Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 83


Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway.

Xia Y, Ye B, Ding J, Yu Y, Alptekin A, Thangaraju M, Prasad PD, Ding ZC, Park EJ, Choi JH, Gao B, Fiehn O, Yan C, Dong Z, Zha Y, Ding HF.

Cancer Res. 2019 Aug 1;79(15):3837-3850. doi: 10.1158/0008-5472.CAN-18-3541. Epub 2019 May 14.


Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model.

Piranlioglu R, Lee E, Ouzounova M, Bollag RJ, Vinyard AH, Arbab AS, Marasco D, Guzel M, Cowell JK, Thangaraju M, Chadli A, Hassan KA, Wicha MS, Celis E, Korkaya H.

Nat Commun. 2019 Mar 29;10(1):1430. doi: 10.1038/s41467-019-09015-1.


Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study.

Khodaverdian V, Tapadar S, MacDonald IA, Xu Y, Ho PY, Bridges A, Rajpurohit P, Sanghani BA, Fan Y, Thangaraju M, Hathaway NA, Oyelere AK.

Sci Rep. 2019 Mar 18;9(1):4802. doi: 10.1038/s41598-019-39214-1.


Alcohol-induced ketonemia is associated with lowering of blood glucose, downregulation of gluconeogenic genes, and depletion of hepatic glycogen in type 2 diabetic db/db mice.

Srinivasan MP, Shawky NM, Kaphalia BS, Thangaraju M, Segar L.

Biochem Pharmacol. 2019 Feb;160:46-61. doi: 10.1016/j.bcp.2018.12.005. Epub 2018 Dec 7.


α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling.

Tripathy J, Tripathy A, Thangaraju M, Suar M, Elangovan S.

Life Sci. 2018 Aug 15;207:15-22. doi: 10.1016/j.lfs.2018.05.039. Epub 2018 May 23.


Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.

Swafford D, Shanmugam A, Ranganathan P, Hussein MS, Koni PA, Prasad PD, Thangaraju M, Manicassamy S.

J Immunol. 2018 May 1;200(9):3259-3268. doi: 10.4049/jimmunol.1701086. Epub 2018 Mar 30.


Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression.

Chaudhary K, Promsote W, Ananth S, Veeranan-Karmegam R, Tawfik A, Arjunan P, Martin P, Smith SB, Thangaraju M, Kisselev O, Ganapathy V, Gnana-Prakasam JP.

Sci Rep. 2018 Feb 14;8(1):3025. doi: 10.1038/s41598-018-21276-2.


GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis.

Ranganathan P, Shanmugam A, Swafford D, Suryawanshi A, Bhattacharjee P, Hussein MS, Koni PA, Prasad PD, Kurago ZB, Thangaraju M, Ganapathy V, Manicassamy S.

J Immunol. 2018 Mar 1;200(5):1781-1789. doi: 10.4049/jimmunol.1700604. Epub 2018 Jan 31.


Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade.

Ouzounova M, Lee E, Piranlioglu R, El Andaloussi A, Kolhe R, Demirci MF, Marasco D, Asm I, Chadli A, Hassan KA, Thangaraju M, Zhou G, Arbab AS, Cowell JK, Korkaya H.

Nat Commun. 2017 Apr 6;8:14979. doi: 10.1038/ncomms14979.


Promoter Methylation Modulates Indoleamine 2,3-Dioxygenase 1 Induction by Activated T Cells in Human Breast Cancers.

Noonepalle SK, Gu F, Lee EJ, Choi JH, Han Q, Kim J, Ouzounova M, Shull AY, Pei L, Hsu PY, Kolhe R, Shi F, Choi J, Chiou K, Huang TH, Korkaya H, Deng L, Xin HB, Huang S, Thangaraju M, Sreekumar A, Ambs S, Tang SC, Munn DH, Shi H.

Cancer Immunol Res. 2017 Apr;5(4):330-344. doi: 10.1158/2326-6066.CIR-16-0182. Epub 2017 Mar 6.


Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.

Pathania R, Ramachandran S, Mariappan G, Thakur P, Shi H, Choi JH, Manicassamy S, Kolhe R, Prasad PD, Sharma S, Lokeshwar BL, Ganapathy V, Thangaraju M.

Cancer Res. 2016 Jun 1;76(11):3224-35. doi: 10.1158/0008-5472.CAN-15-2249. Epub 2016 Apr 5.


Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine.

Manoharan I, Suryawanshi A, Hong Y, Ranganathan P, Shanmugam A, Ahmad S, Swafford D, Manicassamy B, Ramesh G, Koni PA, Thangaraju M, Manicassamy S.

J Immunol. 2016 Jun 1;196(11):4739-49. doi: 10.4049/jimmunol.1501489. Epub 2016 Apr 25.


Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity.

Hong Y, Manoharan I, Suryawanshi A, Shanmugam A, Swafford D, Ahmad S, Chinnadurai R, Manicassamy B, He Y, Mellor AL, Thangaraju M, Munn DH, Manicassamy S.

Oncoimmunology. 2015 Dec 14;5(4):e1115941. eCollection 2016 Apr.


SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms.

Bhutia YD, Babu E, Ramachandran S, Yang S, Thangaraju M, Ganapathy V.

Biochem J. 2016 May 1;473(9):1113-24. doi: 10.1042/BJ20150751. Review.


Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis.

Arjunan P, Gnanaprakasam JP, Ananth S, Romej MA, Rajalakshmi VK, Prasad PD, Martin PM, Gurusamy M, Thangaraju M, Bhutia YD, Ganapathy V.

Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1612-9. doi: 10.1167/iovs.15-17437.


Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer.

Babu E, Bhutia YD, Ramachandran S, Gnanaprakasam JP, Prasad PD, Thangaraju M, Ganapathy V.

Biochem J. 2015 Jul 1;469(1):17-23. doi: 10.1042/BJ20150437. Epub 2015 May 13.


Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets.

Jain A, Samykutty A, Jackson C, Browning D, Bollag WB, Thangaraju M, Takahashi S, Singh SR.

Cancer Lett. 2015 Aug 28;365(1):122-31. doi: 10.1016/j.canlet.2015.05.017. Epub 2015 May 21.


DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.

Pathania R, Ramachandran S, Elangovan S, Padia R, Yang P, Cinghu S, Veeranan-Karmegam R, Arjunan P, Gnana-Prakasam JP, Sadanand F, Pei L, Chang CS, Choi JH, Shi H, Manicassamy S, Prasad PD, Sharma S, Ganapathy V, Jothi R, Thangaraju M.

Nat Commun. 2015 Apr 24;6:6910. doi: 10.1038/ncomms7910.


IFNγ Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer.

Bardhan K, Paschall AV, Yang D, Chen MR, Simon PS, Bhutia YD, Martin PM, Thangaraju M, Browning DD, Ganapathy V, Heaton CM, Gu K, Lee JR, Liu K.

Cancer Immunol Res. 2015 Jul;3(7):795-805. doi: 10.1158/2326-6066.CIR-14-0164. Epub 2015 Mar 3.


Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.

Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo MM, Manicassamy B, Koni PA, Thangaraju M, Sun Z, Mellor AL, Munn DH, Manicassamy S.

J Immunol. 2015 Apr 1;194(7):3295-304. doi: 10.4049/jimmunol.1402691. Epub 2015 Feb 20.


Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.

Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V.

Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9.


The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.

Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Lan L, Singh N, Martin PM, Hawthorn L, Prasad PD, Ganapathy V, Thangaraju M.

Cancer Res. 2014 Feb 15;74(4):1166-78. doi: 10.1158/0008-5472.CAN-13-1451. Epub 2013 Dec 26.


Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host.

Ganapathy V, Thangaraju M, Prasad PD, Martin PM, Singh N.

Curr Opin Pharmacol. 2013 Dec;13(6):869-74. doi: 10.1016/j.coph.2013.08.006. Epub 2013 Aug 23. Review.


Molecular mechanism of SLC5A8 inactivation in breast cancer.

Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Srinivas SR, Babu E, Hawthorn L, Schoenlein PV, Boettger T, Smith SB, Prasad PD, Ganapathy V, Thangaraju M.

Mol Cell Biol. 2013 Oct;33(19):3920-35. doi: 10.1128/MCB.01702-12. Epub 2013 Aug 5.


Sodium-coupled vitamin C transporter (SVCT2): expression, function, and regulation in intervertebral disc cells.

Chothe PP, Chutkan N, Sangani R, Wenger KH, Prasad PD, Thangaraju M, Hamrick MW, Isales CM, Ganapathy V, Fulzele S.

Spine J. 2013 May;13(5):549-57. doi: 10.1016/j.spinee.2013.01.022. Epub 2013 Feb 13.


Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells.

Gnana-Prakasam JP, Veeranan-Karmegam R, Coothankandaswamy V, Reddy SK, Martin PM, Thangaraju M, Smith SB, Ganapathy V.

Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):63-71. doi: 10.1167/iovs.12-10312.


The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function.

Coothankandaswamy V, Elangovan S, Singh N, Prasad PD, Thangaraju M, Ganapathy V.

Biochem J. 2013 Feb 15;450(1):169-78. doi: 10.1042/BJ20121248.


NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression.

Liu F, Bardhan K, Yang D, Thangaraju M, Ganapathy V, Waller JL, Liles GB, Lee JR, Liu K.

J Biol Chem. 2012 Jul 20;287(30):25530-40. doi: 10.1074/jbc.M112.356279. Epub 2012 Jun 5.


Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa.

Wang R, Kwon IK, Thangaraju M, Singh N, Liu K, Jay P, Hofmann F, Ganapathy V, Browning DD.

Am J Physiol Gastrointest Liver Physiol. 2012 Jul 15;303(2):G209-19. doi: 10.1152/ajpgi.00500.2011. Epub 2012 May 3.


Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells.

Zimmerman MA, Singh N, Martin PM, Thangaraju M, Ganapathy V, Waller JL, Shi H, Robertson KD, Munn DH, Liu K.

Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1405-15. doi: 10.1152/ajpgi.00543.2011. Epub 2012 Apr 19.


Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim.

Periyasamy-Thandavan S, Takhar S, Singer A, Dohn MR, Jackson WH, Welborn AE, LeRoith D, Marrero M, Thangaraju M, Huang S, Schoenlein PV.

Breast Cancer Res. 2012 Mar 19;14(2):R52.


GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.

Gambhir D, Ananth S, Veeranan-Karmegam R, Elangovan S, Hester S, Jennings E, Offermanns S, Nussbaum JJ, Smith SB, Thangaraju M, Ganapathy V, Martin PM.

Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2208-17. doi: 10.1167/iovs.11-8447.


SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer.

Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, Thangaraju M.

Cancer Res. 2011 Nov 1;71(21):6654-64. doi: 10.1158/0008-5472.CAN-11-1446. Epub 2011 Sep 15.


SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer.

Karunakaran S, Ramachandran S, Coothankandaswamy V, Elangovan S, Babu E, Periyasamy-Thandavan S, Gurav A, Gnanaprakasam JP, Singh N, Schoenlein PV, Prasad PD, Thangaraju M, Ganapathy V.

J Biol Chem. 2011 Sep 9;286(36):31830-8. doi: 10.1074/jbc.M111.229518. Epub 2011 Jul 19.


Cyclic 3',5'-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia.

Kwon IK, Wang R, Prakash N, Bozard R, Baudino TA, Liu K, Thangaraju M, Dong Z, Browning DD.

Cancer. 2011 Dec 1;117(23):5282-93. doi: 10.1002/cncr.26192. Epub 2011 May 11.


Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.

Babu E, Ramachandran S, CoothanKandaswamy V, Elangovan S, Prasad PD, Ganapathy V, Thangaraju M.

Oncogene. 2011 Sep 22;30(38):4026-37. doi: 10.1038/onc.2011.113. Epub 2011 Apr 18.


Assessing the Zinc solubilization ability of Gluconacetobacter diazotrophicus in maize rhizosphere using labelled (65)Zn compounds.

Sarathambal C, Thangaraju M, Paulraj C, Gomathy M.

Indian J Microbiol. 2010 Oct;50(Suppl 1):103-9. doi: 10.1007/s12088-010-0066-1. Epub 2010 Nov 25.


Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.

Ha Y, Dun Y, Thangaraju M, Duplantier J, Dong Z, Liu K, Ganapathy V, Smith SB.

Invest Ophthalmol Vis Sci. 2011 Jan 25;52(1):527-40. doi: 10.1167/iovs.10-5731. Print 2011 Jan.


Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis.

Li Y, Zhang M, Chen H, Dong Z, Ganapathy V, Thangaraju M, Huang S.

Cancer Res. 2010 Oct 15;70(20):7894-904. doi: 10.1158/0008-5472.CAN-10-1675. Epub 2010 Aug 24.


Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases.

Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S, Ganapathy V.

J Biol Chem. 2010 Sep 3;285(36):27601-8. doi: 10.1074/jbc.M110.102947. Epub 2010 Jul 2.


PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4.

Kwon IK, Wang R, Thangaraju M, Shuang H, Liu K, Dashwood R, Dulin N, Ganapathy V, Browning DD.

Oncogene. 2010 Jun 10;29(23):3423-34. doi: 10.1038/onc.2010.91. Epub 2010 Mar 29.


Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8.

Cresci GA, Thangaraju M, Mellinger JD, Liu K, Ganapathy V.

J Gastrointest Surg. 2010 Mar;14(3):449-61. doi: 10.1007/s11605-009-1045-x. Epub 2009 Dec 22.


Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine.

Anderson CM, Jevons M, Thangaraju M, Edwards N, Conlon NJ, Woods S, Ganapathy V, Thwaites DT.

J Pharmacol Exp Ther. 2010 Jan;332(1):220-8. doi: 10.1124/jpet.109.159822. Epub 2009 Sep 29.


Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger.

Gnana-Prakasam JP, Thangaraju M, Liu K, Ha Y, Martin PM, Smith SB, Ganapathy V.

Biochem J. 2009 Nov 11;424(2):243-52. doi: 10.1042/BJ20090424.


Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate.

Thangaraju M, Karunakaran SK, Itagaki S, Gopal E, Elangovan S, Prasad PD, Ganapathy V.

Cancer. 2009 Oct 15;115(20):4655-66. doi: 10.1002/cncr.24532.


GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.

Thangaraju M, Cresci GA, Liu K, Ananth S, Gnanaprakasam JP, Browning DD, Mellinger JD, Smith SB, Digby GJ, Lambert NA, Prasad PD, Ganapathy V.

Cancer Res. 2009 Apr 1;69(7):2826-32. doi: 10.1158/0008-5472.CAN-08-4466. Epub 2009 Mar 10.


Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond.

Ganapathy V, Thangaraju M, Prasad PD.

Pharmacol Ther. 2009 Jan;121(1):29-40. doi: 10.1016/j.pharmthera.2008.09.005. Epub 2008 Nov 1. Review.


Method and quantity of liquid formulation of phosphobacteria required for seed inoculation.

Gomathy M, Thangaraju M, Gunasekaran S, Gopal NO, Gopal H.

Pak J Biol Sci. 2008 Jan 1;11(1):86-91.


Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.

Thangaraju M, Carswell KN, Prasad PD, Ganapathy V.

Biochem J. 2009 Jan 1;417(1):379-89. doi: 10.1042/BJ20081132.


Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer.

Thangaraju M, Cresci G, Itagaki S, Mellinger J, Browning DD, Berger FG, Prasad PD, Ganapathy V.

J Gastrointest Surg. 2008 Oct;12(10):1773-81; discussion 1781-2. doi: 10.1007/s11605-008-0573-0. Epub 2008 Jul 26.


Supplemental Content

Loading ...
Support Center