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Items: 1 to 50 of 216

1.

Immunogenicity of a recombinant fusion construct composed of intrinsically unstructured, low polymorphic segments derived from merozoite surface protein 2 and trophozoite exported protein 1.

Tiendrebeogo RW, Spallek R, Oehlmann W, Singh M, Theisen M, Nebie I, Moret R, Roussilhon C, Corradin G.

Vaccine. 2019 Aug 23;37(36):5332-5340. doi: 10.1016/j.vaccine.2019.07.048. Epub 2019 Jul 26.

PMID:
31358409
2.

Individual distress and dyadic adjustment over the course of couple therapy and three-year follow-up: A replication study.

Tilden T, Theisen M, Wampold BE, Johnson SU, Hoffart A.

Psychother Res. 2019 Jul 29:1-12. doi: 10.1080/10503307.2019.1645369. [Epub ahead of print]

PMID:
31354074
3.

Pfs230 and Pfs48/45 Fusion Proteins Elicit Strong Transmission-Blocking Antibody Responses Against Plasmodium falciparum.

Singh SK, Thrane S, Chourasia BK, Teelen K, Graumans W, Stoter R, van Gemert GJ, van de Vegte-Bolmer MG, Nielsen MA, Salanti A, Sander AF, Sauerwein RW, Jore MM, Theisen M.

Front Immunol. 2019 Jun 5;10:1256. doi: 10.3389/fimmu.2019.01256. eCollection 2019.

4.

Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort.

Adamou R, Dechavanne C, Sadissou I, d'Almeida T, Bouraima A, Sonon P, Amoussa R, Cottrell G, Le Port A, Theisen M, Remarque EJ, Longacre S, Moutairou K, Massougbodji A, Luty AJF, Nuel G, Migot-Nabias F, Sanni A, Garcia A, Milet J, Courtin D.

Malar J. 2019 Jun 11;18(1):194. doi: 10.1186/s12936-019-2831-x.

5.

A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection.

Kose N, Fox JM, Sapparapu G, Bombardi R, Tennekoon RN, de Silva AD, Elbashir SM, Theisen MA, Humphris-Narayanan E, Ciaramella G, Himansu S, Diamond MS, Crowe JE Jr.

Sci Immunol. 2019 May 17;4(35). pii: eaaw6647. doi: 10.1126/sciimmunol.aaw6647.

PMID:
31101672
6.

Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates.

Zhu X, Yin L, Theisen M, Zhuo J, Siddiqui S, Levy B, Presnyak V, Frassetto A, Milton J, Salerno T, Benenato KE, Milano J, Lynn A, Sabnis S, Burke K, Besin G, Lukacs CM, Guey LT, Finn PF, Martini PGV.

Am J Hum Genet. 2019 Apr 4;104(4):625-637. doi: 10.1016/j.ajhg.2019.02.003. Epub 2019 Mar 14.

PMID:
30879639
7.

Breadth of Functional Antibodies Is Associated With Plasmodium falciparum Merozoite Phagocytosis and Protection Against Febrile Malaria.

Kana IH, Singh SK, Garcia-Senosiain A, Dodoo D, Singh S, Adu B, Theisen M.

J Infect Dis. 2019 Jun 19;220(2):275-284. doi: 10.1093/infdis/jiz088.

PMID:
30820557
8.

Low Concordance of Patient-Reported Outcomes With Clinical and Clinical Trial Documentation.

Fares CM, Williamson TJ, Theisen MK, Cummings A, Bornazyan K, Carroll J, Spiegel ML, Stanton AL, Garon EB.

JCO Clin Cancer Inform. 2018 Dec;2:1-12. doi: 10.1200/CCI.18.00059.

9.

Controlled human malaria infection of healthy lifelong malaria-exposed adults to assess safety, immunogenicity and efficacy of the asexual blood stage malaria vaccine candidate GMZ2.

Dejon-Agobe JC, Ateba-Ngoa U, Lalremruata A, Homoet A, Engelhorn J, Paterne Nouatin O, Edoa JR, Fernandes JF, Esen M, Mouwenda YD, Betouke Ongwe EM, Massinga-Loembe M, Hoffman SL, Sim BKL, Theisen M, Kremsner PG, Adegnika AA, Lell B, Mordmüller B.

Clin Infect Dis. 2018 Dec 18. doi: 10.1093/cid/ciy1087. [Epub ahead of print]

PMID:
30561539
10.

Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes.

Bybjerg-Grauholm J, Hagen CM, Gonçalves VF, Bækvad-Hansen M, Hansen CS, Hedley PL, Kanters JK, Nielsen J, Theisen M, Mors O, Kennedy J, Als TD, Demur AB, Nordentoft M, Børglum A, Mortensen PB, Werge TM, Hougaard DM, Christiansen M.

PLoS One. 2018 Dec 13;13(12):e0208829. doi: 10.1371/journal.pone.0208829. eCollection 2018.

11.

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia.

An D, Schneller JL, Frassetto A, Liang S, Zhu X, Park JS, Theisen M, Hong SJ, Zhou J, Rajendran R, Levy B, Howell R, Besin G, Presnyak V, Sabnis S, Murphy-Benenato KE, Kumarasinghe ES, Salerno T, Mihai C, Lukacs CM, Chandler RJ, Guey LT, Venditti CP, Martini PGV.

Cell Rep. 2018 Aug 28;24(9):2520. doi: 10.1016/j.celrep.2018.08.049. No abstract available.

12.

SURGE complex of Plasmodium falciparum in the rhoptry-neck (SURFIN4.2-RON4-GLURP) contributes to merozoite invasion.

Quintana MDP, Ch'ng JH, Zandian A, Imam M, Hultenby K, Theisen M, Nilsson P, Qundos U, Moll K, Chan S, Wahlgren M.

PLoS One. 2018 Aug 9;13(8):e0201669. doi: 10.1371/journal.pone.0201669. eCollection 2018.

13.

The Candidate Blood-stage Malaria Vaccine P27A Induces a Robust Humoral Response in a Fast Track to the Field Phase 1 Trial in Exposed and Nonexposed Volunteers.

Steiner-Monard V, Kamaka K, Karoui O, Roethlisberger S, Audran R, Daubenberger C, Fayet-Mello A, Erdmann-Voisin A, Felger I, Geiger K, Govender L, Houard S, Huber E, Mayor C, Mkindi C, Portevin D, Rusch S, Schmidlin S, Tiendrebeogo RW, Theisen M, Thierry AC, Vallotton L, Corradin G, Leroy O, Abdulla S, Shekalaghe S, Genton B, Spertini F, Jongo SA.

Clin Infect Dis. 2019 Jan 18;68(3):466-474. doi: 10.1093/cid/ciy514.

PMID:
29945169
14.

Molecular and Functional Characterization of Fcγ Receptor IIIb-Ligand Interaction: Implications for Neutrophil-Mediated Immune Mechanisms in Malaria.

Simtong P, Romphruk AV, Traum A, Burg-Roderfeld M, Bein G, Jakubowski K, Dominik A, Theisen M, Kana IH, Sachs UJ, Santoso S.

Infect Immun. 2018 Jul 23;86(8). pii: e00924-17. doi: 10.1128/IAI.00924-17. Print 2018 Aug.

15.

Plasmodium falciparum MSP3 Exists in a Complex on the Merozoite Surface and Generates Antibody Response during Natural Infection.

Deshmukh A, Chourasia BK, Mehrotra S, Kana IH, Paul G, Panda A, Kaur I, Singh SK, Rathore S, Das A, Gupta P, Kalamuddin M, Gakhar SK, Mohmmed A, Theisen M, Malhotra P.

Infect Immun. 2018 Jul 23;86(8). pii: e00067-18. doi: 10.1128/IAI.00067-18. Print 2018 Aug.

16.

Cytophilic Antibodies Against Key Plasmodium falciparum Blood Stage Antigens Contribute to Protection Against Clinical Malaria in a High Transmission Region of Eastern India.

Kana IH, Garcia-Senosiain A, Singh SK, Tiendrebeogo RW, Chourasia BK, Malhotra P, Sharma SK, Das MK, Singh S, Adu B, Theisen M.

J Infect Dis. 2018 Aug 14;218(6):956-965. doi: 10.1093/infdis/jiy258.

PMID:
29733355
17.

Characterization of Plasmodium falciparum and Plasmodium vivax recent exposure in an area of significantly decreased transmission intensity in Central Vietnam.

Kattenberg JH, Erhart A, Truong MH, Rovira-Vallbona E, Vu KAD, Nguyen THN, Nguyen VH, Nguyen VV, Bannister-Tyrrell M, Theisen M, Bennet A, Lover AA, Tran TD, Nguyen XX, Rosanas-Urgell A.

Malar J. 2018 Apr 27;17(1):180. doi: 10.1186/s12936-018-2326-1.

18.

Publisher Correction: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity.

Stone WJR, Campo JJ, Ouédraogo AL, Meerstein-Kessel L, Morlais I, Da D, Cohuet A, Nsango S, Sutherland CJ, van de Vegte-Bolmer M, Siebelink-Stoter R, van Gemert GJ, Graumans W, Lanke K, Shandling AD, Pablo JV, Teng AA, Jones S, de Jong RM, Fabra-García A, Bradley J, Roeffen W, Lasonder E, Gremo G, Schwarzer E, Janse CJ, Singh SK, Theisen M, Felgner P, Marti M, Drakeley C, Sauerwein R, Bousema T, Jore MM.

Nat Commun. 2018 Apr 11;9(1):1498. doi: 10.1038/s41467-018-03769-w.

19.

Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum.

Singh SK, Tiendrebeogo RW, Chourasia BK, Kana IH, Singh S, Theisen M.

Microb Cell Fact. 2018 Apr 5;17(1):55. doi: 10.1186/s12934-018-0902-2.

20.

Protein-protein interaction studies reveal the Plasmodium falciparum merozoite surface protein-1 region involved in a complex formation that binds to human erythrocytes.

Paul G, Deshmukh A, Kumar Chourasia B, Kalamuddin M, Panda A, Kumar Singh S, Gupta PK, Mohmmed A, Chauhan VS, Theisen M, Malhotra P.

Biochem J. 2018 Mar 29;475(6):1197-1209. doi: 10.1042/BCJ20180017.

PMID:
29511044
21.

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity.

Stone WJR, Campo JJ, Ouédraogo AL, Meerstein-Kessel L, Morlais I, Da D, Cohuet A, Nsango S, Sutherland CJ, van de Vegte-Bolmer M, Siebelink-Stoter R, van Gemert GJ, Graumans W, Lanke K, Shandling AD, Pablo JV, Teng AA, Jones S, de Jong RM, Fabra-García A, Bradley J, Roeffen W, Lasonder E, Gremo G, Schwarzer E, Janse CJ, Singh SK, Theisen M, Felgner P, Marti M, Drakeley C, Sauerwein R, Bousema T, Jore MM.

Nat Commun. 2018 Feb 8;9(1):558. doi: 10.1038/s41467-017-02646-2. Erratum in: Nat Commun. 2018 Apr 11;9(1):1498.

22.
23.

Dynamics of anti-MSP3 and Pfs230 antibody responses and multiplicity of infection in asymptomatic children from southern Ghana.

Amoah LE, Acquah FK, Ayanful-Torgby R, Oppong A, Abankwa J, Obboh EK, Singh SK, Theisen M.

Parasit Vectors. 2018 Jan 5;11(1):13. doi: 10.1186/s13071-017-2607-5.

24.

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia.

An D, Schneller JL, Frassetto A, Liang S, Zhu X, Park JS, Theisen M, Hong SJ, Zhou J, Rajendran R, Levy B, Howell R, Besin G, Presnyak V, Sabnis S, Murphy-Benenato KE, Kumarasinghe ES, Salerno T, Mihai C, Lukacs CM, Chandler RJ, Guey LT, Venditti CP, Martini PGV.

Cell Rep. 2017 Dec 19;21(12):3548-3558. doi: 10.1016/j.celrep.2017.11.081. Erratum in: Cell Rep. 2018 Aug 28;24(9):2520.

25.

Production and Purification of Filovirus Glycoproteins in Insect and Mammalian Cell Lines.

Clarke EC, Collar AL, Ye C, Caì Y, Anaya E, Rinaldi D, Martinez B, Yarborough S, Merle C, Theisen M, Wada J, Kuhn JH, Bradfute SB.

Sci Rep. 2017 Nov 8;7(1):15091. doi: 10.1038/s41598-017-15416-3.

26.

Natural antibody responses to Plasmodium falciparum MSP3 and GLURP(R0) antigens are associated with low parasite densities in malaria patients living in the Central Region of Ghana.

Amoah LE, Nuvor SV, Obboh EK, Acquah FK, Asare K, Singh SK, Boampong JN, Theisen M, Williamson KC.

Parasit Vectors. 2017 Aug 23;10(1):395. doi: 10.1186/s13071-017-2338-7.

27.

Antibody responses to two new Lactococcus lactis-produced recombinant Pfs48/45 and Pfs230 proteins increase with age in malaria patients living in the Central Region of Ghana.

Acquah FK, Obboh EK, Asare K, Boampong JN, Nuvor SV, Singh SK, Theisen M, Williamson KC, Amoah LE.

Malar J. 2017 Aug 1;16(1):306. doi: 10.1186/s12936-017-1955-0.

28.

The GMZ2 malaria vaccine: from concept to efficacy in humans.

Theisen M, Adu B, Mordmüller B, Singh S.

Expert Rev Vaccines. 2017 Sep;16(9):907-917. doi: 10.1080/14760584.2017.1355246. Epub 2017 Jul 21. Review.

PMID:
28699823
29.

End-of-life perceptions among physicians in intensive care units managed by anesthesiologists in Germany: a survey about structure, current implementation and deficits.

Weiss M, Michalsen A, Toenjes A, Porzsolt F, Bein T, Theisen M, Brinkmann A, Groesdonk H, Putensen C, Bach F, Henzler D; On behalf on the Working Group Epidemiology and Ethics of the German Society of Anesthesiology and Intensive Care Medicine (DGAI).

BMC Anesthesiol. 2017 Jul 11;17(1):93. doi: 10.1186/s12871-017-0384-5.

30.

Expression, Purification and Characterization of GMZ2'.10C, a Complex Disulphide-Bonded Fusion Protein Vaccine Candidate against the Asexual and Sexual Life-Stages of the Malaria-Causing Plasmodium falciparum Parasite.

Mistarz UH, Singh SK, Nguyen TTTN, Roeffen W, Yang F, Lissau C, Madsen SM, Vrang A, Tiendrebeogo RW, Kana IH, Sauerwein RW, Theisen M, Rand KD.

Pharm Res. 2017 Sep;34(9):1970-1983. doi: 10.1007/s11095-017-2208-1. Epub 2017 Jun 23.

PMID:
28646324
31.

Improving the malaria transmission-blocking activity of a Plasmodium falciparum 48/45 based vaccine antigen by SpyTag/SpyCatcher mediated virus-like display.

Singh SK, Thrane S, Janitzek CM, Nielsen MA, Theander TG, Theisen M, Salanti A, Sander AF.

Vaccine. 2017 Jun 27;35(30):3726-3732. doi: 10.1016/j.vaccine.2017.05.054. Epub 2017 May 31.

PMID:
28578824
32.

Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine.

Singh SK, Roeffen W, Mistarz UH, Chourasia BK, Yang F, Rand KD, Sauerwein RW, Theisen M.

Microb Cell Fact. 2017 May 31;16(1):97. doi: 10.1186/s12934-017-0710-0.

33.

Malaria epidemiology in an area of stable transmission in tribal population of Jharkhand, India.

Das MK, Prajapati BK, Tiendrebeogo RW, Ranjan K, Adu B, Srivastava A, Khera HK, Chauhan N, Tevatiya S, Kana IH, Sharma SK, Singh S, Theisen M.

Malar J. 2017 May 2;16(1):181. doi: 10.1186/s12936-017-1833-9.

34.

Recognition of Plasmodium falciparum mature gametocyte-infected erythrocytes by antibodies of semi-immune adults and malaria-exposed children from Gabon.

Gebru T, Ajua A, Theisen M, Esen M, Ngoa UA, Issifou S, Adegnika AA, Kremsner PG, Mordmüller B, Held J.

Malar J. 2017 Apr 26;16(1):176. doi: 10.1186/s12936-017-1827-7.

35.

Distinct cis-acting regions control six6 expression during eye field and optic cup stages of eye formation.

Ledford KL, Martinez-De Luna RI, Theisen MA, Rawlins KD, Viczian AS, Zuber ME.

Dev Biol. 2017 Jun 15;426(2):418-428. doi: 10.1016/j.ydbio.2017.04.003. Epub 2017 Apr 21.

36.

Kinetically accessible yield (KAY) for redirection of metabolism to produce exo-metabolites.

Lafontaine Rivera JG, Theisen MK, Chen PW, Liao JC.

Metab Eng. 2017 May;41:144-151. doi: 10.1016/j.ymben.2017.03.011. Epub 2017 Apr 5.

37.

Metabolic systems modeling for cell factories improvement.

Chen PW, Theisen MK, Liao JC.

Curr Opin Biotechnol. 2017 Aug;46:114-119. doi: 10.1016/j.copbio.2017.02.005. Epub 2017 Apr 4. Review.

PMID:
28388485
38.

Naturally Acquired Antibodies Target the Glutamate-Rich Protein on Intact Merozoites and Predict Protection Against Febrile Malaria.

Kana IH, Adu B, Tiendrebeogo RW, Singh SK, Dodoo D, Theisen M.

J Infect Dis. 2017 Feb 15;215(4):623-630. doi: 10.1093/infdis/jiw617.

PMID:
28329101
39.

A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stage merozoites.

Paul G, Deshmukh A, Kaur I, Rathore S, Dabral S, Panda A, Singh SK, Mohmmed A, Theisen M, Malhotra P.

Malar J. 2017 Feb 16;16(1):79. doi: 10.1186/s12936-017-1716-0.

40.

Towards clinical development of a Pfs48/45-based transmission blocking malaria vaccine.

Theisen M, Jore MM, Sauerwein R.

Expert Rev Vaccines. 2017 Apr;16(4):329-336. doi: 10.1080/14760584.2017.1276833. Epub 2017 Jan 9. Review.

PMID:
28043178
41.

Efficacy of the GMZ2 malaria vaccine in African children.

Milligan P, Flach C, Theisen M.

Vaccine. 2017 Jan 5;35(2):202. doi: 10.1016/j.vaccine.2016.11.016. No abstract available.

PMID:
28024561
42.

Comparison of N- and O-linked glycosylation patterns of ebolavirus glycoproteins.

Collar AL, Clarke EC, Anaya E, Merrill D, Yarborough S, Anthony SM, Kuhn JH, Merle C, Theisen M, Bradfute SB.

Virology. 2017 Feb;502:39-47. doi: 10.1016/j.virol.2016.12.010. Epub 2016 Dec 13.

43.

Antibody profiling of canine IgG responses to the OspC protein of the Lyme disease spirochetes supports a multivalent approach in vaccine and diagnostic assay development.

Oliver LD Jr, Earnhart CG, Virginia-Rhodes D, Theisen M, Marconi RT.

Vet J. 2016 Dec;218:27-33. doi: 10.1016/j.tvjl.2016.11.001. Epub 2016 Nov 9.

44.

Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors.

Dechavanne C, Sadissou I, Bouraima A, Ahouangninou C, Amoussa R, Milet J, Moutairou K, Massougbodji A, Theisen M, Remarque EJ, Courtin D, Nuel G, Migot-Nabias F, Garcia A.

Sci Rep. 2016 Sep 27;6:33961. doi: 10.1038/srep33961.

45.

A phase 2b randomized, controlled trial of the efficacy of the GMZ2 malaria vaccine in African children.

Sirima SB, Mordmüller B, Milligan P, Ngoa UA, Kironde F, Atuguba F, Tiono AB, Issifou S, Kaddumukasa M, Bangre O, Flach C, Christiansen M, Bang P, Chilengi R, Jepsen S, Kremsner PG, Theisen M; GMZ2 Trial Study Group.

Vaccine. 2016 Aug 31;34(38):4536-4542. doi: 10.1016/j.vaccine.2016.07.041. Epub 2016 Jul 28.

46.

A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts.

He H, Yang Y, Xiang Z, Yu L, Chouitar J, Yu J, D'Amore NR, Li P, Li Z, Bowman D, Theisen M, Brownell JE, Tirrell S.

J Biomark. 2016;2016:1274603. doi: 10.1155/2016/1274603. Epub 2016 May 10.

47.

Synthetic TLR4 agonists enhance functional antibodies and CD4+ T-cell responses against the Plasmodium falciparum GMZ2.6C multi-stage vaccine antigen.

Baldwin SL, Roeffen W, Singh SK, Tiendrebeogo RW, Christiansen M, Beebe E, Carter D, Fox CB, Howard RF, Reed SG, Sauerwein R, Theisen M.

Vaccine. 2016 Apr 27;34(19):2207-15. doi: 10.1016/j.vaccine.2016.03.016. Epub 2016 Mar 17.

PMID:
26994314
48.

Stability of Ensemble Models Predicts Productivity of Enzymatic Systems.

Theisen MK, Lafontaine Rivera JG, Liao JC.

PLoS Comput Biol. 2016 Mar 10;12(3):e1004800. doi: 10.1371/journal.pcbi.1004800. eCollection 2016 Mar.

49.

Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas.

Adu B, Cherif MK, Bosomprah S, Diarra A, Arthur FK, Dickson EK, Corradin G, Cavanagh DR, Theisen M, Sirima SB, Nebie I, Dodoo D.

Malar J. 2016 Feb 27;15:123. doi: 10.1186/s12936-016-1146-4.

50.

Transmission-blocking activity of antibodies to Plasmodium falciparum GLURP.10C chimeric protein formulated in different adjuvants.

Roeffen W, Theisen M, van de Vegte-Bolmer M, van Gemert G, Arens T, Andersen G, Christiansen M, Sevargave L, Singh SK, Kaviraj S, Sauerwein R.

Malar J. 2015 Nov 9;14:443. doi: 10.1186/s12936-015-0972-0.

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