 2018 Dec;232:164-170. doi: 10.1016/j.jss.2018.06.005. Epub 2018 Jul 5.


Targeting of Liver Mannan-Binding Lectin-Associated Serine Protease-3 with RNA Interference Ameliorates Disease in a Mouse Model of Rheumatoid Arthritis.

Banda NK, Desai D, Scheinman RI, Pihl R, Sekine H, Fujita T, Sharma V, Hansen AG, Garred P, Thiel S, Borodovsky A, Holers VM.

Immunohorizons. 2018 Sep;2(8):274-295. doi: 10.4049/immunohorizons.1800053.


Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil.

Tizzot MR, Lidani KCF, Andrade FA, Mendes HW, Beltrame MH, Reiche E, Thiel S, Jensenius JC, de Messias-Reason IJ.

Front Immunol. 2018 Oct 8;9:2292. doi: 10.3389/fimmu.2018.02292. eCollection 2018.


The Role of Complement Activating Collectins and Associated Serine Proteases in Patients With Hematological Malignancies, Receiving High-Dose Chemotherapy, and Autologous Hematopoietic Stem Cell Transplantations (Auto-HSCT).

Świerzko AS, Michalski M, Sokołowska A, Nowicki M, Eppa Ł, Szala-Poździej A, Mitrus I, Szmigielska-Kapłon A, Sobczyk-Kruszelnicka M, Michalak K, Gołos A, Wierzbowska A, Giebel S, Jamroziak K, Kowalski ML, Brzezińska O, Thiel S, Jensenius JC, Kasperkiewicz K, Cedzyński M.

Front Immunol. 2018 Sep 20;9:2153. doi: 10.3389/fimmu.2018.02153. eCollection 2018.


Retrospective Evaluation of Clinical Signs and Gross Pathologic Findings in Birds Infected With Mycobacterium genavense.

Schmitz A, Rinder M, Thiel S, Peschel A, Moser K, Reese S, Korbel R.

J Avian Med Surg. 2018 Sep;32(3):194-204. doi: 10.1647/2017-261.


The crustal geophysical signature of a world-class magmatic mineral system.

Heinson G, Didana Y, Soeffky P, Thiel S, Wise T.

Sci Rep. 2018 Jul 13;8(1):10608. doi: 10.1038/s41598-018-29016-2.


The Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus.

Troldborg A, Thiel S, Trendelenburg M, Friebus-Kardash J, Nehring J, Steffensen R, Hansen SWK, Laska MJ, Deleuran B, Jensenius JC, Voss A, Stengaard-Pedersen K.

J Rheumatol. 2018 Aug;45(8):1136-1144. doi: 10.3899/jrheum.171033. Epub 2018 Jun 15.


The complement lectin pathway after cardiac arrest.

Haugaard SF, Jeppesen AN, Troldborg A, Kirkegaard H, Thiel S, Hvas AM.

Scand J Immunol. 2018 Jun 9:e12680. doi: 10.1111/sji.12680. [Epub ahead of print]


Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin-Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H-Related Protein-5 (FHR5) Deposition.

Medjeral-Thomas NR, Troldborg A, Constantinou N, Lomax-Browne HJ, Hansen AG, Willicombe M, Pusey CD, Cook HT, Thiel S, Pickering MC.

Kidney Int Rep. 2017 Nov 29;3(2):426-438. doi: 10.1016/j.ekir.2017.11.015. eCollection 2018 Mar.


High prevalence of Mycobacterium genavense within flocks of pet birds.

Schmitz A, Korbel R, Thiel S, Wörle B, Gohl C, Rinder M.

Vet Microbiol. 2018 May;218:40-44. doi: 10.1016/j.vetmic.2018.03.026. Epub 2018 Mar 21.


Changes in the Lectin Pathway Following Intracerebral or Spontaneous Subarachnoid Hemorrhage.

Sandgaard E, Troldborg A, Lauridsen SV, Gyldenholm T, Thiel S, Hvas AM.

Mol Neurobiol. 2019 Jan;56(1):78-87. doi: 10.1007/s12035-018-1066-0. Epub 2018 Apr 19.


Models of the complement C1 complex.

Mortensen SA, Sander B, Jensen RK, Pedersen JS, Golas MM, Thiel S, Andersen GR.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3866. doi: 10.1073/pnas.1803577115. Epub 2018 Apr 13. No abstract available.


The C3dg Fragment of Complement Is Superior to Conventional C3 as a Diagnostic Biomarker in Systemic Lupus Erythematosus.

Troldborg A, Jensen L, Deleuran B, Stengaard-Pedersen K, Thiel S, Jensenius JC.

Front Immunol. 2018 Mar 26;9:581. doi: 10.3389/fimmu.2018.00581. eCollection 2018.


Why are some groups physically active and others not? A contrast group analysis in leisure settings.

Thiel A, Thedinga HK, Barkhoff H, Giel K, Schweizer O, Thiel S, Zipfel S.

BMC Public Health. 2018 Mar 20;18(1):377. doi: 10.1186/s12889-018-5283-2.


A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement.

Jensen RK, Pihl R, Gadeberg TAF, Jensen JK, Andersen KR, Thiel S, Laursen NS, Andersen GR.

J Biol Chem. 2018 Apr 27;293(17):6269-6281. doi: 10.1074/jbc.RA117.001179. Epub 2018 Mar 1.


Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine.

Christensen R, Heitmann BL, Andersen KW, Nielsen OH, Sørensen SB, Jawhara M, Bygum A, Hvid L, Grauslund J, Wied J, Glerup H, Fredberg U, Villadsen JA, Kjær SG, Fallingborg J, Moghadd SAGR, Knudsen T, Brodersen J, Frøjk J, Dahlerup JF, Bojesen AB, Sorensen GL, Thiel S, Færgeman NJ, Brandslund I, Bennike TB, Stensballe A, Schmidt EB, Franke A, Ellinghaus D, Rosenstiel P, Raes J, Boye M, Werner L, Nielsen CL, Munk HL, Nexøe AB, Ellingsen T, Holmskov U, Kjeldsen J, Andersen V.

BMJ Open. 2018 Feb 8;8(2):e018166. doi: 10.1136/bmjopen-2017-018166.


The lectin pathway and coagulation in lung cancer patients undergoing lobectomy - A randomised controlled trial.

Larsen JB, Troldborg A, Christensen TD, Hvas CL, Thiel S, Hvas AM.

Thromb Res. 2018 Mar;163:92-99. doi: 10.1016/j.thromres.2018.01.042. Epub 2018 Feb 6.


Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism.

Oroszlán G, Dani R, Szilágyi A, Závodszky P, Thiel S, Gál P, Dobó J.

Front Immunol. 2017 Dec 18;8:1821. doi: 10.3389/fimmu.2017.01821. eCollection 2017.


Effect of Optimization of Glycaemic Control on Mannan-Binding Lectin in Type 1 Diabetes.

Dørflinger GH, Holt CB, Thiel S, Østergaard JA, Hansen TK.

J Diabetes Res. 2017;2017:1249729. doi: 10.1155/2017/1249729. Epub 2017 Nov 26.


Communication of healthcare professionals: Is there ageism?

Schroyen S, Adam S, Marquet M, Jerusalem G, Thiel S, Giraudet AL, Missotten P.

Eur J Cancer Care (Engl). 2018 Jan;27(1). doi: 10.1111/ecc.12780. Epub 2017 Sep 27.


Natalizumab during pregnancy and lactation.

Proschmann U, Thomas K, Thiel S, Hellwig K, Ziemssen T.

Mult Scler. 2018 Oct;24(12):1627-1634. doi: 10.1177/1352458517728813. Epub 2017 Aug 31.


Analysis of Factor D Isoforms in Malpuech-Michels-Mingarelli-Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement.

Pihl R, Jensen L, Hansen AG, Thøgersen IB, Andres S, Dagnæs-Hansen F, Oexle K, Enghild JJ, Thiel S.

J Immunol. 2017 Aug 9. pii: ji1700518. doi: 10.4049/jimmunol.1700518. [Epub ahead of print]


Global Autorecognition and Activation of Complement by Mannan-Binding Lectin in a Mouse Model of Type 1 Diabetes.

Axelgaard E, Østergaard JA, Haxha S, Thiel S, Hansen TK.

Mediators Inflamm. 2017;2017:9403754. doi: 10.1155/2017/9403754. Epub 2017 Jun 13.


Reply to Arlaud et al.: Structure of the C1 complex and the unbound C1r2s2 tetramer.

Mortensen SA, Sander B, Jensen RK, Pedersen JS, Golas M, Jensenius JC, Hansen AG, Thiel S, Andersen GR.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5768-E5770. doi: 10.1073/pnas.1704353114. Epub 2017 Jul 12. No abstract available.


Use of Hyperlinks in PowerPoint Presentations as an Educational Tool.

Stacy GS, Thiel SG.

Acad Radiol. 2017 Oct;24(10):1318-1324. doi: 10.1016/j.acra.2017.03.018. Epub 2017 May 24.


A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine.

Andersen V, Holmskov U, Sørensen SB, Jawhara M, Andersen KW, Bygum A, Hvid L, Grauslund J, Wied J, Glerup H, Fredberg U, Villadsen JA, Kjær SG, Fallingborg J, Moghadd SAGR, Knudsen T, Brodersen J, Frøjk J, Dahlerup JF, Nielsen OH, Christensen R, Bojesen AB, Sorensen GL, Thiel S, Færgeman NJ, Brandslund I, Stensballe A, Schmidt EB, Franke A, Ellinghaus D, Rosenstiel P, Raes J, Heitmann B, Boye M, Nielsen CL, Werner L, Kjeldsen J, Ellingsen T.

Nutrients. 2017 May 15;9(5). pii: E499. doi: 10.3390/nu9050499.


Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin.

Axelgaard E, Østergaard JA, Thiel S, Hansen TK.

J Diabetes Res. 2017;2017:6368780. doi: 10.1155/2017/6368780. Epub 2017 Feb 28.


Treatment of multiple sclerosis during pregnancy - safety considerations.

Thöne J, Thiel S, Gold R, Hellwig K.

Expert Opin Drug Saf. 2017 May;16(5):523-534. doi: 10.1080/14740338.2017.1311321. Epub 2017 Apr 17. Review.


Plasma levels of MASP-1, MASP-3 and MAp44 in patients with type 2 diabetes: influence of glycaemic control, body composition and polymorphisms in the MASP1 gene.

Krogh SS, Holt CB, Steffensen R, Funck KL, Høyem P, Laugesen E, Poulsen PL, Thiel S, Hansen TK.

Clin Exp Immunol. 2017 Jul;189(1):103-112. doi: 10.1111/cei.12963. Epub 2017 Apr 20.


Incident microalbuminuria and complement factor mannan-binding lectin-associated protein 19 in people with newly diagnosed type 1 diabetes.

Østergaard JA, Thiel S, Hoffmann-Petersen IT, Hovind P, Parving HH, Tarnow L, Rossing P, Hansen TK.

Diabetes Metab Res Rev. 2017 Jul;33(5). doi: 10.1002/dmrr.2895. Epub 2017 Apr 11.


Functional and structural insight into properdin control of complement alternative pathway amplification.

Pedersen DV, Roumenina L, Jensen RK, Gadeberg TA, Marinozzi C, Picard C, Rybkine T, Thiel S, Sørensen UB, Stover C, Fremeaux-Bacchi V, Andersen GR.

EMBO J. 2017 Apr 13;36(8):1084-1099. doi: 10.15252/embj.201696173. Epub 2017 Mar 6.


Endogenous Natural Complement Inhibitor Regulates Cardiac Development.

Mortensen SA, Skov LL, Kjaer-Sorensen K, Hansen AG, Hansen S, Dagnæs-Hansen F, Jensenius JC, Oxvig C, Thiel S, Degn SE.

J Immunol. 2017 Apr 15;198(8):3118-3126. doi: 10.4049/jimmunol.1601958. Epub 2017 Mar 3.


Nanosilver as a disinfectant in dental unit waterlines: Assessment of the physicochemical transformations of the AgNPs.

Gitipour A, Al-Abed SR, Thiel SW, Scheckel KG, Tolaymat T.

Chemosphere. 2017 Apr;173:245-252. doi: 10.1016/j.chemosphere.2017.01.050. Epub 2017 Jan 12.


Structure and activation of C1, the complex initiating the classical pathway of the complement cascade.

Mortensen SA, Sander B, Jensen RK, Pedersen JS, Golas MM, Jensenius JC, Hansen AG, Thiel S, Andersen GR.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):986-991. doi: 10.1073/pnas.1616998114. Epub 2017 Jan 19.


[Normoglycaemic ketoacidosis in pregnant patients with diabetes; early recognition is critical].

van der Valk ES, Smits M, Klomp CM, Lunshof MS, van Guldener C, van Thiel SW.

Ned Tijdschr Geneeskd. 2016;160:D551. Dutch.


M-ficolin is present in Aspergillus fumigatus infected lung and modulates epithelial cell immune responses elicited by fungal cell wall polysaccharides.

Jensen K, Lund KP, Christensen KB, Holm AT, Dubey LK, Moeller JB, Jepsen CS, Schlosser A, Galgóczy L, Thiel S, Holmskov U, Sorensen GL.

Virulence. 2017 Nov 17;8(8):1870-1879. doi: 10.1080/21505594.2016.1278337. Epub 2017 Feb 16. No abstract available.


Lectin complement pathway proteins in healthy individuals.

Troldborg A, Hansen A, Hansen SW, Jensenius JC, Stengaard-Pedersen K, Thiel S.

Clin Exp Immunol. 2017 Apr;188(1):138-147. doi: 10.1111/cei.12909. Epub 2017 Jan 18.

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