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Long-term intranasal insulin aspart: a profile of gene expression, memory, and insulin receptors in aged F344 rats.

Frazier HN, Ghoweri AO, Sudkamp E, Johnson ES, Anderson KL, Fox G, Vatthanaphone K, Xia M, Lin RL, Hargis-Staggs KE, Porter NM, Pauly JR, Blalock EM, Thibault O.

J Gerontol A Biol Sci Med Sci. 2019 Jun 10. pii: glz105. doi: 10.1093/gerona/glz105. [Epub ahead of print]


Broadening the definition of brain insulin resistance in aging and Alzheimer's disease.

Frazier HN, Ghoweri AO, Anderson KL, Lin RL, Porter NM, Thibault O.

Exp Neurol. 2019 Mar;313:79-87. doi: 10.1016/j.expneurol.2018.12.007. Epub 2018 Dec 18. Review.


Aging-Related Calcium Dysregulation in Rat Entorhinal Neurons Homologous with the Human Entorhinal Neurons in which Alzheimer's Disease Neurofibrillary Tangles First Appear.

Gant JC, Kadish I, Chen KC, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Alzheimers Dis. 2018;66(4):1371-1378. doi: 10.3233/JAD-180618.


Insulin Receptor Plasma Membrane Levels Increased by the Progesterone Receptor Membrane Component 1.

Hampton KK, Anderson K, Frazier H, Thibault O, Craven RJ.

Mol Pharmacol. 2018 Jul;94(1):665-673. doi: 10.1124/mol.117.110510. Epub 2018 Apr 19.


Expression of a Constitutively Active Human Insulin Receptor in Hippocampal Neurons Does Not Alter VGCC Currents.

Frazier HN, Anderson KL, Maimaiti S, Ghoweri AO, Kraner SD, Popa GJ, Hampton KK, Mendenhall MD, Norris CM, Craven RJ, Thibault O.

Neurochem Res. 2019 Jan;44(1):269-280. doi: 10.1007/s11064-018-2510-2. Epub 2018 Mar 23.


FK506-Binding Protein 12.6/1b, a Negative Regulator of [Ca2+], Rescues Memory and Restores Genomic Regulation in the Hippocampus of Aging Rats.

Gant JC, Blalock EM, Chen KC, Kadish I, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2018 Jan 24;38(4):1030-1041. doi: 10.1523/JNEUROSCI.2234-17.2017. Epub 2017 Dec 18.


Novel calcium-related targets of insulin in hippocampal neurons.

Maimaiti S, Frazier HN, Anderson KL, Ghoweri AO, Brewer LD, Porter NM, Thibault O.

Neuroscience. 2017 Nov 19;364:130-142. doi: 10.1016/j.neuroscience.2017.09.019. Epub 2017 Sep 20.


In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome.

Berkowitz BA, Lenning J, Khetarpal N, Tran C, Wu JY, Berri AM, Dernay K, Haacke EM, Shafie-Khorassani F, Podolsky RH, Gant JC, Maimaiti S, Thibault O, Murphy GG, Bennett BM, Roberts R.

FASEB J. 2017 Sep;31(9):4179-4186. doi: 10.1096/fj.201700229R. Epub 2017 Jun 7.


Inhibition of the integrin/FAK signaling axis and c-Myc synergistically disrupts ovarian cancer malignancy.

Xu B, Lefringhouse J, Liu Z, West D, Baldwin LA, Ou C, Chen L, Napier D, Chaiswing L, Brewer LD, St Clair D, Thibault O, van Nagell JR, Zhou BP, Drapkin R, Huang JA, Lu ML, Ueland FR, Yang XH.

Oncogenesis. 2017 Jan 30;6(1):e295. doi: 10.1038/oncsis.2016.86.


Calcium's role as nuanced modulator of cellular physiology in the brain.

Frazier HN, Maimaiti S, Anderson KL, Brewer LD, Gant JC, Porter NM, Thibault O.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):981-987. doi: 10.1016/j.bbrc.2016.08.105. Epub 2016 Aug 20. Review.


Impact of Single or Repeated Dose Intranasal Zinc-free Insulin in Young and Aged F344 Rats on Cognition, Signaling, and Brain Metabolism.

Anderson KL, Frazier HN, Maimaiti S, Bakshi VV, Majeed ZR, Brewer LD, Porter NM, Lin AL, Thibault O.

J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):189-197. doi: 10.1093/gerona/glw065. Epub 2016 Apr 10.


Pioglitazone Inhibits the Development of Hyperalgesia and Sensitization of Spinal Nociresponsive Neurons in Type 2 Diabetes.

Griggs RB, Donahue RR, Adkins BG, Anderson KL, Thibault O, Taylor BK.

J Pain. 2016 Mar;17(3):359-73. doi: 10.1016/j.jpain.2015.11.006. Epub 2015 Dec 12.


CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion.

Zhou P, Erfani S, Liu Z, Jia C, Chen Y, Xu B, Deng X, Alfáro JE, Chen L, Napier D, Lu M, Huang JA, Liu C, Thibault O, Segal R, Zhou BP, Kyprianou N, Horbinski C, Yang XH.

Oncotarget. 2015 Oct 6;6(30):29675-93. doi: 10.18632/oncotarget.4896.


Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus.

Gant JC, Chen KC, Kadish I, Blalock EM, Thibault O, Porter NM, Landfield PW.

J Neurosci. 2015 Jul 29;35(30):10878-87. doi: 10.1523/JNEUROSCI.1248-15.2015.


Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging.

Maimaiti S, Anderson KL, DeMoll C, Brewer LD, Rauh BA, Gant JC, Blalock EM, Porter NM, Thibault O.

J Gerontol A Biol Sci Med Sci. 2016 Jan;71(1):30-9. doi: 10.1093/gerona/glu314. Epub 2015 Feb 6.


Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca(2+) biomarkers of aging.

Maimaiti S, DeMoll C, Anderson KL, Griggs RB, Taylor BK, Porter NM, Thibault O.

Brain Res. 2015 Sep 24;1621:214-21. doi: 10.1016/j.brainres.2014.10.052. Epub 2014 Nov 6.


Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats.

Latimer CS, Brewer LD, Searcy JL, Chen KC, Popović J, Kraner SD, Thibault O, Blalock EM, Landfield PW, Porter NM.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):E4359-66. doi: 10.1073/pnas.1404477111. Epub 2014 Sep 29.


Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging.

Buechel HM, Popovic J, Staggs K, Anderson KL, Thibault O, Blalock EM.

Front Aging Neurosci. 2014 Feb 12;6:13. doi: 10.3389/fnagi.2014.00013. eCollection 2014.


FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?

Gant JC, Blalock EM, Chen KC, Kadish I, Porter NM, Norris CM, Thibault O, Landfield PW.

Eur J Pharmacol. 2014 Sep 15;739:74-82. doi: 10.1016/j.ejphar.2013.10.070. Epub 2013 Nov 28. Review.


Hippocampal calcium dysregulation at the nexus of diabetes and brain aging.

Thibault O, Anderson KL, DeMoll C, Brewer LD, Landfield PW, Porter NM.

Eur J Pharmacol. 2013 Nov 5;719(1-3):34-43. doi: 10.1016/j.ejphar.2013.07.024. Epub 2013 Jul 17. Review.


Effect of high-fat diet on metabolic indices, cognition, and neuronal physiology in aging F344 rats.

Pancani T, Anderson KL, Brewer LD, Kadish I, DeMoll C, Landfield PW, Blalock EM, Porter NM, Thibault O.

Neurobiol Aging. 2013 Aug;34(8):1977-87. doi: 10.1016/j.neurobiolaging.2013.02.019. Epub 2013 Mar 29.


Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease.

Searcy JL, Phelps JT, Pancani T, Kadish I, Popovic J, Anderson KL, Beckett TL, Murphy MP, Chen KC, Blalock EM, Landfield PW, Porter NM, Thibault O.

J Alzheimers Dis. 2012;30(4):943-61. doi: 10.3233/JAD-2012-111661.


Reduction in neuronal L-type calcium channel activity in a double knock-in mouse model of Alzheimer's disease.

Thibault O, Pancani T, Landfield PW, Norris CM.

Biochim Biophys Acta. 2012 Apr;1822(4):546-9. doi: 10.1016/j.bbadis.2012.01.004. Epub 2012 Jan 10.


Reversal of glial and neurovascular markers of unhealthy brain aging by exercise in middle-aged female mice.

Latimer CS, Searcy JL, Bridges MT, Brewer LD, Popović J, Blalock EM, Landfield PW, Thibault O, Porter NM.

PLoS One. 2011;6(10):e26812. doi: 10.1371/journal.pone.0026812. Epub 2011 Oct 25.


Imaging of a glucose analog, calcium and NADH in neurons and astrocytes: dynamic responses to depolarization and sensitivity to pioglitazone.

Pancani T, Anderson KL, Porter NM, Thibault O.

Cell Calcium. 2011 Dec;50(6):548-58. doi: 10.1016/j.ceca.2011.09.002. Epub 2011 Oct 5.


Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age.

Buechel HM, Popovic J, Searcy JL, Porter NM, Thibault O, Blalock EM.

PLoS One. 2011 Apr 4;6(4):e18387. doi: 10.1371/journal.pone.0018387.


Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons.

Gant JC, Chen KC, Norris CM, Kadish I, Thibault O, Blalock EM, Porter NM, Landfield PW.

J Neurosci. 2011 Feb 2;31(5):1693-703. doi: 10.1523/JNEUROSCI.4805-10.2011.


Effects of long-term pioglitazone treatment on peripheral and central markers of aging.

Blalock EM, Phelps JT, Pancani T, Searcy JL, Anderson KL, Gant JC, Popovic J, Avdiushko MG, Cohen DA, Chen KC, Porter NM, Thibault O.

PLoS One. 2010 Apr 29;5(4):e10405. doi: 10.1371/journal.pone.0010405.


Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys.

Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, Dowling A, Zhang Z, Sullivan P, Porter NM, Landfield PW.

J Neurosci. 2010 Apr 28;30(17):6058-71. doi: 10.1523/JNEUROSCI.3956-09.2010.


Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons.

Pancani T, Phelps JT, Searcy JL, Kilgore MW, Chen KC, Porter NM, Thibault O.

J Neurochem. 2009 Jun;109(6):1800-11. doi: 10.1111/j.1471-4159.2009.06107.x. Epub 2009 May 11.


Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment.

Kadish I, Thibault O, Blalock EM, Chen KC, Gant JC, Porter NM, Landfield PW.

J Neurosci. 2009 Feb 11;29(6):1805-16. doi: 10.1523/JNEUROSCI.4599-08.2009.


Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy.

Gant JC, Thibault O, Blalock EM, Yang J, Bachstetter A, Kotick J, Schauwecker PE, Hauser KF, Smith GM, Mervis R, Li Y, Barnes GN.

Epilepsia. 2009 Apr;50(4):629-45. doi: 10.1111/j.1528-1167.2008.01725.x. Epub 2008 Jul 24.


Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging.

Norris CM, Blalock EM, Chen KC, Porter NM, Thibault O, Kraner SD, Landfield PW.

Neurobiol Aging. 2010 Feb;31(2):328-38. doi: 10.1016/j.neurobiolaging.2008.03.026.


Action potential throughput in aged rat hippocampal neurons: regulation by selective forms of hyperpolarization.

Gant JC, Thibault O.

Neurobiol Aging. 2009 Dec;30(12):2053-64. doi: 10.1016/j.neurobiolaging.2008.02.006. Epub 2008 Mar 25.


Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store.

Thibault O, Gant JC, Landfield PW.

Aging Cell. 2007 Jun;6(3):307-17. Epub 2007 Apr 26. Review.


Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels.

Brewer LD, Thibault O, Staton J, Thibault V, Rogers JT, Garcia-Ramos G, Kraner S, Landfield PW, Porter NM.

Brain Res. 2007 Jun 2;1151:20-31. Epub 2007 Mar 12.


Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats.

Rowe WB, Blalock EM, Chen KC, Kadish I, Wang D, Barrett JE, Thibault O, Porter NM, Rose GM, Landfield PW.

J Neurosci. 2007 Mar 21;27(12):3098-110.


Electrophysiological mechanisms of delayed excitotoxicity: positive feedback loop between NMDA receptor current and depolarization-mediated glutamate release.

Norris CM, Blalock EM, Thibault O, Brewer LD, Clodfelter GV, Porter NM, Landfield PW.

J Neurophysiol. 2006 Nov;96(5):2488-500. Epub 2006 Aug 16.


Chronic 1alpha,25-(OH)2 vitamin D3 treatment reduces Ca2+ -mediated hippocampal biomarkers of aging.

Brewer LD, Porter NM, Kerr DS, Landfield PW, Thibault O.

Cell Calcium. 2006 Sep;40(3):277-86. Epub 2006 Jun 14.


The neurobiology of aging.

Kelly KM, Nadon NL, Morrison JH, Thibault O, Barnes CA, Blalock EM.

Epilepsy Res. 2006 Jan;68 Suppl 1:S5-20. Epub 2005 Dec 28. Review.


Sustained Ca2+-induced Ca2+-release underlies the post-glutamate lethal Ca2+ plateau in older cultured hippocampal neurons.

Clodfelter GV, Porter NM, Landfield PW, Thibault O.

Eur J Pharmacol. 2002 Jul 5;447(2-3):189-200.


Preface. Ca2+ and neuronal pathology.

Verkhratsky A, Landfield PW, Thibault O.

Eur J Pharmacol. 2002 Jul 5;447(2-3):115-7. No abstract available.


Group I metabotropic glutamate receptor inhibition selectively blocks a prolonged Ca(2+) elevation associated with age-dependent excitotoxicity.

Attucci S, Clodfelter GV, Thibault O, Staton J, Moroni F, Landfield PW, Porter NM.

Neuroscience. 2002;112(1):183-94.


Expression of alpha 1D subunit mRNA is correlated with L-type Ca2+ channel activity in single neurons of hippocampal "zipper" slices.

Chen KC, Blalock EM, Thibault O, Kaminker P, Landfield PW.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4357-62.


Calcium dysregulation in neuronal aging and Alzheimer's disease: history and new directions.

Thibault O, Porter NM, Chen KC, Blalock EM, Kaminker PG, Clodfelter GV, Brewer LD, Landfield PW.

Cell Calcium. 1998 Nov-Dec;24(5-6):417-33. Review. No abstract available.


Calcium channel density and hippocampal cell death with age in long-term culture.

Porter NM, Thibault O, Thibault V, Chen KC, Landfield PW.

J Neurosci. 1997 Jul 15;17(14):5629-39.


Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons.

Campbell LW, Hao SY, Thibault O, Blalock EM, Landfield PW.

J Neurosci. 1996 Oct 1;16(19):6286-95.


Increase in single L-type calcium channels in hippocampal neurons during aging.

Thibault O, Landfield PW.

Science. 1996 May 17;272(5264):1017-20.


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