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Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report.

Ruhl AP, Sadreameli SC, Allen JL, Bennett DP, Campbell AD, Coates TD, Diallo DA, Field JJ, Fiorino EK, Gladwin MT, Glassberg JA, Gordeuk VR, Graham LM, Greenough A, Howard J, Kato GJ, Knight-Madden J, Kopp BT, Koumbourlis AC, Lanzkron SM, Liem RI, Machado RF, Mehari A, Morris CR, Ogunlesi FO, Rosen CL, Smith-Whitley K, Tauber D, Terry N, Thein SL, Vichinsky E, Weir NA, Cohen RT, Klings ES.

Ann Am Thorac Soc. 2019 Sep;16(9):e17-e32. doi: 10.1513/AnnalsATS.201906-433ST.


Electrochemical Oxidation as a Tool for Generating Vitamin D Metabolites.

Navarro Suarez L, Thein S, Kallinich C, Rohn S.

Molecules. 2019 Jun 26;24(13). pii: E2369. doi: 10.3390/molecules24132369.


A Growing Population of Older Adults with Sickle Cell Disease.

Shet AS, Thein SL.

Clin Geriatr Med. 2019 Aug;35(3):349-367. doi: 10.1016/j.cger.2019.03.006. Epub 2019 May 9. Review.


Differential loss to follow-up rates among adult tuberculosis patients - Findings from the largest private sector tuberculosis clinic database in Myanmar.

Aung YK, Swe PP, Kyaw Z, Thein ST.

PLoS One. 2019 Jun 17;14(6):e0218450. doi: 10.1371/journal.pone.0218450. eCollection 2019.


The carrier state for sickle cell disease is not completely harmless.

Xu JZ, Thein SL.

Haematologica. 2019 Jun;104(6):1106-1111. doi: 10.3324/haematol.2018.206060. Epub 2019 May 16. No abstract available.


IKKβ slows Huntington's disease progression in R6/1 mice.

Ochaba J, Fote G, Kachemov M, Thein S, Yeung SY, Lau AL, Hernandez S, Lim RG, Casale M, Neel MJ, Monuki ES, Reidling J, Housman DE, Thompson LM, Steffan JS.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10952-10961. doi: 10.1073/pnas.1814246116. Epub 2019 May 14.


Interactions of an Anti-Sickling Drug with Hemoglobin in Red Blood Cells from a Patient with Sickle Cell Anemia.

Strader MB, Liang H, Meng F, Harper J, Ostrowski DA, Henry ER, Shet AS, Eaton WA, Thein SL, Alayash AI.

Bioconjug Chem. 2019 Mar 20;30(3):568-571. doi: 10.1021/acs.bioconjchem.9b00130. Epub 2019 Feb 28.


Voxelotor treatment of a patient with sickle cell disease and very severe anemia.

Shet AS, Mendelsohn L, Harper J, Ostrowski D, Henry ER, Gwaabe E, Nichols J, Alayash AI, Eaton WA, Thein SL.

Am J Hematol. 2019 Apr;94(4):E88-E90. doi: 10.1002/ajh.25389. Epub 2019 Jan 8. No abstract available.


Improving detection of tuberculosis among household contacts of index tuberculosis patients by an integrated approach in Myanmar: a cross-sectional study.

Htet KKK, Liabsuetrakul T, Thein S, McNeil EB, Chongsuvivatwong V.

BMC Infect Dis. 2018 Dec 14;18(1):660. doi: 10.1186/s12879-018-3586-7.


Genetic Modifiers of Fetal Haemoglobin in Sickle Cell Disease.

Menzel S, Thein SL.

Mol Diagn Ther. 2019 Apr;23(2):235-244. doi: 10.1007/s40291-018-0370-8. Review.


A ten year review of the sickle cell program in Muhimbili National Hospital, Tanzania.

Makani J, Tluway F, Makubi A, Soka D, Nkya S, Sangeda R, Mgaya J, Rwezaula S, Kirkham FJ, Kindole C, Osati E, Meda E, Snow RW, Newton CR, Roberts D, Aboud M, Thein SL, Cox SE, Luzzatto L, Mmbando BP.

BMC Hematol. 2018 Nov 14;18:33. doi: 10.1186/s12878-018-0125-0. eCollection 2018.


L-Arginine Increases Postprandial Circulating GLP-1 and PYY Levels in Humans.

Amin A, Neophytou C, Thein S, Martin NM, Alamshah A, Spreckley E, Bloom SR, Murphy KG.

Obesity (Silver Spring). 2018 Nov;26(11):1721-1726. doi: 10.1002/oby.22323.


The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase.

Vogel S, Arora T, Wang X, Mendelsohn L, Nichols J, Allen D, Shet AS, Combs CA, Quezado ZMN, Thein SL.

Blood Adv. 2018 Oct 23;2(20):2672-2680. doi: 10.1182/bloodadvances.2018021709.


Treatment outcome of tuberculosis patients detected using accelerated vs. passive case finding in Myanmar.

Khaing PS, Kyaw NTT, Satyanarayana S, Oo NL, Aung TH, Oo HM, Kyaw KWY, Soe KT, Thein S, Thwin T, Aung ST.

Int J Tuberc Lung Dis. 2018 Oct 1;22(10):1145-1151. doi: 10.5588/ijtld.18.0038.


How I treat the older adult with sickle cell disease.

Thein SL, Howard J.

Blood. 2018 Oct 25;132(17):1750-1760. doi: 10.1182/blood-2018-03-818161. Epub 2018 Sep 11. Review.


GlycA is not a useful biomarker of inflammation in sickle cell disease.

Weisman JK, Meeks D, Mendelsohn L, Remaley AT, Sampson M, Allen DT, Nichols J, Shet AS, Thein SL.

Int J Lab Hematol. 2018 Dec;40(6):704-709. doi: 10.1111/ijlh.12907. Epub 2018 Aug 27.


Sickle cell disease-Unanswered questions and future directions in therapy.

Thein SL, Tisdale J.

Semin Hematol. 2018 Apr;55(2):51-52. doi: 10.1053/j.seminhematol.2018.05.010. Epub 2018 May 26. No abstract available.


Abnormal Ventilation-Perfusion Scan Is Associated with Pulmonary Hypertension in Sickle Cell Adults.

Mehari A, Igbineweka N, Allen D, Nichols J, Thein SL, Weir NA.

J Nucl Med. 2019 Jan;60(1):86-92. doi: 10.2967/jnumed.118.211466. Epub 2018 Jun 7.


A survey of genetic fetal-haemoglobin modifiers in Nigerian patients with sickle cell anaemia.

Adeyemo TA, Ojewunmi OO, Oyetunji IA, Rooks H, Rees DC, Akinsulie AO, Akanmu AS, Thein SL, Menzel S.

PLoS One. 2018 Jun 7;13(6):e0197927. doi: 10.1371/journal.pone.0197927. eCollection 2018.


Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models.

Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS.

J Huntingtons Dis. 2018;7(2):137-150. doi: 10.3233/JHD-170274.


MYB - A regulatory factor in hematopoiesis.

Wang X, Angelis N, Thein SL.

Gene. 2018 Jul 30;665:6-17. doi: 10.1016/j.gene.2018.04.065. Epub 2018 Apr 25. Review.


Sickle Cell Anemia and Its Phenotypes.

Williams TN, Thein SL.

Annu Rev Genomics Hum Genet. 2018 Aug 31;19:113-147. doi: 10.1146/annurev-genom-083117-021320. Epub 2018 Apr 11. Review.


Switching from fetal to adult hemoglobin.

Wang X, Thein SL.

Nat Genet. 2018 Apr;50(4):478-480. doi: 10.1038/s41588-018-0094-z. No abstract available.


Community-based MDR-TB care project improves treatment initiation in patients diagnosed with MDR-TB in Myanmar.

Wai PP, Shewade HD, Kyaw NTT, Thein S, Si Thu A, Kyaw KWY, Aye NN, Phyo AM, Maung HMW, Soe KT, Aung ST.

PLoS One. 2018 Mar 29;13(3):e0194087. doi: 10.1371/journal.pone.0194087. eCollection 2018.


Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction.

Tewari S, Renney G, Brewin J, Gardner K, Kirkham F, Inusa B, Barrett JE, Menzel S, Thein SL, Ward M, Rees DC.

Haematologica. 2018 Jul;103(7):1136-1142. doi: 10.3324/haematol.2018.187815. Epub 2018 Mar 15.


Pain and opioid use after reversal of sickle cell disease following HLA-matched sibling haematopoietic stem cell transplant.

Darbari DS, Liljencrantz J, Ikechi A, Martin S, Roderick MC, Fitzhugh CD, Tisdale JF, Thein SL, Hsieh M.

Br J Haematol. 2019 Feb;184(4):690-693. doi: 10.1111/bjh.15169. Epub 2018 Mar 12. No abstract available.


Evaluation of a tuberculosis active case finding project in peri-urban areas, Myanmar: 2014-2016.

Aye S, Majumdar SS, Oo MM, Tripathy JP, Satyanarayana S, Kyaw NTT, Kyaw KWY, Oo NL, Thein S, Thu MK, Soe KT, Aung ST.

Int J Infect Dis. 2018 May;70:93-100. doi: 10.1016/j.ijid.2018.02.012. Epub 2018 Feb 21.


g(HbF): a genetic model of fetal hemoglobin in sickle cell disease.

Gardner K, Fulford T, Silver N, Rooks H, Angelis N, Allman M, Nkya S, Makani J, Howard J, Kesse-Adu R, Rees DC, Stuart-Smith S, Yeghen T, Awogbade M, Sangeda RZ, Mgaya J, Patel H, Newhouse S, Menzel S, Thein SL.

Blood Adv. 2018 Feb 13;2(3):235-239. doi: 10.1182/bloodadvances.2017009811.


Platelets at the crossroads of thrombosis, inflammation and haemolysis.

Vogel S, Thein SL.

Br J Haematol. 2018 Mar;180(5):761-767. doi: 10.1111/bjh.15117. Epub 2018 Jan 30.


National scale-up of tuberculosis-human immunodeficiency virus collaborative activities in Myanmar from 2005 to 2016 and tuberculosis treatment outcomes for patients with human immunodeficiency virus-positive tuberculosis in the Mandalay Region in 2015.

Theingi P, Harries AD, Wai KT, Shewade HD, Saw S, Win T, Thein S, Kyi MS, Nyunt Oo H, Aung ST.

Trans R Soc Trop Med Hyg. 2017 Sep 1;111(9):402-409. doi: 10.1093/trstmh/trx073.


Overnight auto-adjusting continuous airway pressure + standard care compared with standard care alone in the prevention of morbidity in sickle cell disease phase II (POMS2b): study protocol for a randomised controlled trial.

Howard J, Slee AE, Skene S, Inusa B, Kawadler J, Downes M, Gavlak J, Koelbel M, Stotesbury H, Chorozoglou M, Tebbs S, Chakravorty S, Awogbade M, Rees DC, Gupta A, Murphy PB, Hart N, Sahota S, Nwosu C, Gwam M, Saunders D, Muthurangu V, Barber N, Ako E, Thein SL, Marshall M, Reading IC, Cheng MYE, Kirkham FJ, Liossi C.

Trials. 2018 Jan 22;19(1):55. doi: 10.1186/s13063-017-2419-0.


High treatment success rate among multidrug-resistant tuberculosis patients in Myanmar, 2012-2014: a retrospective cohort study.

Thu MK, Kumar AMV, Soe KT, Saw S, Thein S, Mynit Z, Maung HMW, Aung ST.

Trans R Soc Trop Med Hyg. 2017 Sep 1;111(9):410-417. doi: 10.1093/trstmh/trx074.


Patients with MDR-TB on domiciliary care in programmatic settings in Myanmar: Effect of a support package on preventing early deaths.

Wai PP, Shewade HD, Kyaw NTT, Kyaw KWY, Thein S, Si Thu A, Oo MM, Htwe PS, Tun MMT, Win Maung HM, Soe KT, Aung ST.

PLoS One. 2017 Dec 20;12(12):e0187223. doi: 10.1371/journal.pone.0187223. eCollection 2017.


Heterogeneity of respiratory disease in children and young adults with sickle cell disease.

Lunt A, Mortimer L, Rees D, Height S, Thein SL, Greenough A.

Thorax. 2018 Jun;73(6):575-577. doi: 10.1136/thoraxjnl-2017-210206. Epub 2017 Nov 29.


Catheter-related right atrial thrombus in sickle cell disease.

Zhao C, Sathya B, Nadal Rios R, Arai AE, Brofferio A, Thein SL, Ruhl AP.

Clin Case Rep. 2017 Sep 20;5(11):1898-1900. doi: 10.1002/ccr3.1187. eCollection 2017 Nov.


Genetic Basis and Genetic Modifiers of β-Thalassemia and Sickle Cell Disease.

Thein SL.

Adv Exp Med Biol. 2017;1013:27-57. doi: 10.1007/978-1-4939-7299-9_2. Review.


Therapeutic advances in sickle cell disease in the last decade.

Shet AS, Thein SL.

Indian J Med Res. 2017 Jun;145(6):708-712. doi: 10.4103/ijmr.IJMR_1153_17. No abstract available.


Political transition and emergent forest-conservation issues in Myanmar.

Prescott GW, Sutherland WJ, Aguirre D, Baird M, Bowman V, Brunner J, Connette GM, Cosier M, Dapice D, De Alban JDT, Diment A, Fogerite J, Fox J, Hlaing W, Htun S, Hurd J, LaJeunesse Connette K, Lasmana F, Lim CL, Lynam A, Maung AC, McCarron B, McCarthy JF, McShea WJ, Momberg F, Mon MS, Myint T, Oberndorf R, Oo TN, Phelps J, Rao M, Schmidt-Vogt D, Speechly H, Springate-Baginski O, Steinmetz R, Talbott K, Than MM, Thaung TL, Thawng SCL, Thein KM, Thein S, Tizard R, Whitten T, Williams G, Wilson T, Woods K, Ziegler AD, Zrust M, Webb EL.

Conserv Biol. 2017 Dec;31(6):1257-1270. doi: 10.1111/cobi.13021. Epub 2017 Oct 14. Review.


Increased prevalence of renal cysts in patients with sickle cell disease.

Meeks D, Navaratnarajah A, Drasar E, Jaffer O, Wilkins CJ, Thein SL, Sharpe CC.

BMC Nephrol. 2017 Sep 21;18(1):298. doi: 10.1186/s12882-017-0714-3.


A Plea for the Newborn Diagnosis of Hb S-Hereditary Persistence of Fetal Hemoglobin.

Serjeant GR, Serjeant BE, Hambleton IR, Oakley M, Thein SL, Clark B.

Hemoglobin. 2017 May;41(3):216-217. doi: 10.1080/03630269.2017.1360336. Epub 2017 Sep 5.


Engagement of public and private medical facilities in tuberculosis care in Myanmar: contributions and trends over an eight-year period.

Nwe TT, Saw S, Le Win L, Mon MM, van Griensven J, Zhou S, Chinnakali P, Shah S, Thein S, Aung ST.

Infect Dis Poverty. 2017 Sep 1;6(1):123. doi: 10.1186/s40249-017-0337-8.


Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania.

Nkya S, Mgaya J, Urio F, Makubi A, Thein SL, Menzel S, Cox SE, Newton CR, Kirkham FJ, Mmbando BP, Makani J.

EBioMedicine. 2017 Sep;23:146-149. doi: 10.1016/j.ebiom.2017.08.006. Epub 2017 Aug 8.


Molecular basis of β thalassemia and potential therapeutic targets.

Thein SL.

Blood Cells Mol Dis. 2018 May;70:54-65. doi: 10.1016/j.bcmd.2017.06.001. Epub 2017 Jun 20. Review.


Detection of Hb Rothschild HBB: c.[112T>A or 112T>C], Through High Index of Suspicion on Abnormal Pulse Oximetry.

Alli NA, Wessels P, Rampersad N, Clark BE, Thein SL.

Hemoglobin. 2017 Mar;41(2):137-139. doi: 10.1080/03630269.2017.1324796. Epub 2017 Jun 16.


Association of plasma CD40L with acute chest syndrome in sickle cell anemia.

Garrido VT, Sonzogni L, Mtatiro SN, Costa FF, Conran N, Thein SL.

Cytokine. 2017 Sep;97:104-107. doi: 10.1016/j.cyto.2017.05.017. Epub 2017 Jun 10.


Defining sepsis: inspiring proposals meet practical realities.

Munang M, Chaudhri S, Himayakanthan M, Laird S, Moltu A, Naworynsky N, Pollard C, Saeed T, Scott P, Chan C, Sussman M, Thein S, Trafford G, Balaji A, Jenkins N, Moran E.

Lancet Infect Dis. 2017 Jun;17(6):577-578. doi: 10.1016/S1473-3099(17)30267-0. No abstract available.


Next-generation sequencing as a tool for breakpoint analysis in rearrangements of the globin gene clusters.

Clark BE, Shooter C, Smith F, Brawand D, Thein SL.

Int J Lab Hematol. 2017 May;39 Suppl 1:111-120. doi: 10.1111/ijlh.12680. Review.


Sepsis quality standards are laudable but have low specificity.

Moran E, Munang M, Chan C, Chaudhri S, Himayakanthan M, Laird S, Moltu A, Naworynsky N, Pollard C, Saeed T, Scott P, Sussman M, Thein S, Trafford G, Balaji A, Jenkins N.

BMJ. 2017 Apr 25;357:j1974. doi: 10.1136/bmj.j1974. No abstract available.


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