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Anesth Pain Med. 2018 Sep 22;8(5):e79677. doi: 10.5812/aapm.79677. eCollection 2018 Oct.

The Comparison of the Effect of Mannitol and N Acetyl Cysteine on Liver Function in Partial Hepatectomy.

Author information

1
Department of Anesthesia, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2
Department of Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3
Department of Anesthesia, Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4
Department of Anesthesia, Pain Research Center, Yasouj University of Medical Sciences, Yasouj, Iran.
5
Department of Surgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

The alterations in liver function in patients after major liver resection are complex. Partial hepatectomy surgery is considered as a selective therapeutic approach in many benign and malignant liver tumors, secondary metastases, and liver trauma. According to surgical techniques most often based on vascular control and hepatic venous closure (Pringle maneuver), related complications such as ischemia and decreased venous return during and after surgery can be seen. In this study, the effects of Mannitol and N-acetylcysteine, on liver function, after hepatectomy surgery, were compared. This study was shown that infusion N-acetylcysteine next to mannitol, in partial hepatectomy surgeries, was not the significant difference to improve liver function, hemodynamic status, and laboratory tests.

KEYWORDS:

Liver Function; Mannitol; N-acetylcysteine; Partial Hepatectomy

Conflict of interest statement

Conflict of Interests:Authors of this manuscript have no conflict of interests.

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