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Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age.

Grudzinska FS, Brodlie M, Scholefield BR, Jackson T, Scott A, Thickett DR, Sapey E.

Thorax. 2019 Nov 15. pii: thoraxjnl-2018-212826. doi: 10.1136/thoraxjnl-2018-212826. [Epub ahead of print]


Mepolizumab rescue therapy for acute pneumonitis secondary to DRESS.

Thein OS, Sutton B, Thickett DR, Parekh D.

BMJ Case Rep. 2019 Oct 10;12(10). pii: e231355. doi: 10.1136/bcr-2019-231355.


Wnt signaling regulates trans-differentiation of stem cell like type 2 alveolar epithelial cells to type 1 epithelial cells.

Abdelwahab EMM, Rapp J, Feller D, Csongei V, Pal S, Bartis D, Thickett DR, Pongracz JE.

Respir Res. 2019 Sep 6;20(1):204. doi: 10.1186/s12931-019-1176-x.


Early identification of severe community-acquired pneumonia: a retrospective observational study.

Grudzinska FS, Aldridge K, Hughes S, Nightingale P, Parekh D, Bangash M, Dancer R, Patel J, Sapey E, Thickett DR, Dosanjh DP.

BMJ Open Respir Res. 2019 Jun 5;6(1):e000438. doi: 10.1136/bmjresp-2019-000438. eCollection 2019.


Simvastatin Improves Neutrophil Function and Clinical Outcomes in Pneumonia. A Pilot Randomized Controlled Clinical Trial.

Sapey E, Patel JM, Greenwood H, Walton GM, Grudzinska F, Parekh D, Mahida RY, Dancer RCA, Lugg ST, Howells PA, Hazeldine J, Newby P, Scott A, Nightingale P, Hill AT, Thickett DR.

Am J Respir Crit Care Med. 2019 Nov 15;200(10):1282-1293. doi: 10.1164/rccm.201812-2328OC.


Dysregulated alveolar function and complications in smokers following oesophagectomy.

Lugg ST, Alridge KA, Howells PA, Parekh D, Scott A, Mahida RY, Park D, Tucker O, Gao F, Perkins GD, Thickett DR, Dancer RCA.

ERJ Open Res. 2019 Mar 4;5(1). pii: 00089-2018. doi: 10.1183/23120541.00089-2018. eCollection 2019 Feb.


Vitamin D to Prevent Lung Injury Following Esophagectomy-A Randomized, Placebo-Controlled Trial.

Parekh D, Dancer RCA, Scott A, D'Souza VK, Howells PA, Mahida RY, Tang JCY, Cooper MS, Fraser WD, Tan L, Gao F, Martineau AR, Tucker O, Perkins GD, Thickett DR.

Crit Care Med. 2018 Dec;46(12):e1128-e1135. doi: 10.1097/CCM.0000000000003405.


Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages.

Scott A, Lugg ST, Aldridge K, Lewis KE, Bowden A, Mahida RY, Grudzinska FS, Dosanjh D, Parekh D, Foronjy R, Sapey E, Naidu B, Thickett DR.

Thorax. 2018 Dec;73(12):1161-1169. doi: 10.1136/thoraxjnl-2018-211663. Epub 2018 Aug 13.


Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality.

Patel JM, Sapey E, Parekh D, Scott A, Dosanjh D, Gao F, Thickett DR.

Mediators Inflamm. 2018 Apr 11;2018:4065362. doi: 10.1155/2018/4065362. eCollection 2018.


Effect of anti-podoplanin antibody administration during lipopolysaccharide-induced lung injury in mice.

Lax S, Rayes J, Thickett DR, Watson SP.

BMJ Open Respir Res. 2017 Nov 8;4(1):e000257. doi: 10.1136/bmjresp-2017-000257. eCollection 2017.


ARDS following oesophagectomy: a comparison of two trials.

Howells PA, Aldridge KA, Parekh D, Park D, Tucker O, Dancer RCA, Gao F, Perkins GD, Thickett DR.

BMJ Open Respir Res. 2017 Nov 2;4(1):e000207. doi: 10.1136/bmjresp-2017-000207. eCollection 2017.


ResolvinD1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production.

Zheng S, Wang Q, D'Souza V, Bartis D, Dancer R, Parekh D, Gao F, Lian Q, Jin S, Thickett DR.

Lab Invest. 2018 Jan;98(1):130-140. doi: 10.1038/labinvest.2017.114. Epub 2017 Oct 30.


Statin therapy in patients with community-acquired pneumonia.

Grudzinska FS, Dosanjh DP, Parekh D, Dancer RC, Patel J, Nightingale P, Walton GM, Sapey E, Thickett DR.

Clin Med (Lond). 2017 Oct;17(5):403-407. doi: 10.7861/clinmedicine.17-5-403.


Characterization of systemic neutrophil function in patients undergoing colorectal cancer resection.

Richardson JJR, Hendrickse C, Gao-Smith F, Thickett DR.

J Surg Res. 2017 Dec;220:410-418.e1. doi: 10.1016/j.jss.2017.07.036. Epub 2017 Sep 8.


Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse.

Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1016-L1029. doi: 10.1152/ajplung.00023.2017. Epub 2017 Aug 24.


Neutrophil Extracellular Trap Production in Patients with Colorectal Cancer In Vitro.

Richardson JJR, Hendrickse C, Gao-Smith F, Thickett DR.

Int J Inflam. 2017;2017:4915062. doi: 10.1155/2017/4915062. Epub 2017 Jul 30.


Pulmonary Infections in the Elderly Lead to Impaired Neutrophil Targeting, Which Is Improved by Simvastatin.

Sapey E, Patel JM, Greenwood HL, Walton GM, Hazeldine J, Sadhra C, Parekh D, Dancer RCA, Nightingale P, Lord JM, Thickett DR.

Am J Respir Crit Care Med. 2017 Nov 15;196(10):1325-1336. doi: 10.1164/rccm.201704-0814OC.


Smoking and timing of cessation on postoperative pulmonary complications after curative-intent lung cancer surgery.

Lugg ST, Tikka T, Agostini PJ, Kerr A, Adams K, Kalkat MS, Steyn RS, Rajesh PB, Bishay E, Thickett DR, Naidu B.

J Cardiothorac Surg. 2017 Jun 19;12(1):52. doi: 10.1186/s13019-017-0614-4.


Lipoxin A4 promotes lung epithelial repair whilst inhibiting fibroblast proliferation.

Zheng S, D'Souza VK, Bartis D, Dancer RC, Parekh D, Naidu B, Gao-Smith F, Wang Q, Jin S, Lian Q, Thickett DR.

ERJ Open Res. 2016 Oct 3;2(3). pii: 00079-2015. eCollection 2016 Jul.


Vitamin D Deficiency in Human and Murine Sepsis.

Parekh D, Patel JM, Scott A, Lax S, Dancer RC, D'Souza V, Greenwood H, Fraser WD, Gao F, Sapey E, Perkins GD, Thickett DR.

Crit Care Med. 2017 Feb;45(2):282-289. doi: 10.1097/CCM.0000000000002095.


Evidence for chemokine synergy during neutrophil migration in ARDS.

Williams AE, José RJ, Mercer PF, Brealey D, Parekh D, Thickett DR, O'Kane C, McAuley DF, Chambers RC.

Thorax. 2017 Jan;72(1):66-73. doi: 10.1136/thoraxjnl-2016-208597. Epub 2016 Aug 5.


Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis.

Bartis D, Crowley LE, D'Souza VK, Borthwick L, Fisher AJ, Croft AP, Pongrácz JE, Thompson R, Langman G, Buckley CD, Thickett DR.

BMC Pulm Med. 2016 Apr 14;16(1):51. doi: 10.1186/s12890-016-0211-7.


Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.

Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS.

Thorax. 2016 Dec;71(12):1130-1136. doi: 10.1136/thoraxjnl-2015-207886. Epub 2016 Feb 2.


Long-term impact of developing a postoperative pulmonary complication after lung surgery.

Lugg ST, Agostini PJ, Tikka T, Kerr A, Adams K, Bishay E, Kalkat MS, Steyn RS, Rajesh PB, Thickett DR, Naidu B.

Thorax. 2016 Feb;71(2):171-6. doi: 10.1136/thoraxjnl-2015-207697.


Optimal Vitamin D Supplementation Levels for Cardiovascular Disease Protection.

Lugg ST, Howells PA, Thickett DR.

Dis Markers. 2015;2015:864370. doi: 10.1155/2015/864370. Epub 2015 Sep 8. Review.


Exchange protein directly activated by cyclic AMP (EPAC) activation reverses neutrophil dysfunction induced by β2-agonists, corticosteroids, and critical illness.

Scott J, Harris GJ, Pinder EM, Macfarlane JG, Hellyer TP, Rostron AJ, Conway Morris A, Thickett DR, Perkins GD, McAuley DF, Widdrington JD, Wiscombe S, Baudouin SV, Roy AI, Linnett VC, Wright SE, Ruchaud-Sparagano MH, Simpson AJ.

J Allergy Clin Immunol. 2016 Feb;137(2):535-44. doi: 10.1016/j.jaci.2015.07.036. Epub 2015 Sep 18.


Association between prehospital vitamin D status and incident acute respiratory failure in critically ill patients: a retrospective cohort study.

Thickett DR, Moromizato T, Litonjua AA, Amrein K, Quraishi SA, Lee-Sarwar KA, Mogensen KM, Purtle SW, Gibbons FK, Camargo CA Jr, Giovannucci E, Christopher KB.

BMJ Open Respir Res. 2015 Jun 13;2(1):e000074. doi: 10.1136/bmjresp-2014-000074. eCollection 2015.


Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS).

Dancer RC, Parekh D, Lax S, D'Souza V, Zheng S, Bassford CR, Park D, Bartis DG, Mahida R, Turner AM, Sapey E, Wei W, Naidu B, Stewart PM, Fraser WD, Christopher KB, Cooper MS, Gao F, Sansom DM, Martineau AR, Perkins GD, Thickett DR.

Thorax. 2015 Jul;70(7):617-24. doi: 10.1136/thoraxjnl-2014-206680. Epub 2015 Apr 22.


The increasing need for biomarkers in intensive care unit-acquired weakness--are microRNAs the solution?

Lugg ST, Howells PA, Thickett DR.

Crit Care. 2015 Apr 22;19:189. doi: 10.1186/s13054-015-0901-1.


Using a non-invasive assessment of lung injury in a murine model of acute lung injury.

Lax S, Wilson MR, Takata M, Thickett DR.

BMJ Open Respir Res. 2014 Jan 3;1(1):e000014. doi: 10.1136/bmjresp-2013-000014. eCollection 2014.


Improving care for patients with idiopathic pulmonary fibrosis (IPF) in the UK: a round table discussion.

Thickett DR, Kendall C, Spencer LG, Screaton N, Wallace WA, Pinnock H, Bott J, Pigram L, Watson S, Millar AB.

Thorax. 2014 Dec;69(12):1136-40. doi: 10.1136/thoraxjnl-2014-206284. Epub 2014 Oct 21.


Simvastatin to modify neutrophil function in older patients with septic pneumonia (SNOOPI): study protocol for a randomised placebo-controlled trial.

Greenwood H, Patel J, Mahida R, Wang Q, Parekh D, Dancer RC, Khiroya H, Sapey E, Thickett DR.

Trials. 2014 Aug 22;15:332. doi: 10.1186/1745-6215-15-332.


Alternatives to animal research in acute lung injury.

Parekh D, Dancer RC, Thickett DR.

BMJ. 2014 Jul 10;349:g4171. doi: 10.1136/bmj.g4171. No abstract available.


Reply: Importance of the kidney, vessels, and heart with administration of β2 adrenergic receptor agonists in patients susceptible to acute respiratory distress syndrome.

Thickett DR, McAuley DF, Perkins GD.

Am J Respir Crit Care Med. 2014 Jun 1;189(11):1447-8. doi: 10.1164/rccm.201404-0654LE. No abstract available.


Authors' response: Epithelial-mesenchymal Transition (EMT) is a common molecular programme in epithelial cells which can be triggered by injury.

Bartis D, Thickett DR.

Thorax. 2014 Aug;69(8):769. doi: 10.1136/thoraxjnl-2014-205647. Epub 2014 May 28. No abstract available.


Positron emission tomography aids diagnosis of relapsing polychondritis.

Mahida RY, Bowman S, Naidu B, Thickett DR.

BMJ Case Rep. 2014 Mar 5;2014. pii: bcr2013203367. doi: 10.1136/bcr-2013-203367.


The beta agonist lung injury trial prevention. A randomized controlled trial.

Perkins GD, Gates S, Park D, Gao F, Knox C, Holloway B, McAuley DF, Ryan J, Marzouk J, Cooke MW, Lamb SE, Thickett DR; BALTI-Prevention Collaborators.

Am J Respir Crit Care Med. 2014 Mar 15;189(6):674-83. doi: 10.1164/rccm.201308-1549OC.


Epithelial-mesenchymal transition in lung development and disease: does it exist and is it important?

Bartis D, Mise N, Mahida RY, Eickelberg O, Thickett DR.

Thorax. 2014 Aug;69(8):760-5. doi: 10.1136/thoraxjnl-2013-204608. Epub 2013 Dec 12. Review.


Statins for sepsis: distinguishing signal from the noise when designing clinical trials.

Patel JM, Thickett DR, Gao F, Sapey E.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):874. doi: 10.1164/rccm.201302-0392LE. No abstract available.


Beta-Agonist Lung injury TrIal-2 (BALTI-2): a multicentre, randomised, double-blind, placebo-controlled trial and economic evaluation of intravenous infusion of salbutamol versus placebo in patients with acute respiratory distress syndrome.

Gates S, Perkins GD, Lamb SE, Kelly C, Thickett DR, Young JD, McAuley DF, Snaith C, McCabe C, Hulme CT, Gao Smith F.

Health Technol Assess. 2013 Sep;17(38):v-vi, 1-87. doi: 10.3310/hta17380.


Interferon gamma release assays and the NICE 2011 guidelines on the diagnosis of latent tuberculosis.

Mujakperuo HR, Thompson RD, Thickett DR.

Clin Med (Lond). 2013 Aug;13(4):362-6. doi: 10.7861/clinmedicine.13-4-362.


Reduced cortisol metabolism during critical illness.

Cooper MS, Thickett DR, Stewart PM.

N Engl J Med. 2013 Aug 1;369(5):480. doi: 10.1056/NEJMc1306703. No abstract available.


Vitamin D to prevent acute lung injury following oesophagectomy (VINDALOO): study protocol for a randomised placebo controlled trial.

Parekh D, Dancer RC, Lax S, Cooper MS, Martineau AR, Fraser WD, Tucker O, Alderson D, Perkins GD, Gao-Smith F, Thickett DR.

Trials. 2013 Apr 17;14:100. doi: 10.1186/1745-6215-14-100.


Vitamin D deficiency and acute lung injury.

Parekh D, Thickett DR, Turner AM.

Inflamm Allergy Drug Targets. 2013 Aug;12(4):253-61. Review.


Clinical review: Statins and trauma--a systematic review.

Jansen JO, Lord JM, Thickett DR, Midwinter MJ, McAuley DF, Gao F.

Crit Care. 2013 May 29;17(3):227. doi: 10.1186/cc12499. Review.


Molecular determinants of acute muscle wasting in the ICU: a role for growth and differentiation factor-15?

Turner AM, Thickett DR.

Crit Care Med. 2013 Apr;41(4):1141-2. doi: 10.1097/CCM.0b013e31827c9f46. No abstract available.


Down-regulation of canonical and up-regulation of non-canonical Wnt signalling in the carcinogenic process of squamous cell lung carcinoma.

Bartis D, Csongei V, Weich A, Kiss E, Barko S, Kovacs T, Avdicevic M, D'Souza VK, Rapp J, Kvell K, Jakab L, Nyitrai M, Molnar TF, Thickett DR, Laszlo T, Pongracz JE.

PLoS One. 2013;8(3):e57393. doi: 10.1371/journal.pone.0057393. Epub 2013 Mar 7.


Pirfenidone for IPF: pro/con debate; the 'con' viewpoint.

Raghu G, Thickett DR.

Thorax. 2013 Jul;68(7):605-8. doi: 10.1136/thoraxjnl-2011-201269. Epub 2013 Mar 5. No abstract available.


Randomized double-blind placebo-controlled trial of 40 mg/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial).

Patel JM, Snaith C, Thickett DR, Linhartova L, Melody T, Hawkey P, Barnett AH, Jones A, Hong T, Cooke MW, Perkins GD, Gao F.

Crit Care. 2012 Dec 11;16(6):R231. doi: 10.1186/cc11895.


Co-trimoxazole for idiopathic pulmonary fibrosis: time for TIPAC-2?

Mujakperuo H, McGrath EE, Thickett DR.

Thorax. 2013 Feb;68(2):123-4. doi: 10.1136/thoraxjnl-2012-202531. Epub 2012 Dec 1. No abstract available.


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