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AJNR Am J Neuroradiol. 1996 Sep;17(8):1589-91.

Whipple disease confined to the central nervous system in childhood.

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Department of Medical Imaging, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium.


In a case of pediatric Whipple disease confined to the central nervous system, white matter lesions initially appeared as areas of very low signal intensity on T1-weighted MR images and as areas of hyperintensity on proton density-weighted and T2-weighted images, and showed slight peripheral enhancement on delayed contrast-enhanced T1-weighted images. On MR studies obtained 3 and 6 months after antibiotic therapy, the lesions had decreased in size and no longer enhanced. They became progressively less hypointense on T1-weighted images and less hyperintense on T2-weighted images.

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