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Items: 21


Facile Synthesis, Geometry, and 2'-Substituent-Dependent in Vivo Activity of 5'-(E)- and 5'-(Z)-Vinylphosphonate-Modified siRNA Conjugates.

Parmar RG, Brown CR, Matsuda S, Willoughby JLS, Theile CS, Charissé K, Foster DJ, Zlatev I, Jadhav V, Maier MA, Egli M, Manoharan M, Rajeev KG.

J Med Chem. 2018 Feb 8;61(3):734-744. doi: 10.1021/acs.jmedchem.7b01147. Epub 2018 Jan 27.


Strengths and Weaknesses of the Current Dental Hygiene Educational System.

Theile CW.

J Dent Educ. 2017 Sep;81(9):eS38-eS44. doi: 10.21815/JDE.017.034.


siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L.

Nucleic Acids Res. 2017 May 5;45(8):5008. doi: 10.1093/nar/gkw1298. No abstract available.


siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L.

Nucleic Acids Res. 2017 Apr 7;45(6):3528-3536. doi: 10.1093/nar/gkw1171.


Rapid capture and labeling of cells on single domain antibodies-functionalized flow cell.

Chen GY, Li Z, Duarte JN, Esteban A, Cheloha RW, Theile CS, Fink GR, Ploegh HL.

Biosens Bioelectron. 2017 Mar 15;89(Pt 2):789-794. doi: 10.1016/j.bios.2016.10.015. Epub 2016 Oct 5.


The Oral Health Care Manager in a Patient-Centered Health Facility.

Theile CW, Strauss SM, Northridge ME, Birenz S.

J Evid Based Dent Pract. 2016 Jun;16 Suppl:34-42. doi: 10.1016/j.jebdp.2016.01.026. Epub 2016 Feb 4.


5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V.

Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130. Epub 2016 Apr 28.


Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.

Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E705-14. doi: 10.1073/pnas.1521763113. Epub 2016 Jan 25.


Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells.

Chen GY, Li Z, Theile CS, Bardhan NM, Kumar PV, Duarte JN, Maruyama T, Rashidfarrokh A, Belcher AM, Ploegh HL.

Chemistry. 2015 Nov 23;21(48):17178-83. doi: 10.1002/chem.201503057. Epub 2015 Oct 16.


Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments.

Li Z, Theile CS, Chen GY, Bilate AM, Duarte JN, Avalos AM, Fang T, Barberena R, Sato S, Ploegh HL.

Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11706-10. doi: 10.1002/anie.201505277. Epub 2015 Aug 7.


Site-specific protein modification using immobilized sortase in batch and continuous-flow systems.

Witte MD, Wu T, Guimaraes CP, Theile CS, Blom AE, Ingram JR, Li Z, Kundrat L, Goldberg SD, Ploegh HL.

Nat Protoc. 2015 Mar;10(3):508-16. doi: 10.1038/nprot.2015.026. Epub 2015 Feb 26.


Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors.

Wuethrich I, Peeters JG, Blom AE, Theile CS, Li Z, Spooner E, Ploegh HL, Guimaraes CP.

PLoS One. 2014 Oct 2;9(10):e109883. doi: 10.1371/journal.pone.0109883. eCollection 2014.


Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes.

Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T, Dougan SK, Ploegh HL, Lodish HF.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10131-6. doi: 10.1073/pnas.1409861111. Epub 2014 Jun 30.


Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells.

Avalos AM, Bilate AM, Witte MD, Tai AK, He J, Frushicheva MP, Thill PD, Meyer-Wentrup F, Theile CS, Chakraborty AK, Zhuang X, Ploegh HL.

J Exp Med. 2014 Feb 10;211(2):365-79. doi: 10.1084/jem.20131603. Epub 2014 Feb 3.


A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.

Walters BJ, Hallengren JJ, Theile CS, Ploegh HL, Wilson SM, Dobrunz LE.

J Physiol. 2014 Feb 15;592(4):571-86. doi: 10.1113/jphysiol.2013.266015. Epub 2013 Nov 11.


Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry.

Witte MD, Theile CS, Wu T, Guimaraes CP, Blom AE, Ploegh HL.

Nat Protoc. 2013 Sep;8(9):1808-19. doi: 10.1038/nprot.2013.103. Epub 2013 Aug 29.


Site-specific N-terminal labeling of proteins using sortase-mediated reactions.

Theile CS, Witte MD, Blom AE, Kundrat L, Ploegh HL, Guimaraes CP.

Nat Protoc. 2013 Sep;8(9):1800-7. doi: 10.1038/nprot.2013.102. Epub 2013 Aug 29.


Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions.

Guimaraes CP, Witte MD, Theile CS, Bozkurt G, Kundrat L, Blom AE, Ploegh HL.

Nat Protoc. 2013 Sep;8(9):1787-99. doi: 10.1038/nprot.2013.101. Epub 2013 Aug 29.


Synthesis and properties of DNA containing cyclonucleosides.

Yueh H, Yu H, Theile CS, Pal A, Horhota A, Greco N, Christianson CV, McLaughlin LW.

Nucleosides Nucleotides Nucleic Acids. 2012;31(9):661-79.


An efficient synthetic approach to 6,5'-(S)- and 6,5'-(R)-cyclouridine.

Theile CS, McLaughlin LW.

Chem Commun (Camb). 2012 Jun 7;48(45):5587-9. doi: 10.1039/c2cc31597a. Epub 2012 Apr 24.


Pyrovanadolysis, a pyrophosphorolysis-like reaction mediated by pyrovanadate, Mn2+, and DNA polymerase of bacteriophage T7.

Akabayov B, Kulczyk AW, Akabayov SR, Theile C, McLaughlin LW, Beauchamp B, van Oijen AM, Richardson CC.

J Biol Chem. 2011 Aug 19;286(33):29146-57. doi: 10.1074/jbc.M111.250944. Epub 2011 Jun 21.

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