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Complement in malaria immunity and vaccines.

Kurtovic L, Boyle MJ, Opi DH, Kennedy AT, Tham WH, Reiling L, Chan JA, Beeson JG.

Immunol Rev. 2019 Sep 26. doi: 10.1111/imr.12802. [Epub ahead of print] Review.


Plasmodium vivax Reticulocyte Binding Proteins for invasion into reticulocytes.

Chan LJ, Dietrich MH, Nguitragool W, Tham WH.

Cell Microbiol. 2019 Aug 30:e13110. doi: 10.1111/cmi.13110. [Epub ahead of print] Review.


Antibodies to Plasmodium vivax reticulocyte binding protein 2b are associated with protection against P. vivax malaria in populations living in low malaria transmission regions of Brazil and Thailand.

He WQ, Karl S, White MT, Nguitragool W, Monteiro W, Kuehn A, Gruszczyk J, França CT, Sattabongkot J, Lacerda MVG, Tham WH, Mueller I.

PLoS Negl Trop Dis. 2019 Aug 19;13(8):e0007596. doi: 10.1371/journal.pntd.0007596. eCollection 2019 Aug.


Complement Receptor 1 availability on red blood cell surface modulates Plasmodium vivax invasion of human reticulocytes.

Prajapati SK, Borlon C, Rovira-Vallbona E, Gruszczyk J, Menant S, Tham WH, Kattenberg JH, Villasis E, De Meulenaere K, Gamboa D, Vinetz J, Fujita R, Xuan XN, Urbano Ferreira M, Niño CH, Patarroyo MA, Spanakos G, Kestens L, Abbeele JVD, Rosanas-Urgell A.

Sci Rep. 2019 Jun 20;9(1):8943. doi: 10.1038/s41598-019-45228-6.


Current Status and Growth of Nuclear Theranostics in Singapore.

Huang HL, Tong AKT, Thang SP, Yan SX, Lam WWC, Loke KSH, Tang CYL, Cheng LTJ, Ooi GSK, Low HC, Magsombol BM, Tham WY, Goh CXY, Tan CJ, Khor YM, Zaheer S, Bharadwaj P, Xie W, Ng DCE.

Nucl Med Mol Imaging. 2019 Apr;53(2):96-101. doi: 10.1007/s13139-019-00580-3. Epub 2019 Jan 25.


Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes.

Healer J, Wong W, Thompson JK, He W, Birkinshaw RW, Miura K, Long CA, Soroka V, Søgaard TMM, Jørgensen T, de Jongh WA, Weir C, Svahn E, Czabotar PE, Tham WH, Mueller I, Barlow PN, Cowman AF.

Cell Microbiol. 2019 Jul;21(7):e13030. doi: 10.1111/cmi.13030. Epub 2019 Apr 24.


Deformity Correction Using the "Sandwich" Technique for a Non-Union Hoffa Fracture.

Tham WW, Khor YP, Chee YH.

Ann Acad Med Singapore. 2019 Feb;48(2):63-66. No abstract available.


Clinics in diagnostic imaging (194). SVC aneurysm.

Tan PY, Tham WP, Yong YR.

Singapore Med J. 2019 Jan;60(1):17-21. doi: 10.11622/smedj.2019005.


Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria.

He WQ, Shakri AR, Bhardwaj R, França CT, Stanisic DI, Healer J, Kiniboro B, Robinson LJ, Guillotte-Blisnick M, Huon C, Siba P, Cowman A, King CL, Tham WH, Chitnis CE, Mueller I.

PLoS Negl Trop Dis. 2019 Feb 15;13(2):e0006987. doi: 10.1371/journal.pntd.0006987. eCollection 2019 Feb.


Perioperative pregabalin does not reduce opioid requirements in total knee arthroplasty.

Yik JH, Tham WYW, Tay KH, Shen L, Krishna L.

Knee Surg Sports Traumatol Arthrosc. 2019 Jul;27(7):2104-2110. doi: 10.1007/s00167-019-05385-7. Epub 2019 Feb 9.


Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.

Gilson PR, Nguyen W, Poole WA, Teixeira JE, Thompson JK, Guo K, Stewart RJ, Ashton TD, White KL, Sanz LM, Gamo FJ, Charman SA, Wittlin S, Duffy J, Tonkin CJ, Tham WH, Crabb BS, Cooke BM, Huston CD, Cowman AF, Sleebs BE.

Antimicrob Agents Chemother. 2019 Feb 26;63(3). pii: e01804-18. doi: 10.1128/AAC.01804-18. Print 2019 Mar.


Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.

Wong W, Huang R, Menant S, Hong C, Sandow JJ, Birkinshaw RW, Healer J, Hodder AN, Kanjee U, Tonkin CJ, Heckmann D, Soroka V, Søgaard TMM, Jørgensen T, Duraisingh MT, Czabotar PE, de Jongh WA, Tham WH, Webb AI, Yu Z, Cowman AF.

Nature. 2019 Jan;565(7737):118-121. doi: 10.1038/s41586-018-0779-6. Epub 2018 Dec 12.


Evolutionary history of human Plasmodium vivax revealed by genome-wide analyses of related ape parasites.

Loy DE, Plenderleith LJ, Sundararaman SA, Liu W, Gruszczyk J, Chen YJ, Trimboli S, Learn GH, MacLean OA, Morgan ALK, Li Y, Avitto AN, Giles J, Calvignac-Spencer S, Sachse A, Leendertz FH, Speede S, Ayouba A, Peeters M, Rayner JC, Tham WH, Sharp PM, Hahn BH.

Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8450-E8459. doi: 10.1073/pnas.1810053115. Epub 2018 Aug 20.


Implicated Food Products for Listeriosis and Changes in Serovars of Listeria monocytogenes Affecting Humans in Recent Decades.

Lopez-Valladares G, Danielsson-Tham ML, Tham W.

Foodborne Pathog Dis. 2018 Jul;15(7):387-397. doi: 10.1089/fpd.2017.2419. Epub 2018 Jun 29. Review.


Cryo-EM structure of an essential Plasmodium vivax invasion complex.

Gruszczyk J, Huang RK, Chan LJ, Menant S, Hong C, Murphy JM, Mok YF, Griffin MDW, Pearson RD, Wong W, Cowman AF, Yu Z, Tham WH.

Nature. 2018 Jul;559(7712):135-139. doi: 10.1038/s41586-018-0249-1. Epub 2018 Jun 27.


Age exerts a continuous effect in the outcomes of Asian breast cancer patients treated with breast-conserving therapy.

Wong FY, Tham WY, Nei WL, Lim C, Miao H.

Cancer Commun (Lond). 2018 Jun 26;38(1):39. doi: 10.1186/s40880-018-0310-3.


18F-FDG PET Brain in a Patient With Fatal Familial Insomnia.

Tham WY, Thian YL, Ratnagopal P, Xie W.

Clin Nucl Med. 2018 Aug;43(8):e274-e275. doi: 10.1097/RLU.0000000000002152.


Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.

Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH.

Science. 2018 Jan 5;359(6371):48-55. doi: 10.1126/science.aan1078.


Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development.

França CT, White MT, He WQ, Hostetler JB, Brewster J, Frato G, Malhotra I, Gruszczyk J, Huon C, Lin E, Kiniboro B, Yadava A, Siba P, Galinski MR, Healer J, Chitnis C, Cowman AF, Takashima E, Tsuboi T, Tham WH, Fairhurst RM, Rayner JC, King CL, Mueller I.

Elife. 2017 Sep 26;6. pii: e28673. doi: 10.7554/eLife.28673.


Trend and predictors of unplanned hospitalization of older patients during the first year after admission into a home medical service.

Mittal R, Tan CS, Tham WY, Seong LPS, Tan TL, Koh GC.

Home Health Care Serv Q. 2017 Jul-Sep;36(3-4):145-163. doi: 10.1080/01621424.2017.1381868. Epub 2017 Oct 23.


The Molecular Basis of Erythrocyte Invasion by Malaria Parasites.

Cowman AF, Tonkin CJ, Tham WH, Duraisingh MT.

Cell Host Microbe. 2017 Aug 9;22(2):232-245. doi: 10.1016/j.chom.2017.07.003. Review.


Recruitment of Human C1 Esterase Inhibitor Controls Complement Activation on Blood Stage Plasmodium falciparum Merozoites.

Kennedy AT, Wijeyewickrema LC, Huglo A, Lin C, Pike R, Cowman AF, Tham WH.

J Immunol. 2017 Jun 15;198(12):4728-4737. doi: 10.4049/jimmunol.1700067. Epub 2017 May 8.


Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand.

Longley RJ, França CT, White MT, Kumpitak C, Sa-Angchai P, Gruszczyk J, Hostetler JB, Yadava A, King CL, Fairhurst RM, Rayner JC, Tham WH, Nguitragool W, Sattabongkot J, Mueller I.

Malar J. 2017 Apr 28;16(1):178. doi: 10.1186/s12936-017-1826-8.


Percutaneous Endovascular Treatment to Salvage Non-Maturing Arteriovenous Fistulas in a Multiethnic Asian Population.

Tham WP, Burgmans MC, Tan BS, Tay KH, Irani FG, Gogna A, Patel A, Lo RH, Chng SP, Choong HL, Chan SX.

Ann Acad Med Singapore. 2017 Feb;46(2):64-71.


Beating Rayleigh's Curse by Imaging Using Phase Information.

Tham WK, Ferretti H, Steinberg AM.

Phys Rev Lett. 2017 Feb 17;118(7):070801. doi: 10.1103/PhysRevLett.118.070801. Epub 2017 Feb 15.


Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion.

Sisquella X, Nebl T, Thompson JK, Whitehead L, Malpede BM, Salinas ND, Rogers K, Tolia NH, Fleig A, O'Neill J, Tham WH, David Horgen F, Cowman AF.

Elife. 2017 Feb 22;6. pii: e21083. doi: 10.7554/eLife.21083.


Editorial: Molecular Approaches to Malaria, 2016.

Tham WH, Barry A, Hansen DS, Cooke BM.

Int J Parasitol. 2017 Feb;47(2-3):75. doi: 10.1016/j.ijpara.2017.01.002. No abstract available.


Simulating and Optimising Quantum Thermometry Using Single Photons.

Tham WK, Ferretti H, Sadashivan AV, Steinberg AM.

Sci Rep. 2016 Dec 15;6:38822. doi: 10.1038/srep38822.


Plasmodium vivax vaccine research - we've only just begun.

Tham WH, Beeson JG, Rayner JC.

Int J Parasitol. 2017 Feb;47(2-3):111-118. doi: 10.1016/j.ijpara.2016.09.006. Epub 2016 Nov 27. Review.


Lineage II (Serovar 1/2a and 1/2c) Human Listeria monocytogenes Pulsed-Field Gel Electrophoresis Types Divided into PFGE Groups Using the Band Patterns Below 145.5 kb.

Lopez-Valladares G, Danielsson-Tham ML, Goering RV, Tham W.

Foodborne Pathog Dis. 2017 Jan;14(1):8-16. doi: 10.1089/fpd.2016.2173. Epub 2016 Nov 18.


Spectrum of dermatological conditions seen in the intensive care unit.

Tham WY, Koh HY, Lee HY.

Clin Exp Dermatol. 2016 Dec;41(8):920-921. doi: 10.1111/ced.12901. Epub 2016 Oct 27. No abstract available.


Plasmodium vivax Reticulocyte Binding Proteins Are Key Targets of Naturally Acquired Immunity in Young Papua New Guinean Children.

França CT, He WQ, Gruszczyk J, Lim NT, Lin E, Kiniboro B, Siba PM, Tham WH, Mueller I.

PLoS Negl Trop Dis. 2016 Sep 27;10(9):e0005014. doi: 10.1371/journal.pntd.0005014. eCollection 2016 Sep.


Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application.

Ou B, Yang Y, Tham WL, Chen L, Guo J, Zhu G.

Appl Microbiol Biotechnol. 2016 Oct;100(20):8693-9. doi: 10.1007/s00253-016-7829-5. Epub 2016 Sep 17. Review.


Impact of acquisition of 16S rRNA methylase RmtB on the fitness of Escherichia coli.

Ou B, Chen L, Song Y, Yang Y, Zhang Q, Yang Y, Li L, Tham WL, Francis DH, Zhu G.

J Glob Antimicrob Resist. 2016 Sep;6:32-38. doi: 10.1016/j.jgar.2016.02.004. Epub 2016 Apr 6.


Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes.

Volz JC, Yap A, Sisquella X, Thompson JK, Lim NT, Whitehead LW, Chen L, Lampe M, Tham WH, Wilson D, Nebl T, Marapana D, Triglia T, Wong W, Rogers KL, Cowman AF.

Cell Host Microbe. 2016 Jul 13;20(1):60-71. doi: 10.1016/j.chom.2016.06.004. Epub 2016 Jun 30.


Stronger Limits on Hypothetical Yukawa Interactions in the 30-8000 nm Range.

Chen YJ, Tham WK, Krause DE, López D, Fischbach E, Decca RS.

Phys Rev Lett. 2016 Jun 3;116(22):221102. doi: 10.1103/PhysRevLett.116.221102. Epub 2016 Jun 2.


Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement.

Gruszczyk J, Lim NT, Arnott A, He WQ, Nguitragool W, Roobsoong W, Mok YF, Murphy JM, Smith KR, Lee S, Bahlo M, Mueller I, Barry AE, Tham WH.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):E191-200. doi: 10.1073/pnas.1516512113. Epub 2015 Dec 29.


Gene Models, Expression Repertoire, and Immune Response of Plasmodium vivax Reticulocyte Binding Proteins.

Hietanen J, Chim-Ong A, Chiramanewong T, Gruszczyk J, Roobsoong W, Tham WH, Sattabongkot J, Nguitragool W.

Infect Immun. 2015 Dec 28;84(3):677-85. doi: 10.1128/IAI.01117-15.


Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-Stage Plasmodium falciparum Infection.

Kennedy AT, Schmidt CQ, Thompson JK, Weiss GE, Taechalertpaisarn T, Gilson PR, Barlow PN, Crabb BS, Cowman AF, Tham WH.

J Immunol. 2016 Feb 1;196(3):1239-48. doi: 10.4049/jimmunol.1501581. Epub 2015 Dec 23.


Plasmodium falciparum Adhesins Play an Essential Role in Signalling and Activation of Invasion into Human Erythrocytes.

Tham WH, Lim NT, Weiss GE, Lopaticki S, Ansell BR, Bird M, Lucet I, Dorin-Semblat D, Doerig C, Gilson PR, Crabb BS, Cowman AF.

PLoS Pathog. 2015 Dec 22;11(12):e1005343. doi: 10.1371/journal.ppat.1005343. eCollection 2015 Dec.


A Look Back in Time: Sir Robert Jones, 'Father of Modern Orthopaedics'.

Tham W, Sng S, Lum YM, Chee YH.

Malays Orthop J. 2014 Nov;8(3):37-41. doi: 10.5704/MOJ.1411.009.


Characterization of Inhibitors and Monoclonal Antibodies That Modulate the Interaction between Plasmodium falciparum Adhesin PfRh4 with Its Erythrocyte Receptor Complement Receptor 1.

Lim NT, Harder MJ, Kennedy AT, Lin CS, Weir C, Cowman AF, Call MJ, Schmidt CQ, Tham WH.

J Biol Chem. 2015 Oct 16;290(42):25307-21. doi: 10.1074/jbc.M115.657171. Epub 2015 Aug 31.


Malaria: a master lock for deadly parasites.

Tham WH, Kennedy AT.

Nature. 2015 Jun 11;522(7555):158-9. doi: 10.1038/522158a. No abstract available.


More than just immune evasion: Hijacking complement by Plasmodium falciparum.

Schmidt CQ, Kennedy AT, Tham WH.

Mol Immunol. 2015 Sep;67(1):71-84. doi: 10.1016/j.molimm.2015.03.006. Epub 2015 Mar 26. Review.


Division of Human Listeria monocytogenes Pulsed-Field Gel Electrophoresis (PFGE) Types Belonging to Lineage I (Serovar 4b, 1/2b, and 3b) into PFGE Groups.

Lopez-Valladares G, Danielsson-Tham ML, Goering RV, Tham W.

Foodborne Pathog Dis. 2015 May;12(5):447-53. doi: 10.1089/fpd.2014.1880. Epub 2015 Mar 24.


Pernicious anaemia presenting as hyperpigmentation.

Tham WY, Oh CC, Koh HY.

Clin Exp Dermatol. 2015 Aug;40(6):626-8. doi: 10.1111/ced.12600. Epub 2015 Mar 18.


Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes.

Weiss GE, Gilson PR, Taechalertpaisarn T, Tham WH, de Jong NW, Harvey KL, Fowkes FJ, Barlow PN, Rayner JC, Wright GJ, Cowman AF, Crabb BS.

PLoS Pathog. 2015 Feb 27;11(2):e1004670. doi: 10.1371/journal.ppat.1004670. eCollection 2015 Feb.


Interactive knee cartilage extraction using efficient segmentation software: data from the osteoarthritis initiative.

Gan HS, Tan TS, Wong LX, Tham WK, Sayuti KA, Abdul Karim AH, bin Abdul Kadir MR.

Biomed Mater Eng. 2014;24(6):3145-57. doi: 10.3233/BME-141137.


Medical image visual appearance improvement using bihistogram Bezier curve contrast enhancement: data from the Osteoarthritis Initiative.

Gan HS, Swee TT, Abdul Karim AH, Sayuti KA, Abdul Kadir MR, Tham WK, Wong LX, Chaudhary KT, Ali J, Yupapin PP.

ScientificWorldJournal. 2014;2014:294104. doi: 10.1155/2014/294104. Epub 2014 May 20.

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