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Items: 1 to 50 of 241


Nrf2-modulation by seleno-hormetic agents and its potential for radiation protection.

Bartolini D, Tew KD, Marinelli R, Galli F, Wang GY.

Biofactors. 2019 Oct 16. doi: 10.1002/biof.1578. [Epub ahead of print] Review.


S-Glutathionylated Serine Proteinase Inhibitors as Biomarkers for Radiation Exposure in Prostate Cancer Patients.

Zhang L, Zhang J, Ye Z, Manevich Y, Townsend DM, Marshall DT, Tew KD.

Sci Rep. 2019 Sep 24;9(1):13792. doi: 10.1038/s41598-019-50288-9.


Racial disparities, cancer and response to oxidative stress.

Zhang J, Ye ZW, Townsend DM, Hughes-Halbert C, Tew KD.

Adv Cancer Res. 2019;144:343-383. doi: 10.1016/bs.acr.2019.03.012. Epub 2019 Apr 23.


Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1.

Zhang L, Zhang J, Ye Z, Manevich Y, Ball LE, Bethard JR, Jiang YL, Broome AM, Dalton AC, Wang GY, Townsend DM, Tew KD.

Cancer Res. 2019 Aug 15;79(16):4072-4085. doi: 10.1158/0008-5472.CAN-18-3503. Epub 2019 Jun 21.


Oxidative stress induces senescence in breast cancer stem cells.

Zhong G, Qin S, Townsend D, Schulte BA, Tew KD, Wang GY.

Biochem Biophys Res Commun. 2019 Jul 5;514(4):1204-1209. doi: 10.1016/j.bbrc.2019.05.098. Epub 2019 May 17.


A seleno-hormetine protects bone marrow hematopoietic cells against ionizing radiation-induced toxicities.

Bartolini D, Wang Y, Zhang J, Giustarini D, Rossi R, Wang GY, Torquato P, Townsend DM, Tew KD, Galli F.

PLoS One. 2019 Apr 29;14(4):e0205626. doi: 10.1371/journal.pone.0205626. eCollection 2019.


Pharmacology of ME-344, a novel cytotoxic isoflavone.

Zhang L, Zhang J, Ye Z, Townsend DM, Tew KD.

Adv Cancer Res. 2019;142:187-207. doi: 10.1016/bs.acr.2019.01.005. Epub 2019 Mar 6.


MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation.

Bräutigam L, Zhang J, Dreij K, Spahiu L, Holmgren A, Abe H, Tew KD, Townsend DM, Kelner MJ, Morgenstern R, Johansson K.

Redox Biol. 2018 Jul;17:171-179. doi: 10.1016/j.redox.2018.04.013. Epub 2018 Apr 16.


An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation.

Zhang J, Ye ZW, Singh S, Townsend DM, Tew KD.

Free Radic Biol Med. 2018 May 20;120:204-216. doi: 10.1016/j.freeradbiomed.2018.03.038. Epub 2018 Mar 23. Review.


S-Glutathionylation of estrogen receptor α affects dendritic cell function.

Zhang J, Ye ZW, Chen W, Manevich Y, Mehrotra S, Ball L, Janssen-Heininger Y, Tew KD, Townsend DM.

J Biol Chem. 2018 Mar 23;293(12):4366-4380. doi: 10.1074/jbc.M117.814327. Epub 2018 Jan 26.


ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target.

Davis W Jr, Tew KD.

Biochem Pharmacol. 2018 May;151:188-200. doi: 10.1016/j.bcp.2017.11.018. Epub 2017 Dec 6. Review.



Tew KD, Galli F.

Adv Cancer Res. 2017;136:xi-xiv. doi: 10.1016/S0065-230X(17)30046-5. No abstract available.


Selenocompounds in Cancer Therapy: An Overview.

Bartolini D, Sancineto L, Fabro de Bem A, Tew KD, Santi C, Radi R, Toquato P, Galli F.

Adv Cancer Res. 2017;136:259-302. doi: 10.1016/bs.acr.2017.07.007. Epub 2017 Sep 28. Review.


MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer.

Yang A, Qin S, Schulte BA, Ethier SP, Tew KD, Wang GY.

Cancer Res. 2017 Dec 1;77(23):6641-6650. doi: 10.1158/0008-5472.CAN-16-3452. Epub 2017 Sep 26.


Commentary on "Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents".

Tew KD.

Cancer Res. 2016 Sep 1;76(17):4916-7. doi: 10.1158/0008-5472.CAN-16-1974.


Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM.

JCI Insight. 2016 Jun 2;1(8). pii: 85717. doi: 10.1172/jci.insight.85717.


Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344.

Manevich Y, Reyes L, Britten CD, Townsend DM, Tew KD.

J Pharmacol Exp Ther. 2016 Aug;358(2):199-208. doi: 10.1124/jpet.115.229344. Epub 2016 Jun 2.


Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells.

van Gisbergen MW, Cebula M, Zhang J, Ottosson-Wadlund A, Dubois L, Lambin P, Tew KD, Townsend DM, Haenen GR, Drittij-Reijnders MJ, Saneyoshi H, Araki M, Shishido Y, Ito Y, Arnér ES, Abe H, Morgenstern R, Johansson K.

Mol Pharm. 2016 Jun 6;13(6):2010-25. doi: 10.1021/acs.molpharmaceut.6b00140. Epub 2016 Apr 28.


Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells.

Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM.

Redox Biol. 2016 Aug;8:375-82. doi: 10.1016/j.redox.2016.03.005. Epub 2016 Mar 26.


Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response.

Ye ZW, Zhang J, Ancrum T, Manevich Y, Townsend DM, Tew KD.

Antioxid Redox Signal. 2017 Feb 20;26(6):247-261. doi: 10.1089/ars.2015.6486. Epub 2016 Mar 16.


Glutathione-Associated Enzymes In Anticancer Drug Resistance.

Tew KD.

Cancer Res. 2016 Jan 1;76(1):7-9. doi: 10.1158/0008-5472.CAN-15-3143. Epub 2016 Jan 3. No abstract available.


Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase.

Kenche H, Ye ZW, Vedagiri K, Richards DM, Gao XH, Tew KD, Townsend DM, Blumental-Perry A.

J Biol Chem. 2016 Feb 26;291(9):4763-78. doi: 10.1074/jbc.M115.712331. Epub 2016 Jan 4.


S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide.

Grek CL, Reyes L, Townsend DM, Tew KD.

BBA Clin. 2014 Sep 3;2:31-9. doi: 10.1016/j.bbacli.2014.08.003. eCollection 2014 Dec.


Editor's Note.

Tew KD.

J Pharmacol Exp Ther. 2016 Jan;356(1):1. doi: 10.1124/jpet.115.230847. No abstract available.


Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation.

Bartolini D, Piroddi M, Tidei C, Giovagnoli S, Pietrella D, Manevich Y, Tew KD, Giustarini D, Rossi R, Townsend DM, Santi C, Galli F.

Free Radic Biol Med. 2015 Jan;78:56-65. doi: 10.1016/j.freeradbiomed.2014.10.008. Epub 2014 Oct 18.


Oxidative stress, redox regulation and diseases of cellular differentiation.

Ye ZW, Zhang J, Townsend DM, Tew KD.

Biochim Biophys Acta. 2015 Aug;1850(8):1607-21. doi: 10.1016/j.bbagen.2014.11.010. Epub 2014 Nov 15. Review.


Glutathione S-transferase P influences redox and migration pathways in bone marrow.

Zhang J, Ye ZW, Gao P, Reyes L, Jones EE, Branham-O'Connor M, Blumer JB, Drake RR, Manevich Y, Townsend DM, Tew KD.

PLoS One. 2014 Sep 12;9(9):e107478. doi: 10.1371/journal.pone.0107478. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0119266.


Pleiotropic functions of glutathione S-transferase P.

Zhang J, Grek C, Ye ZW, Manevich Y, Tew KD, Townsend DM.

Adv Cancer Res. 2014;122:143-75. doi: 10.1016/B978-0-12-420117-0.00004-9.


Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome.

Manevich Y, Hutchens S, Halushka PV, Tew KD, Townsend DM, Jauch EC, Borg K.

Free Radic Biol Med. 2014 Jul;72:210-21. doi: 10.1016/j.freeradbiomed.2014.04.002. Epub 2014 Apr 12.


Causes and consequences of cysteine S-glutathionylation.

Grek CL, Zhang J, Manevich Y, Townsend DM, Tew KD.

J Biol Chem. 2013 Sep 13;288(37):26497-504. doi: 10.1074/jbc.R113.461368. Epub 2013 Jul 16. Review.


Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation.

Manevich Y, Hutchens S, Tew KD, Townsend DM.

Free Radic Biol Med. 2013 Jan;54:62-70. doi: 10.1016/j.freeradbiomed.2012.10.556. Epub 2012 Nov 6.


Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility.

Bowers RR, Manevich Y, Townsend DM, Tew KD.

Biochemistry. 2012 Oct 2;51(39):7740-54. doi: 10.1021/bi301006w. Epub 2012 Sep 19.


Ablation of the ATP-binding cassette transporter, Abca2 modifies response to estrogen-based therapies.

Mack JT, Brown CB, Garrett TE, Uys JD, Townsend DM, Tew KD.

Biomed Pharmacother. 2012 Sep;66(6):403-8. doi: 10.1016/j.biopha.2012.06.007. Epub 2012 Jul 2.


Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain.

Grünewald E, Tew KD, Porteous DJ, Thomson PA.

ACS Chem Neurosci. 2012 Jun 20;3(6):459-72. doi: 10.1021/cn300008p. Epub 2012 Apr 15.


Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis.

Anathy V, Roberson E, Cunniff B, Nolin JD, Hoffman S, Spiess P, Guala AS, Lahue KG, Goldman D, Flemer S, van der Vliet A, Heintz NH, Budd RC, Tew KD, Janssen-Heininger YM.

Mol Cell Biol. 2012 Sep;32(17):3464-78. doi: 10.1128/MCB.00125-12. Epub 2012 Jul 2.


Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice.

Calpe-Berdiel L, Zhao Y, de Graauw M, Ye D, van Santbrink PJ, Mommaas AM, Foks A, Bot M, Meurs I, Kuiper J, Mack JT, Van Eck M, Tew KD, van Berkel TJ.

Atherosclerosis. 2012 Aug;223(2):332-41. doi: 10.1016/j.atherosclerosis.2012.05.039. Epub 2012 Jun 12.


S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor α Stability and Function.

Xiong Y, Manevich Y, Tew KD, Townsend DM.

Int J Cell Biol. 2012;2012:273549. doi: 10.1155/2012/273549. Epub 2012 May 13.


Glutathione-s-transferases as determinants of cell survival and death.

Tew KD, Townsend DM.

Antioxid Redox Signal. 2012 Dec 15;17(12):1728-37. doi: 10.1089/ars.2012.4640. Epub 2012 Jun 13. Review.


S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs.

Grek CL, Townsend DM, Uys JD, Manevich Y, Coker WJ 3rd, Pazoles CJ, Tew KD.

Cancer Res. 2012 May 1;72(9):2383-93. doi: 10.1158/0008-5472.CAN-11-4088. Epub 2012 Mar 8.


NrF2 ⁄Keap1 as gatekeepers of redox homeostasis – do they prevent or cause cancer?

Tew KD.

Pigment Cell Melanoma Res. 2011 Dec;24(6):1078-9. doi: 10.1111/j.1755-148X.2011.00913.x. No abstract available.


Drug resistance in cancer. Editorial.

Tew KD.

Biochem Pharmacol. 2012 Apr 15;83(8):985-6. doi: 10.1016/j.bcp.2011.11.023. Epub 2011 Nov 29. No abstract available.


Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.

Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T.

J Biol Chem. 2012 Jan 6;287(2):1100-11. doi: 10.1074/jbc.M111.288258. Epub 2011 Nov 15.


Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity.

Uys JD, Knackstedt L, Hurt P, Tew KD, Manevich Y, Hutchens S, Townsend DM, Kalivas PW.

Neuropsychopharmacology. 2011 Nov;36(12):2551-60. doi: 10.1038/npp.2011.143. Epub 2011 Jul 27.


The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer.

Tew KD, Manevich Y, Grek C, Xiong Y, Uys J, Townsend DM.

Free Radic Biol Med. 2011 Jul 15;51(2):299-313. doi: 10.1016/j.freeradbiomed.2011.04.013. Epub 2011 Apr 22. Review.


Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification.

Tew KD, Townsend DM.

Drug Metab Rev. 2011 May;43(2):179-93. doi: 10.3109/03602532.2011.552912. Epub 2011 Feb 25. Review.


S-glutathionylation: from molecular mechanisms to health outcomes.

Xiong Y, Uys JD, Tew KD, Townsend DM.

Antioxid Redox Signal. 2011 Jul 1;15(1):233-70. doi: 10.1089/ars.2010.3540. Epub 2011 May 25. Review.


Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase.

Manevich Y, Townsend DM, Hutchens S, Tew KD.

PLoS One. 2010 Nov 30;5(11):e14151. doi: 10.1371/journal.pone.0014151.


Redox platforms in cancer drug discovery and development.

Tew KD, Townsend DM.

Curr Opin Chem Biol. 2011 Feb;15(1):156-61. doi: 10.1016/j.cbpa.2010.10.016. Epub 2010 Nov 11. Review.


ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration.

Mack JT, Helke KL, Normand G, Green C, Townsend DM, Tew KD.

Cancer Lett. 2011 Jan 28;300(2):154-61. doi: 10.1016/j.canlet.2010.09.017. Epub 2010 Oct 30.


The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies.

Grek CL, Townsend DM, Tew KD.

Pharmacol Ther. 2011 Feb;129(2):172-84. doi: 10.1016/j.pharmthera.2010.09.008. Epub 2010 Oct 15. Review.

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