Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 117


Histone Deacetylase Expressions in Hepatocellular Carcinoma and Functional Effects of Histone Deacetylase Inhibitors on Liver Cancer Cells In Vitro.

Freese K, Seitz T, Dietrich P, Lee SML, Thasler WE, Bosserhoff A, Hellerbrand C.

Cancers (Basel). 2019 Oct 18;11(10). pii: E1587. doi: 10.3390/cancers11101587.


Bone Morphogenetic Protein-8B Expression is Induced in Steatotic Hepatocytes and Promotes Hepatic Steatosis and Inflammation In Vitro.

Mahli A, Seitz T, Beckröge T, Freese K, Thasler WE, Benkert M, Dietrich P, Weiskirchen R, Bosserhoff A, Hellerbrand C.

Cells. 2019 May 15;8(5). pii: E457. doi: 10.3390/cells8050457.


A Novel Chimeric Oncolytic Virus Vector for Improved Safety and Efficacy as a Platform for the Treatment of Hepatocellular Carcinoma.

Abdullahi S, Jäkel M, Behrend SJ, Steiger K, Topping G, Krabbe T, Colombo A, Sandig V, Schiergens TS, Thasler WE, Werner J, Lichtenthaler SF, Schmid RM, Ebert O, Altomonte J.

J Virol. 2018 Nov 12;92(23). pii: e01386-18. doi: 10.1128/JVI.01386-18. Print 2018 Dec 1.


Preparation and Culture of Human Liver Resident Immune Cells.

Feng H, Ou B, Dong W, Thasler WE.

Curr Protoc Cell Biol. 2018 Sep;80(1):e50. doi: 10.1002/cpcb.50. Epub 2018 Aug 22.


β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor.

Klag T, Thomas M, Ehmann D, Courth L, Mailänder-Sanchez D, Weiss TS, Dayoub R, Abshagen K, Vollmar B, Thasler WE, Stange EF, Berg CP, Malek NP, Zanger UM, Wehkamp J.

Front Immunol. 2018 Jul 27;9:1735. doi: 10.3389/fimmu.2018.01735. eCollection 2018.


Iso-alpha acids from hops (Humulus lupulus) inhibit hepatic steatosis, inflammation, and fibrosis.

Mahli A, Koch A, Fresse K, Schiergens T, Thasler WE, Schönberger C, Bergheim I, Bosserhoff A, Hellerbrand C.

Lab Invest. 2018 Dec;98(12):1614-1626. doi: 10.1038/s41374-018-0112-x. Epub 2018 Aug 8.


Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation.

Gai Z, Visentin M, Gui T, Zhao L, Thasler WE, Häusler S, Hartling I, Cremonesi A, Hiller C, Kullak-Ublick GA.

Mol Pharmacol. 2018 Aug;94(2):802-811. doi: 10.1124/mol.117.111047. Epub 2018 May 9.


Combined effects of PLK1 and RAS in hepatocellular carcinoma reveal rigosertib as promising novel therapeutic "dual-hit" option.

Dietrich P, Freese K, Mahli A, Thasler WE, Hellerbrand C, Bosserhoff AK.

Oncotarget. 2017 Dec 11;9(3):3605-3618. doi: 10.18632/oncotarget.23188. eCollection 2018 Jan 9.


Bone marrow-derived mesenchymal stromal cells promote colorectal cancer cell death under low-dose irradiation.

Feng H, Zhao JK, Schiergens TS, Wang PX, Ou BC, Al-Sayegh R, Li ML, Lu AG, Yin S, Thasler WE.

Br J Cancer. 2018 Feb 6;118(3):353-365. doi: 10.1038/bjc.2017.415. Epub 2018 Jan 2.


Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B.

Arch Toxicol. 2018 Apr;92(4):1435-1451. doi: 10.1007/s00204-018-2165-4. Epub 2018 Jan 22.


Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth.

Voigt C, May P, Gottschlich A, Markota A, Wenk D, Gerlach I, Voigt S, Stathopoulos GT, Arendt KAM, Heise C, Rataj F, Janssen KP, Königshoff M, Winter H, Himsl I, Thasler WE, Schnurr M, Rothenfußer S, Endres S, Kobold S.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12994-12999. doi: 10.1073/pnas.1705165114. Epub 2017 Nov 17.


IFN-α-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection.

Li Y, Xia Y, Han M, Chen G, Zhang D, Thasler WE, Protzer U, Ning Q.

Sci Rep. 2017 Oct 5;7(1):12715. doi: 10.1038/s41598-017-13082-z.


Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer.

Feng H, Ou BC, Zhao JK, Yin S, Lu AG, Oechsle E, Thasler WE.

J Cancer Res Clin Oncol. 2017 Sep;143(9):1771-1786. doi: 10.1007/s00432-017-2434-2. Epub 2017 May 11. Erratum in: J Cancer Res Clin Oncol. 2017 Jun 16;:.


Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.

Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O.

Biochem Pharmacol. 2017 Jul 15;136:122-135. doi: 10.1016/j.bcp.2017.04.013. Epub 2017 Apr 13.


Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.

Jeske J, Windshügel B, Thasler WE, Schwab M, Burk O.

Arch Toxicol. 2017 Jun;91(6):2375-2390. doi: 10.1007/s00204-017-1948-3. Epub 2017 Mar 13.


Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice.

Sommer J, Mahli A, Freese K, Schiergens TS, Kuecuekoktay FS, Teufel A, Thasler WE, Müller M, Bosserhoff AK, Hellerbrand C.

Oncotarget. 2017 Feb 21;8(8):13059-13072. doi: 10.18632/oncotarget.14371.


Osseous differentiation of human fat tissue grafts: From tissue engineering to tissue differentiation.

Bondarava M, Cattaneo C, Ren B, Thasler WE, Jansson V, Müller PE, Betz OB.

Sci Rep. 2017 Jan 5;7:39712. doi: 10.1038/srep39712.


ERK activation and autophagy impairment are central mediators of irinotecan-induced steatohepatitis.

Mahli A, Saugspier M, Koch A, Sommer J, Dietrich P, Lee S, Thasler R, Schulze-Luehrmann J, Luehrmann A, Thasler WE, Müller M, Bosserhoff A, Hellerbrand C.

Gut. 2018 Apr;67(4):746-756. doi: 10.1136/gutjnl-2016-312485. Epub 2017 Jan 4.


Federated Biobanking with Corporate Service Unit: The Munich Biobank Alliance Blueprint.

Thasler RM, Berghammer AJ, Kirchner T, Slotta-Huspenina J, Becker KF, Schiergens T, Thasler WE, Wichmann HE.

Biopreserv Biobank. 2017 Feb;15(1):75-79. doi: 10.1089/bio.2016.0101. Epub 2016 Dec 19. No abstract available.


Long-term outcomes and propensity score matching analysis: rectal cancer resection for patients with elevated preoperative risk.

Feng H, Schiergens TS, Mao ZH, Zhao J, Shen X, Lu AG, Thasler WE.

Oncotarget. 2017 Apr 11;8(15):25679-25690. doi: 10.18632/oncotarget.13827.


Long-term Quality of Life of Patients With Permanent End Ileostomy: Results of a Nationwide Cross-Sectional Survey.

Schiergens TS, Hoffmann V, Schobel TN, Englert GH, Kreis ME, Thasler WE, Werner J, Kasparek MS.

Dis Colon Rectum. 2017 Jan;60(1):51-60.


Isolation of Hepatocytes and Stellate Cells from a Single Piece of Human Liver.

Lee SM, Schiergens TS, Demmel M, Thasler RM, Thasler WE.

Methods Mol Biol. 2017;1506:247-258.


Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues.

Marzi C, Holdt LM, Fiorito G, Tsai PC, Kretschmer A, Wahl S, Guarrera S, Teupser D, Spector TD, Iacoviello L, Sacerdote C, Strauch K, Lee S, Thasler WE, Peters A, Thorand B, Wolf P, Prokisch H, Tumino R, Gieger C, Krogh V, Panico S, Bell JT, Matullo G, Waldenberger M, Grallert H, Koenig W.

PLoS One. 2016 Nov 8;11(11):e0166015. doi: 10.1371/journal.pone.0166015. eCollection 2016.


Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG.

Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23.


Laparoscopic Complete Mesocolic Excision for Stage II/III Left-Sided Colon Cancers: A Prospective Study and Comparison with D3 Lymph Node Dissection.

Feng H, Zhao XW, Zhang Z, Han DP, Mao ZH, Lu AG, Thasler WE.

J Laparoendosc Adv Surg Tech A. 2016 Aug;26(8):606-13. doi: 10.1089/lap.2016.0120. Epub 2016 May 16.


Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes.

Krattinger R, Boström A, Lee SML, Thasler WE, Schiöth HB, Kullak-Ublick GA, Mwinyi J.

Life Sci. 2016 Jul 1;156:47-56. doi: 10.1016/j.lfs.2016.04.037. Epub 2016 May 10.


microRNA-192 suppresses the expression of the farnesoid X receptor.

Krattinger R, Boström A, Schiöth HB, Thasler WE, Mwinyi J, Kullak-Ublick GA.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1044-51. doi: 10.1152/ajpgi.00297.2015. Epub 2016 Apr 14.


Liver Resection for Non-colorectal Non-neuroendocrine Metastases: Where Do We Stand Today Compared to Colorectal Cancer?

Schiergens TS, Lüning J, Renz BW, Thomas M, Pratschke S, Feng H, Lee SM, Engel J, Rentsch M, Guba M, Werner J, Thasler WE.

J Gastrointest Surg. 2016 Jun;20(6):1163-72. doi: 10.1007/s11605-016-3115-1. Epub 2016 Feb 26.


Time-dependent impact of age and comorbidities on long-term overall survival after liver resection.

Schiergens TS, Lindenthaler A, Thomas MN, Rentsch M, Mittermeier L, Brand K, Küchenhoff H, Lee S, Guba M, Werner J, Thasler WE.

Liver Int. 2016 Sep;36(9):1340-50. doi: 10.1111/liv.13068. Epub 2016 Mar 24.


Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling.

Keller R, Klein M, Thomas M, Dräger A, Metzger U, Templin MF, Joos TO, Thasler WE, Zell A, Zanger UM.

PLoS Comput Biol. 2016 Jan 4;12(1):e1004431. doi: 10.1371/journal.pcbi.1004431. eCollection 2016 Jan.


Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro.

Mahli A, Thasler WE, Patsenker E, Müller S, Stickel F, Müller M, Seitz HK, Cederbaum AI, Hellerbrand C.

Oncotarget. 2015 Dec 8;6(39):41464-78. doi: 10.18632/oncotarget.6203.


Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.

Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U.

Gastroenterology. 2016 Jan;150(1):194-205. doi: 10.1053/j.gastro.2015.09.026. Epub 2015 Sep 28.


Pre-Analytical Determination of the Effect of Extended Warm or Cold Ischaemia on RNA Stability in the Human Ileum Mucosa.

Lee SM, Schelcher C, Thasler R, Schiergens TS, Thasler WE.

PLoS One. 2015 Sep 15;10(9):e0138214. doi: 10.1371/journal.pone.0138214. eCollection 2015.


Thirty-day mortality leads to underestimation of postoperative death after liver resection: A novel method to define the acute postoperative period.

Schiergens TS, Dörsch M, Mittermeier L, Brand K, Küchenhoff H, Lee SM, Feng H, Jauch KW, Werner J, Thasler WE.

Surgery. 2015 Dec;158(6):1530-7. doi: 10.1016/j.surg.2015.07.019. Epub 2015 Aug 19.


Comparison of non-schistosomal rectosigmoid cancer and schistosomal rectosigmoid cancer.

Feng H, Lu AG, Zhao XW, Han DP, Zhao JK, Shi L, Schiergens TS, Lee SM, Zhang WP, Thasler WE.

World J Gastroenterol. 2015 Jun 21;21(23):7225-32. doi: 10.3748/wjg.v21.i23.7225.


Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma.

Engelmann JC, Amann T, Ott-Rötzer B, Nützel M, Reinders Y, Reinders J, Thasler WE, Kristl T, Teufel A, Huber CG, Oefner PJ, Spang R, Hellerbrand C.

PLoS Comput Biol. 2015 May 28;11(5):e1004293. doi: 10.1371/journal.pcbi.1004293. eCollection 2015 May.


STAT3 inhibition reduces toxicity of oncolytic VSV and provides a potentially synergistic combination therapy for hepatocellular carcinoma.

Marozin S, Altomonte J, Muñoz-Álvarez KA, Rizzani A, De Toni EN, Thasler WE, Schmid RM, Ebert O.

Cancer Gene Ther. 2015 Jun;22(6):317-25. doi: 10.1038/cgt.2015.23. Epub 2015 May 1.


Effect of suture technique on the occurrence of incisional hernia after elective midline abdominal wall closure: study protocol for a randomized controlled trial.

Fortelny RH, Baumann P, Thasler WE, Albertsmeier M, Riedl S, Steurer W, Kewer JL, Shamiyeh A.

Trials. 2015 Feb 15;16:52. doi: 10.1186/s13063-015-0572-x.


Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.

Lichtenauer UD, Di Dalmazi G, Slater EP, Wieland T, Kuebart A, Schmittfull A, Schwarzmayr T, Diener S, Wiese D, Thasler WE, Reincke M, Meitinger T, Schott M, Fassnacht M, Bartsch DK, Strom TM, Beuschlein F.

J Clin Endocrinol Metab. 2015 May;100(5):E776-82. doi: 10.1210/jc.2015-1100. Epub 2015 Mar 12.


Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry.

Weiß F, Schnabel A, Planatscher H, van den Berg BH, Serschnitzki B, Nuessler AK, Thasler WE, Weiss TS, Reuss M, Stoll D, Templin MF, Joos TO, Marcus K, Poetz O.

Sci Rep. 2015 Mar 4;5:8759. doi: 10.1038/srep08759.


Human sterol regulatory element-binding protein 1a contributes significantly to hepatic lipogenic gene expression.

Bitter A, Nüssler AK, Thasler WE, Klein K, Zanger UM, Schwab M, Burk O.

Cell Physiol Biochem. 2015;35(2):803-15. doi: 10.1159/000369739. Epub 2015 Jan 30.


DNA methylation of lipid-related genes affects blood lipid levels.

Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, Klopp N, Illig T, Hedman ÅK, Roden M, Hernandez DG, Singleton AB, Thasler WE, Grallert H, Gieger C, Herder C, Teupser D, Meisinger C, Spector TD, Kronenberg F, Prokisch H, Melzer D, Peters A, Deloukas P, Ferrucci L, Waldenberger M.

Circ Cardiovasc Genet. 2015 Apr;8(2):334-42. doi: 10.1161/CIRCGENETICS.114.000804. Epub 2015 Jan 12.


Abdominal bone formation.

Schiergens TS, Reichelt A, Thasler WE, Rentsch M.

J Gastrointest Surg. 2015 Mar;19(3):579-80. doi: 10.1007/s11605-014-2737-4. Epub 2015 Jan 9.


Impact of perioperative allogeneic red blood cell transfusion on recurrence and overall survival after resection of colorectal liver metastases.

Schiergens TS, Rentsch M, Kasparek MS, Frenes K, Jauch KW, Thasler WE.

Dis Colon Rectum. 2015 Jan;58(1):74-82. doi: 10.1097/DCR.0000000000000233.


Toxicogenomics directory of chemically exposed human hepatocytes.

Grinberg M, Stöber RM, Edlund K, Rempel E, Godoy P, Reif R, Widera A, Madjar K, Schmidt-Heck W, Marchan R, Sachinidis A, Spitkovsky D, Hescheler J, Carmo H, Arbo MD, van de Water B, Wink S, Vinken M, Rogiers V, Escher S, Hardy B, Mitic D, Myatt G, Waldmann T, Mardinoglu A, Damm G, Seehofer D, Nüssler A, Weiss TS, Oberemm A, Lampen A, Schaap MM, Luijten M, van Steeg H, Thasler WE, Kleinjans JC, Stierum RH, Leist M, Rahnenführer J, Hengstler JG.

Arch Toxicol. 2014 Dec;88(12):2261-87. doi: 10.1007/s00204-014-1400-x. Epub 2014 Nov 16.


Modulating CD4+ T cell migration in the postischemic liver: hepatic stellate cells as new therapeutic target?

Reifart J, Rentsch M, Mende K, Coletti R, Sobocan M, Thasler WE, Khandoga A.

Transplantation. 2015 Jan;99(1):41-7. doi: 10.1097/TP.0000000000000461.


Downregulation of P-cadherin expression in hepatocellular carcinoma induces tumorigenicity.

Bauer R, Valletta D, Bauer K, Thasler WE, Hartmann A, Müller M, Reichert TE, Hellerbrand C.

Int J Clin Exp Pathol. 2014 Aug 15;7(9):6125-32. eCollection 2014.


An algorithm that predicts the viability and the yield of human hepatocytes isolated from remnant liver pieces obtained from liver resections.

Lee SM, Schelcher C, Laubender RP, Fröse N, Thasler RM, Schiergens TS, Mansmann U, Thasler WE.

PLoS One. 2014 Oct 14;9(10):e107567. doi: 10.1371/journal.pone.0107567. eCollection 2014.


Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease.

Arndt S, Wacker E, Dorn C, Koch A, Saugspier M, Thasler WE, Hartmann A, Bosserhoff AK, Hellerbrand C.

Gut. 2015 Jun;64(6):973-81. doi: 10.1136/gutjnl-2014-306968. Epub 2014 Jul 10.


Augmenter of liver regeneration attenuates inflammatory response in the postischemic mouse liver in vivo.

Khandoga A, Mende K, Iskandarov E, Rosentreter D, Schelcher C, Reifart J, Jauch KW, Thasler WE.

J Surg Res. 2014 Nov;192(1):187-94. doi: 10.1016/j.jss.2014.05.026. Epub 2014 May 20.


Supplemental Content

Loading ...
Support Center