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Items: 10


Characterization of genetic intratumor heterogeneity in colorectal cancer and matching patient-derived spheroid cultures.

Árnadóttir SS, Jeppesen M, Lamy P, Bramsen JB, Nordentoft I, Knudsen M, Vang S, Madsen MR, Thastrup O, Thastrup J, L Andersen C.

Mol Oncol. 2018 Jan;12(1):132-147. doi: 10.1002/1878-0261.12156. Epub 2017 Nov 27.


Short-term spheroid culture of primary colorectal cancer cells as an in vitro model for personalizing cancer medicine.

Jeppesen M, Hagel G, Glenthoj A, Vainer B, Ibsen P, Harling H, Thastrup O, Jørgensen LN, Thastrup J.

PLoS One. 2017 Sep 6;12(9):e0183074. doi: 10.1371/journal.pone.0183074. eCollection 2017.


SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

Thastrup JO, Rafiqi FH, Vitari AC, Pozo-Guisado E, Deak M, Mehellou Y, Alessi DR.

Biochem J. 2012 Jan 1;441(1):325-37. doi: 10.1042/BJ20111879.


Solid-phase synthesis of smac peptidomimetics incorporating triazoloprolines and biarylalanines.

Le Quement ST, Ishoey M, Petersen MT, Thastrup J, Hagel G, Nielsen TE.

ACS Comb Sci. 2011 Nov 14;13(6):667-75. doi: 10.1021/co200078u. Epub 2011 Sep 28.


Identification of nucleolar effects in JNK-deficient cells.

Mialon A, Thastrup J, Kallunki T, Mannermaa L, Westermarck J, Holmström TH.

FEBS Lett. 2008 Sep 3;582(20):3145-51. doi: 10.1016/j.febslet.2008.08.004. Epub 2008 Aug 12.


Structural insights into the recognition of substrates and activators by the OSR1 kinase.

Villa F, Goebel J, Rafiqi FH, Deak M, Thastrup J, Alessi DR, van Aalten DM.

EMBO Rep. 2007 Sep;8(9):839-45. Epub 2007 Aug 17.


c-Jun NH2-terminal kinase 2 is required for Ras transformation independently of activator protein 1.

Nielsen C, Thastrup J, Bøttzauw T, Jäättelä M, Kallunki T.

Cancer Res. 2007 Jan 1;67(1):178-85.


Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.

Zagórska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR.

J Cell Biol. 2007 Jan 1;176(1):89-100. Epub 2006 Dec 26.


Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.

Vitari AC, Thastrup J, Rafiqi FH, Deak M, Morrice NA, Karlsson HK, Alessi DR.

Biochem J. 2006 Jul 1;397(1):223-31.


JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

Dietrich N, Thastrup J, Holmberg C, Gyrd-Hansen M, Fehrenbacher N, Lademann U, Lerdrup M, Herdegen T, Jäättelä M, Kallunki T.

Cell Death Differ. 2004 Mar;11(3):301-13.

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