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Items: 36


Hyperactive LH pulses and elevated kisspeptin and NKB gene expression in the arcuate nucleus of a PCOS mouse model.

Esparza LA, Schafer D, Ho BS, Thackray VG, Kauffman AS.

Endocrinology. 2020 Feb 7. pii: bqaa018. doi: 10.1210/endocr/bqaa018. [Epub ahead of print]


Insulin-induced hypoglycaemia suppresses pulsatile luteinising hormone secretion and arcuate Kiss1 cell activation in female mice.

McCosh RB, Kreisman MJ, Tian K, Ho BS, Thackray VG, Breen KM.

J Neuroendocrinol. 2019 Dec;31(12):e12813. doi: 10.1111/jne.12813. Epub 2019 Dec 12.


Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome.

Arroyo P, Ho BS, Sau L, Kelley ST, Thackray VG.

PLoS One. 2019 Sep 30;14(9):e0223274. doi: 10.1371/journal.pone.0223274. eCollection 2019.


Age- and Sex-Dependent Patterns of Gut Microbial Diversity in Human Adults.

de la Cuesta-Zuluaga J, Kelley ST, Chen Y, Escobar JS, Mueller NT, Ley RE, McDonald D, Huang S, Swafford AD, Knight R, Thackray VG.

mSystems. 2019 May 14;4(4). pii: e00261-19. doi: 10.1128/mSystems.00261-19. eCollection 2019 Jul-Aug.


Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model.

Torres PJ, Ho BS, Arroyo P, Sau L, Chen A, Kelley ST, Thackray VG.

Endocrinology. 2019 May 1;160(5):1193-1204. doi: 10.1210/en.2019-00050.


Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice.

Torres PJ, Skarra DV, Ho BS, Sau L, Anvar AR, Kelley ST, Thackray VG.

BMC Microbiol. 2019 Mar 12;19(1):57. doi: 10.1186/s12866-019-1425-7.


Sex, Microbes, and Polycystic Ovary Syndrome.

Thackray VG.

Trends Endocrinol Metab. 2019 Jan;30(1):54-65. doi: 10.1016/j.tem.2018.11.001. Epub 2018 Nov 29. Review.


American Gut: an Open Platform for Citizen Science Microbiome Research.

McDonald D, Hyde E, Debelius JW, Morton JT, Gonzalez A, Ackermann G, Aksenov AA, Behsaz B, Brennan C, Chen Y, DeRight Goldasich L, Dorrestein PC, Dunn RR, Fahimipour AK, Gaffney J, Gilbert JA, Gogul G, Green JL, Hugenholtz P, Humphrey G, Huttenhower C, Jackson MA, Janssen S, Jeste DV, Jiang L, Kelley ST, Knights D, Kosciolek T, Ladau J, Leach J, Marotz C, Meleshko D, Melnik AV, Metcalf JL, Mohimani H, Montassier E, Navas-Molina J, Nguyen TT, Peddada S, Pevzner P, Pollard KS, Rahnavard G, Robbins-Pianka A, Sangwan N, Shorenstein J, Smarr L, Song SJ, Spector T, Swafford AD, Thackray VG, Thompson LR, Tripathi A, Vázquez-Baeza Y, Vrbanac A, Wischmeyer P, Wolfe E, Zhu Q; American Gut Consortium , Knight R.

mSystems. 2018 May 15;3(3). pii: e00031-18. doi: 10.1128/mSystems.00031-18. eCollection 2018 May-Jun.


Gut Microbial Diversity in Women With Polycystic Ovary Syndrome Correlates With Hyperandrogenism.

Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST, Thackray VG.

J Clin Endocrinol Metab. 2018 Apr 1;103(4):1502-1511. doi: 10.1210/jc.2017-02153.


Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance.

Skarra DV, Hernández-Carretero A, Rivera AJ, Anvar AR, Thackray VG.

Endocrinology. 2017 Sep 1;158(9):2988-3003. doi: 10.1210/en.2016-1898.


The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome.

Kelley ST, Skarra DV, Rivera AJ, Thackray VG.

PLoS One. 2016 Jan 5;11(1):e0146509. doi: 10.1371/journal.pone.0146509. eCollection 2016.


A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice.

Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL.

Biol Reprod. 2015 Sep;93(3):69. doi: 10.1095/biolreprod.115.131631. Epub 2015 Jul 22.


FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes.

Skarra DV, Thackray VG.

Mol Cell Endocrinol. 2015 Apr 15;405:14-24. doi: 10.1016/j.mce.2015.02.006. Epub 2015 Feb 9.


Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes.

Park CH, Skarra DV, Rivera AJ, Arriola DJ, Thackray VG.

PLoS One. 2014 Nov 25;9(11):e113839. doi: 10.1371/journal.pone.0113839. eCollection 2014.


Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors.

Thackray VG.

Mol Cell Endocrinol. 2014 Mar 25;385(1-2):62-70. doi: 10.1016/j.mce.2013.09.034. Epub 2013 Oct 4. Review.


Forkhead box O1 is a repressor of basal and GnRH-induced Fshb transcription in gonadotropes.

Skarra DV, Arriola DJ, Benson CA, Thackray VG.

Mol Endocrinol. 2013 Nov;27(11):1825-39. doi: 10.1210/me.2013-1185. Epub 2013 Sep 24.


A human FSHB promoter SNP associated with low FSH levels in men impairs LHX3 binding and basal FSHB transcription.

Benson CA, Kurz TL, Thackray VG.

Endocrinology. 2013 Sep;154(9):3016-21. doi: 10.1210/en.2013-1294. Epub 2013 Jun 13.


FOXO1 transcription factor inhibits luteinizing hormone β gene expression in pituitary gonadotrope cells.

Arriola DJ, Mayo SL, Skarra DV, Benson CA, Thackray VG.

J Biol Chem. 2012 Sep 28;287(40):33424-35. Epub 2012 Aug 3.


Stress levels of glucocorticoids inhibit LHβ-subunit gene expression in gonadotrope cells.

Breen KM, Thackray VG, Hsu T, Mak-McCully RA, Coss D, Mellon PL.

Mol Endocrinol. 2012 Oct;26(10):1716-31. Epub 2012 Jul 31.


FOXL2 is involved in the synergy between activin and progestins on the follicle-stimulating hormone β-subunit promoter.

Ghochani Y, Saini JK, Mellon PL, Thackray VG.

Endocrinology. 2012 Apr;153(4):2023-33. doi: 10.1210/en.2011-1763. Epub 2012 Jan 31.


A FoxL in the Smad house: activin regulation of FSH.

Coss D, Mellon PL, Thackray VG.

Trends Endocrinol Metab. 2010 Sep;21(9):562-8. doi: 10.1016/j.tem.2010.05.006. Epub 2010 Jul 2. Review.


Runt-related transcription factors impair activin induction of the follicle-stimulating hormone {beta}-subunit gene.

Breen KM, Thackray VG, Coss D, Mellon PL.

Endocrinology. 2010 Jun;151(6):2669-80. doi: 10.1210/en.2009-0949. Epub 2010 Mar 31.


Hormones in synergy: regulation of the pituitary gonadotropin genes.

Thackray VG, Mellon PL, Coss D.

Mol Cell Endocrinol. 2010 Jan 27;314(2):192-203. doi: 10.1016/j.mce.2009.09.003. Epub 2009 Sep 10. Review.


Progesterone Inhibits basal and gonadotropin-releasing hormone induction of luteinizing hormone beta-subunit gene expression.

Thackray VG, Hunnicutt JL, Memon AK, Ghochani Y, Mellon PL.

Endocrinology. 2009 May;150(5):2395-403. doi: 10.1210/en.2008-1027. Epub 2008 Dec 23.


Glucocorticoids induce human glycoprotein hormone alpha-subunit gene expression in the gonadotrope.

Sasson R, Luu SH, Thackray VG, Mellon PL.

Endocrinology. 2008 Jul;149(7):3643-55. doi: 10.1210/en.2007-1100. Epub 2008 Apr 10.


Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements.

Coss D, Thackray VG, Deng CX, Mellon PL.

Mol Endocrinol. 2005 Oct;19(10):2610-23. Epub 2005 Jun 16.


Androgen regulates follicle-stimulating hormone beta gene expression in an activin-dependent manner in immortalized gonadotropes.

Spady TJ, Shayya R, Thackray VG, Ehrensberger L, Bailey JS, Mellon PL.

Mol Endocrinol. 2004 Apr;18(4):925-40. Epub 2003 Dec 30.


Novel activation step required for transcriptional competence of progesterone receptor on chromatin templates.

Thackray VG, Toft DO, Nordeen SK.

Mol Endocrinol. 2003 Dec;17(12):2543-53. Epub 2003 Oct 9.


High-yield purification of functional, full-length steroid receptor coactivator 1 expressed in insect cells.

Thackray VG, Nordeen SK.

Biotechniques. 2002 Feb;32(2):260, 262-3. No abstract available.


Estrogen agonist and antagonist action on the human estrogen receptor in Drosophila.

Thackray VG, Young RH, Hooper JE, Nordeen SK.

Endocrinology. 2000 Oct;141(10):3912-5.


Phylogenetic analyses reveal ancient duplication of estrogen receptor isoforms.

Kelley ST, Thackray VG.

J Mol Evol. 1999 Nov;49(5):609-14.


Differential gene induction by glucocorticoid and progesterone receptors.

Thackray VG, Lieberman BA, Nordeen SK.

J Steroid Biochem Mol Biol. 1998 Aug;66(4):171-8.


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