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Biomark Med. 2014;8(10):1227-38. doi: 10.2217/bmm.14.85.

Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery.

Author information

1
Department of Nephrology & Hypertension, Diabetes & Endocrinology, Otto-von-Guericke University, Magdeburg, Germany.

Abstract

AIM:

To assess the association of genetic variants of catecholamine-O-methyltransferase (COMT) genotypes with acute kidney injury (AKI) and tubular stress after open heart surgery.

PATIENTS & METHODS:

We genotyped 195 patients for the COMT-Val158Met polymorphism and measured creatinine, neutrophil gelatinase-associated lipocalin and midkine. We analyzed the association between such polymorphisms and these kidney-related variables.

RESULTS:

Nonsignificantly more COMT LL patients developed RIFLE-AKI compared with non-LL patients (p = 0.11). Compared with HL and HH patients, LL patients who developed AKI had lower increases in serum creatinine. COMT LL patients had less pronounced release of tubular stress biomarkers (neutrophil gelatinase-associated lipocalin: p = 0.045, midkine: p = 0.072).

CONCLUSION:

COMT genotype may associate with different patterns of renal functional changes and tubular stress biomarker release response after open heart surgery.

KEYWORDS:

COMT; NGAL; Val158Met SNP; acute kidney injury; midkine; neutrophil gelatinase-associated lipocalin; open heart surgery; rs4680; tubular stress

PMID:
25525983
DOI:
10.2217/bmm.14.85
[Indexed for MEDLINE]

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