Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 130

1.

Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition.

Lee CM, Zane NR, Veal G, Thakker DR.

CPT Pharmacometrics Syst Pharmacol. 2019 Aug 16. doi: 10.1002/psp4.12453. [Epub ahead of print]

2.

Efficacious dose of metformin for breast cancer therapy is determined by cation transporter expression in tumours.

Cai H, Everett RS, Thakker DR.

Br J Pharmacol. 2019 Aug;176(15):2724-2735. doi: 10.1111/bph.14694. Epub 2019 Jun 26.

PMID:
31032880
3.

Cytochrome P450 and flavin-containing monooxygenase families: age-dependent differences in expression and functional activity.

Zane NR, Chen Y, Wang MZ, Thakker DR.

Pediatr Res. 2018 Feb;83(2):527-535. doi: 10.1038/pr.2017.226. Epub 2017 Nov 1.

PMID:
28922349
4.

Widespread brain distribution and activity following i.c.v. infusion of anti-β-secretase (BACE1) in nonhuman primates.

Yadav DB, Maloney JA, Wildsmith KR, Fuji RN, Meilandt WJ, Solanoy H, Lu Y, Peng K, Wilson B, Chan P, Gadkar K, Kosky A, Goo M, Daugherty A, Couch JA, Keene T, Hayes K, Nikolas LJ, Lane D, Switzer R, Adams E, Watts RJ, Scearce-Levie K, Prabhu S, Shafer L, Thakker DR, Hildebrand K, Atwal JK.

Br J Pharmacol. 2017 Nov;174(22):4173-4185. doi: 10.1111/bph.14021. Epub 2017 Oct 6.

5.

Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis.

Proctor WR, Ming X, Bourdet D, Han TK, Everett RS, Thakker DR.

J Pharm Sci. 2016 Feb;105(2):484-496. doi: 10.1016/j.xphs.2015.11.040. Review.

PMID:
26869413
6.
7.

Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells.

Cai H, Zhang Y, Han TK, Everett RS, Thakker DR.

Int J Cancer. 2016 May 1;138(9):2281-92. doi: 10.1002/ijc.29965. Epub 2016 Jan 8.

8.

A Tribute to Ronald T. Borchardt--Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man.

Schowen KB, Schowen RL, Borchardt SE, Borchardt PM, Artursson P, Audus KL, Augustijns P, Nicolazzo JA, Raub TJ, Schöneich C, Siahaan TJ, Takakura Y, Thakker DR, Wolfe MS.

J Pharm Sci. 2016 Feb;105(2):370-385. doi: 10.1002/jps.24687. Epub 2016 Jan 29. No abstract available.

PMID:
26453244
9.

Centrally Delivered BACE1 Inhibitor Activates Microglia, and Reverses Amyloid Pathology and Cognitive Deficit in Aged Tg2576 Mice.

Thakker DR, Sankaranarayanan S, Weatherspoon MR, Harrison J, Pierdomenico M, Heisel JM, Thompson LA, Haskell R, Grace JE, Taylor SJ, Albright CF, Shafer LL.

J Neurosci. 2015 Apr 29;35(17):6931-6. doi: 10.1523/JNEUROSCI.2262-14.2015.

10.

Response to: "Prediction of Voriconazole Non-Linear Pharmacokinetics Using a Paediatric Physiologically Based Pharmacokinetic Modelling Approach".

Zane NR, Thakker DR.

Clin Pharmacokinet. 2015 May;54(5):569-72. doi: 10.1007/s40262-015-0254-6. No abstract available.

PMID:
25735635
11.

Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers.

Han TK, Proctor WR, Costales CL, Cai H, Everett RS, Thakker DR.

J Pharmacol Exp Ther. 2015 Mar;352(3):519-28. doi: 10.1124/jpet.114.220350. Epub 2015 Jan 6.

12.

A physiologically based pharmacokinetic model for voriconazole disposition predicts intestinal first-pass metabolism in children.

Zane NR, Thakker DR.

Clin Pharmacokinet. 2014 Dec;53(12):1171-82. doi: 10.1007/s40262-014-0181-y.

PMID:
25245942
13.

Exploring the role of the pharmacist in global health.

Steeb DR, Joyner PU, Thakker DR.

J Am Pharm Assoc (2003). 2014 Sep-Oct;54(5):552-5. doi: 10.1331/JAPhA.2014.13251.

PMID:
25216886
14.

Intestinal first-pass metabolism by cytochrome p450 and not p-glycoprotein is the major barrier to amprenavir absorption.

Dufek MB, Bridges AS, Thakker DR.

Drug Metab Dispos. 2013 Sep;41(9):1695-702. doi: 10.1124/dmd.113.052191. Epub 2013 Jul 2.

PMID:
23821186
15.

Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes.

Han TK, Everett RS, Proctor WR, Ng CM, Costales CL, Brouwer KL, Thakker DR.

Mol Pharmacol. 2013 Aug;84(2):182-9. doi: 10.1124/mol.112.084517. Epub 2013 May 16.

16.

Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse.

O'Connor RM, Thakker DR, Schmutz M, van der Putten H, Hoyer D, Flor PJ, Cryan JF.

Neuropharmacology. 2013 Sep;72:66-73. doi: 10.1016/j.neuropharm.2013.03.028. Epub 2013 Apr 17.

PMID:
23603202
17.

Sorafenib hepatobiliary disposition: mechanisms of hepatic uptake and disposition of generated metabolites.

Swift B, Nebot N, Lee JK, Han T, Proctor WR, Thakker DR, Lang D, Radtke M, Gnoth MJ, Brouwer KL.

Drug Metab Dispos. 2013 Jun;41(6):1179-86. doi: 10.1124/dmd.112.048181. Epub 2013 Mar 12.

18.

Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ.

Donica CL, Awwad HO, Thakker DR, Standifer KM.

Mol Pharmacol. 2013 May;83(5):907-18. doi: 10.1124/mol.112.084632. Epub 2013 Feb 8. Review.

19.

P-glycoprotein increases portal bioavailability of loperamide in mouse by reducing first-pass intestinal metabolism.

Dufek MB, Knight BM, Bridges AS, Thakker DR.

Drug Metab Dispos. 2013 Mar;41(3):642-50. doi: 10.1124/dmd.112.049965. Epub 2013 Jan 3.

PMID:
23288866
20.

Compartmental and enzyme kinetic modeling to elucidate the biotransformation pathway of a centrally acting antitrypanosomal prodrug.

Generaux CN, Ainslie GR, Bridges AS, Ismail MA, Boykin DW, Tidwell RR, Thakker DR, Paine MF.

Drug Metab Dispos. 2013 Feb;41(2):518-28. doi: 10.1124/dmd.112.048231. Epub 2012 Dec 6.

PMID:
23223498
21.

Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum.

Grondin R, Kaytor MD, Ai Y, Nelson PT, Thakker DR, Heisel J, Weatherspoon MR, Blum JL, Burright EN, Zhang Z, Kaemmerer WF.

Brain. 2012 Apr;135(Pt 4):1197-209. doi: 10.1093/brain/awr333. Epub 2012 Jan 16.

22.

Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters.

Ming X, Knight BM, Thakker DR.

Mol Pharm. 2011 Oct 3;8(5):1677-86. doi: 10.1021/mp200026v. Epub 2011 Aug 5.

PMID:
21780830
23.

Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding.

Yanni SB, Smith PB, Benjamin DK Jr, Augustijns PF, Thakker DR, Annaert PP.

Biopharm Drug Dispos. 2011 May;32(4):222-32. doi: 10.1002/bdd.752. Epub 2011 Mar 30.

24.

Direct activation of human phospholipase C by its well known inhibitor u73122.

Klein RR, Bourdon DM, Costales CL, Wagner CD, White WL, Williams JD, Hicks SN, Sondek J, Thakker DR.

J Biol Chem. 2011 Apr 8;286(14):12407-16. doi: 10.1074/jbc.M110.191783. Epub 2011 Jan 25.

25.

In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats.

Yanni SB, Augustijns PF, Benjamin DK Jr, Brouwer KL, Thakker DR, Annaert PP.

Drug Metab Dispos. 2010 Oct;38(10):1848-56. doi: 10.1124/dmd.110.033811. Epub 2010 Jul 6.

26.

In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3.

Yanni SB, Annaert PP, Augustijns P, Ibrahim JG, Benjamin DK Jr, Thakker DR.

Drug Metab Dispos. 2010 Jan;38(1):25-31. doi: 10.1124/dmd.109.029769.

27.

Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil.

Ming X, Thakker DR.

Biochem Pharmacol. 2010 Feb 1;79(3):455-62. doi: 10.1016/j.bcp.2009.08.029. Epub 2009 Sep 6.

PMID:
19735648
28.

Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice.

Thakker DR, Weatherspoon MR, Harrison J, Keene TE, Lane DS, Kaemmerer WF, Stewart GR, Shafer LL.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4501-6. doi: 10.1073/pnas.0813404106. Epub 2009 Feb 25.

29.

Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters.

Ming X, Ju W, Wu H, Tidwell RR, Hall JE, Thakker DR.

Drug Metab Dispos. 2009 Feb;37(2):424-30. doi: 10.1124/dmd.108.024083. Epub 2008 Oct 29.

PMID:
18971316
30.

Mechanisms underlying saturable intestinal absorption of metformin.

Proctor WR, Bourdet DL, Thakker DR.

Drug Metab Dispos. 2008 Aug;36(8):1650-8. doi: 10.1124/dmd.107.020180. Epub 2008 May 5.

PMID:
18458049
31.

Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes.

Yanni SB, Annaert PP, Augustijns P, Bridges A, Gao Y, Benjamin DK Jr, Thakker DR.

Drug Metab Dispos. 2008 Jun;36(6):1119-25. doi: 10.1124/dmd.107.019646. Epub 2008 Mar 24.

32.
33.

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity.

Fendt M, Schmid S, Thakker DR, Jacobson LH, Yamamoto R, Mitsukawa K, Maier R, Natt F, Hüsken D, Kelly PH, McAllister KH, Hoyer D, van der Putten H, Cryan JF, Flor PJ.

Mol Psychiatry. 2008 Oct;13(10):970-9. Epub 2007 Aug 21.

PMID:
17712315
34.

Emerging use of non-viral RNA interference in the brain.

Cryan JF, Thakker DR, Hoyer D.

Biochem Soc Trans. 2007 Apr;35(Pt 2):411-5.

PMID:
17371288
35.

Global down-regulation of gene expression in the brain using RNA interference, with emphasis on monoamine transporters and GPCRs: implications for target characterization in psychiatric and neurological disorders.

Hoyer D, Thakker DR, Natt F, Maier R, Huesken D, Müller M, Flor P, VAN DER Putten H, Schmutz M, Bilbe G, Cryan JF.

J Recept Signal Transduct Res. 2006;26(5-6):527-47.

PMID:
17118797
36.

Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: a major challenge.

Knight B, Troutman M, Thakker DR.

Curr Opin Pharmacol. 2006 Oct;6(5):528-32. Epub 2006 Aug 8. Review.

PMID:
16899406
39.

Interfering with the brain: use of RNA interference for understanding the pathophysiology of psychiatric and neurological disorders.

Thakker DR, Hoyer D, Cryan JF.

Pharmacol Ther. 2006 Mar;109(3):413-38. Epub 2005 Sep 23. Review.

PMID:
16183135
40.
41.

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain.

Thakker DR, Natt F, Hüsken D, van der Putten H, Maier R, Hoyer D, Cryan JF.

Mol Psychiatry. 2005 Aug;10(8):782-9, 714.

PMID:
15940298
42.

Orphanin FQ/nociceptin potentiates [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin-Induced mu-opioid receptor phosphorylation.

Ozsoy HZ, Thakker DR, Standifer KM.

Mol Pharmacol. 2005 Aug;68(2):447-56. Epub 2005 May 12.

PMID:
15890842
43.

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference.

Thakker DR, Natt F, Hüsken D, Maier R, Müller M, van der Putten H, Hoyer D, Cryan JF.

Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17270-5. Epub 2004 Nov 29.

44.
45.

Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry.

Zhou L, Thakker DR, Voyksner RD, Anbazhagan M, Boykin DW, Hall JE, Tidwell RR.

J Mass Spectrom. 2004 Apr;39(4):351-60.

PMID:
15103648
46.
49.
50.

Mu-opioid-induced desensitization of opioid receptor-like 1 and mu-opioid receptors: differential intracellular signaling determines receptor sensitivity.

Mandyam CD, Thakker DR, Standifer KM.

J Pharmacol Exp Ther. 2003 Sep;306(3):965-72. Epub 2003 May 15.

PMID:
12750434

Supplemental Content

Loading ...
Support Center