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NADPH oxidase is the major source of placental superoxide in early pregnancy: association with MAPK pathway activation.

Hernandez I, Fournier T, Chissey A, Therond P, Slama A, Beaudeux JL, Zerrad-Saadi A.

Sci Rep. 2019 Sep 27;9(1):13962. doi: 10.1038/s41598-019-50417-4.


Functional Analysis of ESCRT-Positive Extracellular Vesicles in the Drosophila Wing Imaginal Disc.

Matusek T, Thérond P, Fürthauer M.

Methods Mol Biol. 2019;1998:31-47. doi: 10.1007/978-1-4939-9492-2_3.


Murine platelet production is suppressed by S1P release in the hematopoietic niche, not facilitated by blood S1P sensing.

Niazi H, Zoghdani N, Couty L, Leuci A, Nitzsche A, Allende ML, Mariko B, Ishaq R, Aslan Y, Becker PH, Gazit SL, Poirault-Chassac S, Decouture B, Baudrie V, De Candia E, Kono M, Benarab A, Gaussem P, Tharaux PL, Chun J, Provot S, Debili N, Therond P, Proia RL, Bachelot-Loza C, Camerer E.

Blood Adv. 2019 Jun 11;3(11):1702-1713. doi: 10.1182/bloodadvances.2019031948.


Distinct phospholipid and sphingolipid species are linked to altered HDL function in apolipoprotein A-I deficiency.

Zakiev E, Rached F, Lhomme M, Darabi-Amin M, Ponnaiah M, Becker PH, Therond P, Serrano CV Jr, Santos RD, Chapman MJ, Orekhov A, Kontush A.

J Clin Lipidol. 2019 May - Jun;13(3):468-480.e8. doi: 10.1016/j.jacl.2019.02.004. Epub 2019 Feb 25.


Protein association changes in the Hedgehog signaling complex mediate differential signaling strength.

Giordano C, Ruel L, Poux C, Therond P.

Development. 2018 Dec 12;145(24). pii: dev166850. doi: 10.1242/dev.166850.


Evidence that MRP4 is Only Partly Involved in S1P Secretion during Platelet Activation.

Decouture B, Becker PH, Therond P, Gaussem P, Bachelot-Loza C.

Thromb Haemost. 2018 Jun;118(6):1116-1118. doi: 10.1055/s-0038-1641754. Epub 2018 Apr 18. No abstract available.


Duality of statin action on lipoprotein subpopulations in the mixed dyslipidemia of metabolic syndrome: Quantity vs quality over time and implication of CETP.

Chapman MJ, Orsoni A, Robillard P, Therond P, Giral P.

J Clin Lipidol. 2018 May - Jun;12(3):784-800.e4. doi: 10.1016/j.jacl.2018.02.001. Epub 2018 Feb 9.


Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases.

Gaignard P, Liere P, Thérond P, Schumacher M, Slama A, Guennoun R.

Front Aging Neurosci. 2017 Dec 7;9:406. doi: 10.3389/fnagi.2017.00406. eCollection 2017. Review.


Small dense HDLs display potent vasorelaxing activity, reflecting their elevated content of sphingosine-1-phosphate.

Perségol L, Darabi M, Dauteuille C, Lhomme M, Chantepie S, Rye KA, Therond P, Chapman MJ, Salvayre R, Nègre-Salvayre A, Lesnik P, Monier S, Kontush A.

J Lipid Res. 2018 Jan;59(1):25-34. doi: 10.1194/jlr.M076927. Epub 2017 Nov 17.


Blood lipid tests in 2017.

Couderc R, Antar M, Bonnefont-Rousselot D, Paul JL, Therond P.

Ann Biol Clin (Paris). 2017 Dec 1;75(6):646-652. doi: 10.1684/abc.2017.1303. Review.


Impact of mutations within the [Fe-S] cluster or the lipoic acid biosynthesis pathways on mitochondrial protein expression profiles in fibroblasts from patients.

Lebigot E, Gaignard P, Dorboz I, Slama A, Rio M, de Lonlay P, Héron B, Sabourdy F, Boespflug-Tanguy O, Cardoso A, Habarou F, Ottolenghi C, Thérond P, Bouton C, Golinelli-Cohen MP, Boutron A.

Mol Genet Metab. 2017 Nov;122(3):85-94. doi: 10.1016/j.ymgme.2017.08.001. Epub 2017 Aug 3.


Troponin elevation in other conditions than acute coronary syndromes.

Masri W, Le Guillou E, Hamdi E, Ghazal K, Lebigot E, Cosson C, Cynober FB, Therond P.

Ann Biol Clin (Paris). 2017 Aug 1;75(4):411-419. doi: 10.1684/abc.2017.1262.


Sex differences in brain mitochondrial metabolism: influence of endogenous steroids and stroke.

Gaignard P, Fréchou M, Liere P, Thérond P, Schumacher M, Slama A, Guennoun R.

J Neuroendocrinol. 2018 Feb;30(2). doi: 10.1111/jne.12497. Review.


Structure-function relationships in reconstituted HDL: Focus on antioxidative activity and cholesterol efflux capacity.

Cukier AMO, Therond P, Didichenko SA, Guillas I, Chapman MJ, Wright SD, Kontush A.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):890-900. doi: 10.1016/j.bbalip.2017.05.010. Epub 2017 May 18.


UQCRC2 mutation in a patient with mitochondrial complex III deficiency causing recurrent liver failure, lactic acidosis and hypoglycemia.

Gaignard P, Eyer D, Lebigot E, Oliveira C, Therond P, Boutron A, Slama A.

J Hum Genet. 2017 Jul;62(7):729-731. doi: 10.1038/jhg.2017.22. Epub 2017 Mar 9.


Statin action enriches HDL3 in polyunsaturated phospholipids and plasmalogens and reduces LDL-derived phospholipid hydroperoxides in atherogenic mixed dyslipidemia.

Orsoni A, Thérond P, Tan R, Giral P, Robillard P, Kontush A, Meikle PJ, Chapman MJ.

J Lipid Res. 2016 Nov;57(11):2073-2087. Epub 2016 Aug 31.


Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

Touat-Hamici Z, Weidmann H, Blum Y, Proust C, Durand H, Iannacci F, Codoni V, Gaignard P, Thérond P, Civelek M, Karabina SA, Lusis AJ, Cambien F, Ninio E.

Cardiovasc Res. 2016 Dec;112(3):702-713. Epub 2016 Sep 30.


Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock.

Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, Chun J, Coughlin SR, Bachelot-Loza C, Hla T, Ho-Tin-Noé B, Camerer E.

Circ Res. 2016 Sep 30;119(8):e110-26. doi: 10.1161/CIRCRESAHA.116.308929. Epub 2016 Aug 31.


Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112: Effects on Cholesterol Efflux, Anti-Inflammatory and Antioxidative Activity.

Didichenko SA, Navdaev AV, Cukier AM, Gille A, Schuetz P, Spycher MO, Thérond P, Chapman MJ, Kontush A, Wright SD.

Circ Res. 2016 Sep 2;119(6):751-63. doi: 10.1161/CIRCRESAHA.116.308685. Epub 2016 Jul 19.


Small, dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis.

Hussein H, Saheb S, Couturier M, Atassi M, Orsoni A, Carrié A, Therond P, Chantepie S, Robillard P, Bruckert E, Chapman MJ, Kontush A.

J Clin Lipidol. 2016 Jan-Feb;10(1):124-33. doi: 10.1016/j.jacl.2015.10.006. Epub 2015 Oct 17.


Progesterone reduces brain mitochondrial dysfunction after transient focal ischemia in male and female mice.

Gaignard P, Fréchou M, Schumacher M, Thérond P, Mattern C, Slama A, Guennoun R.

J Cereb Blood Flow Metab. 2016 Mar;36(3):562-8. doi: 10.1177/0271678X15610338. Epub 2015 Oct 14.


Formaldehyde Crosses the Human Placenta and Affects Human Trophoblast Differentiation and Hormonal Functions.

Pidoux G, Gerbaud P, Guibourdenche J, Thérond P, Ferreira F, Simasotchi C, Evain-Brion D, Gil S.

PLoS One. 2015 Jul 17;10(7):e0133506. doi: 10.1371/journal.pone.0133506. eCollection 2015.


Effect of Sex Differences on Brain Mitochondrial Function and Its Suppression by Ovariectomy and in Aged Mice.

Gaignard P, Savouroux S, Liere P, Pianos A, Thérond P, Schumacher M, Slama A, Guennoun R.

Endocrinology. 2015 Aug;156(8):2893-904. doi: 10.1210/en.2014-1913. Epub 2015 Jun 3.


Endocytosis of Hedgehog through dispatched regulates long-range signaling.

D'Angelo G, Matusek T, Pizette S, Thérond PP.

Dev Cell. 2015 Feb 9;32(3):290-303. doi: 10.1016/j.devcel.2014.12.004. Epub 2015 Jan 22.


Fructose 1,6-bisphosphatase deficiency: clinical, biochemical and genetic features in French patients.

Lebigot E, Brassier A, Zater M, Imanci D, Feillet F, Thérond P, de Lonlay P, Boutron A.

J Inherit Metab Dis. 2015 Sep;38(5):881-7. doi: 10.1007/s10545-014-9804-6. Epub 2015 Jan 20.


The ESCRT machinery regulates the secretion and long-range activity of Hedgehog.

Matusek T, Wendler F, Polès S, Pizette S, D'Angelo G, Fürthauer M, Thérond PP.

Nature. 2014 Dec 4;516(7529):99-103. doi: 10.1038/nature13847.


Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.

Ranieri N, Thérond PP, Ruel L.

Nat Commun. 2014 Oct 7;5:5034. doi: 10.1038/ncomms6034.


Liver transcript analysis reveals aberrant splicing due to silent and intronic variations in the ABCB11 gene.

Davit-Spraul A, Oliveira C, Gonzales E, Gaignard P, Thérond P, Jacquemin E.

Mol Genet Metab. 2014 Nov;113(3):225-9. doi: 10.1016/j.ymgme.2014.07.006. Epub 2014 Jul 15.


Resveratrol self-emulsifying system increases the uptake by endothelial cells and improves protection against oxidative stress-mediated death.

Amri A, Le Clanche S, Thérond P, Bonnefont-Rousselot D, Borderie D, Lai-Kuen R, Chaumeil JC, Sfar S, Charrueau C.

Eur J Pharm Biopharm. 2014 Apr;86(3):418-26. doi: 10.1016/j.ejpb.2013.10.015. Epub 2013 Oct 31.


The mechanisms of Hedgehog signalling and its roles in development and disease.

Briscoe J, Thérond PP.

Nat Rev Mol Cell Biol. 2013 Jul;14(7):416-29. doi: 10.1038/nrm3598. Epub 2013 May 30. Review.


Mitochondrial Infantile Liver Disease due to TRMU Gene Mutations: Three New Cases.

Gaignard P, Gonzales E, Ackermann O, Labrune P, Correia I, Therond P, Jacquemin E, Slama A.

JIMD Rep. 2013;11:117-23. doi: 10.1007/8904_2013_230. Epub 2013 Apr 27.


Fibrate treatment induced quantitative and qualitative HDL changes associated with an increase of SR-BI cholesterol efflux capacities in rabbits.

Fournier N, Tuloup-Minguez V, Pourci ML, Thérond P, Jullian JC, Wien F, Leroy M, Dallongeville J, Paul JL, Leroy A.

Biochimie. 2013 Jun;95(6):1278-87. doi: 10.1016/j.biochi.2013.02.001. Epub 2013 Feb 11.


Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling.

Ayers KL, Mteirek R, Cervantes A, Lavenant-Staccini L, Thérond PP, Gallet A.

Development. 2012 Sep;139(17):3168-79. doi: 10.1242/dev.078402.


Penetration of resveratrol into bovine aortic endothelial cells (BAEC): a possible passive diffusion.

Frombaum M, Le Clanche S, Thérond P, Nubret E, Bonnefont-Rousselot D, Borderie D.

C R Biol. 2012 Apr;335(4):247-52. doi: 10.1016/j.crvi.2012.03.013. Epub 2012 Apr 28.


A genome-wide RNAi screen identifies regulators of cholesterol-modified hedgehog secretion in Drosophila.

Aikin R, Cervantes A, D'Angelo G, Ruel L, Lacas-Gervais S, Schaub S, Thérond P.

PLoS One. 2012;7(3):e33665. doi: 10.1371/journal.pone.0033665. Epub 2012 Mar 14.


Release and transportation of Hedgehog molecules.

Thérond PP.

Curr Opin Cell Biol. 2012 Apr;24(2):173-80. doi: 10.1016/ Epub 2012 Feb 24. Review.


Distinct phosphorylations on kinesin costal-2 mediate differential hedgehog signaling strength.

Ranieri N, Ruel L, Gallet A, Raisin S, Thérond PP.

Dev Cell. 2012 Feb 14;22(2):279-94. doi: 10.1016/j.devcel.2011.12.002. Epub 2012 Feb 2.


Radical-induced oxidation of trans-resveratrol.

Camont L, Collin F, Couturier M, Thérond P, Jore D, Gardès-Albert M, Bonnefont-Rousselot D.

Biochimie. 2012 Mar;94(3):741-7. doi: 10.1016/j.biochi.2011.11.005. Epub 2011 Nov 20.


Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: the positive effect of long-term aspirin treatment.

Arfi A, Richard M, Gandolphe C, Bonnefont-Rousselot D, Thérond P, Scherman D.

Mol Genet Metab. 2011 May;103(1):18-25. doi: 10.1016/j.ymgme.2011.01.015. Epub 2011 Feb 3.


Piceatannol is more effective than resveratrol in restoring endothelial cell dimethylarginine dimethylaminohydrolase expression and activity after high-glucose oxidative stress.

Frombaum M, Therond P, Djelidi R, Beaudeux JL, Bonnefont-Rousselot D, Borderie D.

Free Radic Res. 2011 Mar;45(3):293-302. doi: 10.3109/10715762.2010.527337. Epub 2011 Jan 14.


Experimental evidence of the reciprocal oxidation of Bovine Serum Albumin and Linoleate in aqueous solution, initiated by HO* free radicals.

Collin F, Hindo J, Thérond P, Couturier M, Cosson C, Jore D, Gardès-Albert M.

Biochimie. 2010 Sep;92(9):1130-7. doi: 10.1016/j.biochi.2010.05.017. Epub 2010 Jun 4.


Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling.

Raisin S, Ruel L, Ranieri N, Staccini-Lavenant L, Thérond PP.

Dev Biol. 2010 Aug 1;344(1):119-28. doi: 10.1016/j.ydbio.2010.04.021. Epub 2010 May 9.


The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum.

Ayers KL, Gallet A, Staccini-Lavenant L, Thérond PP.

Dev Cell. 2010 Apr 20;18(4):605-20. doi: 10.1016/j.devcel.2010.02.015.


Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling.

Ayers KL, Thérond PP.

Trends Cell Biol. 2010 May;20(5):287-98. doi: 10.1016/j.tcb.2010.02.002. Epub 2010 Mar 5. Review.


Protective effect of post-ischemic treatment with trans-resveratrol on cytokine production and neutrophil recruitment by rat liver.

Hassan-Khabbar S, Vamy M, Cottart CH, Wendum D, Vibert F, Savouret JF, Thérond P, Clot JP, Waligora AJ, Nivet-Antoine V.

Biochimie. 2010 Apr;92(4):405-10. doi: 10.1016/j.biochi.2009.12.009. Epub 2009 Dec 24.


The full-length unprocessed hedgehog protein is an active signaling molecule.

Tokhunts R, Singh S, Chu T, D'Angelo G, Baubet V, Goetz JA, Huang Z, Yuan Z, Ascano M, Zavros Y, Thérond PP, Kunes S, Dahmane N, Robbins DJ.

J Biol Chem. 2010 Jan 22;285(4):2562-8. doi: 10.1074/jbc.M109.078626. Epub 2009 Nov 17.


Imatinib assay by HPLC with photodiode-array UV detection in plasma from patients with chronic myeloid leukemia: Comparison with LC-MS/MS.

Roth O, Spreux-Varoquaux O, Bouchet S, Rousselot P, Castaigne S, Rigaudeau S, Raggueneau V, Therond P, Devillier P, Molimard M, Maneglier B.

Clin Chim Acta. 2010 Feb;411(3-4):140-6. doi: 10.1016/j.cca.2009.10.007. Epub 2009 Oct 22.


HDL3-mediated inactivation of LDL-associated phospholipid hydroperoxides is determined by the redox status of apolipoprotein A-I and HDL particle surface lipid rigidity: relevance to inflammation and atherogenesis.

Zerrad-Saadi A, Therond P, Chantepie S, Couturier M, Rye KA, Chapman MJ, Kontush A.

Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2169-75. doi: 10.1161/ATVBAHA.109.194555. Epub 2009 Sep 17.


Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli.

Ruel L, Thérond PP.

Genes Dev. 2009 Aug 15;23(16):1843-8. doi: 10.1101/gad.1838109.


Modulation of indoleamine-2,3-dioxygenase expression and activity by HIV-1 in human macrophages.

Manéglier B, Malleret B, Guillemin GJ, Spreux-Varoquaux O, Devillier P, Rogez-Kreuz C, Porcheray F, Thérond P, Dormont D, Clayette P.

Fundam Clin Pharmacol. 2009 Oct;23(5):573-81. doi: 10.1111/j.1472-8206.2009.00703.x. Epub 2009 Jul 28.


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