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FIGO position paper: how to stop the caesarean section epidemic.

Visser GHA, Ayres-de-Campos D, Barnea ER, de Bernis L, Di Renzo GC, Vidarte MFE, Lloyd I, Nassar AH, Nicholson W, Shah PK, Stones W, Sun L, Theron GB, Walani S.

Lancet. 2018 Oct 13;392(10155):1286-1287. doi: 10.1016/S0140-6736(18)32113-5. No abstract available.


Congenital Cytomegalovirus and HIV Perinatal Transmission.

Adachi K, Xu J, Ank B, Watts DH, Camarca M, Mofenson LM, Pilotto JH, Joao E, Gray G, Theron G, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Machado DM, Ceriotto M, Morgado MG, Bryson YJ, Veloso VG, Grinsztejn B, Mirochnick M, Moye J, Nielsen-Saines K; MPH for the NICHD HPTN 040 Study Team.

Pediatr Infect Dis J. 2018 Oct;37(10):1016-1021. doi: 10.1097/INF.0000000000001975.


Evaluation of the airway microbiome in non-tuberculous mycobacteria.

Sulaiman I, Wu BG, Li Y, Scott AS, Malecha P, Scaglione B, Wang J, Basavaraj A, Chung S, Bantis K, Carpenito J, Clemente JC, Shen N, Bessich J, Rafeq S, Michaud G, Donington J, Naidoo C, Theron G, Schattner G, Garofano S, Condos R, Kamelhar D, Addrizzo-Harris D, Segal LN.

Eur Respir J. 2018 Aug 9. pii: 1800810. doi: 10.1183/13993003.00810-2018. [Epub ahead of print]


Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial.

Cluver CA, Hannan NJ, van Papendorp E, Hiscock R, Beard S, Mol BW, Theron GB, Hall DR, Decloedt EH, Stander M, Adams KT, Rensburg M, Schubert P, Walker SP, Tong S.

Am J Obstet Gynecol. 2018 Oct;219(4):388.e1-388.e17. doi: 10.1016/j.ajog.2018.07.019. Epub 2018 Jul 26.


Direct genotyping of Mycobacterium tuberculosis from Xpert® MTB/RIF remnants.

Mambuque ET, Abascal E, Venter R, Bulo H, Bouza E, Theron G, García-Basteiro AL, García-de-Viedma D.

Tuberculosis (Edinb). 2018 Jul;111:202-206. doi: 10.1016/ Epub 2018 May 15.


Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug-Resistant Tuberculosis.

de Vos M, Derendinger B, Dolby T, Simpson J, van Helden PD, Rice JE, Wangh LJ, Theron G, Warren RM.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00531-18. doi: 10.1128/JCM.00531-18. Print 2018 Sep.


Commercial products to preserve specimens for tuberculosis diagnosis: a systematic review.

Reeve BWP, McFall SM, Song R, Warren R, Steingart KR, Theron G.

Int J Tuberc Lung Dis. 2018 Jul 1;22(7):741-753. doi: 10.5588/ijtld.17.0816.


Management of postpartum hemorrhage with free-flow pressure controlled uterine balloon.

Theron GB.

Int J Gynaecol Obstet. 2018 Sep;142(3):371-373. doi: 10.1002/ijgo.12533. Epub 2018 Jun 15. No abstract available.


Infectious Morbidity, Mortality and Nutrition in HIV-Exposed, Uninfected, Formula Fed Infants: Results from the HPTN 040/PACTG 1043 Trial.

Yeganeh N, Watts DH, Xu J, Kerin T, Joao EC, Pilotto JH, Theron G, Gray G, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Veloso V, Camarca M, Mofenson L, Moye J, Nielsen-Saines K.

Pediatr Infect Dis J. 2018 May 10. doi: 10.1097/INF.0000000000002082. [Epub ahead of print]


Correlation of Xpert MTB/RIF with measures to assess Mycobacterium tuberculosis bacillary burden in high HIV burden areas of Southern Africa.

Beynon F, Theron G, Respeito D, Mambuque E, Saavedra B, Bulo H, Sanz S, Dheda K, Garcia-Basteiro AL.

Sci Rep. 2018 Mar 26;8(1):5201. doi: 10.1038/s41598-018-23066-2.


Of Testing and Treatment: Implications of Implementing New Regimens for Multidrug-Resistant Tuberculosis.

Dowdy DW, Theron G, Tornheim JA, Warren R, Kendall EA.

Clin Infect Dis. 2017 Oct 1;65(7):1206-1211. doi: 10.1093/cid/cix486.


Detection of tuberculosis by automatic cough sound analysis.

Botha GHR, Theron G, Warren RM, Klopper M, Dheda K, van Helden PD, Niesler TR.

Physiol Meas. 2018 Apr 26;39(4):045005. doi: 10.1088/1361-6579/aab6d0.


Widespread use of incorrect PCR ramp rate negatively impacts multidrug-resistant tuberculosis diagnosis (MTBDRplus).

Derendinger B, de Vos M, Nathavitharana RR, Dolby T, Simpson JA, van Helden PD, Warren RM, Theron G.

Sci Rep. 2018 Feb 16;8(1):3206. doi: 10.1038/s41598-018-21458-y.


Point of care diagnostics for tuberculosis.

García-Basteiro AL, DiNardo A, Saavedra B, Silva DR, Palmero D, Gegia M, Migliori GB, Duarte R, Mambuque E, Centis R, Cuevas LE, Izco S, Theron G.

Pulmonology. 2018 Mar - Apr;24(2):73-85. doi: 10.1016/j.rppnen.2017.12.002. Epub 2018 Feb 14.


False-Positive Xpert MTB/RIF Results in Retested Patients with Previous Tuberculosis: Frequency, Profile, and Prospective Clinical Outcomes.

Theron G, Venter R, Smith L, Esmail A, Randall P, Sood V, Oelfese S, Calligaro G, Warren R, Dheda K.

J Clin Microbiol. 2018 Feb 22;56(3). pii: e01696-17. doi: 10.1128/JCM.01696-17. Print 2018 Mar.


Combined evaluation of sexually transmitted infections in HIV-infected pregnant women and infant HIV transmission.

Adachi K, Xu J, Yeganeh N, Camarca M, Morgado MG, Watts DH, Mofenson LM, Veloso VG, Pilotto JH, Joao E, Gray G, Theron G, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Ceriotto M, Machado DM, Bryson YJ, Grinsztejn B, Moye J, Klausner JD, Bristow CC, Dickover R, Mirochnick M, Nielsen-Saines K; NICHD HPTN 040 Study Team.

PLoS One. 2018 Jan 5;13(1):e0189851. doi: 10.1371/journal.pone.0189851. eCollection 2018.


Human Immunodeficiency Virus Antiretroviral Resistance and Transmission in Mother-Infant Pairs Enrolled in a Large Perinatal Study.

Yeganeh N, Kerin T, Ank B, Watts DH, Camarca M, Joao EC, Pilotto JH, Veloso VG, Bryson Y, Gray G, Theron G, Dickover R, Morgado MG, Santos B, Kreitchmann R, Mofenson L, Nielsen-Saines K.

Clin Infect Dis. 2018 May 17;66(11):1770-1777. doi: 10.1093/cid/cix1104.


Prevention of HIV-1 Transmission Through Breastfeeding: Efficacy and Safety of Maternal Antiretroviral Therapy Versus Infant Nevirapine Prophylaxis for Duration of Breastfeeding in HIV-1-Infected Women With High CD4 Cell Count (IMPAACT PROMISE): A Randomized, Open-Label, Clinical Trial.

Flynn PM, Taha TE, Cababasay M, Fowler MG, Mofenson LM, Owor M, Fiscus S, Stranix-Chibanda L, Coutsoudis A, Gnanashanmugam D, Chakhtoura N, McCarthy K, Mukuzunga C, Makanani B, Moodley D, Nematadzira T, Kusakara B, Patil S, Vhembo T, Bobat R, Mmbaga BT, Masenya M, Nyati M, Theron G, Mulenga H, Butler K, Shapiro DE; PROMISE Study Team.

J Acquir Immune Defic Syndr. 2018 Apr 1;77(4):383-392. doi: 10.1097/QAI.0000000000001612.


The South African Tuberculosis Care Cascade: Estimated Losses and Methodological Challenges.

Naidoo P, Theron G, Rangaka MX, Chihota VN, Vaughan L, Brey ZO, Pillay Y.

J Infect Dis. 2017 Nov 6;216(suppl_7):S702-S713. doi: 10.1093/infdis/jix335.


Mycobacterial genomic DNA from used Xpert MTB/RIF cartridges can be utilised for accurate second-line genotypic drug susceptibility testing and spoligotyping.

Venter R, Derendinger B, de Vos M, Pillay S, Dolby T, Simpson J, Kitchin N, Ruiters A, van Helden PD, Warren RM, Theron G.

Sci Rep. 2017 Nov 1;7(1):14854. doi: 10.1038/s41598-017-14385-x.


Mycobacterium tuberculosis Subculture Results in Loss of Potentially Clinically Relevant Heteroresistance.

Metcalfe JZ, Streicher E, Theron G, Colman RE, Penaloza R, Allender C, Lemmer D, Warren RM, Engelthaler DM.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00888-17. doi: 10.1128/AAC.00888-17. Print 2017 Nov.


Point-of-care screening for hepatitis B virus infection in pregnant women at an antenatal clinic: A South African experience.

Chotun N, Preiser W, van Rensburg CJ, Fernandez P, Theron GB, Glebe D, Andersson MI.

PLoS One. 2017 Jul 21;12(7):e0181267. doi: 10.1371/journal.pone.0181267. eCollection 2017.


Cryptic Microheteroresistance Explains Mycobacterium tuberculosis Phenotypic Resistance.

Metcalfe JZ, Streicher E, Theron G, Colman RE, Allender C, Lemmer D, Warren R, Engelthaler DM.

Am J Respir Crit Care Med. 2017 Nov 1;196(9):1191-1201. doi: 10.1164/rccm.201703-0556OC.


Drug-resistant tuberculosis in patients with minimal symptoms: favourable outcomes in the absence of treatment.

Loveday M, Ramjee A, Osburn G, Master I, Kabera G, Brust JC, Padayatchi N, Warren R, Theron G.

Int J Tuberc Lung Dis. 2017 May 1;21(5):556-563. doi: 10.5588/ijtld.16.0779.


Diagnostic accuracy of the Xpert® MTB/RIF cycle threshold level to predict smear positivity: a meta-analysis.

Lange B, Khan P, Kalmambetova G, Al-Darraji HA, Alland D, Antonenka U, Brown T, Balcells ME, Blakemore R, Denkinger CM, Dheda K, Hoffmann H, Kadyrov A, Lemaitre N, Miller MB, Nikolayevskyy V, Ntinginya EN, Ozkutuk N, Palacios JJ, Popowitch EB, Porcel JM, Teo J, Theron G, Kranzer K.

Int J Tuberc Lung Dis. 2017 May 1;21(5):493-502. doi: 10.5588/ijtld.16.0702. Review.


Cytomegalovirus Urinary Shedding in HIV-infected Pregnant Women and Congenital Cytomegalovirus Infection.

Adachi K, Xu J, Ank B, Watts DH, Mofenson LM, Pilotto JH, Joao E, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Gray G, Theron G, Morgado MG, Bryson YJ, Veloso VG, Klausner JD, Moye J, Nielsen-Saines K; NICHD HPTN 040 Study Team.

Clin Infect Dis. 2017 Aug 1;65(3):405-413. doi: 10.1093/cid/cix222.


The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis.

Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M, Furin J, Nardell EA, London L, Lessem E, Theron G, van Helden P, Niemann S, Merker M, Dowdy D, Van Rie A, Siu GK, Pasipanodya JG, Rodrigues C, Clark TG, Sirgel FA, Esmail A, Lin HH, Atre SR, Schaaf HS, Chang KC, Lange C, Nahid P, Udwadia ZF, Horsburgh CR Jr, Churchyard GJ, Menzies D, Hesseling AC, Nuermberger E, McIlleron H, Fennelly KP, Goemaere E, Jaramillo E, Low M, Jara CM, Padayatchi N, Warren RM.

Lancet Respir Med. 2017 Mar 15. pii: S2213-2600(17)30079-6. doi: 10.1016/S2213-2600(17)30079-6. [Epub ahead of print] Review.


Drug-resistant tuberculosis in 2017: at a crossroads.

Dowdy DW, Theron G, Tornheim JA, Kendall EA.

Lancet Respir Med. 2017 Mar 15. pii: S2213-2600(17)30081-4. doi: 10.1016/S2213-2600(17)30081-4. [Epub ahead of print] No abstract available.


Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study.

Dheda K, Limberis JD, Pietersen E, Phelan J, Esmail A, Lesosky M, Fennelly KP, Te Riele J, Mastrapa B, Streicher EM, Dolby T, Abdallah AM, Ben-Rached F, Simpson J, Smith L, Gumbo T, van Helden P, Sirgel FA, McNerney R, Theron G, Pain A, Clark TG, Warren RM.

Lancet Respir Med. 2017 Apr;5(4):269-281. doi: 10.1016/S2213-2600(16)30433-7. Epub 2017 Jan 19.


Effect of new tuberculosis diagnostic technologies on community-based intensified case finding: a multicentre randomised controlled trial.

Calligaro GL, Zijenah LS, Peter JG, Theron G, Buser V, McNerney R, Bara W, Bandason T, Govender U, Tomasicchio M, Smith L, Mayosi BM, Dheda K.

Lancet Infect Dis. 2017 Apr;17(4):441-450. doi: 10.1016/S1473-3099(16)30384-X. Epub 2017 Jan 5.


Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention.

Fowler MG, Qin M, Fiscus SA, Currier JS, Flynn PM, Chipato T, McIntyre J, Gnanashanmugam D, Siberry GK, Coletti AS, Taha TE, Klingman KL, Martinson FE, Owor M, Violari A, Moodley D, Theron GB, Bhosale R, Bobat R, Chi BH, Strehlau R, Mlay P, Loftis AJ, Browning R, Fenton T, Purdue L, Basar M, Shapiro DE, Mofenson LM; IMPAACT 1077BF/1077FF PROMISE Study Team.

N Engl J Med. 2016 Nov 3;375(18):1726-1737.


The diagnostic accuracy of pericardial and urinary lipoarabinomannan (LAM) assays in patients with suspected tuberculous pericarditis.

Pandie S, Peter JG, Kerbelker ZS, Meldau R, Theron G, Govender U, Ntsekhe M, Dheda K, Mayosi BM.

Sci Rep. 2016 Sep 16;6:32924. doi: 10.1038/srep32924.


GenoType® MTBDRsl assay for resistance to second-line anti-tuberculosis drugs.

Theron G, Peter J, Richardson M, Warren R, Dheda K, Steingart KR.

Cochrane Database Syst Rev. 2016 Sep 8;9:CD010705. doi: 10.1002/14651858.CD010705.pub3. Review.


Acceptability and feasibility of mHealth and community-based directly observed antiretroviral therapy to prevent mother-to-child HIV transmission in South African pregnant women under Option B+: an exploratory study.

Nachega JB, Skinner D, Jennings L, Magidson JF, Altice FL, Burke JG, Lester RT, Uthman OA, Knowlton AR, Cotton MF, Anderson JR, Theron GB.

Patient Prefer Adherence. 2016 Apr 28;10:683-90. doi: 10.2147/PPA.S100002. eCollection 2016.


Chlamydia trachomatis and Neisseria gonorrhoeae in HIV-infected Pregnant Women and Adverse Infant Outcomes.

Adachi K, Klausner JD, Xu J, Ank B, Bristow CC, Morgado MG, Watts DH, Weir F, Persing D, Mofenson LM, Veloso VG, Pilotto JH, Joao E, Gray G, Theron G, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Ceriotto M, Machado DM, Bryson YJ, Grinsztejn B, Bastos FI, Siberry G, Nielsen-Saines K; NICHD HPTN 040 Study Team.

Pediatr Infect Dis J. 2016 Aug;35(8):894-900. doi: 10.1097/INF.0000000000001199.


An automated tuberculosis screening strategy combining X-ray-based computer-aided detection and clinical information.

Melendez J, Sánchez CI, Philipsen RH, Maduskar P, Dawson R, Theron G, Dheda K, van Ginneken B.

Sci Rep. 2016 Apr 29;6:25265. doi: 10.1038/srep25265.


Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic, parallel-group, multicountry, open-label, randomised controlled trial.

Peter JG, Zijenah LS, Chanda D, Clowes P, Lesosky M, Gina P, Mehta N, Calligaro G, Lombard CJ, Kadzirange G, Bandason T, Chansa A, Liusha N, Mangu C, Mtafya B, Msila H, Rachow A, Hoelscher M, Mwaba P, Theron G, Dheda K.

Lancet. 2016 Mar 19;387(10024):1187-97. doi: 10.1016/S0140-6736(15)01092-2. Epub 2016 Mar 10.


Xpert MTB/RIF Results in Patients With Previous Tuberculosis: Can We Distinguish True From False Positive Results?

Theron G, Venter R, Calligaro G, Smith L, Limberis J, Meldau R, Chanda D, Esmail A, Peter J, Dheda K.

Clin Infect Dis. 2016 Apr 15;62(8):995-1001. doi: 10.1093/cid/civ1223. Epub 2016 Feb 16.


The diagnostic accuracy of the MTBDRplus and MTBDRsl assays for drug-resistant TB detection when performed on sputum and culture isolates.

Tomasicchio M, Theron G, Pietersen E, Streicher E, Stanley-Josephs D, van Helden P, Warren R, Dheda K.

Sci Rep. 2016 Feb 10;6:17850. doi: 10.1038/srep17850.


Sensitivity of C-Tb: a novel RD-1-specific skin test for the diagnosis of tuberculosis infection.

Hoff ST, Peter JG, Theron G, Pascoe M, Tingskov PN, Aggerbeck H, Kolbus D, Ruhwald M, Andersen P, Dheda K.

Eur Respir J. 2016 Mar;47(3):919-28. doi: 10.1183/13993003.01464-2015. Epub 2015 Dec 17.


Data for action: collection and use of local data to end tuberculosis.

Theron G, Jenkins HE, Cobelens F, Abubakar I, Khan AJ, Cohen T, Dowdy DW.

Lancet. 2015 Dec 5;386(10010):2324-33. doi: 10.1016/S0140-6736(15)00321-9. Epub 2015 Oct 26. Review.


Double blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset pre-eclampsia (PIE Trial): a study protocol.

Cluver CA, Walker SP, Mol BW, Theron GB, Hall DR, Hiscock R, Hannan N, Tong S.

BMJ Open. 2015 Oct 28;5(10):e008211. doi: 10.1136/bmjopen-2015-008211.


Automated chest-radiography as a triage for Xpert testing in resource-constrained settings: a prospective study of diagnostic accuracy and costs.

Philipsen RH, Sánchez CI, Maduskar P, Melendez J, Peters-Bax L, Peter JG, Dawson R, Theron G, Dheda K, van Ginneken B.

Sci Rep. 2015 Jul 27;5:12215. doi: 10.1038/srep12215.


Burden of tuberculosis in intensive care units in Cape Town, South Africa, and assessment of the accuracy and effect on patient outcomes of the Xpert MTB/RIF test on tracheal aspirate samples for diagnosis of pulmonary tuberculosis: a prospective burden of disease study with a nested randomised controlled trial.

Calligaro GL, Theron G, Khalfey H, Peter J, Meldau R, Matinyenya B, Davids M, Smith L, Pooran A, Lesosky M, Esmail A, Miller MG, Piercy J, Michell L, Dawson R, Raine RI, Joubert I, Dheda K.

Lancet Respir Med. 2015 Aug;3(8):621-30. doi: 10.1016/S2213-2600(15)00198-8. Epub 2015 Jul 22.


Test characteristics and potential impact of the urine LAM lateral flow assay in HIV-infected outpatients under investigation for TB and able to self-expectorate sputum for diagnostic testing.

Peter J, Theron G, Chanda D, Clowes P, Rachow A, Lesosky M, Hoelscher M, Mwaba P, Pym A, Dheda K; TB-NEAT team.

BMC Infect Dis. 2015 Jul 9;15:262. doi: 10.1186/s12879-015-0967-z.


Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study.

Theron G, Peter J, Zijenah L, Chanda D, Mangu C, Clowes P, Rachow A, Lesosky M, Hoelscher M, Pym A, Mwaba P, Mason P, Naidoo P, Pooran A, Sohn H, Pai M, Stein DJ, Dheda K.

BMC Infect Dis. 2015 Jul 1;15:253. doi: 10.1186/s12879-015-0964-2.


Mother-to-child transmission of hepatitis B virus in sub-Saharan Africa: time to act.

Andersson MI, Rajbhandari R, Kew MC, Vento S, Preiser W, Hoepelman AI, Theron G, Cotton M, Cohn J, Glebe D, Lesi O, Thursz M, Peters M, Chung R, Wiysonge C.

Lancet Glob Health. 2015 Jul;3(7):e358-9. doi: 10.1016/S2214-109X(15)00056-X. No abstract available.


Impact of tuberculosis treatment and antiretroviral therapy on serial RD-1-specific quantitative T-cell readouts (QuantiFERON-TB Gold In-Tube), and relationship to treatment-related outcomes and bacterial burden.

Mthiyane T, Rustomjee R, Pym A, Connolly C, Onyebujoh P, Theron G, Dheda K.

Int J Infect Dis. 2015 Jul;36:46-53. doi: 10.1016/j.ijid.2015.05.006. Epub 2015 May 21.


Xpert MTB/RIF to diagnose tuberculosis in children.

Theron G.

Lancet Respir Med. 2015 Jun;3(6):419-21. doi: 10.1016/S2213-2600(15)00111-3. Epub 2015 Mar 24. No abstract available.


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