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Items: 47

1.

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.

Sang JC, Lee JE, Dear AJ, De S, Meisl G, Thackray AM, Bujdoso R, Knowles TPJ, Klenerman D.

Chem Sci. 2019 Mar 25;10(17):4588-4597. doi: 10.1039/c8sc05627g. eCollection 2019 May 7.

2.

Direct Observation of Murine Prion Protein Replication in Vitro.

Sang JC, Meisl G, Thackray AM, Hong L, Ponjavic A, Knowles TPJ, Bujdoso R, Klenerman D.

J Am Chem Soc. 2018 Nov 7;140(44):14789-14798. doi: 10.1021/jacs.8b08311. Epub 2018 Oct 23.

3.

Mammalian prion propagation in PrP transgenic Drosophila.

Thackray AM, Andréoletti O, Bujdoso R.

Brain. 2018 Sep 1;141(9):2700-2710. doi: 10.1093/brain/awy183.

4.

The use of PrP transgenic Drosophila to replace and reduce vertebrate hosts in the bioassay of mammalian prion infectivity.

Thackray AM, Andréoletti O, Bujdoso R.

F1000Res. 2018 May 15;7:595. doi: 10.12688/f1000research.14753.1. eCollection 2018.

5.

Genetic human prion disease modelled in PrP transgenic Drosophila.

Thackray AM, Cardova A, Wolf H, Pradl L, Vorberg I, Jackson WS, Bujdoso R.

Biochem J. 2017 Sep 20;474(19):3253-3267. doi: 10.1042/BCJ20170462.

6.

Bioassay of prion-infected blood plasma in PrP transgenic Drosophila.

Thackray AM, Andreoletti O, Bujdoso R.

Biochem J. 2016 Dec 1;473(23):4399-4412. Epub 2016 Oct 12.

PMID:
27733649
7.

Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response.

Bujdoso R, Landgraf M, Jackson WS, Thackray AM.

World J Virol. 2015 Aug 12;4(3):188-97. doi: 10.5501/wjv.v4.i3.188. Review.

8.

Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP.

Yang S, Thackray AM, Hopkins L, Monie TP, Burke DF, Bujdoso R.

Biomed Res Int. 2014;2014:372491. doi: 10.1155/2014/372491. Epub 2014 Jul 14.

9.

Prion-induced and spontaneous formation of transmissible toxicity in PrP transgenic Drosophila.

Thackray AM, Di Y, Zhang C, Wolf H, Pradl L, Vorberg I, Andréoletti O, Bujdoso R.

Biochem J. 2014 Oct 1;463(1):31-40. doi: 10.1042/BJ20140129.

PMID:
25000212
10.

Cytosolic PrP can participate in prion-mediated toxicity.

Thackray AM, Zhang C, Arndt T, Bujdoso R.

J Virol. 2014 Jul;88(14):8129-38. doi: 10.1128/JVI.00732-14. Epub 2014 May 7.

11.

Single protein molecule detection by glass nanopores.

Li W, Bell NA, Hernández-Ainsa S, Thacker VV, Thackray AM, Bujdoso R, Keyser UF.

ACS Nano. 2013 May 28;7(5):4129-34. doi: 10.1021/nn4004567. Epub 2013 Apr 22.

PMID:
23607870
12.

Evidence for co-infection of ovine prion strains in classical scrapie isolates.

Thackray AM, Lockey R, Beck KE, Spiropoulos J, Bujdoso R.

J Comp Pathol. 2012 Aug-Oct;147(2-3):316-29. doi: 10.1016/j.jcpa.2012.01.009. Epub 2012 Apr 21.

PMID:
22522075
13.

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival.

Thackray AM, Muhammad F, Zhang C, Di Y, Jahn TR, Landgraf M, Crowther DC, Evers JF, Bujdoso R.

Biochem J. 2012 Jun 15;444(3):487-95. doi: 10.1042/BJ20112141.

PMID:
22435640
14.

Prion-induced toxicity in PrP transgenic Drosophila.

Thackray AM, Muhammad F, Zhang C, Denyer M, Spiropoulos J, Crowther DC, Bujdoso R.

Exp Mol Pathol. 2012 Apr;92(2):194-201. doi: 10.1016/j.yexmp.2012.01.005. Epub 2012 Jan 31.

PMID:
22314254
15.

Propagation of ovine prions from "poor" transmitter scrapie isolates in ovine PrP transgenic mice.

Thackray AM, Hopkins L, Lockey R, Spiropoulos J, Bujdoso R.

Exp Mol Pathol. 2012 Feb;92(1):167-74. doi: 10.1016/j.yexmp.2011.11.004. Epub 2011 Nov 19.

PMID:
22120785
16.

Emergence of multiple prion strains from single isolates of ovine scrapie.

Thackray AM, Hopkins L, Lockey R, Spiropoulos J, Bujdoso R.

J Gen Virol. 2011 Jun;92(Pt 6):1482-91. doi: 10.1099/vir.0.028886-0. Epub 2011 Jan 26.

PMID:
21270287
17.

Perturbation of T-cell development by insertional mutation of a PrP transgene.

Zabel M, Greenwood C, Thackray AM, Pulford B, Rens W, Bujdoso R.

Immunology. 2009 Jun;127(2):226-36. doi: 10.1111/j.1365-2567.2008.02944.x. Epub 2008 Oct 21.

18.

Molecular and transmission characteristics of primary-passaged ovine scrapie isolates in conventional and ovine PrP transgenic mice.

Thackray AM, Hopkins L, Spiropoulos J, Bujdoso R.

J Virol. 2008 Nov;82(22):11197-207. doi: 10.1128/JVI.01454-08. Epub 2008 Sep 3.

19.

Copper-induced structural changes in the ovine prion protein are influenced by a polymorphism at codon 112.

Yang S, Thackray AM, Fitzmaurice TJ, Bujdoso R.

Biochim Biophys Acta. 2008 Apr;1784(4):683-92. doi: 10.1016/j.bbapap.2008.01.011. Epub 2008 Jan 31.

PMID:
18280261
20.

The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2.

Fitzmaurice TJ, Burke DF, Hopkins L, Yang S, Yu S, Sy MS, Thackray AM, Bujdoso R.

Biochem J. 2008 Jan 15;409(2):367-75.

PMID:
17931166
21.

Mouse-adapted ovine scrapie prion strains are characterized by different conformers of PrPSc.

Thackray AM, Hopkins L, Klein MA, Bujdoso R.

J Virol. 2007 Nov;81(22):12119-27. Epub 2007 Aug 29.

22.
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24.

Elevated PrPC expression predisposes to increased HSV-1 pathogenicity.

Thackray AM, Bujdoso R.

Antivir Chem Chemother. 2006;17(1):41-52.

PMID:
16542005
25.
26.

Modification of blood cell PrP epitope exposure during prion disease.

Thackray AM, Ryder SJ, Bujdoso R.

Biochem J. 2005 Sep 1;390(Pt 2):563-71.

27.

Accelerated prion disease in the absence of interleukin-10.

Thackray AM, McKenzie AN, Klein MA, Lauder A, Bujdoso R.

J Virol. 2004 Dec;78(24):13697-707.

28.

Conformational variation between allelic variants of cell-surface ovine prion protein.

Thackray AM, Yang S, Wong E, Fitzmaurice TJ, Morgan-Warren RJ, Bujdoso R.

Biochem J. 2004 Jul 1;381(Pt 1):221-9.

30.

Subclinical prion disease induced by oral inoculation.

Thackray AM, Klein MA, Bujdoso R.

J Virol. 2003 Jul;77(14):7991-8.

31.
32.

Temporal pattern of herpes simplex virus type 1 infection and cell death in the mouse brain stem: influence of guanosine nucleoside analogues.

Shaw MM, Gürr WK, Thackray AM, Watts PA, Littler E, Field HJ.

J Virol Methods. 2002 Apr;102(1-2):93-102.

PMID:
11879697
33.

Chronic subclinical prion disease induced by low-dose inoculum.

Thackray AM, Klein MA, Aguzzi A, Bujdoso R.

J Virol. 2002 Mar;76(5):2510-7.

34.
35.

Metal imbalance and compromised antioxidant function are early changes in prion disease.

Thackray AM, Knight R, Haswell SJ, Bujdoso R, Brown DR.

Biochem J. 2002 Feb 15;362(Pt 1):253-8.

38.
39.

Early therapy with valaciclovir or famciclovir reduces but does not abrogate herpes simplex virus neuronal latency.

Field HJ, Thackray AM.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):461-70.

PMID:
10772727
40.
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45.

Comparison of efficacies of famciclovir and valaciclovir against herpes simplex virus type 1 in a murine immunosuppression model.

Field HJ, Tewari D, Sutton D, Thackray AM.

Antimicrob Agents Chemother. 1995 May;39(5):1114-9.

46.

The trigeminal ganglion is a location for equine herpesvirus 1 latency and reactivation in the horse.

Slater JD, Borchers K, Thackray AM, Field HJ.

J Gen Virol. 1994 Aug;75 ( Pt 8):2007-16.

PMID:
8046404
47.

The pathogenesis of wild type and drug resistant mutant strains of bovine herpesvirus-1 (BHV-1) in the natural host.

Gilliam SE, Thackray AM, Brown GA, Field HJ.

Arch Virol. 1993;128(1-2):43-54.

PMID:
8380324

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