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ReVac: a reverse vaccinology computational pipeline for prioritization of prokaryotic protein vaccine candidates.

D'Mello A, Ahearn CP, Murphy TF, Tettelin H.

BMC Genomics. 2019 Dec 16;20(1):981. doi: 10.1186/s12864-019-6195-y.


Differential functional patterns of memory CD4+ and CD8+ T-cells from volunteers immunized with Ty21a typhoid vaccine observed using a recombinant Escherichia coli system expressing S. Typhi proteins.

Salerno-Gonçalves R, Tettelin H, Luo D, Guo Q, Ardito MT, Martin WD, De Groot AS, Sztein MB.

Vaccine. 2020 Jan 10;38(2):258-270. doi: 10.1016/j.vaccine.2019.10.020. Epub 2019 Oct 16.


Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination.

Campo JJ, Le TQ, Pablo JV, Hung C, Teng AA, Tettelin H, Tate A, Hanage WP, Alderson MR, Liang X, Malley R, Lipsitch M, Croucher NJ.

Elife. 2018 Dec 28;7. pii: e37015. doi: 10.7554/eLife.37015.


Using Core Genome Alignments To Assign Bacterial Species.

Chung M, Munro JB, Tettelin H, Dunning Hotopp JC.

mSystems. 2018 Dec 4;3(6). pii: e00236-18. doi: 10.1128/mSystems.00236-18. eCollection 2018 Nov-Dec.


Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperone protein, has broad oncogenic properties.

Zella D, Curreli S, Benedetti F, Krishnan S, Cocchi F, Latinovic OS, Denaro F, Romerio F, Djavani M, Charurat ME, Bryant JL, Tettelin H, Gallo RC.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12005-E12014. doi: 10.1073/pnas.1815660115. Epub 2018 Dec 3. Erratum in: Proc Natl Acad Sci U S A. 2019 Jan 7;:.


Persistence of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease and Regulation of the Hag/MID Adhesin.

Murphy TF, Brauer AL, Pettigrew MM, LaFontaine ER, Tettelin H.

J Infect Dis. 2019 Apr 16;219(9):1448-1455. doi: 10.1093/infdis/jiy680.


Changes in IgA Protease Expression Are Conferred by Changes in Genomes during Persistent Infection by Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease.

Gallo MC, Kirkham C, Eng S, Bebawee RS, Kong Y, Pettigrew MM, Tettelin H, Murphy TF.

Infect Immun. 2018 Jul 23;86(8). pii: e00313-18. doi: 10.1128/IAI.00313-18. Print 2018 Aug.


Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease.

Pettigrew MM, Ahearn CP, Gent JF, Kong Y, Gallo MC, Munro JB, D'Mello A, Sethi S, Tettelin H, Murphy TF.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):E3256-E3265. doi: 10.1073/pnas.1719654115. Epub 2018 Mar 19.


The Streptococcus agalactiae Stringent Response Enhances Virulence and Persistence in Human Blood.

Hooven TA, Catomeris AJ, Bonakdar M, Tallon LJ, Santana-Cruz I, Ott S, Daugherty SC, Tettelin H, Ratner AJ.

Infect Immun. 2017 Dec 19;86(1). pii: e00612-17. doi: 10.1128/IAI.00612-17. Print 2018 Jan.


Whole-Genome Sequences of Bacteremia Isolates of Bordetella holmesii.

Tettelin H, Hooven TA, Zhao X, Su Q, Sadzewicz L, Tallon LJ, Fraser CM, Ratner AJ.

Genome Announc. 2017 Sep 28;5(39). pii: e01023-17. doi: 10.1128/genomeA.01023-17.


Use of a novel antigen expressing system to study the Salmonella enterica serovar Typhi protein recognition by T cells.

Salerno-Gonçalves R, Tettelin H, Lou D, Steiner S, Rezwanul T, Guo Q, Picking WD, Nene V, Sztein MB.

PLoS Negl Trop Dis. 2017 Sep 5;11(9):e0005912. doi: 10.1371/journal.pntd.0005912. eCollection 2017 Sep.


Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.

Shenoy AT, Brissac T, Gilley RP, Kumar N, Wang Y, Gonzalez-Juarbe N, Hinkle WS, Daugherty SC, Shetty AC, Ott S, Tallon LJ, Deshane J, Tettelin H, Orihuela CJ.

PLoS Pathog. 2017 Aug 25;13(8):e1006582. doi: 10.1371/journal.ppat.1006582. eCollection 2017 Aug.


Genome-wide discovery of novel M1T1 group A streptococcal determinants important for fitness and virulence during soft-tissue infection.

Le Breton Y, Belew AT, Freiberg JA, Sundar GS, Islam E, Lieberman J, Shirtliff ME, Tettelin H, El-Sayed NM, McIver KS.

PLoS Pathog. 2017 Aug 23;13(8):e1006584. doi: 10.1371/journal.ppat.1006584. eCollection 2017 Aug.


Whole-Exome Sequencing Identifies the 6q12-q16 Linkage Region and a Candidate Gene, TTK, for Pulmonary Nontuberculous Mycobacterial Disease.

Chen F, Szymanski EP, Olivier KN, Liu X, Tettelin H, Holland SM, Duggal P.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1599-1604. doi: 10.1164/rccm.201612-2479OC.


CloVR-Comparative: automated, cloud-enabled comparative microbial genome sequence analysis pipeline.

Agrawal S, Arze C, Adkins RS, Crabtree J, Riley D, Vangala M, Galens K, Fraser CM, Tettelin H, White O, Angiuoli SV, Mahurkar A, Fricke WF.

BMC Genomics. 2017 Apr 27;18(1):332. doi: 10.1186/s12864-017-3717-3.


A comparative study of Cutibacterium (Propionibacterium) acnes clones from acne patients and healthy controls.

Lomholt HB, Scholz CFP, Brüggemann H, Tettelin H, Kilian M.

Anaerobe. 2017 Oct;47:57-63. doi: 10.1016/j.anaerobe.2017.04.006. Epub 2017 Apr 19.


Complete Genome Sequences of Mycobacterium kansasii Strains Isolated from Rhesus Macaques.

Panda A, Nagaraj S, Zhao X, Tettelin H, DeTolla LJ.

Genome Announc. 2017 Apr 20;5(16). pii: e00187-17. doi: 10.1128/genomeA.00187-17.


Transcriptional organization of pneumococcal psrP-secY2A2 and impact of GtfA and GtfB deletion on PsrP-associated virulence properties.

Lizcano A, Akula Suresh Babu R, Shenoy AT, Saville AM, Kumar N, D'Mello A, Hinojosa CA, Gilley RP, Segovia J, Mitchell TJ, Tettelin H, Orihuela CJ.

Microbes Infect. 2017 Jun;19(6):323-333. doi: 10.1016/j.micinf.2017.04.001. Epub 2017 Apr 10.


Capsular Polysaccharide Expression in Commensal Streptococcus Species: Genetic and Antigenic Similarities to Streptococcus pneumoniae.

Skov Sørensen UB, Yao K, Yang Y, Tettelin H, Kilian M.

mBio. 2016 Nov 15;7(6). pii: e01844-16. doi: 10.1128/mBio.01844-16.


In-silico prediction and deep-DNA sequencing validation indicate phase variation in 115 Neisseria meningitidis genes.

Siena E, D'Aurizio R, Riley D, Tettelin H, Guidotti S, Torricelli G, Moxon ER, Medini D.

BMC Genomics. 2016 Oct 28;17(1):843.


Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization.

Blanchette KA, Shenoy AT, Milner J 2nd, Gilley RP, McClure E, Hinojosa CA, Kumar N, Daugherty SC, Tallon LJ, Ott S, King SJ, Ferreira DM, Gordon SB, Tettelin H, Orihuela CJ.

Infect Immun. 2016 Sep 19;84(10):2922-32. doi: 10.1128/IAI.00277-16. Print 2016 Oct.


The essential genome of Streptococcus agalactiae.

Hooven TA, Catomeris AJ, Akabas LH, Randis TM, Maskell DJ, Peters SE, Ott S, Santana-Cruz I, Tallon LJ, Tettelin H, Ratner AJ.

BMC Genomics. 2016 May 26;17:406. doi: 10.1186/s12864-016-2741-z.


Genome stability of Propionibacterium acnes: a comprehensive study of indels and homopolymeric tracts.

Scholz CF, Brüggemann H, Lomholt HB, Tettelin H, Kilian M.

Sci Rep. 2016 Feb 9;6:20662. doi: 10.1038/srep20662.


Clonal Diversification and Changes in Lipid Traits and Colony Morphology in Mycobacterium abscessus Clinical Isolates.

Park IK, Hsu AP, Tettelin H, Shallom SJ, Drake SK, Ding L, Wu UI, Adamo N, Prevots DR, Olivier KN, Holland SM, Sampaio EP, Zelazny AM.

J Clin Microbiol. 2015 Nov;53(11):3438-47. doi: 10.1128/JCM.02015-15. Epub 2015 Aug 19.


Pulmonary Nontuberculous Mycobacterial Infection. A Multisystem, Multigenic Disease.

Szymanski EP, Leung JM, Fowler CJ, Haney C, Hsu AP, Chen F, Duggal P, Oler AJ, McCormack R, Podack E, Drummond RA, Lionakis MS, Browne SK, Prevots DR, Knowles M, Cutting G, Liu X, Devine SE, Fraser CM, Tettelin H, Olivier KN, Holland SM.

Am J Respir Crit Care Med. 2015 Sep 1;192(5):618-28. doi: 10.1164/rccm.201502-0387OC.


Essential Genes in the Core Genome of the Human Pathogen Streptococcus pyogenes.

Le Breton Y, Belew AT, Valdes KM, Islam E, Curry P, Tettelin H, Shirtliff ME, El-Sayed NM, McIver KS.

Sci Rep. 2015 May 21;5:9838. doi: 10.1038/srep09838.


Genomic analysis reveals the molecular basis for capsule loss in the group B Streptococcus population.

Rosini R, Campisi E, De Chiara M, Tettelin H, Rinaudo D, Toniolo C, Metruccio M, Guidotti S, Sørensen UB, Kilian M; DEVANI Consortium, Ramirez M, Janulczyk R, Donati C, Grandi G, Margarit I.

PLoS One. 2015 May 6;10(5):e0125985. doi: 10.1371/journal.pone.0125985. eCollection 2015.


Composite mobile genetic elements disseminating macrolide resistance in Streptococcus pneumoniae.

Chancey ST, Agrawal S, Schroeder MR, Farley MM, Tettelin H, Stephens DS.

Front Microbiol. 2015 Feb 9;6:26. doi: 10.3389/fmicb.2015.00026. eCollection 2015.


Transcriptional attenuation controls macrolide inducible efflux and resistance in Streptococcus pneumoniae and in other Gram-positive bacteria containing mef/mel(msr(D)) elements.

Chancey ST, Bai X, Kumar N, Drabek EF, Daugherty SC, Colon T, Ott S, Sengamalay N, Sadzewicz L, Tallon LJ, Fraser CM, Tettelin H, Stephens DS.

PLoS One. 2015 Feb 19;10(2):e0116254. doi: 10.1371/journal.pone.0116254. eCollection 2015.


Complete Genome Sequence of Streptococcus agalactiae CNCTC 10/84, a Hypervirulent Sequence Type 26 Strain.

Hooven TA, Randis TM, Daugherty SC, Narechania A, Planet PJ, Tettelin H, Ratner AJ.

Genome Announc. 2014 Dec 24;2(6). pii: e01338-14. doi: 10.1128/genomeA.01338-14.


Ten years of pan-genome analyses.

Vernikos G, Medini D, Riley DR, Tettelin H.

Curr Opin Microbiol. 2015 Feb;23:148-54. doi: 10.1016/j.mib.2014.11.016. Epub 2014 Dec 5. Review.


Molecular epidemiology and genomics of group A Streptococcus.

Bessen DE, McShan WM, Nguyen SV, Shetty A, Agrawal S, Tettelin H.

Infect Genet Evol. 2015 Jul;33:393-418. doi: 10.1016/j.meegid.2014.10.011. Epub 2014 Oct 30. Review.


Parallel evolution of Streptococcus pneumoniae and Streptococcus mitis to pathogenic and mutualistic lifestyles.

Kilian M, Riley DR, Jensen A, Brüggemann H, Tettelin H.

mBio. 2014 Jul 22;5(4):e01490-14. doi: 10.1128/mBio.01490-14.


Standardized metadata for human pathogen/vector genomic sequences.

Dugan VG, Emrich SJ, Giraldo-Calderón GI, Harb OS, Newman RM, Pickett BE, Schriml LM, Stockwell TB, Stoeckert CJ Jr, Sullivan DE, Singh I, Ward DV, Yao A, Zheng J, Barrett T, Birren B, Brinkac L, Bruno VM, Caler E, Chapman S, Collins FH, Cuomo CA, Di Francesco V, Durkin S, Eppinger M, Feldgarden M, Fraser C, Fricke WF, Giovanni M, Henn MR, Hine E, Hotopp JD, Karsch-Mizrachi I, Kissinger JC, Lee EM, Mathur P, Mongodin EF, Murphy CI, Myers G, Neafsey DE, Nelson KE, Nierman WC, Puzak J, Rasko D, Roos DS, Sadzewicz L, Silva JC, Sobral B, Squires RB, Stevens RL, Tallon L, Tettelin H, Wentworth D, White O, Will R, Wortman J, Zhang Y, Scheuermann RH.

PLoS One. 2014 Jun 17;9(6):e99979. doi: 10.1371/journal.pone.0099979. eCollection 2014.


High-level relatedness among Mycobacterium abscessus subsp. massiliense strains from widely separated outbreaks.

Tettelin H, Davidson RM, Agrawal S, Aitken ML, Shallom S, Hasan NA, Strong M, de Moura VC, De Groote MA, Duarte RS, Hine E, Parankush S, Su Q, Daugherty SC, Fraser CM, Brown-Elliott BA, Wallace RJ Jr, Holland SM, Sampaio EP, Olivier KN, Jackson M, Zelazny AM.

Emerg Infect Dis. 2014 Mar;20(3):364-71. doi: 10.3201/eid2003.131106.


Genome Sequences of Two Pathogenic Streptococcus agalactiae Isolates from the One-Humped Camel Camelus dromedarius.

Zubair S, de Villiers EP, Younan M, Andersson G, Tettelin H, Riley DR, Jores J, Bongcam-Rudloff E, Bishop RP.

Genome Announc. 2013 Jul 18;1(4). pii: e00515-13. doi: 10.1128/genomeA.00515-13.


New rapid scheme for distinguishing the subspecies of the Mycobacterium abscessus group and identifying Mycobacterium massiliense isolates with inducible clarithromycin resistance.

Shallom SJ, Gardina PJ, Myers TG, Sebastian Y, Conville P, Calhoun LB, Tettelin H, Olivier KN, Uzel G, Sampaio EP, Holland SM, Zelazny AM.

J Clin Microbiol. 2013 Sep;51(9):2943-9. doi: 10.1128/JCM.01132-13. Epub 2013 Jun 26.


Phenotypic, genomic, and transcriptional characterization of Streptococcus pneumoniae interacting with human pharyngeal cells.

Kimaro Mlacha SZ, Romero-Steiner S, Hotopp JC, Kumar N, Ishmael N, Riley DR, Farooq U, Creasy TH, Tallon LJ, Liu X, Goldsmith CS, Sampson J, Carlone GM, Hollingshead SK, Scott JA, Tettelin H.

BMC Genomics. 2013 Jun 9;14:383. doi: 10.1186/1471-2164-14-383.


Transcriptional adaptation of pneumococci and human pharyngeal cells in the presence of a virus infection.

Kimaro Mlacha SZ, Peret TC, Kumar N, Romero-Steiner S, Dunning Hotopp JC, Ishmael N, Grinblat-Huse V, Riley DR, Erdman DD, Carlone GM, Sampson J, Scott JA, Tettelin H.

BMC Genomics. 2013 Jun 7;14:378. doi: 10.1186/1471-2164-14-378.


The two-component response regulator LiaR regulates cell wall stress responses, pili expression and virulence in group B Streptococcus.

Klinzing DC, Ishmael N, Hotopp JCD, Tettelin H, Shields KR, Madoff LC, Puopolo KM.

Microbiology. 2013 Jul;159(Pt 7):1521-1534. doi: 10.1099/mic.0.064444-0. Epub 2013 May 23.


Genome-wide identification of genes required for fitness of group A Streptococcus in human blood.

Le Breton Y, Mistry P, Valdes KM, Quigley J, Kumar N, Tettelin H, McIver KS.

Infect Immun. 2013 Mar;81(3):862-75. doi: 10.1128/IAI.00837-12. Epub 2013 Jan 7.


Genomic insights into the emerging human pathogen Mycobacterium massiliense.

Tettelin H, Sampaio EP, Daugherty SC, Hine E, Riley DR, Sadzewicz L, Sengamalay N, Shefchek K, Su Q, Tallon LJ, Conville P, Olivier KN, Holland SM, Fraser CM, Zelazny AM.

J Bacteriol. 2012 Oct;194(19):5450. doi: 10.1128/JB.01200-12.


Whole genome sequencing to investigate the emergence of clonal complex 23 Neisseria meningitidis serogroup Y disease in the United States.

Krauland MG, Dunning Hotopp JC, Riley DR, Daugherty SC, Marsh JW, Messonnier NE, Mayer LW, Tettelin H, Harrison LH.

PLoS One. 2012;7(4):e35699. doi: 10.1371/journal.pone.0035699. Epub 2012 Apr 27.


CRISPR/cas loci of type II Propionibacterium acnes confer immunity against acquisition of mobile elements present in type I P. acnes.

Brüggemann H, Lomholt HB, Tettelin H, Kilian M.

PLoS One. 2012;7(3):e34171. doi: 10.1371/journal.pone.0034171. Epub 2012 Mar 30.


Differences in genotype and virulence among four multidrug-resistant Streptococcus pneumoniae isolates belonging to the PMEN1 clone.

Hiller NL, Eutsey RA, Powell E, Earl JP, Janto B, Martin DP, Dawid S, Ahmed A, Longwell MJ, Dahlgren ME, Ezzo S, Tettelin H, Daugherty SC, Mitchell TJ, Hillman TA, Buchinsky FJ, Tomasz A, de Lencastre H, Sá-Leão R, Post JC, Hu FZ, Ehrlich GD.

PLoS One. 2011;6(12):e28850. doi: 10.1371/journal.pone.0028850. Epub 2011 Dec 19.


Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production.

Sanchez CJ, Kumar N, Lizcano A, Shivshankar P, Dunning Hotopp JC, Jorgensen JH, Tettelin H, Orihuela CJ.

PLoS One. 2011;6(12):e28738. doi: 10.1371/journal.pone.0028738. Epub 2011 Dec 8.


Using Sybil for interactive comparative genomics of microbes on the web.

Riley DR, Angiuoli SV, Crabtree J, Dunning Hotopp JC, Tettelin H.

Bioinformatics. 2012 Jan 15;28(2):160-6. doi: 10.1093/bioinformatics/btr652. Epub 2011 Nov 24.


Whole-genome association study on tissue tropism phenotypes in group A Streptococcus.

Bessen DE, Kumar N, Hall GS, Riley DR, Luo F, Lizano S, Ford CN, McShan WM, Nguyen SV, Dunning Hotopp JC, Tettelin H.

J Bacteriol. 2011 Dec;193(23):6651-63. doi: 10.1128/JB.05263-11. Epub 2011 Sep 23.

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