Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 316

1.

Voxelotor treatment of a patient with sickle cell disease and very severe anemia.

Shet AS, Mendelsohn L, Harper J, Ostrowski D, Henry ER, Gwaabe E, Nichols J, Alayash AI, Eaton WA, Thein SL.

Am J Hematol. 2018 Dec 27. doi: 10.1002/ajh.25389. [Epub ahead of print] No abstract available.

PMID:
30592074
2.

Genetic Modifiers of Fetal Haemoglobin in Sickle Cell Disease.

Menzel S, Thein SL.

Mol Diagn Ther. 2018 Nov 26. doi: 10.1007/s40291-018-0370-8. [Epub ahead of print] Review.

PMID:
30478714
3.

A ten year review of the sickle cell program in Muhimbili National Hospital, Tanzania.

Makani J, Tluway F, Makubi A, Soka D, Nkya S, Sangeda R, Mgaya J, Rwezaula S, Kirkham FJ, Kindole C, Osati E, Meda E, Snow RW, Newton CR, Roberts D, Aboud M, Thein SL, Cox SE, Luzzatto L, Mmbando BP.

BMC Hematol. 2018 Nov 14;18:33. doi: 10.1186/s12878-018-0125-0. eCollection 2018.

4.

The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase.

Vogel S, Arora T, Wang X, Mendelsohn L, Nichols J, Allen D, Shet AS, Combs CA, Quezado ZMN, Thein SL.

Blood Adv. 2018 Oct 23;2(20):2672-2680. doi: 10.1182/bloodadvances.2018021709.

5.

How I treat the older adult with sickle cell disease.

Thein SL, Howard J.

Blood. 2018 Oct 25;132(17):1750-1760. doi: 10.1182/blood-2018-03-818161. Epub 2018 Sep 11. Review.

PMID:
30206116
6.

GlycA is not a useful biomarker of inflammation in sickle cell disease.

Weisman JK, Meeks D, Mendelsohn L, Remaley AT, Sampson M, Allen DT, Nichols J, Shet AS, Thein SL.

Int J Lab Hematol. 2018 Dec;40(6):704-709. doi: 10.1111/ijlh.12907. Epub 2018 Aug 27.

PMID:
30152174
7.

Sickle cell disease-Unanswered questions and future directions in therapy.

Thein SL, Tisdale J.

Semin Hematol. 2018 Apr;55(2):51-52. doi: 10.1053/j.seminhematol.2018.05.010. Epub 2018 May 26. No abstract available.

PMID:
29958561
8.

Abnormal Ventilation-Perfusion Scan Is Associated with Pulmonary Hypertension in Sickle Cell Adults.

Mehari A, Igbineweka N, Allen D, Nichols J, Thein SL, Weir NA.

J Nucl Med. 2019 Jan;60(1):86-92. doi: 10.2967/jnumed.118.211466. Epub 2018 Jun 7.

PMID:
29880507
9.

A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia.

Adeyemo TA, Ojewunmi OO, Oyetunji IA, Rooks H, Rees DC, Akinsulie AO, Akanmu AS, Thein SL, Menzel S.

PLoS One. 2018 Jun 7;13(6):e0197927. doi: 10.1371/journal.pone.0197927. eCollection 2018.

10.

MYB - A regulatory factor in hematopoiesis.

Wang X, Angelis N, Thein SL.

Gene. 2018 Jul 30;665:6-17. doi: 10.1016/j.gene.2018.04.065. Epub 2018 Apr 25. Review.

PMID:
29704633
11.

Sickle Cell Anemia and Its Phenotypes.

Williams TN, Thein SL.

Annu Rev Genomics Hum Genet. 2018 Aug 31;19:113-147. doi: 10.1146/annurev-genom-083117-021320. Epub 2018 Apr 11.

PMID:
29641911
12.

Switching from fetal to adult hemoglobin.

Wang X, Thein SL.

Nat Genet. 2018 Apr;50(4):478-480. doi: 10.1038/s41588-018-0094-z. No abstract available.

PMID:
29610477
13.

Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction.

Tewari S, Renney G, Brewin J, Gardner K, Kirkham F, Inusa B, Barrett JE, Menzel S, Thein SL, Ward M, Rees DC.

Haematologica. 2018 Jul;103(7):1136-1142. doi: 10.3324/haematol.2018.187815. Epub 2018 Mar 15.

14.

Pain and opioid use after reversal of sickle cell disease following HLA-matched sibling haematopoietic stem cell transplant.

Darbari DS, Liljencrantz J, Ikechi A, Martin S, Roderick MC, Fitzhugh CD, Tisdale JF, Thein SL, Hsieh M.

Br J Haematol. 2019 Feb;184(4):690-693. doi: 10.1111/bjh.15169. Epub 2018 Mar 12. No abstract available.

PMID:
29527656
15.

g(HbF): a genetic model of fetal hemoglobin in sickle cell disease.

Gardner K, Fulford T, Silver N, Rooks H, Angelis N, Allman M, Nkya S, Makani J, Howard J, Kesse-Adu R, Rees DC, Stuart-Smith S, Yeghen T, Awogbade M, Sangeda RZ, Mgaya J, Patel H, Newhouse S, Menzel S, Thein SL.

Blood Adv. 2018 Feb 13;2(3):235-239. doi: 10.1182/bloodadvances.2017009811.

16.

Platelets at the crossroads of thrombosis, inflammation and haemolysis.

Vogel S, Thein SL.

Br J Haematol. 2018 Mar;180(5):761-767. doi: 10.1111/bjh.15117. Epub 2018 Jan 30.

PMID:
29383704
17.

Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial.

Howard J, Slee AE, Skene S, Inusa B, Kawadler J, Downes M, Gavlak J, Koelbel M, Stotesbury H, Chorozoglou M, Tebbs S, Chakravorty S, Awogbade M, Rees DC, Gupta A, Murphy PB, Hart N, Sahota S, Nwosu C, Gwam M, Saunders D, Muthurangu V, Barber N, Ako E, Thein SL, Marshall M, Reading IC, Cheng MYE, Kirkham FJ, Liossi C.

Trials. 2018 Jan 22;19(1):55. doi: 10.1186/s13063-017-2419-0.

18.

Heterogeneity of respiratory disease in children and young adults with sickle cell disease.

Lunt A, Mortimer L, Rees D, Height S, Thein SL, Greenough A.

Thorax. 2018 Jun;73(6):575-577. doi: 10.1136/thoraxjnl-2017-210206. Epub 2017 Nov 29.

PMID:
29187592
19.

Catheter-related right atrial thrombus in sickle cell disease.

Zhao C, Sathya B, Nadal Rios R, Arai AE, Brofferio A, Thein SL, Ruhl AP.

Clin Case Rep. 2017 Sep 20;5(11):1898-1900. doi: 10.1002/ccr3.1187. eCollection 2017 Nov.

20.

Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease.

Thein SL.

Adv Exp Med Biol. 2017;1013:27-57. doi: 10.1007/978-1-4939-7299-9_2. Review.

PMID:
29127676
21.

Therapeutic advances in sickle cell disease in the last decade.

Shet AS, Thein SL.

Indian J Med Res. 2017 Jun;145(6):708-712. doi: 10.4103/ijmr.IJMR_1153_17. No abstract available.

22.

Increased prevalence of renal cysts in patients with sickle cell disease.

Meeks D, Navaratnarajah A, Drasar E, Jaffer O, Wilkins CJ, Thein SL, Sharpe CC.

BMC Nephrol. 2017 Sep 21;18(1):298. doi: 10.1186/s12882-017-0714-3.

23.

A Plea for the Newborn Diagnosis of Hb S-Hereditary Persistence of Fetal Hemoglobin.

Serjeant GR, Serjeant BE, Hambleton IR, Oakley M, Thein SL, Clark B.

Hemoglobin. 2017 May;41(3):216-217. doi: 10.1080/03630269.2017.1360336. Epub 2017 Sep 5.

PMID:
28870138
24.

Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania.

Nkya S, Mgaya J, Urio F, Makubi A, Thein SL, Menzel S, Cox SE, Newton CR, Kirkham FJ, Mmbando BP, Makani J.

EBioMedicine. 2017 Sep;23:146-149. doi: 10.1016/j.ebiom.2017.08.006. Epub 2017 Aug 8.

25.

Molecular basis of β thalassemia and potential therapeutic targets.

Thein SL.

Blood Cells Mol Dis. 2018 May;70:54-65. doi: 10.1016/j.bcmd.2017.06.001. Epub 2017 Jun 20. Review.

PMID:
28651846
26.

Detection of Hb Rothschild HBB: c.[112T>A or 112T>C], Through High Index of Suspicion on Abnormal Pulse Oximetry.

Alli NA, Wessels P, Rampersad N, Clark BE, Thein SL.

Hemoglobin. 2017 Mar;41(2):137-139. doi: 10.1080/03630269.2017.1324796. Epub 2017 Jun 16.

PMID:
28621168
27.

Association of plasma CD40L with acute chest syndrome in sickle cell anemia.

Garrido VT, Sonzogni L, Mtatiro SN, Costa FF, Conran N, Thein SL.

Cytokine. 2017 Sep;97:104-107. doi: 10.1016/j.cyto.2017.05.017. Epub 2017 Jun 10.

PMID:
28609750
28.

Next-generation sequencing as a tool for breakpoint analysis in rearrangements of the globin gene clusters.

Clark BE, Shooter C, Smith F, Brawand D, Thein SL.

Int J Lab Hematol. 2017 May;39 Suppl 1:111-120. doi: 10.1111/ijlh.12680. Review.

PMID:
28447426
29.

Genetic control of erythropoiesis.

Tumburu L, Thein SL.

Curr Opin Hematol. 2017 May;24(3):173-182. doi: 10.1097/MOH.0000000000000333. Review.

PMID:
28212192
30.

Interim assessment of liver damage in patients with sickle cell disease using new non-invasive techniques.

Drasar E, Fitzpatrick E, Gardner K, Awogbade M, Dhawan A, Bomford A, Suddle A, Thein SL.

Br J Haematol. 2017 Feb;176(4):643-650. doi: 10.1111/bjh.14462. Epub 2016 Dec 16.

31.

Sickle cell disease in the older adult.

Thein MS, Igbineweka NE, Thein SL.

Pathology. 2017 Jan;49(1):1-9. doi: 10.1016/j.pathol.2016.10.002. Epub 2016 Nov 30. Review.

PMID:
27914684
32.

Associations between environmental factors and hospital admissions for sickle cell disease.

Piel FB, Tewari S, Brousse V, Analitis A, Font A, Menzel S, Chakravorty S, Thein SL, Inusa B, Telfer P, de Montalembert M, Fuller GW, Katsouyanni K, Rees DC.

Haematologica. 2017 Apr;102(4):666-675. doi: 10.3324/haematol.2016.154245. Epub 2016 Dec 1.

33.

ASH1L (a histone methyltransferase protein) is a novel candidate globin gene regulator revealed by genetic study of an English family with beta-thalassaemia unlinked to the beta-globin locus.

Breton A, Theodorou A, Aktuna S, Sonzogni L, Darling D, Chan L, Menzel S, van der Spek PJ, Swagemakers SM, Grosveld F, Philipsen S, Thein SL.

Br J Haematol. 2016 Nov;175(3):525-530. doi: 10.1111/bjh.14256. Epub 2016 Jul 19.

PMID:
27434206
34.

World Sickle Cell Day 2016 : A time for appraisal.

Thein MS, Thein SL.

Indian J Med Res. 2016 Jun;143(6):678-681. doi: 10.4103/0971-5916.191917. No abstract available.

35.

Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties.

Chu H, McKenna MM, Krump NA, Zheng S, Mendelsohn L, Thein SL, Garrett LJ, Bodine DM, Low PS.

Blood. 2016 Dec 8;128(23):2708-2716. Epub 2016 Sep 29.

36.

Loss of Major DNase I Hypersensitive Sites in Duplicated β-globin Gene Cluster Incompletely Silences HBB Gene Expression.

Reading NS, Shooter C, Song J, Miller R, Agarwal A, Lanikova L, Clark B, Thein SL, Divoky V, Prchal JT.

Hum Mutat. 2016 Nov;37(11):1153-1156. doi: 10.1002/humu.23061. Epub 2016 Aug 25.

PMID:
27492747
37.

Beta thalassaemia intermedia due to co-inheritance of three unique alpha globin cluster duplications characterised by next generation sequencing analysis.

Clark B, Shooter C, Smith F, Brawand D, Steedman L, Oakley M, Rushton P, Rooks H, Wang X, Drousiotou A, Kyrri A, Hadjigavriel M, Will A, Fisher C, Higgs DR, Phylipsen M, Harteveld C, Kleanthous M, Thein SL.

Br J Haematol. 2018 Jan;180(1):160-164. doi: 10.1111/bjh.14294. Epub 2016 Jul 29. No abstract available.

PMID:
27469621
38.

Survival in adults with sickle cell disease in a high-income setting.

Gardner K, Douiri A, Drasar E, Allman M, Mwirigi A, Awogbade M, Thein SL.

Blood. 2016 Sep 8;128(10):1436-8. doi: 10.1182/blood-2016-05-716910. Epub 2016 Jul 20. No abstract available.

39.

Intracranial Aneurysms in Sickle-Cell Disease Are Associated With the Hemoglobin SS Genotype But Not With Moyamoya Syndrome.

Birkeland P, Gardner K, Kesse-Adu R, Davies J, Lauritsen J, Rom Poulsen F, Tolias CM, Thein SL.

Stroke. 2016 Jul;47(7):1710-3. doi: 10.1161/STROKEAHA.116.012664. Epub 2016 Jun 14.

PMID:
27301940
40.

The investigation of resveratrol and analogs as potential inducers of fetal hemoglobin.

Theodorou A, Phylactides M, Forti L, Cramarossa MR, Spyrou P, Gambari R, Thein SL, Kleanthous M.

Blood Cells Mol Dis. 2016 May;58:6-12. doi: 10.1016/j.bcmd.2015.11.007. Epub 2015 Dec 1.

PMID:
27067481
41.

Alpha-thalassaemia trait as a cause of unexplained microcytosis in a South African population.

Loonat SB, Naran NH, Thein SL, Alli NA.

S Afr Med J. 2016 Feb 22;106(3):276-9. doi: 10.7196/SAMJ.2016.v106i3.10005.

PMID:
26915942
42.

Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.

Leonardo FC, Brugnerotto AF, Domingos IF, Fertrin KY, de Albuquerque DM, Bezerra MA, Araújo AS, Saad ST, Costa FF, Menzel S, Conran N, Thein SL.

Br J Haematol. 2016 May;173(3):456-60. doi: 10.1111/bjh.13961. Epub 2016 Feb 16.

PMID:
26888013
43.

Longitudinal assessment of lung function in children with sickle cell disease.

Lunt A, McGhee E, Sylvester K, Rafferty G, Dick M, Rees D, Height S, Thein SL, Greenough A.

Pediatr Pulmonol. 2016 Jul;51(7):717-23. doi: 10.1002/ppul.23367. Epub 2015 Dec 22.

PMID:
26694220
44.

Airway and alveolar nitric oxide production, lung function, and pulmonary blood flow in sickle cell disease.

Lunt A, Ahmed N, Rafferty GF, Dick M, Rees D, Height S, Thein SL, Greenough A.

Pediatr Res. 2016 Feb;79(2):313-7. doi: 10.1038/pr.2015.217. Epub 2015 Oct 22.

PMID:
26492287
45.

Venous thromboembolism in adults with sickle cell disease: experience of a single centre in the UK.

van Hamel Parsons V, Gardner K, Patel R, Thein SL.

Ann Hematol. 2016 Jan;95(2):227-32.

PMID:
26490882
46.

Tissue Iron Distribution Assessed by MRI in Patients with Iron Loading Anemias.

Gutiérrez L, House MJ, Vasavda N, Drašar E, Gonzalez-Gascon Y Marin I, Kulasekararaj AG, St Pierre TG, Thein SL.

PLoS One. 2015 Sep 25;10(9):e0139220. doi: 10.1371/journal.pone.0139220. eCollection 2015.

47.

Genome-wide association analyses based on whole-genome sequencing in Sardinia provide insights into regulation of hemoglobin levels.

Danjou F, Zoledziewska M, Sidore C, Steri M, Busonero F, Maschio A, Mulas A, Perseu L, Barella S, Porcu E, Pistis G, Pitzalis M, Pala M, Menzel S, Metrustry S, Spector TD, Leoni L, Angius A, Uda M, Moi P, Thein SL, Galanello R, Abecasis GR, Schlessinger D, Sanna S, Cucca F.

Nat Genet. 2015 Nov;47(11):1264-71. doi: 10.1038/ng.3307. Epub 2015 Sep 14.

48.

Prevention of Morbidity in sickle cell disease--qualitative outcomes, pain and quality of life in a randomised cross-over pilot trial of overnight supplementary oxygen and auto-adjusting continuous positive airways pressure (POMS2a): study protocol for a randomised controlled trial.

Howard J, Inusa B, Liossi C, Jacob E, Murphy PB, Hart N, Gavlak J, Sahota S, Chorozoglou M, Nwosu C, Gwam M, Gupta A, Rees DC, Thein SL, Reading IC, Kirkham FJ, Cheng MY.

Trials. 2015 Aug 25;16:376. doi: 10.1186/s13063-015-0883-y.

49.

Pulmonary Haemodynamics in Sickle Cell Disease Are Driven Predominantly by a High-Output State Rather Than Elevated Pulmonary Vascular Resistance: A Prospective 3-Dimensional Echocardiography/Doppler Study.

Mushemi-Blake S, Melikian N, Drasar E, Bhan A, Lunt A, Desai SR, Greenough A, Monaghan MJ, Thein SL, Shah AM.

PLoS One. 2015 Aug 13;10(8):e0135472. doi: 10.1371/journal.pone.0135472. eCollection 2015.

50.

Super-elevated LDH and thrombocytopenia are markers of a severe subtype of vaso-occlusive crisis in sickle cell disease.

Gardner K, Thein SL.

Am J Hematol. 2015 Oct;90(10):E206-7. doi: 10.1002/ajh.24126. Epub 2015 Sep 1. No abstract available.

Supplemental Content

Loading ...
Support Center