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Successful sample preparation for serial crystallography experiments.

Beale JH, Bolton R, Marshall SA, Beale EV, Carr SB, Ebrahim A, Moreno-Chicano T, Hough MA, Worrall JAR, Tews I, Owen RL.

J Appl Crystallogr. 2019 Nov 14;52(Pt 6):1385-1396. doi: 10.1107/S1600576719013517. eCollection 2019 Dec 1.


Characterization of two putative Dichelobacter nodosus footrot vaccine antigens identifies the first lysozyme inhibitor in the genus.

Humbert MV, Jackson A, Orr CM, Tews I, Christodoulides M.

Sci Rep. 2019 Jul 11;9(1):10055. doi: 10.1038/s41598-019-46506-z.


On-Site Analysis of Bacterial Communities of the Ultraoligotrophic South Pacific Gyre.

Reintjes G, Tegetmeyer HE, Bürgisser M, Orlić S, Tews I, Zubkov M, Voß D, Zielinski O, Quast C, Glöckner FO, Amann R, Ferdelman TG, Fuchs BM.

Appl Environ Microbiol. 2019 Jul 1;85(14). pii: e00184-19. doi: 10.1128/AEM.00184-19. Print 2019 Jul 15.


Structure of the Recombinant Neisseria gonorrhoeae Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci.

Almonacid-Mendoza HL, Humbert MV, Dijokaite A, Cleary DW, Soo Y, Hung MC, Orr CM, Machelett MM, Tews I, Christodoulides M.

mSphere. 2018 Oct 10;3(5). pii: e00331-18. doi: 10.1128/mSphere.00331-18.


Structural and functional characterization of IdiA/FutA (Tery_3377), an iron-binding protein from the ocean diazotroph Trichodesmium erythraeum.

Polyviou D, Machelett MM, Hitchcock A, Baylay AJ, MacMillan F, Moore CM, Bibby TS, Tews I.

J Biol Chem. 2018 Nov 23;293(47):18099-18109. doi: 10.1074/jbc.RA118.001929. Epub 2018 Sep 14.


Evaluating Anti-CD32b F(ab) Conformation Using Molecular Dynamics and Small-Angle X-Ray Scattering.

Sutton EJ, Bradshaw RT, Orr CM, Frendéus B, Larsson G, Teige I, Cragg MS, Tews I, Essex JW.

Biophys J. 2018 Jul 17;115(2):289-299. doi: 10.1016/j.bpj.2018.03.040.


Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.

Yu X, Chan HTC, Orr CM, Dadas O, Booth SG, Dahal LN, Penfold CA, O'Brien L, Mockridge CI, French RR, Duriez P, Douglas LR, Pearson AR, Cragg MS, Tews I, Glennie MJ, White AL.

Cancer Cell. 2018 Apr 9;33(4):664-675.e4. doi: 10.1016/j.ccell.2018.02.009. Epub 2018 Mar 22.


CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains.

Chancellor A, Tocheva AS, Cave-Ayland C, Tezera L, White A, Al Dulayymi JR, Bridgeman JS, Tews I, Wilson S, Lissin NM, Tebruegge M, Marshall B, Sharpe S, Elliott T, Skylaris CK, Essex JW, Baird MS, Gadola S, Elkington P, Mansour S.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10956-E10964. doi: 10.1073/pnas.1708252114. Epub 2017 Nov 20.


Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases.

Bellini D, Horrell S, Hutchin A, Phippen CW, Strange RW, Cai Y, Wagner A, Webb JS, Tews I, Walsh MA.

Sci Rep. 2017 Feb 10;7:42166. doi: 10.1038/srep42166.


OX40: Structure and function - What questions remain?

Willoughby J, Griffiths J, Tews I, Cragg MS.

Mol Immunol. 2017 Mar;83:13-22. doi: 10.1016/j.molimm.2017.01.006. Epub 2017 Jan 13. Review.


Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis.

Rodrigues MJ, Windeisen V, Zhang Y, Guédez G, Weber S, Strohmeier M, Hanes JW, Royant A, Evans G, Sinning I, Ealick SE, Begley TP, Tews I.

Nat Chem Biol. 2017 Mar;13(3):290-294. doi: 10.1038/nchembio.2273. Epub 2017 Jan 16.


Chiral Three-Nucleon Interactions in Light Nuclei, Neutron-α Scattering, and Neutron Matter.

Lynn JE, Tews I, Carlson J, Gandolfi S, Gezerlis A, Schmidt KE, Schwenk A.

Phys Rev Lett. 2016 Feb 12;116(6):062501. doi: 10.1103/PhysRevLett.116.062501. Epub 2016 Feb 9.


Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.

Mansour S, Tocheva AS, Cave-Ayland C, Machelett MM, Sander B, Lissin NM, Molloy PE, Baird MS, Stübs G, Schröder NW, Schumann RR, Rademann J, Postle AD, Jakobsen BK, Marshall BG, Gosain R, Elkington PT, Elliott T, Skylaris CK, Essex JW, Tews I, Gadola SD.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1266-75. doi: 10.1073/pnas.1519246113. Epub 2016 Feb 16.


Two way street - complementary methods.

Tews I, Cooper J.

Acta Crystallogr D Biol Crystallogr. 2015 Jan 1;71(Pt 1):1-2. doi: 10.1107/S1399004714027321. Epub 2015 Jan 1. No abstract available.


Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator.

Phippen CW, Mikolajek H, Schlaefli HG, Keevil CW, Webb JS, Tews I.

FEBS Lett. 2014 Dec 20;588(24):4631-6. doi: 10.1016/j.febslet.2014.11.002. Epub 2014 Nov 11.


Quantum Monte Carlo calculations with chiral effective field theory interactions.

Gezerlis A, Tews I, Epelbaum E, Gandolfi S, Hebeler K, Nogga A, Schwenk A.

Phys Rev Lett. 2013 Jul 19;111(3):032501. Epub 2013 Jul 18.


Neutron matter at next-to-next-to-next-to-leading order in chiral effective field theory.

Tews I, Krüger T, Hebeler K, Schwenk A.

Phys Rev Lett. 2013 Jan 18;110(3):032504. Epub 2013 Jan 15.


Structure and conservation of the periplasmic targeting factor Tic22 protein from plants and cyanobacteria.

Tripp J, Hahn A, Koenig P, Flinner N, Bublak D, Brouwer EM, Ertel F, Mirus O, Sinning I, Tews I, Schleiff E.

J Biol Chem. 2012 Jul 13;287(29):24164-73. doi: 10.1074/jbc.M112.341644. Epub 2012 May 16.


Assembly of the eukaryotic PLP-synthase complex from Plasmodium and activation of the Pdx1 enzyme.

Guédez G, Hipp K, Windeisen V, Derrer B, Gengenbacher M, Böttcher B, Sinning I, Kappes B, Tews I.

Structure. 2012 Jan 11;20(1):172-84. doi: 10.1016/j.str.2011.11.015.


PLP-dependent enzymes as potential drug targets for protozoan diseases.

Kappes B, Tews I, Binter A, Macheroux P.

Biochim Biophys Acta. 2011 Nov;1814(11):1567-76. doi: 10.1016/j.bbapap.2011.07.018. Epub 2011 Jul 24. Review.


Pyridoxal phosphate: biosynthesis and catabolism.

Mukherjee T, Hanes J, Tews I, Ealick SE, Begley TP.

Biochim Biophys Acta. 2011 Nov;1814(11):1585-96. doi: 10.1016/j.bbapap.2011.06.018. Epub 2011 Jul 8. Review.


Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane.

Lupo D, Vollmer C, Deckers M, Mick DU, Tews I, Sinning I, Rehling P.

Traffic. 2011 Oct;12(10):1457-66. doi: 10.1111/j.1600-0854.2011.01239.x. Epub 2011 Jul 22.


Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33.

Oreb M, Höfle A, Koenig P, Sommer MS, Sinning I, Wang F, Tews I, Schnell DJ, Schleiff E.

Biochem J. 2011 Jun 1;436(2):313-9. doi: 10.1042/BJ20110246.


Defining the structural requirements for ribose 5-phosphate-binding and intersubunit cross-talk of the malarial pyridoxal 5-phosphate synthase.

Derrer B, Windeisen V, Guédez Rodríguez G, Seidler J, Gengenbacher M, Lehmann WD, Rippe K, Sinning I, Tews I, Kappes B.

FEBS Lett. 2010 Oct 8;584(19):4169-74. doi: 10.1016/j.febslet.2010.09.013. Epub 2010 Sep 17.


Conserved properties of polypeptide transport-associated (POTRA) domains derived from cyanobacterial Omp85.

Koenig P, Mirus O, Haarmann R, Sommer MS, Sinning I, Schleiff E, Tews I.

J Biol Chem. 2010 Jun 4;285(23):18016-24. doi: 10.1074/jbc.M110.112649. Epub 2010 Mar 26.


X-ray crystal structure of Saccharomyces cerevisiae Pdx1 provides insights into the oligomeric nature of PLP synthases.

Neuwirth M, Strohmeier M, Windeisen V, Wallner S, Deller S, Rippe K, Sinning I, Macheroux P, Tews I.

FEBS Lett. 2009 Jul 7;583(13):2179-86. doi: 10.1016/j.febslet.2009.06.009. Epub 2009 Jun 11.


Dissection of contributions from invariant amino acids to complex formation and catalysis in the heteromeric pyridoxal 5-phosphate synthase complex from Bacillus subtilis.

Wallner S, Neuwirth M, Flicker K, Tews I, Macheroux P.

Biochemistry. 2009 Mar 10;48(9):1928-35. doi: 10.1021/bi801887r.


pH sensitivity of the GTPase Toc33 as a regulatory circuit for protein translocation into chloroplasts.

Bionda T, Koenig P, Oreb M, Tews I, Schleiff E.

Plant Cell Physiol. 2008 Dec;49(12):1917-21. doi: 10.1093/pcp/pcn171. Epub 2008 Nov 10.


Structural basis for a distinct catalytic mechanism in Trypanosoma brucei tryparedoxin peroxidase.

Melchers J, Diechtierow M, Fehér K, Sinning I, Tews I, Krauth-Siegel RL, Muhle-Goll C.

J Biol Chem. 2008 Oct 31;283(44):30401-11. doi: 10.1074/jbc.M803563200. Epub 2008 Aug 6. Erratum in: J Biol Chem. 2011 Apr 29;286(17):15618.


On the significance of Toc-GTPase homodimers.

Koenig P, Oreb M, Rippe K, Muhle-Goll C, Sinning I, Schleiff E, Tews I.

J Biol Chem. 2008 Aug 22;283(34):23104-12. doi: 10.1074/jbc.M710576200. Epub 2008 Jun 8.


A direct role for phosphatidylinositol-4,5-bisphosphate in unconventional secretion of fibroblast growth factor 2.

Temmerman K, Ebert AD, Müller HM, Sinning I, Tews I, Nickel W.

Traffic. 2008 Jul;9(7):1204-17. doi: 10.1111/j.1600-0854.2008.00749.x. Epub 2008 Apr 16.


The GTPase cycle of the chloroplast import receptors Toc33/Toc34: implications from monomeric and dimeric structures.

Koenig P, Oreb M, Höfle A, Kaltofen S, Rippe K, Sinning I, Schleiff E, Tews I.

Structure. 2008 Apr;16(4):585-96. doi: 10.1016/j.str.2008.01.008.


Policing Tic 'n' Toc, the doorway to chloroplasts.

Oreb M, Tews I, Schleiff E.

Trends Cell Biol. 2008 Jan;18(1):19-27. Review.


Structural and thermodynamic insights into the assembly of the heteromeric pyridoxal phosphate synthase from Plasmodium falciparum.

Flicker K, Neuwirth M, Strohmeier M, Kappes B, Tews I, Macheroux P.

J Mol Biol. 2007 Nov 30;374(3):732-48. Epub 2007 Sep 20.


Two independent routes of de novo vitamin B6 biosynthesis: not that different after all.

Fitzpatrick TB, Amrhein N, Kappes B, Macheroux P, Tews I, Raschle T.

Biochem J. 2007 Oct 1;407(1):1-13. Review.


The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid.

Findeisen F, Linder JU, Schultz A, Schultz JE, Brügger B, Wieland F, Sinning I, Tews I.

J Mol Biol. 2007 Jun 22;369(5):1282-95. Epub 2007 Apr 12.


Functional analysis of PDX2 from Arabidopsis, a glutaminase involved in vitamin B6 biosynthesis.

Tambasco-Studart M, Tews I, Amrhein N, Fitzpatrick TB.

Plant Physiol. 2007 Jun;144(2):915-25. Epub 2007 Apr 27.


Thermodynamic characterization of the protein-protein interaction in the heteromeric Bacillus subtilis pyridoxalphosphate synthase.

Neuwirth M, Flicker K, Strohmeier M, Tews I, Macheroux P.

Biochemistry. 2007 May 1;46(17):5131-9. Epub 2007 Apr 5.


Structure of a bacterial pyridoxal 5'-phosphate synthase complex.

Strohmeier M, Raschle T, Mazurkiewicz J, Rippe K, Sinning I, Fitzpatrick TB, Tews I.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19284-9. Epub 2006 Dec 11.


Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv.

Abdel Motaal A, Tews I, Schultz JE, Linder JU.

FEBS J. 2006 Sep;273(18):4219-28. Epub 2006 Aug 21.


The molecular chaperone Hsp90 delivers precursor proteins to the chloroplast import receptor Toc64.

Qbadou S, Becker T, Mirus O, Tews I, Soll J, Schleiff E.

EMBO J. 2006 May 3;25(9):1836-47. Epub 2006 Apr 13.


Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights.

Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Müller S, Macheroux P, Tews I, Kappes B.

J Biol Chem. 2006 Feb 10;281(6):3633-41. Epub 2005 Dec 8.


Cell surface counter receptors are essential components of the unconventional export machinery of galectin-1.

Seelenmeyer C, Wegehingel S, Tews I, Künzler M, Aebi M, Nickel W.

J Cell Biol. 2005 Oct 24;171(2):373-81.


The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme.

Tews I, Findeisen F, Sinning I, Schultz A, Schultz JE, Linder JU.

Science. 2005 May 13;308(5724):1020-3.


Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A.

Lowe ED, Tews I, Cheng KY, Brown NR, Gul S, Noble ME, Gamblin SJ, Johnson LN.

Biochemistry. 2002 Dec 31;41(52):15625-34.


Impact of a plastid-bearing endocytobiont on apicomplexan genomes.

Sato S, Tews I, Wilson RJ.

Int J Parasitol. 2000 Apr 10;30(4):427-39. Review.


Structure-function studies on the chitinolytic enzymes of Serratia marcescens chitinase and chitobiase.

Vorgias CE, Perrakis A, Tews I.

Ann N Y Acad Sci. 1996 Oct 12;799:190-2. No abstract available.


Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease.

Tews I, Perrakis A, Oppenheim A, Dauter Z, Wilson KS, Vorgias CE.

Nat Struct Biol. 1996 Jul;3(7):638-48.


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