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Items: 1 to 50 of 75


The piRNA Response to Retroviral Invasion of the Koala Genome.

Yu T, Koppetsch BS, Pagliarani S, Johnston S, Silverstein NJ, Luban J, Chappell K, Weng Z, Theurkauf WE.

Cell. 2019 Oct 17;179(3):632-643.e12. doi: 10.1016/j.cell.2019.09.002. Epub 2019 Oct 10.


Rapid evolution and conserved function of the piRNA pathway.

Parhad SS, Theurkauf WE.

Open Biol. 2019 Jan 31;9(1):180181. doi: 10.1098/rsob.180181.


Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin.

Zhang G, Tu S, Yu T, Zhang XO, Parhad SS, Weng Z, Theurkauf WE.

Cell Rep. 2018 Sep 25;24(13):3413-3422.e4. doi: 10.1016/j.celrep.2018.08.081.


Structural insights into Rhino-Deadlock complex for germline piRNA cluster specification.

Yu B, Lin YA, Parhad SS, Jin Z, Ma J, Theurkauf WE, Zhang ZZ, Huang Y.

EMBO Rep. 2018 Jul;19(7). pii: e45418. doi: 10.15252/embr.201745418. Epub 2018 Jun 1.


A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes.

Bozler J, Kacsoh BZ, Chen H, Theurkauf WE, Weng Z, Bosco G.

PLoS Genet. 2017 Oct 30;13(10):e1007054. doi: 10.1371/journal.pgen.1007054. eCollection 2017 Oct.


Adaptive Evolution Leads to Cross-Species Incompatibility in the piRNA Transposon Silencing Machinery.

Parhad SS, Tu S, Weng Z, Theurkauf WE.

Dev Cell. 2017 Oct 9;43(1):60-70.e5. doi: 10.1016/j.devcel.2017.08.012. Epub 2017 Sep 14.


The HP1 homolog rhino anchors a nuclear complex that suppresses piRNA precursor splicing.

Zhang Z, Wang J, Schultz N, Zhang F, Parhad SS, Tu S, Vreven T, Zamore PD, Weng Z, Theurkauf WE.

Cell. 2014 Jun 5;157(6):1353-63. doi: 10.1016/j.cell.2014.04.030.


TEMP: a computational method for analyzing transposable element polymorphism in populations.

Zhuang J, Wang J, Theurkauf W, Weng Z.

Nucleic Acids Res. 2014 Jun;42(11):6826-38. doi: 10.1093/nar/gku323. Epub 2014 Apr 21.


Antisense piRNA amplification, but not piRNA production or nuage assembly, requires the Tudor-domain protein Qin.

Zhang Z, Koppetsch BS, Wang J, Tipping C, Weng Z, Theurkauf WE, Zamore PD.

EMBO J. 2014 Mar 18;33(6):536-9. doi: 10.1002/embj.201384895. No abstract available.


Transposition-driven genomic heterogeneity in the Drosophila brain.

Perrat PN, DasGupta S, Wang J, Theurkauf W, Weng Z, Rosbash M, Waddell S.

Science. 2013 Apr 5;340(6128):91-5. doi: 10.1126/science.1231965.


Recurrent and recent selective sweeps in the piRNA pathway.

Simkin A, Wong A, Poh YP, Theurkauf WE, Jensen JD.

Evolution. 2013 Apr;67(4):1081-90. doi: 10.1111/evo.12011. Epub 2013 Jan 17.


Strand-specific libraries for high throughput RNA sequencing (RNA-Seq) prepared without poly(A) selection.

Zhang Z, Theurkauf WE, Weng Z, Zamore PD.

Silence. 2012 Dec 28;3(1):9. doi: 10.1186/1758-907X-3-9.


UAP56 couples piRNA clusters to the perinuclear transposon silencing machinery.

Zhang F, Wang J, Xu J, Zhang Z, Koppetsch BS, Schultz N, Vreven T, Meignin C, Davis I, Zamore PD, Weng Z, Theurkauf WE.

Cell. 2012 Nov 9;151(4):871-884. doi: 10.1016/j.cell.2012.09.040.


Adaptation to P element transposon invasion in Drosophila melanogaster.

Khurana JS, Wang J, Xu J, Koppetsch BS, Thomson TC, Nowosielska A, Li C, Zamore PD, Weng Z, Theurkauf WE.

Cell. 2011 Dec 23;147(7):1551-63. doi: 10.1016/j.cell.2011.11.042.


Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains.

Zhang Z, Xu J, Koppetsch BS, Wang J, Tipping C, Ma S, Weng Z, Theurkauf WE, Zamore PD.

Mol Cell. 2011 Nov 18;44(4):572-84. doi: 10.1016/j.molcel.2011.10.011. Erratum in: Mol Cell. 2011 Dec 23;44(6):1005.


Distinct functions for the Drosophila piRNA pathway in genome maintenance and telomere protection.

Khurana JS, Xu J, Weng Z, Theurkauf WE.

PLoS Genet. 2010 Dec 16;6(12):e1001246. doi: 10.1371/journal.pgen.1001246.


piRNAs, transposon silencing, and Drosophila germline development.

Khurana JS, Theurkauf W.

J Cell Biol. 2010 Nov 29;191(5):905-13. doi: 10.1083/jcb.201006034. Review.


piRNA function in germline development.

Khurana JS, Theurkauf WE.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2008 Jul 30.


William Theurkauf.

Theurkauf W.

Curr Biol. 2010 May 11;20(9):R389-90. No abstract available.


A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells.

Varmark H, Kwak S, Theurkauf WE.

Cell Cycle. 2010 Jan 15;9(2):312-20. Epub 2010 Jan 23.


The Drosophila HP1 homolog Rhino is required for transposon silencing and piRNA production by dual-strand clusters.

Klattenhoff C, Xi H, Li C, Lee S, Xu J, Khurana JS, Zhang F, Schultz N, Koppetsch BS, Nowosielska A, Seitz H, Zamore PD, Weng Z, Theurkauf WE.

Cell. 2009 Sep 18;138(6):1137-49. doi: 10.1016/j.cell.2009.07.014. Epub 2009 Sep 3.


DNA damage-induced cell death is enhanced by progression through mitosis.

Varmark H, Sparks CA, Nordberg JJ, Koppetsch BS, Theurkauf WE.

Cell Cycle. 2009 Sep 15;8(18):2951-63. Epub 2009 Sep 16.


Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies.

Li C, Vagin VV, Lee S, Xu J, Ma S, Xi H, Seitz H, Horwich MD, Syrzycka M, Honda BM, Kittler EL, Zapp ML, Klattenhoff C, Schulz N, Theurkauf WE, Weng Z, Zamore PD.

Cell. 2009 May 1;137(3):509-21. doi: 10.1016/j.cell.2009.04.027. Epub 2009 Apr 23.


An essential role for the RNA-binding protein Smaug during the Drosophila maternal-to-zygotic transition.

Benoit B, He CH, Zhang F, Votruba SM, Tadros W, Westwood JT, Smibert CA, Lipshitz HD, Theurkauf WE.

Development. 2009 Mar;136(6):923-32. doi: 10.1242/dev.031815.


Components of the RNAi machinery that mediate long-distance chromosomal associations are dispensable for meiotic and early somatic homolog pairing in Drosophila melanogaster.

Blumenstiel JP, Fu R, Theurkauf WE, Hawley RS.

Genetics. 2008 Nov;180(3):1355-65. doi: 10.1534/genetics.108.092650. Epub 2008 Sep 14.


Biogenesis and germline functions of piRNAs.

Klattenhoff C, Theurkauf W.

Development. 2008 Jan;135(1):3-9. Epub 2007 Nov 21. Review.


grp (chk1) replication-checkpoint mutations and DNA damage trigger a Chk2-dependent block at the Drosophila midblastula transition.

Takada S, Kwak S, Koppetsch BS, Theurkauf WE.

Development. 2007 May;134(9):1737-44. Epub 2007 Apr 4.


rasiRNAs, DNA damage, and embryonic axis specification.

Theurkauf WE, Klattenhoff C, Bratu DP, McGinnis-Schultz N, Koppetsch BS, Cook HA.

Cold Spring Harb Symp Quant Biol. 2006;71:171-80.


Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response.

Klattenhoff C, Bratu DP, McGinnis-Schultz N, Koppetsch BS, Cook HA, Theurkauf WE.

Dev Cell. 2007 Jan;12(1):45-55.


Centrosomes in cellular regulation.

Doxsey S, McCollum D, Theurkauf W.

Annu Rev Cell Dev Biol. 2005;21:411-34. Review.


Dynein and the actin cytoskeleton control kinesin-driven cytoplasmic streaming in Drosophila oocytes.

Serbus LR, Cha BJ, Theurkauf WE, Saxton WM.

Development. 2005 Aug;132(16):3743-52.


Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein.

Förstemann K, Tomari Y, Du T, Vagin VV, Denli AM, Bratu DP, Klattenhoff C, Theurkauf WE, Zamore PD.

PLoS Biol. 2005 Jul;3(7):e236. Epub 2005 May 24.


RISC assembly defects in the Drosophila RNAi mutant armitage.

Tomari Y, Du T, Haley B, Schwarz DS, Bennett R, Cook HA, Koppetsch BS, Theurkauf WE, Zamore PD.

Cell. 2004 Mar 19;116(6):831-41.


The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification.

Cook HA, Koppetsch BS, Wu J, Theurkauf WE.

Cell. 2004 Mar 19;116(6):817-29.


Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior.

Cha BJ, Serbus LR, Koppetsch BS, Theurkauf WE.

Nat Cell Biol. 2002 Aug;4(8):592-8.


Arp2/3-dependent pseudocleavage [correction of psuedocleavage] furrow assembly in syncytial Drosophila embryos.

Stevenson V, Hudson A, Cooley L, Theurkauf WE.

Curr Biol. 2002 Apr 30;12(9):705-11.


Development. The message is in the translation.

Richter JD, Theurkauf WE.

Science. 2001 Jul 6;293(5527):60-2. No abstract available.


TACCing down the spindle poles.

Theurkauf WE.

Nat Cell Biol. 2001 Jul;3(7):E159-61. No abstract available.


Centrosomes and the Scrambled protein coordinate microtubule-independent actin reorganization.

Stevenson VA, Kramer J, Kuhn J, Theurkauf WE.

Nat Cell Biol. 2001 Jan;3(1):68-75.


CPEB, maskin, and cyclin B1 mRNA at the mitotic apparatus: implications for local translational control of cell division.

Groisman I, Huang YS, Mendez R, Cao Q, Theurkauf W, Richter JD.

Cell. 2000 Oct 27;103(3):435-47.


Actin cytoskeleton: putting a CAP on actin polymerization.

Stevenson VA, Theurkauf WE.

Curr Biol. 2000 Oct 5;10(19):R695-7. Review.


Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes.

Guilherme A, Emoto M, Buxton JM, Bose S, Sabini R, Theurkauf WE, Leszyk J, Czech MP.

J Biol Chem. 2000 Dec 8;275(49):38151-9.


DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos.

Sibon OC, Kelkar A, Lemstra W, Theurkauf WE.

Nat Cell Biol. 2000 Feb;2(2):90-5.


The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition.

Sibon OC, Laurençon A, Hawley R, Theurkauf WE.

Curr Biol. 1999 Mar 25;9(6):302-12.


Identification and characterization of mitotic mutations in Drosophila.

Theurkauf WE, Heck MM.

Methods Cell Biol. 1999;61:317-46. Review. No abstract available.


Oocyte differentiation: a motor makes a difference.

Theurkauf WE.

Curr Biol. 1997 Sep 1;7(9):R548-51. Review.

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