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Application of High-Sensitivity Troponin in Suspected Myocardial Infarction.

Neumann JT, Twerenbold R, Ojeda F, Sörensen NA, Chapman AR, Shah ASV, Anand A, Boeddinghaus J, Nestelberger T, Badertscher P, Mokhtari A, Pickering JW, Troughton RW, Greenslade J, Parsonage W, Mueller-Hennessen M, Gori T, Jernberg T, Morris N, Liebetrau C, Hamm C, Katus HA, Münzel T, Landmesser U, Salomaa V, Iacoviello L, Ferrario MM, Giampaoli S, Kee F, Thorand B, Peters A, Borchini R, Jørgensen T, Söderberg S, Sans S, Tunstall-Pedoe H, Kuulasmaa K, Renné T, Lackner KJ, Worster A, Body R, Ekelund U, Kavsak PA, Keller T, Lindahl B, Wild P, Giannitsis E, Than M, Cullen LA, Mills NL, Mueller C, Zeller T, Westermann D, Blankenberg S.

N Engl J Med. 2019 Jun 27;380(26):2529-2540. doi: 10.1056/NEJMoa1803377.


Long-term outcomes in patients with pulmonary embolism: results from a longitudinal cohort study.

Lamba M, Pickering J, Than M, Iles S, Beckert L.

Intern Med J. 2019 Jun 18. doi: 10.1111/imj.14409. [Epub ahead of print]


Diagnosis of acute myocardial infarction in the presence of left bundle branch block.

Nestelberger T, Cullen L, Lindahl B, Reichlin T, Greenslade JH, Giannitsis E, Christ M, Morawiec B, Miro O, Martín-Sánchez FJ, Wussler DN, Koechlin L, Twerenbold R, Parsonage W, Boeddinghaus J, Rubini Gimenez M, Puelacher C, Wildi K, Buerge T, Badertscher P, DuFaydeLavallaz J, Strebel I, Croton L, Bendig G, Osswald S, Pickering JW, Than M, Mueller C; APACE, ADAPT and TRAPID-AMI Investigators.

Heart. 2019 May 29. pii: heartjnl-2018-314673. doi: 10.1136/heartjnl-2018-314673. [Epub ahead of print]


B-Type Natriuretic Peptides and Cardiac Troponins for Diagnosis and Risk-Stratification of Syncope.

du Fay de Lavallaz J, Badertscher P, Nestelberger T, Zimmermann T, Miró Ò, Salgado E, Christ M, Geigy N, Cullen L, Than M, Martin-Sanchez FJ, Di Somma S, Peacock WF, Morawiec B, Walter J, Twerenbold R, Puelacher C, Wussler D, Boeddinghaus J, Koechlin L, Strebel I, Keller DI, Lohrmann J, Michou E, Kühne M, Reichlin T, Mueller C.

Circulation. 2019 Feb 25. doi: 10.1161/CIRCULATIONAHA.118.038358. [Epub ahead of print]


An RCT of brief cognitive therapy versus treatment as usual in patients with non-cardiac chest pain.

Mulder R, Zarifeh J, Boden J, Lacey C, Tyrer P, Tyrer H, Than M, Troughton R.

Int J Cardiol. 2019 Aug 15;289:6-11. doi: 10.1016/j.ijcard.2019.01.067. Epub 2019 Feb 5.


Validity of a Novel Point-of-Care Troponin Assay for Single-Test Rule-Out of Acute Myocardial Infarction-Reply.

Pickering JW, Young JM, Than MP.

JAMA Cardiol. 2019 Feb 6. doi: 10.1001/jamacardio.2018.4843. [Epub ahead of print] No abstract available.


Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.

Van Lam van T, Ivanova T, Hardes K, Heindl MR, Morty RE, Böttcher-Friebertshäuser E, Lindberg I, Than ME, Dahms SO, Steinmetzer T.

ChemMedChem. 2019 Mar 22;14(6):673-685. doi: 10.1002/cmdc.201800807. Epub 2019 Feb 20.


MeSsAGe risk score: tool for renal biopsy decision in steroid-dependent nephrotic syndrome.

Chan CY, Resontoc LP, Qader MA, Chan YH, Liu ID, Lau PY, Than M, Yeo WS, Loh AH, Tan PH, Wei C, Reiser J, Biswas SK, Ng KH, Yap HK.

Pediatr Res. 2019 Mar;85(4):477-483. doi: 10.1038/s41390-019-0277-z. Epub 2019 Jan 15.


CT coronary angiography does not reduce mortality or myocardial infarction in low-risk patients with acute chest pain.

Adamson PD, Than MP.

BMJ Evid Based Med. 2018 Nov 5. pii: bmjebm-2018-111090. doi: 10.1136/bmjebm-2018-111090. [Epub ahead of print] No abstract available.


Validity of a Novel Point-of-Care Troponin Assay for Single-Test Rule-Out of Acute Myocardial Infarction.

Pickering JW, Young JM, George PM, Watson AS, Aldous SJ, Troughton RW, Pemberton CJ, Richards AM, Cullen LA, Than MP.

JAMA Cardiol. 2018 Nov 1;3(11):1108-1112. doi: 10.1001/jamacardio.2018.3368.


Prospective validation of prognostic and diagnostic syncope scores in the emergency department.

du Fay de Lavallaz J, Badertscher P, Nestelberger T, Isenrich R, Miró Ò, Salgado E, Geigy N, Christ M, Cullen L, Than M, Martin-Sanchez FJ, Bustamante Mandrión J, Di Somma S, Peacock WF, Kawecki D, Boeddinghaus J, Twerenbold R, Puelacher C, Wussler D, Strebel I, Keller DI, Poepping I, Kühne M, Mueller C, Reichlin T; BASEL IX Investigators, Giménez MR, Walter J, Kozhuharov N, Shrestha S, Mueller D, Sazgary L, Morawiec B, Muzyk P, Nowalany-Kozielska E, Freese M, Stelzig C, Meissner K, Kulangara C, Hartmann B, Ferel I, Sabti Z, Greenslade J, Hawkins T, Rentsch K, von Eckardstein A, Buser A, Kloos W, Lohrmann J, Osswald S.

Int J Cardiol. 2018 Oct 15;269:114-121. doi: 10.1016/j.ijcard.2018.06.088. Epub 2018 Jun 21.


A comparison of emergency department medical records to parental self-reporting of traumatic brain injury symptoms.

McKinlay A, Lin A, Than M.

Concussion. 2018 Apr 6;3(1):CNC52. doi: 10.2217/cnc-2017-0017. eCollection 2018 Mar.


Circadian, weekly, seasonal, and temperature-dependent patterns of syncope aetiology in patients at increased risk of cardiac syncope.

du Fay de Lavallaz J, Badertscher P, Nestelberger T, Flores D, Miró Ò, Salgado E, Geigy N, Christ M, Cullen L, Than M, Martin-Sanchez FJ, Rodriguez-Adrada E, Di Somma S, Peacock WF, Kawecki D, Boeddinghaus J, Twerenbold R, Puelacher C, Wussler D, Strebel I, Keller DI, Poepping I, Kühne M, Reichlin T, Mueller C; BASEL IX Investigators .

Europace. 2019 Mar 1;21(3):511-521. doi: 10.1093/europace/euy186.


Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department.

Kavsak PA, Neumann JT, Cullen L, Than M, Shortt C, Greenslade JH, Pickering JW, Ojeda F, Ma J, Clayton N, Sherbino J, Hill SA, McQueen M, Westermann D, Sörensen NA, Parsonage WA, Griffith L, Mehta SR, Devereaux PJ, Richards M, Troughton R, Pemberton C, Aldous S, Blankenberg S, Worster A.

CMAJ. 2018 Aug 20;190(33):E974-E984. doi: 10.1503/cmaj.180144.


Development of a digital clinical pathway for emergency medicine: Lessons from usability testing and implementation failure.

Gutenstein M, Pickering JW, Than M.

Health Informatics J. 2018 Jun 1:1460458218779099. doi: 10.1177/1460458218779099. [Epub ahead of print]


Acute kidney injury in patients presenting with chest pain to the emergency department, a descriptive study of the most common discharge diagnoses and mortality.

Hertzberg D, Holzmann MJ, Than M, Pickering JW.

Eur J Emerg Med. 2019 Aug;26(4):242-248. doi: 10.1097/MEJ.0000000000000552.


Detectable High-Sensitivity Cardiac Troponin within the Population Reference Interval Conveys High 5-Year Cardiovascular Risk: An Observational Study.

Than MP, Aldous SJ, Troughton RW, Pemberton CJ, Richards AM, Frampton CMA, Florkowski CM, George PM, Bailey S, Young JM, Cullen L, Greenslade JH, Parsonage WA, Everett BM, Peacock WF, Jaffe AS, Pickering JW.

Clin Chem. 2018 Jul;64(7):1044-1053. doi: 10.1373/clinchem.2017.285700. Epub 2018 May 14.


Combining High-Sensitivity Cardiac Troponin I and Cardiac Troponin T in the Early Diagnosis of Acute Myocardial Infarction.

van der Linden N, Wildi K, Twerenbold R, Pickering JW, Than M, Cullen L, Greenslade J, Parsonage W, Nestelberger T, Boeddinghaus J, Badertscher P, Rubini Giménez M, Klinkenberg LJJ, Bekers O, Schöni A, Keller DI, Sabti Z, Puelacher C, Cupa J, Schumacher L, Kozhuharov N, Grimm K, Shrestha S, Flores D, Freese M, Stelzig C, Strebel I, Miró Ò, Rentsch K, Morawiec B, Kawecki D, Kloos W, Lohrmann J, Richards AM, Troughton R, Pemberton C, Osswald S, van Dieijen-Visser MP, Mingels AM, Reichlin T, Meex SJR, Mueller C.

Circulation. 2018 Sep 4;138(10):989-999. doi: 10.1161/CIRCULATIONAHA.117.032003.


Prohormones in the Early Diagnosis of Cardiac Syncope.

Badertscher P, Nestelberger T, de Lavallaz JDF, Than M, Morawiec B, Kawecki D, Miró Ò, López B, Martin-Sanchez FJ, Bustamante J, Geigy N, Christ M, Di Somma S, Peacock WF, Cullen L, Sarasin F, Flores D, Tschuck M, Boeddinghaus J, Twerenbold R, Wildi K, Sabti Z, Puelacher C, Rubini Giménez M, Kozhuharov N, Shrestha S, Strebel I, Rentsch K, Keller DI, Poepping I, Buser A, Kloos W, Lohrmann J, Kuehne M, Osswald S, Reichlin T, Mueller C.

J Am Heart Assoc. 2017 Dec 14;6(12). pii: e006592. doi: 10.1161/JAHA.117.006592.


Evaluating Rapid Rule-out of Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay at Presentation.

Greenslade J, Cho E, Van Hise C, Hawkins T, Parsonage W, Ungerer J, Tate J, Pretorius C, Than M, Cullen L.

Clin Chem. 2018 May;64(5):820-829. doi: 10.1373/clinchem.2017.283887. Epub 2018 Feb 1.


X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.

Dahms SO, Hardes K, Steinmetzer T, Than ME.

Biochemistry. 2018 Feb 13;57(6):925-934. doi: 10.1021/acs.biochem.7b01124. Epub 2018 Jan 26.


Efficacy of High-Sensitivity Troponin T in Identifying Very-Low-Risk Patients With Possible Acute Coronary Syndrome.

Peacock WF, Baumann BM, Bruton D, Davis TE, Handy B, Jones CW, Hollander JE, Limkakeng AT, Mehrotra A, Than M, Ziegler A, Dinkel C.

JAMA Cardiol. 2018 Feb 1;3(2):104-111. doi: 10.1001/jamacardio.2017.4625.


Modification of the Thrombolysis in Myocardial Infarction risk score for patients presenting with chest pain to the emergency department.

Greenslade JH, Chung K, Parsonage WA, Hawkins T, Than M, Pickering JW, Cullen L.

Emerg Med Australas. 2018 Feb;30(1):47-54. doi: 10.1111/1742-6723.12913. Epub 2017 Dec 12.


ICare-ACS (Improving Care Processes for Patients With Suspected Acute Coronary Syndrome): A Study of Cross-System Implementation of a National Clinical Pathway.

Than MP, Pickering JW, Dryden JM, Lord SJ, Aitken SA, Aldous SJ, Allan KE, Ardagh MW, Bonning JWN, Callender R, Chapman LRE, Christiansen JP, Cromhout APJ, Cullen L, Deely JM, Devlin GP, Ferrier KA, Florkowski CM, Frampton CMA, George PM, Hamilton GJ, Jaffe AS, Kerr AJ, Larkin GL, Makower RM, Matthews TJE, Parsonage WA, Peacock WF, Peckler BF, van Pelt NC, Poynton L, Richards AM, Scott AG, Simmonds MB, Smyth D, Thomas OP, To ACY, Du Toit SA, Troughton RW, Yates KM; ICare-ACS Implementation Group.

Circulation. 2018 Jan 23;137(4):354-363. doi: 10.1161/CIRCULATIONAHA.117.031984. Epub 2017 Nov 14.


A Risk Assessment Score and Initial High-sensitivity Troponin Combine to Identify Low Risk of Acute Myocardial Infarction in the Emergency Department.

Pickering JW, Flaws D, Smith SW, Greenslade J, Cullen L, Parsonage W, Carlton E, Mark Richards A, Troughton R, Pemberton C, George PM, Than MP.

Acad Emerg Med. 2018 Apr;25(4):434-443. doi: 10.1111/acem.13343. Epub 2017 Dec 11.


Association of High-Sensitivity Cardiac Troponin I Concentration With Cardiac Outcomes in Patients With Suspected Acute Coronary Syndrome.

Chapman AR, Lee KK, McAllister DA, Cullen L, Greenslade JH, Parsonage W, Worster A, Kavsak PA, Blankenberg S, Neumann J, Sörensen NA, Westermann D, Buijs MM, Verdel GJE, Pickering JW, Than MP, Twerenbold R, Badertscher P, Sabti Z, Mueller C, Anand A, Adamson P, Strachan FE, Ferry A, Sandeman D, Gray A, Body R, Keevil B, Carlton E, Greaves K, Korley FK, Metkus TS, Sandoval Y, Apple FS, Newby DE, Shah ASV, Mills NL.

JAMA. 2017 Nov 21;318(19):1913-1924. doi: 10.1001/jama.2017.17488. Review. Erratum in: JAMA. 2018 Mar 20;319(11):1168. Soerensen NA [corrected to Sorensen NA].


Optimization of Substrate-Analogue Furin Inhibitors.

Ivanova T, Hardes K, Kallis S, Dahms SO, Than ME, Künzel S, Böttcher-Friebertshäuser E, Lindberg I, Jiao GS, Bartenschlager R, Steinmetzer T.

ChemMedChem. 2017 Dec 7;12(23):1953-1968. doi: 10.1002/cmdc.201700596. Epub 2017 Nov 16.


External validation of heart-type fatty acid binding protein, high-sensitivity cardiac troponin, and electrocardiography as rule-out for acute myocardial infarction.

Van Hise CB, Greenslade JH, Parsonage W, Than M, Young J, Cullen L.

Clin Biochem. 2018 Feb;52:161-163. doi: 10.1016/j.clinbiochem.2017.10.001. Epub 2017 Oct 18.


Political transition and emergent forest-conservation issues in Myanmar.

Prescott GW, Sutherland WJ, Aguirre D, Baird M, Bowman V, Brunner J, Connette GM, Cosier M, Dapice D, De Alban JDT, Diment A, Fogerite J, Fox J, Hlaing W, Htun S, Hurd J, LaJeunesse Connette K, Lasmana F, Lim CL, Lynam A, Maung AC, McCarron B, McCarthy JF, McShea WJ, Momberg F, Mon MS, Myint T, Oberndorf R, Oo TN, Phelps J, Rao M, Schmidt-Vogt D, Speechly H, Springate-Baginski O, Steinmetz R, Talbott K, Than MM, Thaung TL, Thawng SCL, Thein KM, Thein S, Tizard R, Whitten T, Williams G, Wilson T, Woods K, Ziegler AD, Zrust M, Webb EL.

Conserv Biol. 2017 Dec;31(6):1257-1270. doi: 10.1111/cobi.13021. Epub 2017 Oct 14. Review.


Improved Assessment of Chest pain Trial (IMPACT): assessing patients with possible acute coronary syndromes.

Cullen L, Greenslade JH, Hawkins T, Hammett C, O'Kane S, Ryan K, Parker K, Schluter J, Dalton E, Brown AF, Than M, Peacock WF, Jaffe A, O'Rourke PK, Parsonage WA.

Med J Aust. 2017 Aug 4;207(5):195-200.


Assessment of the 2016 National Institute for Health and Care Excellence high-sensitivity troponin rule-out strategy.

Carlton EW, Pickering JW, Greenslade J, Cullen L, Than M, Kendall J, Body R, Parsonage WA, Khattab A, Greaves K.

Heart. 2018 Apr;104(8):665-672. doi: 10.1136/heartjnl-2017-311983. Epub 2017 Sep 1.


Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.

Dahms SO, Jiao GS, Than ME.

ACS Chem Biol. 2017 Sep 15;12(9):2474. doi: 10.1021/acschembio.7b00633. Epub 2017 Aug 7. No abstract available.


Preinjury characteristics of children with mild traumatic brain injury: Is "other injury" an appropriate comparison group"?

McKinlay A, Albicini M, Than M.

J Clin Exp Neuropsychol. 2018 Apr;40(3):285-291. doi: 10.1080/13803395.2017.1342771. Epub 2017 Jun 29.


Assessing the quality of primary care referrals to surgery of patients with diabetes in the East of England: A multi-centre cross-sectional cohort study.

Pournaras DJ, Photi ES, Barnett N, Challand CP, Chatzizacharias NA, Dlamini NP, Doulias T, Foley A, Hernon J, Kumar B, Martin J, Nunney I, Oglesby F, Panagiotopoulou I, Sengupta N, Shivakumar O, Sinclair P, Stather P, Than MM, Wells AC, Xanthis A, Dhatariya K.

Int J Clin Pract. 2017 Jul;71(7). doi: 10.1111/ijcp.12971. Epub 2017 Jun 15. Erratum in: Int J Clin Pract. 2017 Nov;71(11):.


Direct Comparison of 2 Rule-Out Strategies for Acute Myocardial Infarction: 2-h Accelerated Diagnostic Protocol vs 2-h Algorithm.

Wildi K, Cullen L, Twerenbold R, Greenslade JH, Parsonage W, Boeddinghaus J, Nestelberger T, Sabti Z, Rubini-Giménez M, Puelacher C, Cupa J, Schumacher L, Badertscher P, Grimm K, Kozhuharov N, Stelzig C, Freese M, Rentsch K, Lohrmann J, Kloos W, Buser A, Reichlin T, Pickering JW, Than M, Mueller C.

Clin Chem. 2017 Jul;63(7):1227-1236. doi: 10.1373/clinchem.2016.268359. Epub 2017 May 17.


Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis.

Pickering JW, Than MP, Cullen L, Aldous S, Ter Avest E, Body R, Carlton EW, Collinson P, Dupuy AM, Ekelund U, Eggers KM, Florkowski CM, Freund Y, George P, Goodacre S, Greenslade JH, Jaffe AS, Lord SJ, Mokhtari A, Mueller C, Munro A, Mustapha S, Parsonage W, Peacock WF, Pemberton C, Richards AM, Sanchis J, Staub LP, Troughton R, Twerenbold R, Wildi K, Young J.

Ann Intern Med. 2017 May 16;166(10):715-724. doi: 10.7326/M16-2562. Epub 2017 Apr 18. Erratum in: Ann Intern Med. 2017 Oct 3;167(7):528.


Response by Than et al to Letter Regarding Article, "Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction".

Than MP, Pickering JW, Cullen L, Kavsak PA.

Circulation. 2017 Apr 18;135(16):e923-e924. doi: 10.1161/CIRCULATIONAHA.117.027479. No abstract available.


Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor.

Dahms SO, Jiao GS, Than ME.

ACS Chem Biol. 2017 May 19;12(5):1211-1216. doi: 10.1021/acschembio.6b01110. Epub 2017 Apr 17. Erratum in: ACS Chem Biol. 2017 Sep 15;12 (9):2474.


Validating the Manchester Acute Coronary Syndromes (MACS) and Troponin-only Manchester Acute Coronary Syndromes (T-MACS) rules for the prediction of acute myocardial infarction in patients presenting to the emergency department with chest pain.

Greenslade JH, Nayer R, Parsonage W, Doig S, Young J, Pickering JW, Than M, Hammett C, Cullen L.

Emerg Med J. 2017 Aug;34(8):517-523. doi: 10.1136/emermed-2016-206366. Epub 2017 Mar 31.


Renal Function and Scaled Troponin in Patients Presenting to the Emergency Department with Symptoms of Myocardial Infarction.

Vasudevan A, Singer AJ, DeFilippi C, Headden G, Schussler JM, Daniels LB, Reed M, Than MP, Birkhahn R, Smith SW, Barrett TW, Arnold W, Peacock WF, McCullough PA.

Am J Nephrol. 2017;45(4):304-309. doi: 10.1159/000458451. Epub 2017 Feb 14.


The small number problem in diagnostic algorithms and why we need to bootstrap.

Pickering JW, Than MP.

Clin Biochem. 2017 Jun;50(9):540-541. doi: 10.1016/j.clinbiochem.2017.02.009. Epub 2017 Feb 10. No abstract available.


Interpretation of positive troponin results among patients with and without myocardial infarction.

Tecson KM, Arnold W, Barrett T, Birkhahn R, Daniels LB, DeFilippi C, Headden G, Peacock WF, Reed M, Singer AJ, Schussler JM, Smith S, Than MP, McCullough PA.

Proc (Bayl Univ Med Cent). 2017 Jan;30(1):11-15.


Missed myocardial infarctions in ED patients prospectively categorized as low risk by established risk scores.

Singer AJ, Than MP, Smith S, McCullough P, Barrett TW, Birkhahn R, Reed M, Thode HC, Arnold WD, Daniels LB, de Filippi C, Headden G, Peacock WF.

Am J Emerg Med. 2017 May;35(5):704-709. doi: 10.1016/j.ajem.2017.01.003. Epub 2017 Jan 5.


Acute Kidney Injury and mortality prognosis in Acute Coronary Syndrome patients: A meta-analysis.

Pickering JW, Blunt IRH, Than MP.

Nephrology (Carlton). 2018 Mar;23(3):237-246. doi: 10.1111/nep.12984. Review.


Immediate Rule-Out of Acute Myocardial Infarction Using Electrocardiogram and Baseline High-Sensitivity Troponin I.

Neumann JT, Sörensen NA, Ojeda F, Schwemer T, Lehmacher J, Gönner S, Jarsetz N, Keller T, Schaefer S, Renné T, Landmesser U, Clemmensen P, Makarova N, Schnabel RB, Zeller T, Karakas M, Pickering JW, Than M, Parsonage W, Greenslade J, Cullen L, Westermann D, Blankenberg S.

Clin Chem. 2017 Jan;63(1):394-402. doi: 10.1373/clinchem.2016.262659. Epub 2016 Nov 30.


Does Uric Acid Level Provide Additional Risk Stratification Information in Emergency Patients With Symptoms of Possible Acute Coronary Syndrome?

Jin H, Greenslade JH, Parsonage WA, Hawkins T, Than M, Cullen L.

Crit Pathw Cardiol. 2016 Dec;15(4):169-173.


Assessment of the European Society of Cardiology 0-Hour/1-Hour Algorithm to Rule-Out and Rule-In Acute Myocardial Infarction.

Pickering JW, Greenslade JH, Cullen L, Flaws D, Parsonage W, Aldous S, George P, Worster A, Kavsak PA, Than MP.

Circulation. 2016 Nov 15;134(20):1532-1541. Epub 2016 Oct 17.


The VHOT (Vindaloo Hastens Outpouring of Troponins) Study.

Tankel AS, Nagree Y, Jones P, Mountain D, Macdonald SP, Hill P, Than M.

Emerg Med Australas. 2016 Dec;28(6):654-657. doi: 10.1111/1742-6723.12679. Epub 2016 Oct 4.


The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.

Dahms SO, Creemers JW, Schaub Y, Bourenkov GP, Zögg T, Brandstetter H, Than ME.

Sci Rep. 2016 Sep 27;6:34303. doi: 10.1038/srep34303.


Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.

Dahms SO, Arciniega M, Steinmetzer T, Huber R, Than ME.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11196-11201. Epub 2016 Sep 19.

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