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Werneburg GT, Nguyen A, Henderson NS, Rackley RR, Shoskes DA, Le Sueur AL, Corcoran AT, Katz AE, Kim J, Rohan AJ, Thanassi DG.

J Urol. 2020 Feb;203(2):364. doi: 10.1097/01.JU.0000614960.58990.78. Epub 2019 Nov 14. No abstract available.


The Natural History and Composition of Urinary Catheter Biofilms: Early Uropathogen Colonization with Intraluminal and Distal Predominance.

Werneburg GT, Nguyen A, Henderson NS, Rackley RR, Shoskes DA, Le Sueur AL, Corcoran AT, Katz AE, Kim J, Rohan AJ, Thanassi DG.

J Urol. 2020 Feb;203(2):357-364. doi: 10.1097/JU.0000000000000492. Epub 2019 Aug 20.


The small molecule nitazoxanide selectively disrupts BAM-mediated folding of the outer membrane usher protein.

Psonis JJ, Chahales P, Henderson NS, Rigel NW, Hoffman PS, Thanassi DG.

J Biol Chem. 2019 Sep 27;294(39):14357-14369. doi: 10.1074/jbc.RA119.009616. Epub 2019 Aug 7.


Therapeutic Approaches Targeting the Assembly and Function of Chaperone-Usher Pili.

Psonis JJ, Thanassi DG.

EcoSal Plus. 2019 Mar;8(2). doi: 10.1128/ecosalplus.ESP-0033-2018. Review.


Contributions of TolC Orthologs to Francisella tularensis Schu S4 Multidrug Resistance, Modulation of Host Cell Responses, and Virulence.

Kopping EJ, Doyle CR, Sampath V, Thanassi DG.

Infect Immun. 2019 Mar 25;87(4). pii: e00823-18. doi: 10.1128/IAI.00823-18. Print 2019 Apr.


Peptide-Based Inhibitors of Fimbrial Biogenesis in Porphyromonas gingivalis.

Alaei SR, Park JH, Walker SG, Thanassi DG.

Infect Immun. 2019 Feb 21;87(3). pii: e00750-18. doi: 10.1128/IAI.00750-18. Print 2019 Mar.


Handover mechanism of the growing pilus by the bacterial outer-membrane usher FimD.

Du M, Yuan Z, Yu H, Henderson N, Sarowar S, Zhao G, Werneburg GT, Thanassi DG, Li H.

Nature. 2018 Oct;562(7727):444-447. doi: 10.1038/s41586-018-0587-z. Epub 2018 Oct 3.


Pili Assembled by the Chaperone/Usher Pathway in Escherichia coli and Salmonella.

Werneburg GT, Thanassi DG.

EcoSal Plus. 2018 Mar;8(1). doi: 10.1128/ecosalplus.ESP-0007-2017. Review.


Amino acid deprivation and central carbon metabolism regulate the production of outer membrane vesicles and tubes by Francisella.

Sampath V, McCaig WD, Thanassi DG.

Mol Microbiol. 2018 Feb;107(4):523-541. doi: 10.1111/mmi.13897. Epub 2018 Jan 3.


Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases.

Parashar K, Kopping E, Frank D, Sampath V, Thanassi DG, Carpino N.

Infect Immun. 2017 Aug 18;85(9). pii: e00406-17. doi: 10.1128/IAI.00406-17. Print 2017 Sep.


Identification and characterization of peptidases secreted by quahog parasite unknown (QPX), the protistan parasite of hard clams.

Rubin E, Werneburg GT, Pales Espinosa E, Thanassi DG, Allam B.

Dis Aquat Organ. 2016 Nov 22;122(1):21-33.


Correction: Allosteric signalling in the outer membrane translocation domain of PapC usher.

Farabella I, Pham T, Henderson NS, Geibel S, Phan G, Thanassi DG, Delcour AH, Waksman G, Topf M.

Elife. 2016 Sep 27;5. pii: e21585. doi: 10.7554/eLife.21585. No abstract available.


The Escherichia coli P and Type 1 Pilus Assembly Chaperones PapD and FimC Are Monomeric in Solution.

Sarowar S, Hu OJ, Werneburg GT, Thanassi DG, Li H.

J Bacteriol. 2016 Aug 11;198(17):2360-9. doi: 10.1128/JB.00366-16. Print 2016 Sep 1.


Effect of chaperone-adhesin complex on plug release by the PapC usher.

Pham T, Werneburg GT, Henderson NS, Thanassi DG, Delcour AH.

FEBS Lett. 2016 Jul;590(14):2172-9. doi: 10.1002/1873-3468.12257. Epub 2016 Jul 4.


Electrostatic networks control plug stabilization in the PapC usher.

Pham T, Henderson NS, Werneburg GT, Thanassi DG, Delcour AH.

Mol Membr Biol. 2015 Aug-Dec;32(5-8):198-207. doi: 10.3109/09687688.2016.1160450. Epub 2016 May 16.


Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane.

Chahales P, Hoffman PS, Thanassi DG.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2028-38. doi: 10.1128/AAC.02221-15. Print 2016 Apr.


Structure, Function, and Assembly of Adhesive Organelles by Uropathogenic Bacteria.

Chahales P, Thanassi DG.

Microbiol Spectr. 2015 Oct;3(5). doi: 10.1128/microbiolspec.UTI-0018-2013. Review.


The pilus usher controls protein interactions via domain masking and is functional as an oligomer.

Werneburg GT, Henderson NS, Portnoy EB, Sarowar S, Hultgren SJ, Li H, Thanassi DG.

Nat Struct Mol Biol. 2015 Jul;22(7):540-6. doi: 10.1038/nsmb.3044. Epub 2015 Jun 8.


A more flexible lipoprotein sorting pathway.

Chahales P, Thanassi DG.

J Bacteriol. 2015 May;197(10):1702-4. doi: 10.1128/JB.00051-15. Epub 2015 Mar 9.


Allosteric signalling in the outer membrane translocation domain of PapC usher.

Farabella I, Pham T, Henderson NS, Geibel S, Phan G, Thanassi DG, Delcour AH, Waksman G, Topf M.

Elife. 2014 Oct 28;3. doi: 10.7554/eLife.03532. Erratum in: Elife. 2016;5. pii: e21585. doi: 10.7554/eLife.21585.


TolC-dependent modulation of host cell death by the Francisella tularensis live vaccine strain.

Doyle CR, Pan JA, Mena P, Zong WX, Thanassi DG.

Infect Immun. 2014 May;82(5):2068-78. doi: 10.1128/IAI.00044-14. Epub 2014 Mar 10.


EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice.

Ma Z, Banik S, Rane H, Mora VT, Rabadi SM, Doyle CR, Thanassi DG, Bakshi CS, Malik M.

Mol Microbiol. 2014 Mar;91(5):976-95. doi: 10.1111/mmi.12509. Epub 2014 Feb 8.


Molecular basis of usher pore gating in Escherichia coli pilus biogenesis.

Volkan E, Kalas V, Pinkner JS, Dodson KW, Henderson NS, Pham T, Waksman G, Delcour AH, Thanassi DG, Hultgren SJ.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20741-6. doi: 10.1073/pnas.1320528110. Epub 2013 Dec 2.


FeoB-mediated uptake of iron by Francisella tularensis.

Thomas-Charles CA, Zheng H, Palmer LE, Mena P, Thanassi DG, Furie MB.

Infect Immun. 2013 Aug;81(8):2828-37. doi: 10.1128/IAI.00170-13. Epub 2013 May 28.


Purification of the outer membrane usher protein and periplasmic chaperone-subunit complexes from the P and type 1 pilus systems.

Henderson NS, Thanassi DG.

Methods Mol Biol. 2013;966:37-52. doi: 10.1007/978-1-62703-245-2_3.


Production of outer membrane vesicles and outer membrane tubes by Francisella novicida.

McCaig WD, Koller A, Thanassi DG.

J Bacteriol. 2013 Mar;195(6):1120-32. doi: 10.1128/JB.02007-12. Epub 2012 Dec 21.


Roles of chaperone/usher pathways of Yersinia pestis in a murine model of plague and adhesion to host cells.

Hatkoff M, Runco LM, Pujol C, Jayatilaka I, Furie MB, Bliska JB, Thanassi DG.

Infect Immun. 2012 Oct;80(10):3490-500. doi: 10.1128/IAI.00434-12. Epub 2012 Jul 30.


Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine.

Volkan E, Ford BA, Pinkner JS, Dodson KW, Henderson NS, Thanassi DG, Waksman G, Hultgren SJ.

Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9563-8. doi: 10.1073/pnas.1207085109. Epub 2012 May 29.


Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function.

Thanassi DG, Bliska JB, Christie PJ.

FEMS Microbiol Rev. 2012 Nov;36(6):1046-82. doi: 10.1111/j.1574-6976.2012.00342.x. Epub 2012 May 24. Review.


Phenotypic, morphological, and functional heterogeneity of splenic immature myeloid cells in the host response to tularemia.

Rasmussen JW, Tam JW, Okan NA, Mena P, Furie MB, Thanassi DG, Benach JL, van der Velden AW.

Infect Immun. 2012 Jul;80(7):2371-81. doi: 10.1128/IAI.00365-12. Epub 2012 Apr 23.


Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate.

Phan G, Remaut H, Wang T, Allen WJ, Pirker KF, Lebedev A, Henderson NS, Geibel S, Volkan E, Yan J, Kunze MB, Pinkner JS, Ford B, Kay CW, Li H, Hultgren SJ, Thanassi DG, Waksman G.

Nature. 2011 Jun 2;474(7349):49-53. doi: 10.1038/nature10109.


Function of the usher N-terminus in catalysing pilus assembly.

Henderson NS, Ng TW, Talukder I, Thanassi DG.

Mol Microbiol. 2011 Feb;79(4):954-67. doi: 10.1111/j.1365-2958.2010.07505.x. Epub 2010 Dec 22.


The long and the short of bacterial adhesion regulation.

Thanassi DG.

J Bacteriol. 2011 Jan;193(2):327-8. doi: 10.1128/JB.01345-10. Epub 2010 Nov 19. No abstract available.


Contributions of chaperone/usher systems to cell binding, biofilm formation and Yersinia pestis virulence.

Felek S, Jeong JJ, Runco LM, Murray S, Thanassi DG, Krukonis ES.

Microbiology. 2011 Mar;157(Pt 3):805-818. doi: 10.1099/mic.0.044826-0. Epub 2010 Nov 18.


The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs.

Zeituni AE, McCaig W, Scisci E, Thanassi DG, Cutler CW.

J Bacteriol. 2010 Aug;192(16):4103-10. doi: 10.1128/JB.00275-10. Epub 2010 Jun 18.


The differential affinity of the usher for chaperone-subunit complexes is required for assembly of complete pili.

Li Q, Ng TW, Dodson KW, So SS, Bayle KM, Pinkner JS, Scarlata S, Hultgren SJ, Thanassi DG.

Mol Microbiol. 2010 Apr;76(1):159-72. doi: 10.1111/j.1365-2958.2010.07089.x. Epub 2010 Feb 24.


A foreign protein incorporated on the Tip of T3 pili in Lactococcus lactis elicits systemic and mucosal immunity.

Quigley BR, Hatkoff M, Thanassi DG, Ouattara M, Eichenbaum Z, Scott JR.

Infect Immun. 2010 Mar;78(3):1294-303. doi: 10.1128/IAI.01037-09. Epub 2009 Dec 22.


A tolC mutant of Francisella tularensis is hypercytotoxic compared to the wild type and elicits increased proinflammatory responses from host cells.

Platz GJ, Bublitz DC, Mena P, Benach JL, Furie MB, Thanassi DG.

Infect Immun. 2010 Mar;78(3):1022-31. doi: 10.1128/IAI.00992-09. Epub 2009 Dec 22.


Modulating effects of the plug, helix, and N- and C-terminal domains on channel properties of the PapC usher.

Mapingire OS, Henderson NS, Duret G, Thanassi DG, Delcour AH.

J Biol Chem. 2009 Dec 25;284(52):36324-33. doi: 10.1074/jbc.M109.055798. Epub 2009 Oct 22.


Linkage of T3 and Cpa pilins in the Streptococcus pyogenes M3 pilus.

Quigley BR, Zähner D, Hatkoff M, Thanassi DG, Scott JR.

Mol Microbiol. 2009 Jun;72(6):1379-94. doi: 10.1111/j.1365-2958.2009.06727.x. Epub 2009 May 8.


Use of a combined cryo-EM and X-ray crystallography approach to reveal molecular details of bacterial pilus assembly by the chaperone/usher pathway.

Li H, Thanassi DG.

Curr Opin Microbiol. 2009 Jun;12(3):326-32. doi: 10.1016/j.mib.2009.03.002. Epub 2009 Apr 6. Review.


Roles of putative type II secretion and type IV pilus systems in the virulence of uropathogenic Escherichia coli.

Kulkarni R, Dhakal BK, Slechta ES, Kurtz Z, Mulvey MA, Thanassi DG.

PLoS One. 2009;4(3):e4752. doi: 10.1371/journal.pone.0004752. Epub 2009 Mar 9.


Characterization of the Francisella tularensis subsp. novicida type IV pilus.

Zogaj X, Chakraborty S, Liu J, Thanassi DG, Klose KE.

Microbiology. 2008 Jul;154(Pt 7):2139-2150. doi: 10.1099/mic.0.2008/018077-0.


Fiber formation across the bacterial outer membrane by the chaperone/usher pathway.

Remaut H, Tang C, Henderson NS, Pinkner JS, Wang T, Hultgren SJ, Thanassi DG, Waksman G, Li H.

Cell. 2008 May 16;133(4):640-52. doi: 10.1016/j.cell.2008.03.033.


Type IV pili in Francisella tularensis: roles of pilF and pilT in fiber assembly, host cell adherence, and virulence.

Chakraborty S, Monfett M, Maier TM, Benach JL, Frank DW, Thanassi DG.

Infect Immun. 2008 Jul;76(7):2852-61. doi: 10.1128/IAI.01726-07. Epub 2008 Apr 21.


Biogenesis of the fraction 1 capsule and analysis of the ultrastructure of Yersinia pestis.

Runco LM, Myrczek S, Bliska JB, Thanassi DG.

J Bacteriol. 2008 May;190(9):3381-5. doi: 10.1128/JB.01840-07. Epub 2008 Feb 29.


A conserved and immunodominant lipoprotein of Francisella tularensis is proinflammatory but not essential for virulence.

Forestal CA, Gil H, Monfett M, Noah CE, Platz GJ, Thanassi DG, Benach JL, Furie MB.

Microb Pathog. 2008 Jun;44(6):512-23. doi: 10.1016/j.micpath.2008.01.003. Epub 2008 Jan 17.


Characterization of six novel chaperone/usher systems in Yersinia pestis.

Felek S, Runco LM, Thanassi DG, Krukonis ES.

Adv Exp Med Biol. 2007;603:97-105. No abstract available.


Fimbriae: Classification and Biochemistry.

Thanassi DG, Nuccio SP, Shu Kin So S, Bäumler AJ.

EcoSal Plus. 2007 Apr;2(2). doi: 10.1128/ecosalplus.


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