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Items: 19


Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.

Esther CR Jr, Muhlebach MS, Ehre C, Hill DB, Wolfgang MC, Kesimer M, Ramsey KA, Markovetz MR, Garbarine IC, Forest MG, Seim I, Zorn B, Morrison CB, Delion MF, Thelin WR, Villalon D, Sabater JR, Turkovic L, Ranganathan S, Stick SM, Boucher RC.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaav3488. doi: 10.1126/scitranslmed.aav3488.


Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice.

Hancock LA, Hennessy CE, Solomon GM, Dobrinskikh E, Estrella A, Hara N, Hill DB, Kissner WJ, Markovetz MR, Grove Villalon DE, Voss ME, Tearney GJ, Carroll KS, Shi Y, Schwarz MI, Thelin WR, Rowe SM, Yang IV, Evans CM, Schwartz DA.

Nat Commun. 2018 Dec 18;9(1):5363. doi: 10.1038/s41467-018-07768-9.


An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases.

Ehre C, Rushton ZL, Wang B, Hothem LN, Morrison CB, Fontana NC, Markovetz MR, Delion MF, Kato T, Villalon D, Thelin WR, Esther CR Jr, Hill DB, Grubb BR, Livraghi-Butrico A, Donaldson SH, Boucher RC.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):171-180. doi: 10.1164/rccm.201802-0245OC.


Concentration and Temperature Effects on Water and Salt Permeabilities in Osmosis and Implications in Pressure-Retarded Osmosis.

Sivertsen E, Holt T, Thelin WR.

Membranes (Basel). 2018 Jul 8;8(3). pii: E39. doi: 10.3390/membranes8030039.


The in vitro effect of nebulised hypertonic saline on human bronchial epithelium.

Goralski JL, Wu D, Thelin WR, Boucher RC, Button B.

Eur Respir J. 2018 May 17;51(5). pii: 1702652. doi: 10.1183/13993003.02652-2017. Print 2018 May.


Mechanosensitive ATP release maintains proper mucus hydration of airways.

Button B, Okada SF, Frederick CB, Thelin WR, Boucher RC.

Sci Signal. 2013 Jun 11;6(279):ra46. doi: 10.1126/scisignal.2003755.


Expression profiles of aquaporins in rat conjunctiva, cornea, lacrimal gland and Meibomian gland.

Yu D, Thelin WR, Randell SH, Boucher RC.

Exp Eye Res. 2012 Oct;103:22-32. doi: 10.1016/j.exer.2012.07.005. Epub 2012 Jul 22.


Regional differences in rat conjunctival ion transport activities.

Yu D, Thelin WR, Rogers TD, Stutts MJ, Randell SH, Grubb BR, Boucher RC.

Am J Physiol Cell Physiol. 2012 Oct 1;303(7):C767-80. doi: 10.1152/ajpcell.00195.2012. Epub 2012 Jul 18.


Effect of topically applied epithelial sodium channel inhibitors on tear production in normal mice and in mice with induced aqueous tear deficiency.

Thelin WR, Johnson MR, Hirsh AJ, Kublin CL, Zoukhri D.

J Ocul Pharmacol Ther. 2012 Aug;28(4):433-8. doi: 10.1089/jop.2011.0157. Epub 2012 Mar 28.


The oral mucosa as a therapeutic target for xerostomia.

Thelin WR, Brennan MT, Lockhart PB, Singh ML, Fox PC, Papas AS, Boucher RC.

Oral Dis. 2008 Nov;14(8):683-9. doi: 10.1111/j.1601-0825.2008.01486.x. Review.


Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.

Zachos NC, Hodson C, Kovbasnjuk O, Li X, Thelin WR, Cha B, Milgram S, Donowitz M.

Cell Physiol Biochem. 2008;22(5-6):693-704. doi: 10.1159/000185553. Epub 2008 Dec 9.


Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease.

Hirsh AJ, Zhang J, Zamurs A, Fleegle J, Thelin WR, Caldwell RA, Sabater JR, Abraham WM, Donowitz M, Cha B, Johnson KB, St George JA, Johnson MR, Boucher RC.

J Pharmacol Exp Ther. 2008 Apr;325(1):77-88. doi: 10.1124/jpet.107.130443. Epub 2008 Jan 24.


The epithelium as a target for therapy in cystic fibrosis.

Thelin WR, Boucher RC.

Curr Opin Pharmacol. 2007 Jun;7(3):290-5. Epub 2007 May 1. Review.


Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR.

Thelin WR, Chen Y, Gentzsch M, Kreda SM, Sallee JL, Scarlett CO, Borchers CH, Jacobson K, Stutts MJ, Milgram SL.

J Clin Invest. 2007 Feb;117(2):364-74. Epub 2007 Jan 18.


The cystic fibrosis transmembrane conductance regulator is regulated by a direct interaction with the protein phosphatase 2A.

Thelin WR, Kesimer M, Tarran R, Kreda SM, Grubb BR, Sheehan JK, Stutts MJ, Milgram SL.

J Biol Chem. 2005 Dec 16;280(50):41512-20. Epub 2005 Oct 20.


Beyond the brush border: NHERF4 blazes new NHERF turf.

Thelin WR, Hodson CA, Milgram SL.

J Physiol. 2005 Aug 15;567(Pt 1):13-9. Epub 2005 Jul 1. Review.


Improved protein identification through the use of unstained gels.

Loiselle DR, Thelin WR, Parker CE, Dicheva NN, Kesner BA, Mocanu V, Wang F, Milgram SL, Warren MR, Borchers CH.

J Proteome Res. 2005 May-Jun;4(3):992-7.


A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor.

Scott RO, Thelin WR, Milgram SL.

J Biol Chem. 2002 Jun 21;277(25):22934-41. Epub 2002 Apr 11.

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