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Emerging Role of Cellular Prion Protein in the Maintenance and Expansion of Glioma Stem Cells.

Thellung S, Corsaro A, Bosio AG, Zambito M, Barbieri F, Mazzanti M, Florio T.

Cells. 2019 Nov 18;8(11). pii: E1458. doi: 10.3390/cells8111458. Review.


Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms.

Gatto F, Barbieri F, Arvigo M, Thellung S, Amarù J, Albertelli M, Ferone D, Florio T.

Int J Mol Sci. 2019 Aug 13;20(16). pii: E3940. doi: 10.3390/ijms20163940. Review.


Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity.

Thellung S, Corsaro A, Nizzari M, Barbieri F, Florio T.

Int J Mol Sci. 2019 Feb 19;20(4). pii: E901. doi: 10.3390/ijms20040901. Review.


In Silico Identification and Experimental Validation of Novel Anti-Alzheimer's Multitargeted Ligands from a Marine Source Featuring a "2-Aminoimidazole plus Aromatic Group" Scaffold.

Vitale RM, Rispoli V, Desiderio D, Sgammato R, Thellung S, Canale C, Vassalli M, Carbone M, Ciavatta ML, Mollo E, Felicità V, Arcone R, Gavagnin Capoggiani M, Masullo M, Florio T, Amodeo P.

ACS Chem Neurosci. 2018 Jun 20;9(6):1290-1303. doi: 10.1021/acschemneuro.7b00416. Epub 2018 Mar 7.


Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death.

Thellung S, Scoti B, Corsaro A, Villa V, Nizzari M, Gagliani MC, Porcile C, Russo C, Pagano A, Tacchetti C, Cortese K, Florio T.

Cell Death Dis. 2018 Feb 7;9(2):166. doi: 10.1038/s41419-017-0252-8.


In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity.

Gatti M, Solari A, Pattarozzi A, Campanella C, Thellung S, Maniscalco L, De Maria R, Würth R, Corsaro A, Bajetto A, Ratto A, Ferrari A, Daga A, Barbieri F, Florio T.

Exp Cell Res. 2018 Feb 1;363(1):48-64. doi: 10.1016/j.yexcr.2018.01.002. Epub 2018 Jan 4.


Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90-231 Neurotoxic Effects in Cerebellar Granule Neurons.

Thellung S, Gatta E, Pellistri F, Villa V, Corsaro A, Nizzari M, Robello M, Florio T.

Neurotox Res. 2017 Oct;32(3):381-397. doi: 10.1007/s12640-017-9749-2. Epub 2017 May 25.


Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells.

Corsaro A, Bajetto A, Thellung S, Begani G, Villa V, Nizzari M, Pattarozzi A, Solari A, Gatti M, Pagano A, Würth R, Daga A, Barbieri F, Florio T.

Oncotarget. 2016 Jun 21;7(25):38638-38657. doi: 10.18632/oncotarget.9575.


Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide.

Villa V, Thellung S, Bajetto A, Gatta E, Robello M, Novelli F, Tasso B, Tonelli M, Florio T.

Pharmacol Res. 2016 Nov;113(Pt A):500-514. doi: 10.1016/j.phrs.2016.09.010. Epub 2016 Sep 22.


Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma.

Barbieri F, Bajetto A, Thellung S, Würth R, Florio T.

Expert Opin Drug Discov. 2016 Nov;11(11):1093-1109. Epub 2016 Sep 20. Review.


Canine osteosarcoma cell lines contain stem-like cancer cells: biological and pharmacological characterization.

Gatti M, Wurth R, Vito G, Pattarozzi A, Campanella C, Thellung S, Maniscalco L, De Maria R, Villa V, Corsaro A, Nizzari M, Bajetto A, Ratto A, Ferrari A, Barbieri F, Florio T.

Jpn J Vet Res. 2016 May;64(2):101-12.


Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds.

Würth R, Thellung S, Bajetto A, Mazzanti M, Florio T, Barbieri F.

Drug Discov Today. 2016 Jan;21(1):190-199. doi: 10.1016/j.drudis.2015.09.017. Epub 2015 Oct 9. Review.


Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies.

Thellung S, Favoni RE, Würth R, Nizzari M, Pattarozzi A, Daga A, Florio T, Barbieri F.

Curr Drug Targets. 2016;17(7):824-49. Review.


In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors.

Barbieri F, Thellung S, Ratto A, Carra E, Marini V, Fucile C, Bajetto A, Pattarozzi A, Würth R, Gatti M, Campanella C, Vito G, Mattioli F, Pagano A, Daga A, Ferrari A, Florio T.

BMC Cancer. 2015 Apr 7;15:228. doi: 10.1186/s12885-015-1235-8.


Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation.

Gentile MT, Ciniglia C, Reccia MG, Volpicelli F, Gatti M, Thellung S, Florio T, Melone MA, Colucci-D'Amato L.

PLoS One. 2015 Mar 18;10(3):e0118864. doi: 10.1371/journal.pone.0118864. eCollection 2015.


Emerging Targets in Pituitary Adenomas: Role of the CXCL12/CXCR4-R7 System.

Barbieri F, Thellung S, Würth R, Gatto F, Corsaro A, Villa V, Nizzari M, Albertelli M, Ferone D, Florio T.

Int J Endocrinol. 2014;2014:753524. doi: 10.1155/2014/753524. Epub 2014 Nov 17. Review.


Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells.

Villa V, Thellung S, Corsaro A, Novelli F, Tasso B, Colucci-D'Amato L, Gatta E, Tonelli M, Florio T.

Mol Neurobiol. 2016 Jan;53(1):57-72. doi: 10.1007/s12035-014-8982-4. Epub 2014 Nov 18.


Peptide receptor targeting in cancer: the somatostatin paradigm.

Barbieri F, Bajetto A, Pattarozzi A, Gatti M, Würth R, Thellung S, Corsaro A, Villa V, Nizzari M, Florio T.

Int J Pept. 2013;2013:926295. doi: 10.1155/2013/926295. Epub 2013 Feb 7.


Role of prion protein aggregation in neurotoxicity.

Corsaro A, Thellung S, Villa V, Nizzari M, Florio T.

Int J Mol Sci. 2012;13(7):8648-69. doi: 10.3390/ijms13078648. Epub 2012 Jul 11. Review.


Excitotoxicity through NMDA receptors mediates cerebellar granule neuron apoptosis induced by prion protein 90-231 fragment.

Thellung S, Gatta E, Pellistri F, Corsaro A, Villa V, Vassalli M, Robello M, Florio T.

Neurotox Res. 2013 May;23(4):301-14. doi: 10.1007/s12640-012-9340-9. Epub 2012 Aug 2.


Calcium binding promotes prion protein fragment 90-231 conformational change toward a membrane destabilizing and cytotoxic structure.

Sorrentino S, Bucciarelli T, Corsaro A, Tosatto A, Thellung S, Villa V, Schininà ME, Maras B, Galeno R, Scotti L, Creati F, Marrone A, Re N, Aceto A, Florio T, Mazzanti M.

PLoS One. 2012;7(7):e38314. doi: 10.1371/journal.pone.0038314. Epub 2012 Jul 11.


In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism.

Carducci C, Carducci C, Santagata S, Adriano E, Artiola C, Thellung S, Gatta E, Robello M, Florio T, Antonozzi I, Leuzzi V, Balestrino M.

BMC Neurosci. 2012 Apr 26;13:41. doi: 10.1186/1471-2202-13-41.


Neurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling.

Nizzari M, Thellung S, Corsaro A, Villa V, Pagano A, Porcile C, Russo C, Florio T.

J Toxicol. 2012;2012:187297. doi: 10.1155/2012/187297. Epub 2012 Feb 8.


CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis.

Ferrari A, Petterino C, Ratto A, Campanella C, Wurth R, Thellung S, Vito G, Barbieri F, Florio T.

BMC Vet Res. 2012 Mar 14;8:27. doi: 10.1186/1746-6148-8-27.


Isolation of stem-like cells from spontaneous feline mammary carcinomas: phenotypic characterization and tumorigenic potential.

Barbieri F, Wurth R, Ratto A, Campanella C, Vito G, Thellung S, Daga A, Cilli M, Ferrari A, Florio T.

Exp Cell Res. 2012 Apr 15;318(7):847-60. doi: 10.1016/j.yexcr.2012.02.008. Epub 2012 Feb 16.


Recombinant human prion protein fragment 90-231, a useful model to study prion neurotoxicity.

Corsaro A, Thellung S, Villa V, Nizzari M, Aceto A, Florio T.

OMICS. 2012 Jan-Feb;16(1-2):50-9. doi: 10.1089/omi.2011.0038.


Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction.

Thellung S, Corsaro A, Villa V, Simi A, Vella S, Pagano A, Florio T.

Cell Death Dis. 2011 Mar 31;2:e138. doi: 10.1038/cddis.2011.21.


High hydrophobic amino acid exposure is responsible of the neurotoxic effects induced by E200K or D202N disease-related mutations of the human prion protein.

Corsaro A, Thellung S, Bucciarelli T, Scotti L, Chiovitti K, Villa V, D'Arrigo C, Aceto A, Florio T.

Int J Biochem Cell Biol. 2011 Mar;43(3):372-82. doi: 10.1016/j.biocel.2010.11.007. Epub 2010 Nov 19.


Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.

Villa V, Tonelli M, Thellung S, Corsaro A, Tasso B, Novelli F, Canu C, Pino A, Chiovitti K, Paludi D, Russo C, Sparatore A, Aceto A, Boido V, Sparatore F, Florio T.

Neurotox Res. 2011 May;19(4):556-74. doi: 10.1007/s12640-010-9189-8. Epub 2010 Apr 20.


Dual modulation of ERK1/2 and p38 MAP kinase activities induced by minocycline reverses the neurotoxic effects of the prion protein fragment 90-231.

Corsaro A, Thellung S, Chiovitti K, Villa V, Simi A, Raggi F, Paludi D, Russo C, Aceto A, Florio T.

Neurotox Res. 2009 Feb;15(2):138-54. doi: 10.1007/s12640-009-9015-3. Epub 2009 Feb 26.


P2X7 pre-synaptic receptors in adult rat cerebrocortical nerve terminals: a role in ATP-induced glutamate release.

Marcoli M, Cervetto C, Paluzzi P, Guarnieri S, Alloisio S, Thellung S, Nobile M, Maura G.

J Neurochem. 2008 Jun 1;105(6):2330-42. doi: 10.1111/j.1471-4159.2008.05322.x.


Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion.

Biasini E, Medrano AZ, Thellung S, Chiesa R, Harris DA.

J Neurochem. 2008 Mar;104(5):1293-308. Epub 2007 Nov 21.


Intracellular accumulation of a mild-denatured monomer of the human PrP fragment 90-231, as possible mechanism of its neurotoxic effects.

Chiovitti K, Corsaro A, Thellung S, Villa V, Paludi D, D'Arrigo C, Russo C, Perico A, Ianieri A, Di Cola D, Vergara A, Aceto A, Florio T.

J Neurochem. 2007 Dec;103(6):2597-609. Epub 2007 Oct 18.


Different structural stability and toxicity of PrP(ARR) and PrP(ARQ) sheep prion protein variants.

Paludi D, Thellung S, Chiovitti K, Corsaro A, Villa V, Russo C, Ianieri A, Bertsch U, Kretzschmar HA, Aceto A, Florio T.

J Neurochem. 2007 Dec;103(6):2291-300. Epub 2007 Oct 4.


ERK1/2 and p38 MAP kinases control prion protein fragment 90-231-induced astrocyte proliferation and microglia activation.

Thellung S, Villa V, Corsaro A, Pellistri F, Venezia V, Russo C, Aceto A, Robello M, Florio T.

Glia. 2007 Nov 1;55(14):1469-85.


Amino-terminally truncated prion protein PrP90-231 induces microglial activation in vitro.

Thellung S, Corsaro A, Villa V, Venezia V, Nizzari M, Bisaglia M, Russo C, Schettini G, Aceto A, Florio T.

Ann N Y Acad Sci. 2007 Jan;1096:258-70.


Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells.

Nizzari M, Venezia V, Bianchini P, Caorsi V, Diaspro A, Repetto E, Thellung S, Corsaro A, Carlo P, Schettini G, Florio T, Russo C.

Ann N Y Acad Sci. 2007 Jan;1096:249-57.


Amyloid precursor protein modulates ERK-1 and -2 signaling.

Venezia V, Nizzari M, Repetto E, Violani E, Corsaro A, Thellung S, Villa V, Carlo P, Schettini G, Florio T, Russo C.

Ann N Y Acad Sci. 2006 Dec;1090:455-65.


SDF-1 controls pituitary cell proliferation through the activation of ERK1/2 and the Ca2+-dependent, cytosolic tyrosine kinase Pyk2.

Massa A, Casagrande S, Bajetto A, Porcile C, Barbieri F, Thellung S, Arena S, Pattarozzi A, Gatti M, Corsaro A, Robello M, Schettini G, Florio T.

Ann N Y Acad Sci. 2006 Dec;1090:385-98.


Characterization of the proapoptotic intracellular mechanisms induced by a toxic conformer of the recombinant human prion protein fragment 90-231.

Villa V, Corsaro A, Thellung S, Paludi D, Chiovitti K, Venezia V, Nizzari M, Russo C, Schettini G, Aceto A, Florio T.

Ann N Y Acad Sci. 2006 Dec;1090:276-91.


Conformation dependent pro-apoptotic activity of the recombinant human prion protein fragment 90-231.

Corsaro A, Paludi D, Villa V, D'Arrigo C, Chiovitti K, Thellung S, Russo C, Di Cola D, Ballerini P, Patrone E, Schettini G, Aceto A, Florio T.

Int J Immunopathol Pharmacol. 2006 Apr-Jun;19(2):339-56.


Chemokine stromal cell-derived factor 1alpha induces proliferation and growth hormone release in GH4C1 rat pituitary adenoma cell line through multiple intracellular signals.

Florio T, Casagrande S, Diana F, Bajetto A, Porcile C, Zona G, Thellung S, Arena S, Pattarozzi A, Corsaro A, Spaziante R, Robello M, Schettini G.

Mol Pharmacol. 2006 Feb;69(2):539-46. Epub 2005 Oct 28.


Identification of a conserved N-capping box important for the structural autonomy of the prion alpha 3-helix: the disease associated D202N mutation destabilizes the helical conformation.

Gallo M, Paludi D, Cicero DO, Chiovitti K, Millo E, Salis A, Damonte G, Corsaro A, Thellung S, Schettini G, Melino S, Florio T, Paci M, Aceto A.

Int J Immunopathol Pharmacol. 2005 Jan-Mar;18(1):95-112.


Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

Corsaro A, Thellung S, Villa V, Principe DR, Paludi D, Arena S, Millo E, Schettini D, Damonte G, Aceto A, Schettini G, Florio T.

Ann N Y Acad Sci. 2003 Dec;1010:610-22.


Expression of somatostatin receptor mRNA in human meningiomas and their implication in in vitro antiproliferative activity.

Arena S, Barbieri F, Thellung S, Pirani P, Corsaro A, Villa V, Dadati P, Dorcaratto A, Lapertosa G, Ravetti JL, Spaziante R, Schettini G, Florio T.

J Neurooncol. 2004 Jan;66(1-2):155-66.


Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.

Florio T, Thellung S, Corsaro A, Bocca L, Arena S, Pattarozzi A, Villa V, Massa A, Diana F, Schettini D, Barbieri F, Ravetti JL, Spaziante R, Giusti M, Schettini G.

Clin Endocrinol (Oxf). 2003 Jul;59(1):115-28.


Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.

Florio T, Morini M, Villa V, Arena S, Corsaro A, Thellung S, Culler MD, Pfeffer U, Noonan DM, Schettini G, Albini A.

Endocrinology. 2003 Apr;144(4):1574-84.


Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis.

Florio T, Arena S, Pattarozzi A, Thellung S, Corsaro A, Villa V, Massa A, Diana F, Spoto G, Forcella S, Damonte G, Filocamo M, Benatti U, Schettini G.

Mol Pharmacol. 2003 Feb;63(2):297-310.


Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide.

Arena S, Pattarozzi A, Thellung S, Villa V, Corsaro A, Massa A, Diana F, Spoto G, Forcella S, Damonte G, Filocamo M, Benatti U, Schettini G, Florioa T.

Ann N Y Acad Sci. 2002 Nov;973:94-104.


Expression in E. coli and purification of recombinant fragments of wild type and mutant human prion protein.

Corsaro A, Thellung S, Russo C, Villa V, Arena S, D'Adamo MC, Paludi D, Rossi Principe D, Damonte G, Benatti U, Aceto A, Tagliavini F, Schettini G, Florio T.

Neurochem Int. 2002 Jul;41(1):55-63.


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