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Items: 24

1.

Synthesis and evaluation of novel potent HCV NS5A inhibitors.

Zhang H, Zhou L, Amblard F, Shi J, Bobeck DR, Tao S, McBrayer TR, Tharnish PM, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4864-8. doi: 10.1016/j.bmcl.2012.05.039. Epub 2012 May 24.

2.

Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors.

Shi J, Zhou L, Amblard F, Bobeck DR, Zhang H, Liu P, Bondada L, McBrayer TR, Tharnish PM, Whitaker T, Coats SJ, Schinazi RF.

Bioorg Med Chem Lett. 2012 May 15;22(10):3488-91. doi: 10.1016/j.bmcl.2012.03.089. Epub 2012 Mar 29.

PMID:
22507961
3.

Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.

Zhang HW, Zhou L, Coats SJ, McBrayer TR, Tharnish PM, Bondada L, Detorio M, Amichai SA, Johns MD, Whitaker T, Schinazi RF.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6788-92. doi: 10.1016/j.bmcl.2011.09.034. Epub 2011 Sep 20.

4.

Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals.

Hurwitz SJ, Asif G, Fromentin E, Tharnish PM, Schinazi RF.

Antimicrob Agents Chemother. 2010 Mar;54(3):1248-55. doi: 10.1128/AAC.01209-09. Epub 2009 Dec 28.

5.

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.

Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF.

Antivir Chem Chemother. 2009 Oct 19;20(2):99-106. doi: 10.3851/IMP1400.

PMID:
19843980
6.

Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.

Chun BK, Wang P, Hassan A, Du J, Tharnish PM, Murakami E, Stuyver L, Otto MJ, Schinazi RF, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2007;26(1):83-97.

PMID:
17162589
7.

Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.

Stuyver LJ, McBrayer TR, Tharnish PM, Clark J, Hollecker L, Lostia S, Nachman T, Grier J, Bennett MA, Xie MY, Schinazi RF, Morrey JD, Julander JL, Furman PA, Otto MJ.

Antivir Chem Chemother. 2006;17(2):79-87.

PMID:
17042329
8.

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.

Clark JL, Mason JC, Hollecker L, Stuyver LJ, Tharnish PM, McBrayer TR, Otto MJ, Furman PA, Schinazi RF, Watanabe KA.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1712-5. Epub 2005 Dec 20.

PMID:
16368235
9.

Synthesis and anti-hepatitis C virus activity of nucleoside derivatives of N3, 5'-anhydro-4-(beta-D-ribofuranosyl)-8-aza-purin-2-ones.

Hassan AE, Wang P, McBrayer TR, Tharnish PM, Stuyver LJ, Schinazi RF, Otto MJ, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):961-4.

PMID:
16248072
10.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one and its 3'-deoxysugar analogue as potential anti-hepatitis C virus agents.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Stuyver LJ, Schinazi RF, Otto MJ, Watanabe KA.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):957-60.

PMID:
16248071
11.

Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides.

Shi J, Du J, Ma T, Pankiewicz KW, Patterson SE, Hassan AE, Tharnish PM, McBrayer TR, Lostia S, Stuyver LJ, Watanabe KA, Chu CK, Schinazi RF, Otto MJ.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):875-9.

PMID:
16248053
12.

Synthesis and structure-activity relationships of novel anti-hepatitis C agents: N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one derivatives.

Wang P, Du J, Rachakonda S, Chun BK, Tharnish PM, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA.

J Med Chem. 2005 Oct 6;48(20):6454-60.

PMID:
16190771
13.

Cytostatic 6-arylpurine nucleosides. 6. SAR in anti-HCV and cytostatic activity of extended series of 6-hetarylpurine ribonucleosides.

Hocek M, Naus P, Pohl R, Votruba I, Furman PA, Tharnish PM, Otto MJ.

J Med Chem. 2005 Sep 8;48(18):5869-73.

PMID:
16134952
14.

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication.

Clark JL, Hollecker L, Mason JC, Stuyver LJ, Tharnish PM, Lostia S, McBrayer TR, Schinazi RF, Watanabe KA, Otto MJ, Furman PA, Stec WJ, Patterson SE, Pankiewicz KW.

J Med Chem. 2005 Aug 25;48(17):5504-8.

PMID:
16107149
15.

Characterization of hepatitis B virus inhibition by novel 2'-fluoro-2',3'-unsaturated beta-D- and L-nucleosides.

Pai SB, Pai RB, Xie MY, Beker T, Shi J, Tharnish PM, Chu CK, Schinazi RF.

Antivir Chem Chemother. 2005;16(3):183-92.

PMID:
16004081
16.

Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system.

Shi J, Du J, Ma T, Pankiewicz KW, Patterson SE, Tharnish PM, McBrayer TR, Stuyver LJ, Otto MJ, Chu CK, Schinazi RF, Watanabe KA.

Bioorg Med Chem. 2005 Mar 1;13(5):1641-52.

PMID:
15698782
17.

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

Wang P, Hollecker L, Pankiewicz KW, Patterson SE, Whitaker T, McBrayer TR, Tharnish PM, Sidwell RW, Stuyver LJ, Otto MJ, Schinazi RF, Watanabe KA.

J Med Chem. 2004 Nov 18;47(24):6100-3.

PMID:
15537363
18.

Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine.

Stuyver LJ, McBrayer TR, Whitaker T, Tharnish PM, Ramesh M, Lostia S, Cartee L, Shi J, Hobbs A, Schinazi RF, Watanabe KA, Otto MJ.

Antimicrob Agents Chemother. 2004 Feb;48(2):651-4.

19.

Dynamics of subgenomic hepatitis C virus replicon RNA levels in Huh-7 cells after exposure to nucleoside antimetabolites.

Stuyver LJ, McBrayer TR, Tharnish PM, Hassan AE, Chu CK, Pankiewicz KW, Watanabe KA, Schinazi RF, Otto MJ.

J Virol. 2003 Oct;77(19):10689-94.

20.

N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity.

Shi J, Mathew JS, Tharnish PM, Rachakonda S, Pai SB, Adams M, Grier JP, Gallagher K, Zhang H, Wu JT, Shi G, Geleziunas R, Erickson-Viitanen S, Stuyver L, Otto MJ, Watanabe KA, Schinazi RF.

Antivir Chem Chemother. 2003 Mar;14(2):81-90.

PMID:
12856919
21.

Marine natural products as lead anti-HIV agents.

Gochfeld DJ, El Sayed KA, Yousaf M, Hu JF, Bartyzel P, Dunbar DC, Wilkins SP, Zjawiony JK, Schinazi RF, Schlueter Wirtz S, Tharnish PM, Hamann MT.

Mini Rev Med Chem. 2003 Aug;3(5):401-24. Review.

PMID:
12769693
22.

Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.

Stuyver LJ, Whitaker T, McBrayer TR, Hernandez-Santiago BI, Lostia S, Tharnish PM, Ramesh M, Chu CK, Jordan R, Shi J, Rachakonda S, Watanabe KA, Otto MJ, Schinazi RF.

Antimicrob Agents Chemother. 2003 Jan;47(1):244-54.

23.

Antiviral activities and cellular toxicities of modified 2',3'-dideoxy-2',3'-didehydrocytidine analogues.

Stuyver LJ, Lostia S, Adams M, Mathew JS, Pai BS, Grier J, Tharnish PM, Choi Y, Chong Y, Choo H, Chu CK, Otto MJ, Schinazi RF.

Antimicrob Agents Chemother. 2002 Dec;46(12):3854-60.

24.

Enantioselective synthesis and biological evaluation of 5-o-carboranyl pyrimidine nucleosides.

Mourier NS, Eleuteri A, Hurwitz SJ, Tharnish PM, Schinazi RF.

Bioorg Med Chem. 1999 Dec;7(12):2759-66.

PMID:
10658581

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