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Determinants of Restoration of CD4 and CD8 Cell Counts and their Ratio in HIV-1 Positive Individuals with Sustained Virological Suppression on Antiretroviral Therapy.

Gras L, May M, Ryder LP, Trickey A, Helleberg M, Obel N, Thiebaut R, Guest J, Gill J, Crane H, Lima VD, Monforte AD, Sterling TR, Miro J, Moreno S, Stephan C, Smith C, Tate J, Shepherd L, Saag M, Rieger A, Gillor D, Cavassini M, Montero M, Ingle SM, Reiss P, Costagliola D, Wit FWNM, Sterne J, de Wolf F, Geskus R; Antiretroviral Therapy Cohort Collaboration (ART-CC).

J Acquir Immune Defic Syndr. 2018 Dec 3. doi: 10.1097/QAI.0000000000001913. [Epub ahead of print]


Lasso regularization for left-censored Gaussian outcome and high-dimensional predictors.

Soret P, Avalos M, Wittkop L, Commenges D, Thiébaut R.

BMC Med Res Methodol. 2018 Dec 4;18(1):159. doi: 10.1186/s12874-018-0609-4.


HIV-1 T cell epitopes targeted to Rhesus macaque CD40 and DCIR: A comparative study of prototype dendritic cell targeting therapeutic vaccine candidates.

Flamar AL, Bonnabau H, Zurawski S, Lacabaratz C, Montes M, Richert L, Wiedemann A, Galmin L, Weiss D, Cristillo A, Hudacik L, Salazar A, Peltekian C, Thiebaut R, Zurawski G, Levy Y.

PLoS One. 2018 Nov 30;13(11):e0207794. doi: 10.1371/journal.pone.0207794. eCollection 2018.


A new method for evaluating the impacts of semantic similarity measures on the annotation of gene sets.

Ayllón-Benítez A, Mougin F, Allali J, Thiébaut R, Thébault P.

PLoS One. 2018 Nov 27;13(11):e0208037. doi: 10.1371/journal.pone.0208037. eCollection 2018.


B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape.

Lucar O, Sadjo Diallo M, Bayard C, Samri A, Tarantino N, Debré P, Thiébaut R, Brun-Vézinet F, Matheron S, Cheynier R, Vieillard V; ANRS CO5 IMMUNOVIR-2 Study group.

AIDS. 2019 Jan 27;33(1):23-32. doi: 10.1097/QAD.0000000000002061.


Viral rebound in semen after antiretroviral treatment interruption in an HIV therapeutic vaccine double-blind trial.

Palich R, Ghosn J, Chaillon A, Boilet V, Nere ML, Chaix ML, Delobel P, Molina JM, Lucht F, Bouchaud O, Rieux V, Thiebaut R, Levy Y, Delaugerre C, Lelievre JD; VRI02/ANRS149 LIGHT Vaccine Trial Group.

AIDS. 2019 Feb 1;33(2):279-284. doi: 10.1097/QAD.0000000000002058.


cytometree: A binary tree algorithm for automatic gating in cytometry analysis.

Commenges D, Alkhassim C, Gottardo R, Hejblum B, Thiébaut R.

Cytometry A. 2018 Nov;93(11):1132-1140. doi: 10.1002/cyto.a.23601. Epub 2018 Oct 2.


Adaptive protocols based on predictions from a mechanistic model of the effect of IL7 on CD4 counts.

Villain L, Commenges D, Pasin C, Prague M, Thiébaut R.

Stat Med. 2019 Jan 30;38(2):221-235. doi: 10.1002/sim.7957. Epub 2018 Sep 26.


Artificial Intelligence in Public Health and Epidemiology.

Thiébaut R, Thiessard F; Section Editors for the IMIA Yearbook Section on Public Health and Epidemiology Informatics.

Yearb Med Inform. 2018 Aug;27(1):207-210. doi: 10.1055/s-0038-1667082. Epub 2018 Aug 29. Review.


Validation of miR-31-3p Expression to Predict Cetuximab Efficacy When Used as First-Line Treatment in RAS Wild-Type Metastatic Colorectal Cancer.

Laurent-Puig P, Grisoni ML, Heinemann V, Liebaert F, Neureiter D, Jung A, Montestruc F, Gaston-Mathe Y, Thiébaut R, Stintzing S.

Clin Cancer Res. 2019 Jan 1;25(1):134-141. doi: 10.1158/1078-0432.CCR-18-1324. Epub 2018 Aug 14.


Microbial Translocation Does Not Drive Immune Activation in Ugandan Children Infected With HIV.

Fitzgerald FC, Lhomme E, Harris K, Kenny J, Doyle R, Kityo C, Shaw LP, Abongomera G, Musiime V, Cook A, Brown JR, Brooks A, Owen-Powell E, Gibb DM, Prendergast AJ, Sarah Walker A, Thiebaut R, Klein N; CHAPAS-3 Trial Team .

J Infect Dis. 2019 Jan 1;219(1):89-100. doi: 10.1093/infdis/jiy495.


Prevention of Ebola virus disease through vaccination: where we are in 2018.

Lévy Y, Lane C, Piot P, Beavogui AH, Kieh M, Leigh B, Doumbia S, D'Ortenzio E, Lévy-Marchal C, Pierson J, Watson-Jones D, Nguyen VK, Larson H, Lysander J, Lacabaratz C, Thiebaut R, Augier A, Ishola D, Kennedy S, Chêne G, Greenwood B, Neaton J, Yazdanpanah Y.

Lancet. 2018 Sep 1;392(10149):787-790. doi: 10.1016/S0140-6736(18)31710-0. Epub 2018 Aug 10. No abstract available.


Controlling IL-7 Injections in HIV-Infected Patients.

Pasin C, Dufour F, Villain L, Zhang H, Thiébaut R.

Bull Math Biol. 2018 Sep;80(9):2349-2377. doi: 10.1007/s11538-018-0465-8. Epub 2018 Aug 2.


The impact of population dynamics on the population HIV care cascade: results from the ANRS 12249 Treatment as Prevention trial in rural KwaZulu-Natal (South Africa).

Larmarange J, Diallo MH, McGrath N, Iwuji C, Plazy M, Thiébaut R, Tanser F, Bärnighausen T, Pillay D, Dabis F, Orne-Gliemann J; ANRS 12249 TasP Study Group.

J Int AIDS Soc. 2018 Jul;21 Suppl 4:e25128. doi: 10.1002/jia2.25128.


Ebola vaccine development: Systematic review of pre-clinical and clinical studies, and meta-analysis of determinants of antibody response variability after vaccination.

Gross L, Lhomme E, Pasin C, Richert L, Thiebaut R.

Int J Infect Dis. 2018 Sep;74:83-96. doi: 10.1016/j.ijid.2018.06.022. Epub 2018 Jul 5. Review.


Sparse partial least squares with group and subgroup structure.

Sutton M, Thiébaut R, Liquet B.

Stat Med. 2018 Oct 15;37(23):3338-3356. doi: 10.1002/sim.7821. Epub 2018 Jun 11.


Prenatal therapy with pyrimethamine + sulfadiazine vs spiramycin to reduce placental transmission of toxoplasmosis: a multicenter, randomized trial.

Mandelbrot L, Kieffer F, Sitta R, Laurichesse-Delmas H, Winer N, Mesnard L, Berrebi A, Le Bouar G, Bory JP, Cordier AG, Ville Y, Perrotin F, Jouannic JM, Biquard F, d'Ercole C, Houfflin-Debarge V, Villena I, Thiébaut R; TOXOGEST Study Group.

Am J Obstet Gynecol. 2018 Oct;219(4):386.e1-386.e9. doi: 10.1016/j.ajog.2018.05.031. Epub 2018 Jun 2.


Technical Validation of a Reverse-Transcription Quantitative Polymerase Chain Reaction In Vitro Diagnostic Test for the Determination of MiR-31-3p Expression Levels in Formalin-Fixed Paraffin-Embedded Metastatic Colorectal Cancer Tumor Specimens.

Ramon L, David C, Fontaine K, Lallet E, Marcaillou C, Martin-Lannerée S, Decaulne V, Vazart C, Gélibert AH, Abdelali RB, Costa JM, Rousseau F, Thiébaut R, Yost L, Gaston-Mathé Y.

Biomark Insights. 2018 Mar 16;13:1177271918763357. doi: 10.1177/1177271918763357. eCollection 2018.


Risk factors for colonization and infection by Pseudomonas aeruginosa in patients hospitalized in intensive care units in France.

Hoang S, Georget A, Asselineau J, Venier AG, Leroyer C, Rogues AM, Thiébaut R.

PLoS One. 2018 Mar 9;13(3):e0193300. doi: 10.1371/journal.pone.0193300. eCollection 2018.


No compensatory lung growth after resection in a one-year follow-up cohort of patients with lung cancer.

Glénet S, de Bisschop C, Delcambre F, Thiébaut R, Laurent F, Jougon J, Velly JF, Georges A, Guénard H.

J Thorac Dis. 2017 Oct;9(10):3938-3945. doi: 10.21037/jtd.2017.08.135.


Association between miR-31-3p expression and cetuximab efficacy in patients with KRAS wild-type metastatic colorectal cancer: a post-hoc analysis of the New EPOC trial.

Pugh S, Thiébaut R, Bridgewater J, Grisoni ML, Moutasim K, Rousseau F, Thomas GJ, Griffiths G, Liebaert F, Primrose J, Laurent-Puig P.

Oncotarget. 2017 Sep 27;8(55):93856-93866. doi: 10.18632/oncotarget.21291. eCollection 2017 Nov 7.


Universal test and treat and the HIV epidemic in rural South Africa: a phase 4, open-label, community cluster randomised trial.

Iwuji CC, Orne-Gliemann J, Larmarange J, Balestre E, Thiebaut R, Tanser F, Okesola N, Makowa T, Dreyer J, Herbst K, McGrath N, Bärnighausen T, Boyer S, De Oliveira T, Rekacewicz C, Bazin B, Newell ML, Pillay D, Dabis F; ANRS 12249 TasP Study Group.

Lancet HIV. 2018 Mar;5(3):e116-e125. doi: 10.1016/S2352-3018(17)30205-9. Epub 2017 Nov 30.


CD4 cell count response to first-line combination ART in HIV-2+ patients compared with HIV-1+ patients: a multinational, multicohort European study.

Wittkop L, Arsandaux J, Trevino A, Schim van der Loeff M, Anderson J, van Sighem A, Böni J, Brun-Vezinet F, Soriano V, Boufassa F, Brockmeyer N, Calmy A, Dabis F, Jarrin I, Dorrucci M, Duque V, Fätkenheuer G, Zangerle R, Ferrer E, Porter K, Judd A, Sipsas NV, Lambotte O, Shepherd L, Leport C, Morrison C, Mussini C, Obel N, Ruelle J, Schwarze-Zander C, Sonnerborg A, Teira R, Torti C, Valadas E, Colin C, Friis-Møller N, Costagliola D, Thiebaut R, Chene G, Matheron S; COHERE in EuroCoord and ACHIeV2e Study Group.

J Antimicrob Chemother. 2017 Oct 1;72(10):2869-2878. doi: 10.1093/jac/dkx210.


Serum suppression of tumorigenicity 2 level is an independent predictor of all-cause mortality in HIV-infected patients.

Thiébaut R, Hue S, Le Marec F, Lelièvre JD, Dupon M, Foucat E, Lazaro E, Dabis F, Duffau P, Wittkop L, Surenaud M, Pellegrin I, Lacabaratz C, Bonnet F, Lévy Y; ANRS CO3 Aquitaine Cohort.

AIDS. 2017 Nov 13;31(17):2355-2365. doi: 10.1097/QAD.0000000000001628.


Public Health and Epidemiology Informatics.

Thiébaut R, Thiessard F.

Yearb Med Inform. 2017 Aug;26(1):248-251. doi: 10.15265/IY-2017-036. Epub 2017 Sep 11. Review.


Visualizing omics and clinical data: Which challenges for dealing with their variety?

Mougin F, Auber D, Bourqui R, Diallo G, Dutour I, Jouhet V, Thiessard F, Thiébaut R, Thébault P.

Methods. 2018 Jan 1;132:3-18. doi: 10.1016/j.ymeth.2017.08.012. Epub 2017 Sep 6. Review.


Systems Vaccinology Identifies an Early Innate Immune Signature as a Correlate of Antibody Responses to the Ebola Vaccine rVSV-ZEBOV.

Rechtien A, Richert L, Lorenzo H, Martrus G, Hejblum B, Dahlke C, Kasonta R, Zinser M, Stubbe H, Matschl U, Lohse A, Krähling V, Eickmann M, Becker S; VEBCON Consortium, Thiébaut R, Altfeld M, Addo MM.

Cell Rep. 2017 Aug 29;20(9):2251-2261. doi: 10.1016/j.celrep.2017.08.023.


Reliable assessment of the incidence of childhood autoimmune hemolytic anemia.

Aladjidi N, Jutand MA, Beaubois C, Fernandes H, Jeanpetit J, Coureau G, Gilleron V, Kostrzewa A, Lauroua P, Jeanne M, Thiébaut R, Leblanc T, Leverger G, Perel Y.

Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26683. Epub 2017 Jul 27.


Percutaneous Image-Guided Cryoablation as Second-Line Therapy of Soft-Tissue Venous Vascular Malformations of Extremities: A Prospective Study of Safety and 6-Month Efficacy.

Cornelis FH, Labrèze C, Pinsolle V, Le Bras Y, Castermans C, Bader C, Thiebaut R, Midy D, Grenier N.

Cardiovasc Intervent Radiol. 2017 Sep;40(9):1358-1366. doi: 10.1007/s00270-017-1636-y. Epub 2017 Mar 30.


Integrative Analysis of Immunological Data to Explore Chronic Immune T-Cell Activation in Successfully Treated HIV Patients.

Picat MQ, Pellegrin I, Bitard J, Wittkop L, Proust-Lima C, Liquet B, Moreau JF, Bonnet F, Blanco P, Thiébaut R; ANRS CO3 Aquitaine Cohort.

PLoS One. 2017 Jan 3;12(1):e0169164. doi: 10.1371/journal.pone.0169164. eCollection 2017.


No Positive Association between Vitamin D Level and Immune Responses to Hepatitis B and Streptococcus pneumoniae Vaccination in HIV-Infected Adults.

Viard JP, Assuied A, Lévy Y, Souberbielle JC, Thiébaut R, Carrat F, Chêne G, Launay O, Richert L.

PLoS One. 2016 Dec 15;11(12):e0168640. doi: 10.1371/journal.pone.0168640. eCollection 2016.


Optimization and evaluation of Luminex performance with supernatants of antigen-stimulated peripheral blood mononuclear cells.

Surenaud M, Manier C, Richert L, Thiébaut R, Levy Y, Hue S, Lacabaratz C.

BMC Immunol. 2016 Nov 11;17(1):44.


Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

Thiébaut R, Esmiol S, Lecine P, Mahfouz B, Hermant A, Nicoletti C, Parnis S, Perroy J, Borg JP, Pascoe L, Hugot JP, Ollendorff V.

PLoS One. 2016 Nov 3;11(11):e0165420. doi: 10.1371/journal.pone.0165420. eCollection 2016.


Reply to Bordoni et al.

Thiébaut R, Lévy Y.

Clin Infect Dis. 2016 Dec 15;63(12):1684-1685. Epub 2016 Sep 23. No abstract available.


Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naïve patients.

Bouteloup V, Sabin C, Mocroft A, Gras L, Pantazis N, Le Moing V, d'Arminio Monforte A, Mary-Krause M, Roca B, Miro JM, Battegay M, Brockmeyer N, Berenguer J, Morlat P, Obel N, De Wit S, Fätkenheuer G, Zangerle R, Ghosn J, Pérez-Hoyos S, Campbell M, Prins M, Chêne G, Meyer L, Dorrucci M, Torti C, Thiébaut R; Standard Reference Distribution of CD4 Response to HAART Project Team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord.

HIV Med. 2017 Jan;18(1):33-44. doi: 10.1111/hiv.12389. Epub 2016 Sep 14.


Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers.

Angin M, Wong G, Papagno L, Versmisse P, David A, Bayard C, Charmeteau-De Muylder B, Besseghir A, Thiébaut R, Boufassa F, Pancino G, Sauce D, Lambotte O, Brun-Vézinet F, Matheron S, Rowland-Jones SL, Cheynier R, Sáez-Cirión A, Appay V; ANRS CO5 IMMUNOVIR-2 Study Group.

J Immunol. 2016 Oct 1;197(7):2787-95. doi: 10.4049/jimmunol.1600693. Epub 2016 Aug 26.


Low CD4/CD8 Ratio Is Associated with Non AIDS-Defining Cancers in Patients on Antiretroviral Therapy: ANRS CO8 (Aproco/Copilote) Prospective Cohort Study.

Hema MN, Ferry T, Dupon M, Cuzin L, Verdon R, Thiébaut R, Protopopescu C, Leport C, Raffi F, Le Moing V; ANRS CO 8 (APROCO/COPILOTE) study group.

PLoS One. 2016 Aug 22;11(8):e0161594. doi: 10.1371/journal.pone.0161594. eCollection 2016.


Uptake of Home-Based HIV Testing, Linkage to Care, and Community Attitudes about ART in Rural KwaZulu-Natal, South Africa: Descriptive Results from the First Phase of the ANRS 12249 TasP Cluster-Randomised Trial.

Iwuji CC, Orne-Gliemann J, Larmarange J, Okesola N, Tanser F, Thiebaut R, Rekacewicz C, Newell ML, Dabis F; ANRS 12249 TasP trial group.

PLoS Med. 2016 Aug 9;13(8):e1002107. doi: 10.1371/journal.pmed.1002107. eCollection 2016 Aug.


Dynamic models for estimating the effect of HAART on CD4 in observational studies: Application to the Aquitaine Cohort and the Swiss HIV Cohort Study.

Prague M, Commenges D, Gran JM, Ledergerber B, Young J, Furrer H, Thiébaut R.

Biometrics. 2017 Mar;73(1):294-304. doi: 10.1111/biom.12564. Epub 2016 Jul 26.


Intrinsic Defect in Keratinocyte Function Leads to Inflammation in Hidradenitis Suppurativa.

Hotz C, Boniotto M, Guguin A, Surenaud M, Jean-Louis F, Tisserand P, Ortonne N, Hersant B, Bosc R, Poli F, Bonnabau H, Thiébaut R, Godot V, Wolkenstein P, Hocini H, Lévy Y, Hüe S.

J Invest Dermatol. 2016 Sep;136(9):1768-1780. doi: 10.1016/j.jid.2016.04.036. Epub 2016 May 17.


Early CD4+ T Cell Responses Are Associated with Subsequent CD8+ T Cell Responses to an rAd5-Based Prophylactic Prime-Boost HIV Vaccine Strategy.

Lhomme E, Richert L, Moodie Z, Pasin C, Kalams SA, Morgan C, Self S, De Rosa SC, Thiébaut R.

PLoS One. 2016 Apr 28;11(4):e0152952. doi: 10.1371/journal.pone.0152952. eCollection 2016.


Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques.

Zurawski G, Zurawski S, Flamar AL, Richert L, Wagner R, Tomaras GD, Montefiori DC, Roederer M, Ferrari G, Lacabaratz C, Bonnabau H, Klucar P, Wang Z, Foulds KE, Kao SF, Yates NL, LaBranche C, Jacobs BL, Kibler K, Asbach B, Kliche A, Salazar A, Reed S, Self S, Gottardo R, Galmin L, Weiss D, Cristillo A, Thiebaut R, Pantaleo G, Levy Y.

PLoS One. 2016 Apr 14;11(4):e0153484. doi: 10.1371/journal.pone.0153484. eCollection 2016.


Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates.

Le Grand R, Dereuddre-Bosquet N, Dispinseri S, Gosse L, Desjardins D, Shen X, Tolazzi M, Ochsenbauer C, Saidi H, Tomaras G, Prague M, Barnett SW, Thiebaut R, Cope A, Scarlatti G, Shattock RJ.

J Virol. 2016 May 12;90(11):5315-5328. doi: 10.1128/JVI.00230-16. Print 2016 Jun 1.


Repeated Cycles of Recombinant Human Interleukin 7 in HIV-Infected Patients With Low CD4 T-Cell Reconstitution on Antiretroviral Therapy: Results of 2 Phase II Multicenter Studies.

Thiébaut R, Jarne A, Routy JP, Sereti I, Fischl M, Ive P, Speck RF, D'Offizi G, Casari S, Commenges D, Foulkes S, Natarajan V, Croughs T, Delfraissy JF, Tambussi G, Levy Y, Lederman MM.

Clin Infect Dis. 2016 May 1;62(9):1178-1185. doi: 10.1093/cid/ciw065. Epub 2016 Feb 7.


Immunologic response in treatment-naïve HIV-2-infected patients: the IeDEA West Africa cohort.

Balestre E, Ekouevi DK, Tchounga B, Eholie SP, Messou E, Sawadogo A, Thiébaut R, May MT, Sterne JA, Dabis F; International Epidemiological Database to Evaluate AIDS (IeDEA) West Africa Collaboration.

J Int AIDS Soc. 2016 Feb 8;19(1):20044. doi: 10.7448/IAS.19.1.20044. eCollection 2016.


A Method to Estimate the Size and Characteristics of HIV-positive Populations Using an Individual-based Stochastic Simulation Model.

Nakagawa F, van Sighem A, Thiebaut R, Smith C, Ratmann O, Cambiano V, Albert J, Amato-Gauci A, Bezemer D, Campbell C, Commenges D, Donoghoe M, Ford D, Kouyos R, Lodwick R, Lundgren J, Pantazis N, Pharris A, Quinten C, Thorne C, Touloumi G, Delpech V, Phillips A; SSOPHIE project working group in EuroCoord.

Epidemiology. 2016 Mar;27(2):247-56. doi: 10.1097/EDE.0000000000000423. Erratum in: Epidemiology. 2016 May;27(3):e24.


Association of immune-activation and senescence markers with non-AIDS-defining comorbidities in HIV-suppressed patients.

Duffau P, Wittkop L, Lazaro E, le Marec F, Cognet C, Blanco P, Moreau JF, Dauchy FA, Cazanave C, Vandenhende MA, Bonnet F, Thiebaut R, Pellegrin I; ANRS CO3 Aquitaine Cohort Study Group.

AIDS. 2015 Oct 23;29(16):2099-108. doi: 10.1097/QAD.0000000000000807.


Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study.

Pantazis N, Porter K, Costagliola D, De Luca A, Ghosn J, Guiguet M, Johnson AM, Kelleher AD, Morrison C, Thiebaut R, Wittkop L, Touloumi G; CASCADE Collaboration in EuroCoord.

Lancet HIV. 2014 Dec;1(3):e119-26. doi: 10.1016/S2352-3018(14)00002-2. Epub 2014 Nov 18.


Guidelines for reporting methodological challenges and evaluating potential bias in dementia research.

Weuve J, Proust-Lima C, Power MC, Gross AL, Hofer SM, Thiébaut R, Chêne G, Glymour MM, Dufouil C; MELODEM Initiative.

Alzheimers Dement. 2015 Sep;11(9):1098-109. doi: 10.1016/j.jalz.2015.06.1885. Review.


Group and sparse group partial least square approaches applied in genomics context.

Liquet B, de Micheaux PL, Hejblum BP, Thiébaut R.

Bioinformatics. 2016 Jan 1;32(1):35-42. doi: 10.1093/bioinformatics/btv535. Epub 2015 Sep 10.


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