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Items: 24

1.

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

Yuan X, Gavriilaki E, Thanassi JA, Yang G, Baines AC, Podos SD, Huang Y, Huang M, Brodsky RA.

Haematologica. 2017 Mar;102(3):466-475. doi: 10.3324/haematol.2016.153312. Epub 2016 Nov 3.

2.

Mechanistic assessment of DNA ligase as an antibacterial target in Staphylococcus aureus.

Podos SD, Thanassi JA, Pucci MJ.

Antimicrob Agents Chemother. 2012 Aug;56(8):4095-102. doi: 10.1128/AAC.00215-12. Epub 2012 May 14.

3.

Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using a spirocyclic diene derived acylnitroso Diels-Alder reaction.

Ji C, Lin W, Moraski GC, Thanassi JA, Pucci MJ, Franzblau SG, Möllmann U, Miller MJ.

Bioorg Med Chem. 2012 Jun 1;20(11):3422-8. doi: 10.1016/j.bmc.2012.04.026. Epub 2012 Apr 18.

4.

Bactericidal activity of ACH-702 against nondividing and biofilm Staphylococci.

Podos SD, Thanassi JA, Leggio M, Pucci MJ.

Antimicrob Agents Chemother. 2012 Jul;56(7):3812-8. doi: 10.1128/AAC.00092-12. Epub 2012 Apr 30.

5.

One-step syntheses of nitrofuranyl benzimidazoles that are active against multidrug-resistant bacteria.

Moraski GC, Thanassi JA, Podos SD, Pucci MJ, Miller MJ.

J Antibiot (Tokyo). 2011 Oct;64(10):667-671. doi: 10.1038/ja.2011.67. Epub 2011 Aug 3.

6.

In vitro and in vivo profiles of ACH-702, an isothiazoloquinolone, against bacterial pathogens.

Pucci MJ, Podos SD, Thanassi JA, Leggio MJ, Bradbury BJ, Deshpande M.

Antimicrob Agents Chemother. 2011 Jun;55(6):2860-71. doi: 10.1128/AAC.01666-10. Epub 2011 Apr 4.

7.

Selenophene-containing inhibitors of type IIA bacterial topoisomerases.

Wiles JA, Phadke AS, Bradbury BJ, Pucci MJ, Thanassi JA, Deshpande M.

J Med Chem. 2011 May 12;54(9):3418-25. doi: 10.1021/jm2002124. Epub 2011 Apr 13.

PMID:
21443219
8.

Exploration of the activity of 7-pyrrolidino-8-methoxyisothiazoloquinolones against methicillin-resistant Staphylococcus aureus (MRSA).

Kim HY, Wiles JA, Wang Q, Pais GC, Lucien E, Hashimoto A, Nelson DM, Thanassi JA, Podos SD, Deshpande M, Pucci MJ, Bradbury BJ.

J Med Chem. 2011 May 12;54(9):3268-82. doi: 10.1021/jm101604v. Epub 2011 Apr 15.

PMID:
21425851
9.

In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.

Pucci MJ, Ackerman M, Thanassi JA, Shoen CM, Cynamon MH.

Antimicrob Agents Chemother. 2010 Aug;54(8):3478-80. doi: 10.1128/AAC.00287-10. Epub 2010 Jun 1.

10.

Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.

Cheng J, Thanassi JA, Thoma CL, Bradbury BJ, Deshpande M, Pucci MJ.

Antimicrob Agents Chemother. 2007 Jul;51(7):2445-53. Epub 2007 May 14.

11.

Small molecule inhibitors of E. coli primase, a novel bacterial target.

Agarwal A, Louise-May S, Thanassi JA, Podos SD, Cheng J, Thoma C, Liu C, Wiles JA, Nelson DM, Phadke AS, Bradbury BJ, Deshpande MS, Pucci MJ.

Bioorg Med Chem Lett. 2007 May 15;17(10):2807-10. Epub 2007 Feb 25.

PMID:
17350255
12.

In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens.

Pucci MJ, Cheng J, Podos SD, Thoma CL, Thanassi JA, Buechter DD, Mushtaq G, Vigliotti GA Jr, Bradbury BJ, Deshpande M.

Antimicrob Agents Chemother. 2007 Apr;51(4):1259-67. Epub 2007 Jan 22.

13.

Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.

Wang Q, Lucien E, Hashimoto A, Pais GC, Nelson DM, Song Y, Thanassi JA, Marlor CW, Thoma CL, Cheng J, Podos SD, Ou Y, Deshpande M, Pucci MJ, Buechter DD, Bradbury BJ, Wiles JA.

J Med Chem. 2007 Jan 25;50(2):199-210.

PMID:
17228862
14.

Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents.

Wiles JA, Hashimoto A, Thanassi JA, Cheng J, Incarvito CD, Deshpande M, Pucci MJ, Bradbury BJ.

J Med Chem. 2006 Jan 12;49(1):39-42.

PMID:
16392790
15.

Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells.

Wiles JA, Wang Q, Lucien E, Hashimoto A, Song Y, Cheng J, Marlor CW, Ou Y, Podos SD, Thanassi JA, Thoma CL, Deshpande M, Pucci MJ, Bradbury BJ.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1272-6. Epub 2005 Dec 7.

PMID:
16337791
16.

Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus.

Wiles JA, Song Y, Wang Q, Lucien E, Hashimoto A, Cheng J, Marlor CW, Ou Y, Podos SD, Thanassi JA, Thoma CL, Deshpande M, Pucci MJ, Bradbury BJ.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1277-81. Epub 2005 Dec 7.

PMID:
16337789
17.

98th General Meeting of the American Society for Microbiology. May 17-21, 1998; Atlanta, GA.

Dougherty TJ, Pucci MJ, Beaulieu D, Thanassi JA, Casperson ME, Ferraro CA, Barrett JF, Frosco M.

Expert Opin Investig Drugs. 1998 Sep;7(9):1539-57.

PMID:
15992051
18.

Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.

Thanassi JA, Hartman-Neumann SL, Dougherty TJ, Dougherty BA, Pucci MJ.

Nucleic Acids Res. 2002 Jul 15;30(14):3152-62.

19.

Identification and characterization of cell wall-cell division gene clusters in pathogenic gram-positive cocci.

Pucci MJ, Thanassi JA, Discotto LF, Kessler RE, Dougherty TJ.

J Bacteriol. 1997 Sep;179(17):5632-5.

20.

Role of mecA transcriptional regulation in the phenotypic expression of methicillin resistance in Staphylococcus aureus.

Niemeyer DM, Pucci MJ, Thanassi JA, Sharma VK, Archer GL.

J Bacteriol. 1996 Sep;178(18):5464-71.

21.

Characterization of IS1272, an insertion sequence-like element from Staphylococcus haemolyticus.

Archer GL, Thanassi JA, Niemeyer DM, Pucci MJ.

Antimicrob Agents Chemother. 1996 Apr;40(4):924-9.

22.
23.

Dissemination among staphylococci of DNA sequences associated with methicillin resistance.

Archer GL, Niemeyer DM, Thanassi JA, Pucci MJ.

Antimicrob Agents Chemother. 1994 Mar;38(3):447-54.

24.

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