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Items: 50

1.

Shedding of BAFF/APRIL Receptors Controls B Cells.

Meinl E, Thaler FS, Lichtenthaler SF.

Trends Immunol. 2018 Sep;39(9):673-676. doi: 10.1016/j.it.2018.07.002. Epub 2018 Jul 30.

PMID:
30072119
2.

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein.

Spadaro M, Winklmeier S, Beltrán E, Macrini C, Höftberger R, Schuh E, Thaler FS, Gerdes LA, Laurent S, Gerhards R, Brändle S, Dornmair K, Breithaupt C, Krumbholz M, Moser M, Krishnamoorthy G, Kamp F, Jenne D, Hohlfeld R, Kümpfel T, Lassmann H, Kawakami N, Meinl E.

Ann Neurol. 2018 Aug;84(2):315-328. doi: 10.1002/ana.25291. Epub 2018 Sep 9.

PMID:
30014603
3.

Cerebral small vessel disease caused by a novel heterozygous mutation in HTRA1.

Thaler FS, Catak C, Einhäupl M, Müller S, Seelos K, Wollenweber FA, Kümpfel T.

J Neurol Sci. 2018 May 15;388:19-21. doi: 10.1016/j.jns.2018.02.043. Epub 2018 Feb 27. No abstract available.

PMID:
29627020
4.

Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis.

Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, Zettl UK, Ehrlich S, Handreka R, Rostásy K, Then Bergh F, Faiss JH, Lieb W, Franke A, Kuhlenbäumer G, Wandinger KP, Leypoldt F; German Network for Research on Autoimmune Encephalitis (GENERATE).

Ann Neurol. 2018 Apr;83(4):863-869. doi: 10.1002/ana.25216.

PMID:
29572931
5.

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.

Trifirò P, Cappa A, Brambillasca S, Botrugno OA, Cera MR, Zuffo RD, Dessanti P, Meroni G, Thaler F, Villa M, Minucci S, Mercurio C, Varasi M, Vianello P.

Future Med Chem. 2017 Jul;9(11):1161-1174. doi: 10.4155/fmc-2017-0003. Epub 2017 Jul 19.

PMID:
28722470
6.

Soluble TACI and soluble BCMA as biomarkers in primary central nervous system lymphoma.

Thaler FS, Laurent SA, Huber M, Mulazzani M, Dreyling M, Ködel U, Kümpfel T, Straube A, Meinl E, von Baumgarten L.

Neuro Oncol. 2017 Nov 29;19(12):1618-1627. doi: 10.1093/neuonc/nox097.

7.

Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement.

Schuh E, Musumeci A, Thaler FS, Laurent S, Ellwart JW, Hohlfeld R, Krug A, Meinl E.

J Immunol. 2017 Apr 15;198(8):3081-3088. doi: 10.4049/jimmunol.1601746. Epub 2017 Mar 10.

8.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

Vianello P, Sartori L, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Villa M, Botrugno OA, Dessanti P, Minucci S, Vultaggio S, Zagarrí E, Varasi M, Mercurio C.

J Med Chem. 2017 Mar 9;60(5):1693-1715. doi: 10.1021/acs.jmedchem.6b01019. Epub 2017 Feb 27.

PMID:
28186757
9.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

Sartori L, Mercurio C, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Villa M, Vultaggio S, Botrugno OA, Dessanti P, Minucci S, Zagarrí E, Carettoni D, Iuzzolino L, Varasi M, Vianello P.

J Med Chem. 2017 Mar 9;60(5):1673-1692. doi: 10.1021/acs.jmedchem.6b01018. Epub 2017 Feb 27.

PMID:
28186755
10.

Reversible cerebral vasoconstriction syndrome and posterior reversible encephalopathy syndrome associated with intracranial hypotension.

Feil K, Forbrig R, Thaler FS, Conrad J, Heck S, Dorn F, Pfister HW, Straube A.

Neurocrit Care. 2017 Feb;26(1):103-108. doi: 10.1007/s12028-016-0320-4.

PMID:
27848124
11.

Compounds and methods for inhibiting histone demethylases: a patent evaluation of US20160102096A1.

Thaler F, Mercurio C.

Expert Opin Ther Pat. 2016 Dec;26(12):1367-1370. Epub 2016 Oct 21.

PMID:
27730846
12.

Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis.

Spadaro M, Gerdes LA, Krumbholz M, Ertl-Wagner B, Thaler FS, Schuh E, Metz I, Blaschek A, Dick A, Brück W, Hohlfeld R, Meinl E, Kümpfel T.

Neurol Neuroimmunol Neuroinflamm. 2016 Jun 30;3(5):e257. doi: 10.1212/NXI.0000000000000257. eCollection 2016 Oct.

13.

Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent.

Vianello P, Botrugno OA, Cappa A, Dal Zuffo R, Dessanti P, Mai A, Marrocco B, Mattevi A, Meroni G, Minucci S, Stazi G, Thaler F, Trifiró P, Valente S, Villa M, Varasi M, Mercurio C.

J Med Chem. 2016 Feb 25;59(4):1501-17. doi: 10.1021/acs.jmedchem.5b01209. Epub 2016 Jan 7.

PMID:
26702542
14.

Synthesis, biological characterization and molecular modeling insights of spirochromanes as potent HDAC inhibitors.

Thaler F, Moretti L, Amici R, Abate A, Colombo A, Carenzi G, Fulco MC, Boggio R, Dondio G, Gagliardi S, Minucci S, Sartori L, Varasi M, Mercurio C.

Eur J Med Chem. 2016 Jan 27;108:53-67. doi: 10.1016/j.ejmech.2015.11.010. Epub 2015 Nov 11.

PMID:
26629860
15.

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.

Vianello P, Botrugno OA, Cappa A, Ciossani G, Dessanti P, Mai A, Mattevi A, Meroni G, Minucci S, Thaler F, Tortorici M, Trifiró P, Valente S, Villa M, Varasi M, Mercurio C.

Eur J Med Chem. 2014 Oct 30;86:352-63. doi: 10.1016/j.ejmech.2014.08.068. Epub 2014 Aug 27.

PMID:
25173853
16.

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo.

Fancelli D, Abate A, Amici R, Bernardi P, Ballarini M, Cappa A, Carenzi G, Colombo A, Contursi C, Di Lisa F, Dondio G, Gagliardi S, Milanesi E, Minucci S, Pain G, Pelicci PG, Saccani A, Storto M, Thaler F, Varasi M, Villa M, Plyte S.

J Med Chem. 2014 Jun 26;57(12):5333-47. doi: 10.1021/jm500547c. Epub 2014 Jun 11.

PMID:
24918261
17.

Towards selective inhibition of histone deacetylase isoforms: what has been achieved, where we are and what will be next.

Thaler F, Mercurio C.

ChemMedChem. 2014 Mar;9(3):523-6. doi: 10.1002/cmdc.201300413. Review.

PMID:
24730063
18.

Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.

Thaler F, Varasi M, Abate A, Carenzi G, Colombo A, Bigogno C, Boggio R, Zuffo RD, Rapetti D, Resconi A, Regalia N, Vultaggio S, Dondio G, Gagliardi S, Minucci S, Mercurio C.

Eur J Med Chem. 2013 Jun;64:273-84. doi: 10.1016/j.ejmech.2013.03.061. Epub 2013 Apr 10.

PMID:
23644210
19.

Current trends in the development of histone deacetylase inhibitors: a review of recent patent applications.

Thaler F.

Pharm Pat Anal. 2012 Mar;1(1):75-90. doi: 10.4155/ppa.11.3. Review.

PMID:
24236715
20.

Spiro[chromane-2,4'-piperidine]-based histone deacetylase inhibitors with improved in vivo activity.

Thaler F, Varasi M, Carenzi G, Colombo A, Abate A, Bigogno C, Boggio R, Carrara S, Cataudella T, Dal Zuffo R, Reali V, Vultaggio S, Dondio G, Gagliardi S, Minucci S, Mercurio C.

ChemMedChem. 2012 Apr;7(4):709-21. doi: 10.1002/cmdc.201200024. Epub 2012 Feb 22.

PMID:
22354629
21.

Next generation histone deacetylase inhibitors: the answer to the search for optimized epigenetic therapies?

Thaler F, Minucci S.

Expert Opin Drug Discov. 2011 Apr;6(4):393-404. doi: 10.1517/17460441.2011.557660. Epub 2011 Feb 23.

PMID:
22646017
22.

Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.

Varasi M, Thaler F, Abate A, Bigogno C, Boggio R, Carenzi G, Cataudella T, Dal Zuffo R, Fulco MC, Rozio MG, Mai A, Dondio G, Minucci S, Mercurio C.

J Med Chem. 2011 Apr 28;54(8):3051-64. doi: 10.1021/jm200146u. Epub 2011 Apr 1.

PMID:
21417419
23.

Unusual complication of apicoaortic conduit: left main coronary artery thrombosis.

Sleilaty G, de Lentdecker P, Thaler F, Ceddaha A, Jebara V, Lansac E, Debauchez M.

Ann Thorac Surg. 2010 Aug;90(2):628-9. doi: 10.1016/j.athoracsur.2010.02.040.

PMID:
20667363
24.

Synthesis and biological characterization of amidopropenyl hydroxamates as HDAC inhibitors.

Thaler F, Varasi M, Colombo A, Boggio R, Munari D, Regalia N, Rozio MG, Reali V, Resconi AE, Mai A, Gagliardi S, Dondio G, Minucci S, Mercurio C.

ChemMedChem. 2010 Aug 2;5(8):1359-72. doi: 10.1002/cmdc.201000166.

PMID:
20572281
25.

Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.

Thaler F, Colombo A, Mai A, Amici R, Bigogno C, Boggio R, Cappa A, Carrara S, Cataudella T, Fusar F, Gianti E, di Ventimiglia SJ, Moroni M, Munari D, Pain G, Regalia N, Sartori L, Vultaggio S, Dondio G, Gagliardi S, Minucci S, Mercurio C, Varasi M.

J Med Chem. 2010 Jan 28;53(2):822-39. doi: 10.1021/jm901502p.

PMID:
20017493
26.

Impact of a five-year surveillance of central venous catheter infections in the REACAT intensive care unit network in France.

L'Hériteau F, Olivier M, Maugat S, Joly C, Merrer J, Thaler F, Grandbastien B, Beaucaire G, Astagneau P.

J Hosp Infect. 2007 Jun;66(2):123-9. Epub 2007 May 22.

PMID:
17517447
27.

[Simultaneous detection by multiplex PCR of atypical bacterial pathogens involved in infections of respiratory tract. Is it useful for the microbiological diagnosis of respiratory infections].

Honderlick P, Philippe B, Picard C, Thaler F, Couderc LJ.

Pathol Biol (Paris). 2006 Oct-Nov;54(8-9):467-9. Epub 2006 Oct 5. French.

PMID:
17027196
28.

Polymer-supported scavengers for purification of labeled proteins.

Thaler F, Zamai M.

Anal Biochem. 2005 Jun 15;341(2):379-81. No abstract available.

PMID:
15907887
29.

Reaction behaviour of dinuclear copper(I) complexes with m-xylyl-based ligands towards dioxygen.

Foxon SP, Utz D, Astner J, Schindler S, Thaler F, Heinemann FW, Liehr G, Mukherjee J, Balamurugan V, Ghosh D, Mukherjee R.

Dalton Trans. 2004 Aug 7;(15):2321-8. Epub 2004 Jun 30.

PMID:
15278125
30.

Cerebral fat embolism induced by facial fat injection.

Thaunat O, Thaler F, Loirat P, Decroix JP, Boulin A.

Plast Reconstr Surg. 2004 Jun;113(7):2235-6. No abstract available.

PMID:
15253237
31.

Structural properties of Gerstmann-Straussler-Scheinker disease amyloid protein.

Salmona M, Morbin M, Massignan T, Colombo L, Mazzoleni G, Capobianco R, Diomede L, Thaler F, Mollica L, Musco G, Kourie JJ, Bugiani O, Sharma D, Inouye H, Kirschner DA, Forloni G, Tagliavini F.

J Biol Chem. 2003 Nov 28;278(48):48146-53. Epub 2003 Sep 11.

32.

Inhibitor affinity chromatography: profiling the specific reactivity of the proteome with immobilized molecules.

Lolli G, Thaler F, Valsasina B, Roletto F, Knapp S, Uggeri M, Bachi A, Matafora V, Storici P, Stewart A, Kalisz HM, Isacchi A.

Proteomics. 2003 Jul;3(7):1287-98.

PMID:
12872229
33.

A new approach to phosphoserine and phosphothreonine analysis in peptides and proteins: chemical modification, enrichment via solid-phase reversible binding, and analysis by mass spectrometry.

Thaler F, Valsasina B, Baldi R, Xie J, Stewart A, Isacchi A, Kalisz HM, Rusconi L.

Anal Bioanal Chem. 2003 Jun;376(3):366-73. Epub 2003 May 7.

PMID:
12734628
34.

Structural, Spectroscopic, Thermodynamic and Kinetic Properties of Copper(II) Complexes with Tripodal Tetraamines.

Thaler F, Hubbard CD, Heinemann FW, van Eldik R, Schindler S, Fábián I, Dittler-Klingemann AM, Hahn FE, Orvig C.

Inorg Chem. 1998 Aug 10;37(16):4022-4029.

PMID:
11670519
35.

Copper(I) complexes, copper(I)/O(2) reactivity, and copper(II) complex adducts, with a series of tetradentate tripyridylalkylamine tripodal ligands.

Schatz M, Becker M, Thaler F, Hampel F, Schindler S, Jacobson RR, Tyeklár Z, Murthy NN, Ghosh P, Chen Q, Zubieta J, Karlin KD.

Inorg Chem. 2001 May 7;40(10):2312-22.

PMID:
11327908
36.

[Microbiological diagnosis of bacteremia from a catheter: a simple method? Results of a retrospective study].

Honderlick P, Thaler F, Cahen P, Couderc LJ, Glaisner S, Piette AM.

Pathol Biol (Paris). 2000 Jun;48(5):467-9. French.

PMID:
10949842
37.
38.

Zinc(II) complexes of tripodal peptides mimicking the zinc(II)-coordination structure of carbonic anhydrase.

Herr U, Spahl W, Trojandt G, Steglich W, Thaler F, van Eldik R.

Bioorg Med Chem. 1999 May;7(5):699-707.

PMID:
10400322
39.

Simplified acute physiology score II for measuring severity of illness in intermediate care units.

Auriant I, Vinatier I, Thaler F, Tourneur M, Loirat P.

Crit Care Med. 1998 Aug;26(8):1368-71.

PMID:
9710096
40.

Fluconazole penetration in cerebral parenchyma in humans at steady state.

Thaler F, Bernard B, Tod M, Jedynak CP, Petitjean O, Derome P, Loirat P.

Antimicrob Agents Chemother. 1995 May;39(5):1154-6.

41.

[Idiopathic retroperitoneal fibrosis disclosed by nephrogenic diabetes insipidus].

Gepner P, Thaler F, Botto H, Piette AM, Loirat P, Chapman A.

Rev Med Interne. 1993 Feb;14(2):112-4. French.

PMID:
8378621
42.

Mediastinitis due to Nocardia asteroides after cardiac transplantation.

Thaler F, Gotainer B, Teodori G, Dubois C, Loirat P.

Intensive Care Med. 1992;18(2):127-8.

PMID:
1613194
43.

[Hyperlactatemia during treatment of acute bronchospasm with salbutamol].

Saint-Jean O, de Rohan Chabot P, Thaler F, Loirat P.

Presse Med. 1987 May 23;16(19):965-6. French. No abstract available.

PMID:
2954150
44.

[Localized hepatic ischemia].

Gayraud M, Thaler F, Roullet-Audy JC, Rebibo G.

Ann Med Interne (Paris). 1987;138(3):220. French. No abstract available.

PMID:
3619253
45.

Differential effect of growth factors on growth stimulation and phenotypic stability of glutamine-synthetase-positive and -negative hepatocytes in primary culture.

Gebhardt R, Cruise J, Houck KA, Luetteke NC, Novotny A, Thaler F, Michalopoulos GK.

Differentiation. 1986;33(1):45-55.

PMID:
2880778
46.
47.

[A simplified severity index in resuscitation. Validation by a prospective study (280 cases)].

Bedock B, Dissait F, Piech JJ, Guelon D, Jouve P, Thaler F.

Presse Med. 1985 Mar 23;14(12):677-80. French.

PMID:
3157962
48.

[An unusual cause of acute respiratory insufficiency, massive inhalation of sawdust].

Thaler F, Haberer JP, Jouve P, Bedes A, Menaut P, Bedu A.

Presse Med. 1984 Sep 1-8;13(30):1844-5. French. No abstract available.

PMID:
6236446
49.
50.

Obsessive-compulsive disorders: a review of the literature.

Salzman L, Thaler FH.

Am J Psychiatry. 1981 Mar;138(3):286-96.

PMID:
6110343

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