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Dopamine Is a Siderophore-Like Iron Chelator That Promotes Salmonella enterica Serovar Typhimurium Virulence in Mice.

Dichtl S, Demetz E, Haschka D, Tymoszuk P, Petzer V, Nairz M, Seifert M, Hoffmann A, Brigo N, Würzner R, Theurl I, Karlinsey JE, Fang FC, Weiss G.

MBio. 2019 Feb 5;10(1). pii: e02624-18. doi: 10.1128/mBio.02624-18.


Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases.

Petzer V, Theurl I, Weiss G.

Pharmaceuticals (Basel). 2018 Dec 11;11(4). pii: E135. doi: 10.3390/ph11040135. Review.


Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome.

Haschka D, Volani C, Stefani A, Tymoszuk P, Mitterling T, Holzknecht E, Heidbreder A, Coassin S, Sumbalova Z, Seifert M, Dichtl S, Theurl I, Gnaiger E, Kronenberg F, Frauscher B, Högl B, Weiss G.

Mov Disord. 2019 Jan;34(1):114-123. doi: 10.1002/mds.27482. Epub 2018 Oct 11.


The crucial impact of iron deficiency definition for the course of precapillary pulmonary hypertension.

Sonnweber T, Nairz M, Theurl I, Petzer V, Tymoszuk P, Haschka D, Rieger E, Kaessmann B, Deri M, Watzinger K, Steringer-Mascherbauer R, Tancevski I, Weiss G, Löffler-Ragg J.

PLoS One. 2018 Aug 30;13(8):e0203396. doi: 10.1371/journal.pone.0203396. eCollection 2018.


Normal and pathological erythropoiesis in adults: from gene regulation to targeted treatment concepts.

Valent P, Büsche G, Theurl I, Uras IZ, Germing U, Stauder R, Sotlar K, Füreder W, Bettelheim P, Pfeilstöcker M, Oberbauer R, Sperr WR, Geissler K, Schwaller J, Moriggl R, Béné MC, Jäger U, Horny HP, Hermine O.

Haematologica. 2018 Oct;103(10):1593-1603. doi: 10.3324/haematol.2018.192518. Epub 2018 Aug 3. Review.


Newly emerging ulceroglandular tularaemia in Western Austria.

Schroll A, Theurl I, Georgi E, Zange S, Rettenbacher T, Bellmann-Weiler R, Weiss G.

Ticks Tick Borne Dis. 2018 Jul;9(5):1331-1333. doi: 10.1016/j.ttbdis.2018.06.003. Epub 2018 Jun 6.


Iron and innate antimicrobial immunity-Depriving the pathogen, defending the host.

Nairz M, Dichtl S, Schroll A, Haschka D, Tymoszuk P, Theurl I, Weiss G.

J Trace Elem Med Biol. 2018 Jul;48:118-133. doi: 10.1016/j.jtemb.2018.03.007. Epub 2018 Mar 10. Review.


Enhanced labile plasma iron and outcome in acute myeloid leukaemia and myelodysplastic syndrome after allogeneic haemopoietic cell transplantation (ALLIVE): a prospective, multicentre, observational trial.

Wermke M, Eckoldt J, Götze KS, Klein SA, Bug G, de Wreede LC, Kramer M, Stölzel F, von Bonin M, Schetelig J, Laniado M, Plodeck V, Hofmann WK, Ehninger G, Bornhäuser M, Wolf D, Theurl I, Platzbecker U.

Lancet Haematol. 2018 May;5(5):e201-e210. doi: 10.1016/S2352-3026(18)30036-X. Epub 2018 Apr 5.


Correction for Wu et al., "Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-κB Signaling".

Wu A, Tymoszuk P, Haschka D, Heeke S, Dichtl S, Petzer V, Seifert M, Hilbe R, Sopper S, Talasz H, Bumann D, Lass-Flörl C, Theurl I, Zhang K, Weiss G.

Infect Immun. 2018 Feb 20;86(3). pii: e00881-17. doi: 10.1128/IAI.00881-17. Print 2018 Mar. No abstract available.


Diagnosis, management and response criteria of iron overload in myelodysplastic syndromes (MDS): updated recommendations of the Austrian MDS platform.

Valent P, Stauder R, Theurl I, Geissler K, Sliwa T, Sperr WR, Bettelheim P, Sill H, Pfeilstöcker M.

Expert Rev Hematol. 2018 Feb;11(2):109-116. doi: 10.1080/17474086.2018.1420473. Epub 2018 Jan 2. Review.


Anemia at older age: etiologies, clinical implications, and management.

Stauder R, Valent P, Theurl I.

Blood. 2018 Feb 1;131(5):505-514. doi: 10.1182/blood-2017-07-746446. Epub 2017 Nov 15. Review.


Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.

Nairz M, Haschka D, Dichtl S, Sonnweber T, Schroll A, Aßhoff M, Mindur JE, Moser PL, Wolf D, Swirski FK, Theurl I, Cerami A, Brines M, Weiss G.

Sci Rep. 2017 Oct 12;7(1):13012. doi: 10.1038/s41598-017-13046-3.


Salmonella utilizes zinc to subvert anti-microbial host defense of macrophages via modulation of NF-κB signaling.

Wu A, Tymoszuk P, Haschka D, Heeke S, Dichtl S, Petzer V, Seifert M, Hilbe R, Sopper S, Talasz H, Bumann D, Lass-Flörl C, Theurl I, Zhang K, Weiss G.

Infect Immun. 2017 Sep 5. pii: IAI.00418-17. doi: 10.1128/IAI.00418-17. [Epub ahead of print] Erratum in: Infect Immun. 2018 Feb 20;86(3):.


Genetic and Dietary Iron Overload Differentially Affect the Course of Salmonella Typhimurium Infection.

Nairz M, Schroll A, Haschka D, Dichtl S, Tymoszuk P, Demetz E, Moser P, Haas H, Fang FC, Theurl I, Weiss G.

Front Cell Infect Microbiol. 2017 Apr 11;7:110. doi: 10.3389/fcimb.2017.00110. eCollection 2017.


"Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels.

Nairz M, Theurl I, Swirski FK, Weiss G.

Pflugers Arch. 2017 Apr;469(3-4):397-418. doi: 10.1007/s00424-017-1944-8. Epub 2017 Mar 1. Review.


Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.

Asshoff M, Petzer V, Warr MR, Haschka D, Tymoszuk P, Demetz E, Seifert M, Posch W, Nairz M, Maciejewski P, Fowles P, Burns CJ, Smith G, Wagner KU, Weiss G, Whitney JA, Theurl I.

Blood. 2017 Mar 30;129(13):1823-1830. doi: 10.1182/blood-2016-09-740092. Epub 2017 Feb 10.


Iron deficiency or anemia of inflammation? : Differential diagnosis and mechanisms of anemia of inflammation.

Nairz M, Theurl I, Wolf D, Weiss G.

Wien Med Wochenschr. 2016 Oct;166(13-14):411-423. Epub 2016 Aug 24. Review.


On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.

Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK.

Nat Med. 2016 Aug;22(8):945-51. doi: 10.1038/nm.4146. Epub 2016 Jul 18.


Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease.

Wieser V, Tymoszuk P, Adolph TE, Grander C, Grabherr F, Enrich B, Pfister A, Lichtmanegger L, Gerner R, Drach M, Moser P, Zoller H, Weiss G, Moschen AR, Theurl I, Tilg H.

J Hepatol. 2016 Apr;64(4):872-80. doi: 10.1016/j.jhep.2015.11.037. Epub 2015 Dec 9.


Lipocalin-2 ensures host defense against Salmonella Typhimurium by controlling macrophage iron homeostasis and immune response.

Nairz M, Schroll A, Haschka D, Dichtl S, Sonnweber T, Theurl I, Theurl M, Lindner E, Demetz E, Aßhoff M, Bellmann-Weiler R, Müller R, Gerner RR, Moschen AR, Baumgartner N, Moser PL, Talasz H, Tilg H, Fang FC, Weiss G.

Eur J Immunol. 2015 Nov;45(11):3073-86. doi: 10.1002/eji.201545569. Epub 2015 Sep 30.


Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.

Schaefer B, Haschka D, Finkenstedt A, Petersen BS, Theurl I, Henninger B, Janecke AR, Wang CY, Lin HY, Veits L, Vogel W, Weiss G, Franke A, Zoller H.

Hum Mol Genet. 2015 Nov 1;24(21):6254-63. doi: 10.1093/hmg/ddv348. Epub 2015 Aug 26.


Increased hepcidin levels in high-altitude pulmonary edema.

Altamura S, Bärtsch P, Dehnert C, Maggiorini M, Weiss G, Theurl I, Muckenthaler MU, Mairbäurl H.

J Appl Physiol (1985). 2015 Feb 1;118(3):292-8. doi: 10.1152/japplphysiol.00940.2014. Epub 2014 Dec 18.


The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism.

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJF, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I.

Cell Metab. 2014 Nov 4;20(5):787-798. doi: 10.1016/j.cmet.2014.09.004.


Myelodysplasia is in the niche: novel concepts and emerging therapies.

Bulycheva E, Rauner M, Medyouf H, Theurl I, Bornhäuser M, Hofbauer LC, Platzbecker U.

Leukemia. 2015 Feb;29(2):259-68. doi: 10.1038/leu.2014.325. Epub 2014 Nov 14. Review.


'Ride on the ferrous wheel'--the cycle of iron in macrophages in health and disease.

Nairz M, Schroll A, Demetz E, Tancevski I, Theurl I, Weiss G.

Immunobiology. 2015 Feb;220(2):280-94. doi: 10.1016/j.imbio.2014.09.010. Epub 2014 Sep 16. Review.


MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription.

Zumbrennen-Bullough KB, Wu Q, Core AB, Canali S, Chen W, Theurl I, Meynard D, Babitt JL.

J Biol Chem. 2014 Aug 22;289(34):23796-808. doi: 10.1074/jbc.M114.577387. Epub 2014 Jul 7.


Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats.

Theurl M, Nairz M, Schroll A, Sonnweber T, Asshoff M, Haschka D, Seifert M, Willenbacher W, Wilflingseder D, Posch W, Murphy AT, Witcher DR, Theurl I, Weiss G.

Haematologica. 2014 Sep;99(9):1516-24. doi: 10.3324/haematol.2013.099481. Epub 2014 Jun 3.


Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis.

Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK.

J Exp Med. 2014 Jun 2;211(6):1243-56. doi: 10.1084/jem.20131471. Epub 2014 May 12.


In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors.

Tymoszuk P, Evens H, Marzola V, Wachowicz K, Wasmer MH, Datta S, Müller-Holzner E, Fiegl H, Böck G, van Rooijen N, Theurl I, Doppler W.

Eur J Immunol. 2014 Aug;44(8):2247-62. doi: 10.1002/eji.201344304. Epub 2014 Jun 16.


Hypoxia induced downregulation of hepcidin is mediated by platelet derived growth factor BB.

Sonnweber T, Nachbaur D, Schroll A, Nairz M, Seifert M, Demetz E, Haschka D, Mitterstiller AM, Kleinsasser A, Burtscher M, Trübsbach S, Murphy AT, Wroblewski V, Witcher DR, Mleczko-Sanecka K, Vecchi C, Muckenthaler MU, Pietrangelo A, Theurl I, Weiss G.

Gut. 2014 Dec;63(12):1951-9. doi: 10.1136/gutjnl-2013-305317. Epub 2014 Mar 5.


Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity.

Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK.

Circulation. 2014 Apr 22;129(16):1677-87. doi: 10.1161/CIRCULATIONAHA.113.006381. Epub 2014 Jan 31.


Local proliferation dominates lesional macrophage accumulation in atherosclerosis.

Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK.

Nat Med. 2013 Sep;19(9):1166-72. doi: 10.1038/nm.3258. Epub 2013 Aug 11.


Lipocalin-2 expressed in innate immune cells is an endogenous inhibitor of inflammation in murine nephrotoxic serum nephritis.

Eller K, Schroll A, Banas M, Kirsch AH, Huber JM, Nairz M, Skvortsov S, Weiss G, Rosenkranz AR, Theurl I.

PLoS One. 2013 Jul 4;8(7):e67693. doi: 10.1371/journal.pone.0067693. Print 2013.


Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers.

Goetze O, Schmitt J, Spliethoff K, Theurl I, Weiss G, Swinkels DW, Tjalsma H, Maggiorini M, Krayenbühl P, Rau M, Fruehauf H, Wojtal KA, Müllhaupt B, Fried M, Gassmann M, Lutz T, Geier A.

Hepatology. 2013 Dec;58(6):2153-62. doi: 10.1002/hep.26581. Epub 2013 Oct 11.


Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection.

Nairz M, Schleicher U, Schroll A, Sonnweber T, Theurl I, Ludwiczek S, Talasz H, Brandacher G, Moser PL, Muckenthaler MU, Fang FC, Bogdan C, Weiss G.

J Exp Med. 2013 May 6;210(5):855-73. doi: 10.1084/jem.20121946. Epub 2013 Apr 29.


A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.

Sun CC, Vaja V, Chen S, Theurl I, Stepanek A, Brown DE, Cappellini MD, Weiss G, Hong CC, Lin HY, Babitt JL.

Nephrol Dial Transplant. 2013 Jul;28(7):1733-43. doi: 10.1093/ndt/gfs584. Epub 2013 Jan 22.


Utility of PCR in diagnosis of invasive fungal infections: real-life data from a multicenter study.

Lass-Flörl C, Mutschlechner W, Aigner M, Grif K, Marth C, Girschikofsky M, Grander W, Greil R, Russ G, Cerkl P, Eller M, Kropshofer G, Eschertzhuber S, Kathrein H, Schmid S, Beer R, Lorenz I, Theurl I, Nachbaur D.

J Clin Microbiol. 2013 Mar;51(3):863-8. doi: 10.1128/JCM.02965-12. Epub 2012 Dec 26.


MRI-based liver iron content predicts for nonrelapse mortality in MDS and AML patients undergoing allogeneic stem cell transplantation.

Wermke M, Schmidt A, Middeke JM, Sockel K, von Bonin M, Schönefeldt C, Mair S, Plodeck V, Laniado M, Weiss G, Schetelig J, Ehninger G, Theurl I, Bornhäuser M, Platzbecker U.

Clin Cancer Res. 2012 Dec 1;18(23):6460-8. doi: 10.1158/1078-0432.CCR-12-1683. Epub 2012 Sep 18.


Lipocalin-2 ameliorates granulocyte functionality.

Schroll A, Eller K, Feistritzer C, Nairz M, Sonnweber T, Moser PA, Rosenkranz AR, Theurl I, Weiss G.

Eur J Immunol. 2012 Dec;42(12):3346-57. doi: 10.1002/eji.201142351. Epub 2012 Nov 7.


High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption.

Sonnweber T, Ress C, Nairz M, Theurl I, Schroll A, Murphy AT, Wroblewski V, Witcher DR, Moser P, Ebenbichler CF, Kaser S, Weiss G.

J Nutr Biochem. 2012 Dec;23(12):1600-8. doi: 10.1016/j.jnutbio.2011.10.013. Epub 2012 Mar 23.


Hepcidin is correlated to soluble hemojuvelin but not to increased GDF15 during pregnancy.

Finkenstedt A, Widschwendter A, Brasse-Lagnel CG, Theurl I, Hubalek M, Dieplinger H, Tselepis C, Ward DG, Vogel W, Zoller H.

Blood Cells Mol Dis. 2012 Apr 15;48(4):233-7. doi: 10.1016/j.bcmd.2012.02.001. Epub 2012 Feb 25.


Innate response activator B cells protect against microbial sepsis.

Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK.

Science. 2012 Feb 3;335(6068):597-601. doi: 10.1126/science.1215173. Epub 2012 Jan 12.


The pleiotropic effects of erythropoietin in infection and inflammation.

Nairz M, Sonnweber T, Schroll A, Theurl I, Weiss G.

Microbes Infect. 2012 Mar;14(3):238-46. doi: 10.1016/j.micinf.2011.10.005. Epub 2011 Nov 4. Review.


Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo.

Theurl I, Schroll A, Nairz M, Seifert M, Theurl M, Sonnweber T, Kulaksiz H, Weiss G.

Haematologica. 2011 Dec;96(12):1761-9. doi: 10.3324/haematol.2011.048926. Epub 2011 Aug 22.


Nifedipine affects the course of Salmonella enterica serovar Typhimurium infection by modulating macrophage iron homeostasis.

Mair SM, Nairz M, Bellmann-Weiler R, Muehlbacher T, Schroll A, Theurl I, Moser PL, Talasz H, Fang FC, Weiss G.

J Infect Dis. 2011 Sep 1;204(5):685-94. doi: 10.1093/infdis/jir395.


Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats.

Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G.

Blood. 2011 Nov 3;118(18):4977-84. doi: 10.1182/blood-2011-03-345066. Epub 2011 Jul 5.


Mass spectrometry analysis of hepcidin peptides in experimental mouse models.

Tjalsma H, Laarakkers CM, van Swelm RP, Theurl M, Theurl I, Kemna EH, van der Burgt YE, Venselaar H, Dutilh BE, Russel FG, Weiss G, Masereeuw R, Fleming RE, Swinkels DW.

PLoS One. 2011 Mar 8;6(3):e16762. doi: 10.1371/journal.pone.0016762.


Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-κB-inducible immune pathways.

Nairz M, Schroll A, Moschen AR, Sonnweber T, Theurl M, Theurl I, Taub N, Jamnig C, Neurauter D, Huber LA, Tilg H, Moser PL, Weiss G.

Immunity. 2011 Jan 28;34(1):61-74. doi: 10.1016/j.immuni.2011.01.002. Epub 2011 Jan 20.


Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.

Pichler I, Minelli C, Sanna S, Tanaka T, Schwienbacher C, Naitza S, Porcu E, Pattaro C, Busonero F, Zanon A, Maschio A, Melville SA, Grazia Piras M, Longo DL, Guralnik J, Hernandez D, Bandinelli S, Aigner E, Murphy AT, Wroblewski V, Marroni F, Theurl I, Gnewuch C, Schadt E, Mitterer M, Schlessinger D, Ferrucci L, Witcher DR, Hicks AA, Weiss G, Uda M, Pramstaller PP.

Hum Mol Genet. 2011 Mar 15;20(6):1232-40. doi: 10.1093/hmg/ddq552. Epub 2010 Dec 28.


Importance of erythropoetin receptor expression in tumour tissue for the clinical course of breast cancer.

Volgger B, Kurz K, Zöschg K, Theurl I, Ciresa-König A, Marth C, Weiss G.

Anticancer Res. 2010 Sep;30(9):3721-6.


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