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Items: 41

1.

Effects of transient overexpression or knockdown of cytochrome P450 reductase on reactive oxygen species generation and hypoxia reoxygenation injury in liver cells.

Pillai VC, Snyder RO, Gumaste U, Thekkumkara TJ, Mehvar R.

Clin Exp Pharmacol Physiol. 2011 Dec;38(12):846-53. doi: 10.1111/j.1440-1681.2011.05622.x.

PMID:
21973081
2.

Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach.

Pillai VC, Yesudas R, Shaik IH, Thekkumkara TJ, Bickel U, Srivenugopal KS, Mehvar R.

Bioconjug Chem. 2010 Feb 17;21(2):203-7. doi: 10.1021/bc900449b.

PMID:
20063878
3.

A functional role for sodium-dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation.

Vemula S, Roder KE, Yang T, Bhat GJ, Thekkumkara TJ, Abbruscato TJ.

J Pharmacol Exp Ther. 2009 Feb;328(2):487-95. doi: 10.1124/jpet.108.146589. Epub 2008 Nov 3.

4.

Regulation of megalin expression in cultured proximal tubule cells by angiotensin II type 1A receptor- and insulin-mediated signaling cross talk.

Hosojima M, Sato H, Yamamoto K, Kaseda R, Soma T, Kobayashi A, Suzuki A, Kabasawa H, Takeyama A, Ikuyama K, Iino N, Nishiyama A, Thekkumkara TJ, Takeda T, Suzuki Y, Gejyo F, Saito A.

Endocrinology. 2009 Feb;150(2):871-8. doi: 10.1210/en.2008-0886. Epub 2008 Oct 16.

PMID:
18927221
5.

Protective effects of diallyl sulfide, a garlic constituent, on the warm hepatic ischemia-reperfusion injury in a rat model.

Shaik IH, George JM, Thekkumkara TJ, Mehvar R.

Pharm Res. 2008 Oct;25(10):2231-42. doi: 10.1007/s11095-008-9601-8. Epub 2008 Jul 15.

PMID:
18626753
6.

Angiotensin II induces phosphorylation of glucose-regulated protein-75 in WB rat liver cells.

Krishna SB, Alfonso LF, Thekkumkara TJ, Abbruscato TJ, Bhat GJ.

Arch Biochem Biophys. 2007 Jan 1;457(1):16-28. Epub 2006 Nov 2.

7.

NGP1-01 is a brain-permeable dual blocker of neuronal voltage- and ligand-operated calcium channels.

Kiewert C, Hartmann J, Stoll J, Thekkumkara TJ, Van der Schyf CJ, Klein J.

Neurochem Res. 2006 Mar;31(3):395-9.

PMID:
16733815
8.

Acute effect of high glucose on long-term cell growth: a role for transient glucose increase in proximal tubule cell injury.

Samikkannu T, Thomas JJ, Bhat GJ, Wittman V, Thekkumkara TJ.

Am J Physiol Renal Physiol. 2006 Jul;291(1):F162-75. Epub 2006 Feb 7.

9.

Protein kinase C family members as a target for regulation of blood-brain barrier Na,K,2Cl-cotransporter during in vitro stroke conditions and nicotine exposure.

Yang T, Roder KE, Bhat GJ, Thekkumkara TJ, Abbruscato TJ.

Pharm Res. 2006 Feb;23(2):291-302. Epub 2006 Feb 7.

PMID:
16450214
10.

ATR blockade reduces IFN-gamma production in lymphocytes in vivo and in vitro.

Weidanz JA, Jacobson LM, Muehrer RJ, Djamali A, Hullett DA, Sprague J, Chiriva-Internati M, Wittman V, Thekkumkara TJ, Becker BN.

Kidney Int. 2005 Jun;67(6):2134-42.

11.

alpha-thrombin rapidly induces tyrosine phosphorylation of a novel, 74-78-kDa stress response protein(s) in lung fibroblast cells.

Bhat GJ, Samikkannu T, Thomas JJ, Thekkumkara TJ.

J Biol Chem. 2004 Nov 19;279(47):48915-22. Epub 2004 Sep 13.

12.
14.

Tight binding of the angiotensin AT(1) receptor antagonist.

Fierensa FL, Vanderheyden PM, Roggeman C, De Backer J, Thekkumkara TJ, Vauquelin G.

Biochem Pharmacol. 2001 May 15;61(10):1227-35.

PMID:
11322926
15.

Extracellular signal-regulated kinase and the small GTP-binding protein p21Rac1 are involved in the regulation of gene transcription by angiotensin II.

Huszár T, Mucsi I, Antus B, Terebessy T, Jeney C, Masszi A, Hunyady L, Mihalik B, Goldberg HJ, Thekkumkara TJ, Rosivall L.

Exp Nephrol. 2001 Mar-Apr;9(2):142-9.

PMID:
11150863
16.

Functional role of a novel cis-acting element (GAGA box) in human type-1 angiotensin II receptor gene transcription.

Wyse BD, Linas SL, Thekkumkara TJ.

J Mol Endocrinol. 2000 Aug;25(1):97-108.

PMID:
10915222
17.

Angiotensin (AT1A) receptor-mediated increases in transcellular sodium transport in proximal tubule cells.

Thekkumkara TJ, Cookson R, Linas SL.

Am J Physiol. 1998 May;274(5):F897-905. doi: 10.1152/ajprenal.1998.274.5.F897.

PMID:
9612327
19.

Molecular mechanisms of angiotensin II (AT1a) receptor endocytosis.

Thomas WG, Thekkumkara TJ, Baker KM.

Clin Exp Pharmacol Physiol. 1996 Sep;23 Suppl 3:S74-80. doi: 10.1111/j.1440-1681.1996.tb02817.x. Review.

PMID:
21143277
20.

Evidence against a role for protein kinase C in the regulation of the angiotensin II (AT1A) receptor.

Thomas WG, Baker KM, Booz GW, Thekkumkara TJ.

Eur J Pharmacol. 1996 Jan 4;295(1):119-22.

PMID:
8925869
21.

Molecular mechanisms of angiotensin II (AT1A) receptor endocytosis.

Thomas WG, Thekkumkara TJ, Baker KM.

Clin Exp Pharmacol Physiol Suppl. 1996;3:S74-80. Review.

PMID:
8993843
22.

Cardiac effects of AII. AT1A receptor signaling, desensitization, and internalization.

Thomas WG, Thekkumkara TJ, Baker KM.

Adv Exp Med Biol. 1996;396:59-69. Review.

PMID:
8726686
23.

A role for cAMP in angiotensin II mediated inhibition of cell growth in AT1A receptor-transfected CHO-K1 cells.

Thekkumkara TJ, Du J, Zwaagstra C, Conrad KM, Krupinski J, Baker KM.

Mol Cell Biochem. 1995 Nov 8;152(1):77-86.

PMID:
8609915
25.

Activation of the STAT pathway by angiotensin II in T3CHO/AT1A cells. Cross-talk between angiotensin II and interleukin-6 nuclear signaling.

Bhat GJ, Thekkumkara TJ, Thomas WG, Conrad KM, Baker KM.

J Biol Chem. 1995 Aug 11;270(32):19059-65.

26.

Sensitive bioassay for the detection and quantification of angiotensin II in tissue culture medium.

Lin C, Baker KM, Thekkumkara TJ, Dostal DE.

Biotechniques. 1995 Jun;18(6):1014-20.

PMID:
7546701
27.

Stable expression of a functional rat angiotensin II (AT1A) receptor in CHO-K1 cells: rapid desensitization by angiotensin II.

Thekkumkara TJ, Du J, Dostal DE, Motel TJ, Thomas WG, Baker KM.

Mol Cell Biochem. 1995 May 10;146(1):79-89.

PMID:
7651382
28.

Overexpression and characterization of human tetrameric pyruvate dehydrogenase and its individual subunits.

Korotchkina LG, Tucker MM, Thekkumkara TJ, Madhusudhan KT, Pons G, Kim H, Patel MS.

Protein Expr Purif. 1995 Feb;6(1):79-90.

PMID:
7756842
30.
31.
32.

Use of alternative polyadenylation sites for tissue-specific transcription of two angiotensin-converting enzyme mRNAs.

Thekkumkara TJ, Livingston W 3rd, Kumar RS, Sen GC.

Nucleic Acids Res. 1992 Feb 25;20(4):683-7.

34.

Angiotensin-converting enzyme: structural relationship of the testicular and the pulmonary forms.

Sen GC, Thekkumkara TJ, Kumar RS.

J Cardiovasc Pharmacol. 1990;16 Suppl 4:S14-8.

PMID:
1705622
36.

Characterization of cDNAs encoding human pyruvate dehydrogenase alpha subunit.

Ho L, Wexler ID, Liu TC, Thekkumkara TJ, Patel MS.

Proc Natl Acad Sci U S A. 1989 Jul;86(14):5330-4.

37.

Molecular biology of the human pyruvate dehydrogenase complex: structural aspects of the E2 and E3 components.

Thekkumkara TJ, Pons G, Mitroo S, Jentoft JE, Patel MS.

Ann N Y Acad Sci. 1989;573:113-29. Review.

PMID:
2483872
38.

Nucleotide sequence of a cDNA for the dihydrolipoamide acetyltransferase component of human pyruvate dehydrogenase complex.

Thekkumkara TJ, Ho L, Wexler ID, Pons G, Liu TC, Patel MS.

FEBS Lett. 1988 Nov 21;240(1-2):45-8.

39.

Heterogeneous expression of protein and mRNA in pyruvate dehydrogenase deficiency.

Wexler ID, Kerr DS, Ho L, Lusk MM, Pepin RA, Javed AA, Mole JE, Jesse BW, Thekkumkara TJ, Pons G, et al.

Proc Natl Acad Sci U S A. 1988 Oct;85(19):7336-40.

40.

Identification of a cDNA clone for the beta-subunit of the pyruvate dehydrogenase component of human pyruvate dehydrogenase complex.

Ho L, Javed AA, Pepin RA, Thekkumkara TJ, Raefsky C, Mole JE, Caliendo AM, Kwon MS, Kerr DS, Patel MS.

Biochem Biophys Res Commun. 1988 Feb 15;150(3):904-8.

PMID:
2829898
41.

Isolation of a cDNA clone for the dihydrolipoamide acetyltransferase component of the human liver pyruvate dehydrogenase complex.

Thekkumkara TJ, Jesse BW, Ho L, Raefsky C, Pepin RA, Javed AA, Pons G, Patel MS.

Biochem Biophys Res Commun. 1987 Jun 15;145(2):903-7.

PMID:
3036145

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